Folliculin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Folliculin

Gene product:

Vesicle coat protein involved in Golgi to plasma membrane transport, putative

Species:

Leishmania major

UniProt:

E9AE42_LEIMA

TriTrypDb:

LmjF.29.1810 , LMJLV39_290025600 , LMJSD75_290025800

Length:

613

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0005765	lysosomal membrane	7	2
GO:0005774	vacuolar membrane	5	2
GO:0005815	microtubule organizing center	2	2
GO:0005819	spindle	5	2
GO:0005829	cytosol	2	2
GO:0005929	cilium	4	2
GO:0016020	membrane	2	2
GO:0031090	organelle membrane	3	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0098588	bounding membrane of organelle	4	2
GO:0098852	lytic vacuole membrane	6	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

E9AE42

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE42

Function

Biological processes
Term	Name	Level	Count
GO:0009966	regulation of signal transduction	4	2
GO:0009967	positive regulation of signal transduction	5	2
GO:0010646	regulation of cell communication	4	2
GO:0010647	positive regulation of cell communication	5	2
GO:0023051	regulation of signaling	3	2
GO:0023056	positive regulation of signaling	4	2
GO:0032006	regulation of TOR signaling	6	2
GO:0032008	positive regulation of TOR signaling	7	2
GO:0043085	positive regulation of catalytic activity	4	2
GO:0043087	regulation of GTPase activity	5	2
GO:0043547	positive regulation of GTPase activity	6	2
GO:0044093	positive regulation of molecular function	3	2
GO:0048518	positive regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0048583	regulation of response to stimulus	3	2
GO:0048584	positive regulation of response to stimulus	4	2
GO:0050789	regulation of biological process	2	2
GO:0050790	regulation of catalytic activity	3	2
GO:0050794	regulation of cellular process	3	2
GO:0051336	regulation of hydrolase activity	4	2
GO:0051345	positive regulation of hydrolase activity	5	2
GO:0065007	biological regulation	1	2
GO:0065009	regulation of molecular function	2	2
GO:1902531	regulation of intracellular signal transduction	5	2
GO:1902533	positive regulation of intracellular signal transduction	6	2
GO:1903432	regulation of TORC1 signaling	7	2
GO:1904263	positive regulation of TORC1 signaling	8	2

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	10
GO:0008047	enzyme activator activity	3	10
GO:0030234	enzyme regulator activity	2	10
GO:0030695	GTPase regulator activity	4	10
GO:0060589	nucleoside-triphosphatase regulator activity	3	10
GO:0098772	molecular function regulator activity	1	10
GO:0140677	molecular function activator activity	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.498
CLV_C14_Caspase3-7	188	192	PF00656	0.502
CLV_NRD_NRD_1	114	116	PF00675	0.271
CLV_NRD_NRD_1	144	146	PF00675	0.390
CLV_NRD_NRD_1	172	174	PF00675	0.382
CLV_NRD_NRD_1	369	371	PF00675	0.204
CLV_NRD_NRD_1	423	425	PF00675	0.511
CLV_PCSK_KEX2_1	113	115	PF00082	0.272
CLV_PCSK_KEX2_1	144	146	PF00082	0.318
CLV_PCSK_KEX2_1	172	174	PF00082	0.351
CLV_PCSK_KEX2_1	369	371	PF00082	0.303
CLV_PCSK_KEX2_1	423	425	PF00082	0.511
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.289
CLV_PCSK_PC7_1	110	116	PF00082	0.271
CLV_PCSK_PC7_1	168	174	PF00082	0.404
CLV_PCSK_SKI1_1	177	181	PF00082	0.415
CLV_PCSK_SKI1_1	273	277	PF00082	0.593
CLV_PCSK_SKI1_1	31	35	PF00082	0.620
CLV_PCSK_SKI1_1	363	367	PF00082	0.454
CLV_PCSK_SKI1_1	369	373	PF00082	0.279
CLV_PCSK_SKI1_1	374	378	PF00082	0.327
CLV_PCSK_SKI1_1	40	44	PF00082	0.432
CLV_PCSK_SKI1_1	448	452	PF00082	0.511
CLV_PCSK_SKI1_1	49	53	PF00082	0.264
DEG_APCC_DBOX_1	114	122	PF00400	0.404
DEG_APCC_DBOX_1	172	180	PF00400	0.335
DEG_APCC_DBOX_1	39	47	PF00400	0.525
DEG_Nend_Nbox_1	1	3	PF02207	0.470
DEG_SPOP_SBC_1	570	574	PF00917	0.491
DOC_AGCK_PIF_2	24	29	PF00069	0.470
DOC_CKS1_1	2	7	PF01111	0.446
DOC_CYCLIN_RxL_1	270	281	PF00134	0.548
DOC_CYCLIN_RxL_1	34	47	PF00134	0.510
DOC_CYCLIN_yCln2_LP_2	2	8	PF00134	0.391
DOC_CYCLIN_yCln2_LP_2	219	225	PF00134	0.480
DOC_CYCLIN_yCln2_LP_2	452	458	PF00134	0.524
DOC_MAPK_gen_1	110	120	PF00069	0.274
DOC_MAPK_gen_1	459	468	PF00069	0.606
DOC_PP1_RVXF_1	271	278	PF00149	0.548
DOC_PP1_RVXF_1	361	368	PF00149	0.271
DOC_PP1_RVXF_1	410	416	PF00149	0.392
DOC_PP4_FxxP_1	102	105	PF00568	0.404
DOC_PP4_FxxP_1	120	123	PF00568	0.404
DOC_USP7_MATH_1	175	179	PF00917	0.325
DOC_USP7_MATH_1	359	363	PF00917	0.314
DOC_USP7_MATH_1	433	437	PF00917	0.691
DOC_USP7_MATH_1	510	514	PF00917	0.676
DOC_USP7_MATH_1	539	543	PF00917	0.575
DOC_USP7_MATH_1	570	574	PF00917	0.497
DOC_WW_Pin1_4	1	6	PF00397	0.476
DOC_WW_Pin1_4	377	382	PF00397	0.471
DOC_WW_Pin1_4	386	391	PF00397	0.544
DOC_WW_Pin1_4	503	508	PF00397	0.555
DOC_WW_Pin1_4	519	524	PF00397	0.675
DOC_WW_Pin1_4	535	540	PF00397	0.466
DOC_WW_Pin1_4	579	584	PF00397	0.672
LIG_14-3-3_CanoR_1	177	185	PF00244	0.279
LIG_14-3-3_CanoR_1	254	262	PF00244	0.651
LIG_14-3-3_CanoR_1	363	368	PF00244	0.331
LIG_14-3-3_CanoR_1	412	416	PF00244	0.501
LIG_14-3-3_CanoR_1	448	453	PF00244	0.523
LIG_14-3-3_CanoR_1	541	547	PF00244	0.606
LIG_14-3-3_CanoR_1	567	575	PF00244	0.628
LIG_Actin_WH2_2	409	425	PF00022	0.498
LIG_APCC_ABBAyCdc20_2	273	279	PF00400	0.551
LIG_BRCT_BRCA1_1	98	102	PF00533	0.305
LIG_Clathr_ClatBox_1	275	279	PF01394	0.554
LIG_Clathr_ClatBox_1	395	399	PF01394	0.511
LIG_FHA_1	178	184	PF00498	0.370
LIG_FHA_1	306	312	PF00498	0.233
LIG_FHA_1	380	386	PF00498	0.584
LIG_FHA_1	473	479	PF00498	0.486
LIG_FHA_2	186	192	PF00498	0.551
LIG_FHA_2	322	328	PF00498	0.335
LIG_FHA_2	441	447	PF00498	0.502
LIG_FHA_2	76	82	PF00498	0.489
LIG_GBD_Chelix_1	334	342	PF00786	0.277
LIG_LIR_Apic_2	353	359	PF02991	0.268
LIG_LIR_Apic_2	534	539	PF02991	0.570
LIG_LIR_Apic_2	99	105	PF02991	0.404
LIG_LIR_Gen_1	11	20	PF02991	0.347
LIG_LIR_Gen_1	124	130	PF02991	0.326
LIG_LIR_Gen_1	136	143	PF02991	0.223
LIG_LIR_Gen_1	157	164	PF02991	0.307
LIG_LIR_Gen_1	21	32	PF02991	0.362
LIG_LIR_Gen_1	373	383	PF02991	0.466
LIG_LIR_Nem_3	11	15	PF02991	0.357
LIG_LIR_Nem_3	124	128	PF02991	0.326
LIG_LIR_Nem_3	136	141	PF02991	0.223
LIG_LIR_Nem_3	157	161	PF02991	0.296
LIG_LIR_Nem_3	21	27	PF02991	0.313
LIG_LIR_Nem_3	28	32	PF02991	0.431
LIG_LIR_Nem_3	373	378	PF02991	0.437
LIG_NRBOX	178	184	PF00104	0.270
LIG_PCNA_yPIPBox_3	31	43	PF02747	0.571
LIG_Pex14_1	290	294	PF04695	0.316
LIG_Pex14_1	536	540	PF04695	0.553
LIG_Pex14_2	116	120	PF04695	0.404
LIG_Pex14_2	532	536	PF04695	0.760
LIG_Pex14_2	8	12	PF04695	0.446
LIG_Rb_pABgroove_1	390	398	PF01858	0.525
LIG_SH2_CRK	158	162	PF00017	0.394
LIG_SH2_CRK	340	344	PF00017	0.390
LIG_SH2_CRK	356	360	PF00017	0.257
LIG_SH2_CRK	492	496	PF00017	0.443
LIG_SH2_GRB2like	68	71	PF00017	0.465
LIG_SH2_NCK_1	158	162	PF00017	0.313
LIG_SH2_NCK_1	340	344	PF00017	0.335
LIG_SH2_PTP2	375	378	PF00017	0.579
LIG_SH2_SRC	68	71	PF00017	0.446
LIG_SH2_SRC	89	92	PF00017	0.470
LIG_SH2_STAP1	158	162	PF00017	0.335
LIG_SH2_STAP1	22	26	PF00017	0.432
LIG_SH2_STAP1	360	364	PF00017	0.298
LIG_SH2_STAP1	456	460	PF00017	0.443
LIG_SH2_STAT3	585	588	PF00017	0.654
LIG_SH2_STAT5	134	137	PF00017	0.335
LIG_SH2_STAT5	26	29	PF00017	0.491
LIG_SH2_STAT5	340	343	PF00017	0.421
LIG_SH2_STAT5	375	378	PF00017	0.568
LIG_SH2_STAT5	456	459	PF00017	0.501
LIG_SH2_STAT5	485	488	PF00017	0.388
LIG_SH2_STAT5	594	597	PF00017	0.579
LIG_SH2_STAT5	68	71	PF00017	0.465
LIG_SH3_3	210	216	PF00018	0.471
LIG_SH3_3	280	286	PF00018	0.536
LIG_SH3_3	373	379	PF00018	0.431
LIG_SH3_3	504	510	PF00018	0.718
LIG_TRAF2_1	198	201	PF00917	0.540
LIG_TRAF2_1	497	500	PF00917	0.571
LIG_TRAF2_1	82	85	PF00917	0.463
LIG_TRFH_1	340	344	PF08558	0.335
LIG_WRC_WIRS_1	364	369	PF05994	0.311
LIG_WRC_WIRS_1	529	534	PF05994	0.539
LIG_WRC_WIRS_1	596	601	PF05994	0.580
LIG_WRC_WIRS_1	97	102	PF05994	0.404
MOD_CDC14_SPxK_1	538	541	PF00782	0.467
MOD_CDK_SPxK_1	535	541	PF00069	0.468
MOD_CK1_1	190	196	PF00069	0.543
MOD_CK1_1	436	442	PF00069	0.535
MOD_CK1_1	464	470	PF00069	0.517
MOD_CK1_1	522	528	PF00069	0.595
MOD_CK1_1	531	537	PF00069	0.574
MOD_CK1_1	542	548	PF00069	0.525
MOD_CK1_1	551	557	PF00069	0.456
MOD_CK1_1	569	575	PF00069	0.609
MOD_CK1_1	79	85	PF00069	0.456
MOD_CK2_1	121	127	PF00069	0.356
MOD_CK2_1	175	181	PF00069	0.305
MOD_CK2_1	440	446	PF00069	0.517
MOD_CK2_1	494	500	PF00069	0.627
MOD_CK2_1	560	566	PF00069	0.755
MOD_CK2_1	75	81	PF00069	0.413
MOD_GlcNHglycan	193	196	PF01048	0.555
MOD_GlcNHglycan	316	319	PF01048	0.271
MOD_GlcNHglycan	468	471	PF01048	0.490
MOD_GlcNHglycan	512	515	PF01048	0.593
MOD_GlcNHglycan	533	536	PF01048	0.688
MOD_GlcNHglycan	542	545	PF01048	0.579
MOD_GlcNHglycan	550	553	PF01048	0.497
MOD_GlcNHglycan	562	565	PF01048	0.557
MOD_GlcNHglycan	568	571	PF01048	0.575
MOD_GlcNHglycan	57	60	PF01048	0.400
MOD_GlcNHglycan	577	580	PF01048	0.740
MOD_GlcNHglycan	91	94	PF01048	0.517
MOD_GSK3_1	144	151	PF00069	0.360
MOD_GSK3_1	177	184	PF00069	0.439
MOD_GSK3_1	185	192	PF00069	0.540
MOD_GSK3_1	338	345	PF00069	0.318
MOD_GSK3_1	359	366	PF00069	0.314
MOD_GSK3_1	436	443	PF00069	0.552
MOD_GSK3_1	444	451	PF00069	0.438
MOD_GSK3_1	462	469	PF00069	0.458
MOD_GSK3_1	527	534	PF00069	0.709
MOD_GSK3_1	535	542	PF00069	0.565
MOD_GSK3_1	566	573	PF00069	0.660
MOD_GSK3_1	575	582	PF00069	0.690
MOD_GSK3_1	75	82	PF00069	0.417
MOD_GSK3_1	96	103	PF00069	0.376
MOD_N-GLC_1	503	508	PF02516	0.636
MOD_N-GLC_1	79	84	PF02516	0.457
MOD_NEK2_1	100	105	PF00069	0.444
MOD_NEK2_1	185	190	PF00069	0.230
MOD_NEK2_1	247	252	PF00069	0.518
MOD_NEK2_1	338	343	PF00069	0.314
MOD_NEK2_1	365	370	PF00069	0.349
MOD_NEK2_1	385	390	PF00069	0.355
MOD_NEK2_1	473	478	PF00069	0.493
MOD_NEK2_1	540	545	PF00069	0.568
MOD_PIKK_1	144	150	PF00454	0.404
MOD_PIKK_1	545	551	PF00454	0.743
MOD_PK_1	34	40	PF00069	0.642
MOD_PKA_1	144	150	PF00069	0.368
MOD_PKA_2	144	150	PF00069	0.368
MOD_PKA_2	411	417	PF00069	0.557
MOD_PKA_2	540	546	PF00069	0.746
MOD_PKA_2	566	572	PF00069	0.690
MOD_PKB_1	459	467	PF00069	0.487
MOD_Plk_1	156	162	PF00069	0.267
MOD_Plk_1	436	442	PF00069	0.680
MOD_Plk_1	461	467	PF00069	0.536
MOD_Plk_1	570	576	PF00069	0.580
MOD_Plk_1	83	89	PF00069	0.344
MOD_Plk_2-3	441	447	PF00069	0.438
MOD_Plk_4	307	313	PF00069	0.292
MOD_Plk_4	34	40	PF00069	0.624
MOD_Plk_4	342	348	PF00069	0.333
MOD_Plk_4	448	454	PF00069	0.494
MOD_Plk_4	83	89	PF00069	0.374
MOD_Plk_4	96	102	PF00069	0.315
MOD_ProDKin_1	1	7	PF00069	0.466
MOD_ProDKin_1	377	383	PF00069	0.477
MOD_ProDKin_1	386	392	PF00069	0.536
MOD_ProDKin_1	503	509	PF00069	0.557
MOD_ProDKin_1	519	525	PF00069	0.675
MOD_ProDKin_1	535	541	PF00069	0.468
MOD_ProDKin_1	579	585	PF00069	0.671
TRG_DiLeu_BaEn_1	47	52	PF01217	0.483
TRG_DiLeu_BaLyEn_6	360	365	PF01217	0.335
TRG_ENDOCYTIC_2	125	128	PF00928	0.404
TRG_ENDOCYTIC_2	158	161	PF00928	0.289
TRG_ENDOCYTIC_2	26	29	PF00928	0.416
TRG_ENDOCYTIC_2	375	378	PF00928	0.423
TRG_ENDOCYTIC_2	492	495	PF00928	0.417
TRG_ER_diArg_1	114	116	PF00400	0.271
TRG_ER_diArg_1	143	145	PF00400	0.378
TRG_ER_diArg_1	422	424	PF00400	0.525
TRG_ER_diArg_1	487	490	PF00400	0.456
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.335
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2V0	Leptomonas seymouri	60%	96%
A0A1X0NZX4	Trypanosomatidae	27%	100%
A0A3Q8IF87	Leishmania donovani	94%	99%
A0A3R7KI94	Trypanosoma rangeli	30%	100%
A4HIY5	Leishmania braziliensis	82%	100%
A4I4N9	Leishmania infantum	94%	99%
C9ZLC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ALP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
V5ATT7	Trypanosoma cruzi	33%	100%