Putative paraflagellar rod protein 1D

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod protein 1D, putative

Species:

Leishmania major

UniProt:

E9AE36_LEIMA

TriTrypDb:

LmjF.29.1750 , LMJLV39_290025000 , LMJSD75_290025300

Length:

595

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 8
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 44
NetGPI	no	yes: 0, no: 44

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	4
GO:0005929	cilium	4	45
GO:0031514	motile cilium	5	45
GO:0031974	membrane-enclosed lumen	2	4
GO:0031981	nuclear lumen	5	4
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	4
GO:0042995	cell projection	2	45
GO:0043226	organelle	2	45
GO:0043227	membrane-bounded organelle	3	45
GO:0043233	organelle lumen	3	4
GO:0070013	intracellular organelle lumen	4	4
GO:0097014	ciliary plasm	5	4
GO:0099568	cytoplasmic region	3	4
GO:0110165	cellular anatomical entity	1	45
GO:0120025	plasma membrane bounded cell projection	3	45
GO:0005930	axoneme	2	1

Expansion

Sequence features

E9AE36

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE36

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	45
GO:0005515	protein binding	2	45
GO:0005516	calmodulin binding	3	45

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.494
CLV_C14_Caspase3-7	512	516	PF00656	0.394
CLV_NRD_NRD_1	13	15	PF00675	0.621
CLV_NRD_NRD_1	147	149	PF00675	0.481
CLV_NRD_NRD_1	270	272	PF00675	0.399
CLV_NRD_NRD_1	346	348	PF00675	0.404
CLV_NRD_NRD_1	357	359	PF00675	0.379
CLV_NRD_NRD_1	535	537	PF00675	0.395
CLV_PCSK_KEX2_1	147	149	PF00082	0.481
CLV_PCSK_KEX2_1	269	271	PF00082	0.368
CLV_PCSK_KEX2_1	299	301	PF00082	0.392
CLV_PCSK_KEX2_1	345	347	PF00082	0.397
CLV_PCSK_KEX2_1	356	358	PF00082	0.409
CLV_PCSK_KEX2_1	445	447	PF00082	0.374
CLV_PCSK_KEX2_1	535	537	PF00082	0.395
CLV_PCSK_KEX2_1	562	564	PF00082	0.579
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.373
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.394
CLV_PCSK_PC1ET2_1	345	347	PF00082	0.391
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.406
CLV_PCSK_PC1ET2_1	445	447	PF00082	0.395
CLV_PCSK_PC1ET2_1	562	564	PF00082	0.579
CLV_PCSK_PC7_1	353	359	PF00082	0.429
CLV_PCSK_PC7_1	558	564	PF00082	0.572
CLV_PCSK_SKI1_1	110	114	PF00082	0.476
CLV_PCSK_SKI1_1	162	166	PF00082	0.505
CLV_PCSK_SKI1_1	266	270	PF00082	0.379
CLV_PCSK_SKI1_1	310	314	PF00082	0.502
CLV_PCSK_SKI1_1	372	376	PF00082	0.397
DEG_APCC_KENBOX_2	312	316	PF00400	0.526
DOC_CKS1_1	1	6	PF01111	0.544
DOC_CYCLIN_RxL_1	369	378	PF00134	0.399
DOC_CYCLIN_RxL_1	425	438	PF00134	0.372
DOC_MAPK_gen_1	120	128	PF00069	0.523
DOC_MAPK_gen_1	14	23	PF00069	0.594
DOC_MAPK_gen_1	372	379	PF00069	0.394
DOC_MAPK_gen_1	452	461	PF00069	0.389
DOC_MAPK_MEF2A_6	372	379	PF00069	0.394
DOC_MAPK_MEF2A_6	455	463	PF00069	0.399
DOC_MAPK_NFAT4_5	372	380	PF00069	0.399
DOC_PP1_RVXF_1	122	129	PF00149	0.488
DOC_PP4_FxxP_1	521	524	PF00568	0.400
DOC_USP7_MATH_1	179	183	PF00917	0.513
DOC_USP7_UBL2_3	480	484	PF12436	0.374
LIG_14-3-3_CanoR_1	124	129	PF00244	0.518
LIG_Actin_WH2_2	132	149	PF00022	0.490
LIG_APCC_ABBA_1	419	424	PF00400	0.399
LIG_APCC_ABBAyCdc20_2	418	424	PF00400	0.399
LIG_BIR_III_4	515	519	PF00653	0.394
LIG_BIR_III_4	6	10	PF00653	0.733
LIG_CtBP_PxDLS_1	86	92	PF00389	0.542
LIG_DLG_GKlike_1	124	131	PF00625	0.644
LIG_eIF4E_1	76	82	PF01652	0.498
LIG_FHA_1	121	127	PF00498	0.536
LIG_FHA_1	159	165	PF00498	0.485
LIG_FHA_1	195	201	PF00498	0.513
LIG_FHA_1	23	29	PF00498	0.571
LIG_FHA_1	387	393	PF00498	0.390
LIG_FHA_2	1	7	PF00498	0.691
LIG_FHA_2	408	414	PF00498	0.374
LIG_FHA_2	545	551	PF00498	0.586
LIG_IRF3_LxIS_1	33	40	PF10401	0.713
LIG_LIR_Apic_2	520	524	PF02991	0.382
LIG_LIR_Gen_1	127	136	PF02991	0.484
LIG_LIR_Gen_1	215	223	PF02991	0.470
LIG_LIR_Gen_1	320	329	PF02991	0.383
LIG_LIR_Gen_1	338	348	PF02991	0.398
LIG_LIR_Gen_1	68	78	PF02991	0.666
LIG_LIR_Nem_3	127	131	PF02991	0.610
LIG_LIR_Nem_3	215	221	PF02991	0.469
LIG_LIR_Nem_3	233	238	PF02991	0.462
LIG_LIR_Nem_3	320	326	PF02991	0.394
LIG_LIR_Nem_3	338	344	PF02991	0.400
LIG_LIR_Nem_3	427	432	PF02991	0.392
LIG_NRBOX	226	232	PF00104	0.586
LIG_PCNA_yPIPBox_3	220	231	PF02747	0.442
LIG_PTB_Apo_2	358	365	PF02174	0.526
LIG_SH2_STAP1	587	591	PF00017	0.585
LIG_SH2_STAT3	252	255	PF00017	0.556
LIG_SH2_STAT5	428	431	PF00017	0.380
LIG_SH2_STAT5	433	436	PF00017	0.371
LIG_SUMO_SIM_par_1	373	378	PF11976	0.399
LIG_TRAF2_1	258	261	PF00917	0.523
LIG_TRAF2_1	547	550	PF00917	0.564
LIG_UBA3_1	227	234	PF00899	0.454
LIG_WRC_WIRS_1	125	130	PF05994	0.505
LIG_WRC_WIRS_1	465	470	PF05994	0.385
MOD_CK1_1	40	46	PF00069	0.603
MOD_CK1_1	544	550	PF00069	0.577
MOD_CK2_1	5	11	PF00069	0.658
MOD_CK2_1	544	550	PF00069	0.521
MOD_CK2_1	566	572	PF00069	0.703
MOD_CK2_1	87	93	PF00069	0.541
MOD_GlcNHglycan	568	571	PF01048	0.631
MOD_GlcNHglycan	572	575	PF01048	0.652
MOD_GlcNHglycan	579	582	PF01048	0.692
MOD_GlcNHglycan	589	592	PF01048	0.723
MOD_GSK3_1	120	127	PF00069	0.544
MOD_GSK3_1	566	573	PF00069	0.682
MOD_N-GLC_1	120	125	PF02516	0.547
MOD_N-GLC_1	171	176	PF02516	0.516
MOD_NEK2_1	146	151	PF00069	0.499
MOD_NEK2_1	171	176	PF00069	0.516
MOD_NEK2_1	375	380	PF00069	0.392
MOD_NEK2_1	386	391	PF00069	0.387
MOD_NEK2_1	432	437	PF00069	0.380
MOD_NEK2_1	566	571	PF00069	0.627
MOD_NEK2_1	87	92	PF00069	0.530
MOD_NEK2_2	160	165	PF00069	0.513
MOD_PIKK_1	126	132	PF00454	0.503
MOD_PIKK_1	146	152	PF00454	0.522
MOD_PIKK_1	171	177	PF00454	0.528
MOD_PIKK_1	186	192	PF00454	0.522
MOD_PIKK_1	260	266	PF00454	0.416
MOD_PIKK_1	42	48	PF00454	0.622
MOD_PIKK_1	87	93	PF00454	0.526
MOD_PKA_2	146	152	PF00069	0.511
MOD_PKA_2	386	392	PF00069	0.417
MOD_PKA_2	534	540	PF00069	0.382
MOD_PKB_1	273	281	PF00069	0.519
MOD_Plk_1	120	126	PF00069	0.525
MOD_Plk_1	132	138	PF00069	0.419
MOD_Plk_1	151	157	PF00069	0.344
MOD_Plk_1	171	177	PF00069	0.523
MOD_Plk_1	260	266	PF00069	0.353
MOD_Plk_1	375	381	PF00069	0.411
MOD_Plk_4	375	381	PF00069	0.397
MOD_Plk_4	435	441	PF00069	0.394
MOD_SUMO_for_1	137	140	PF00179	0.513
MOD_SUMO_for_1	478	481	PF00179	0.404
MOD_SUMO_rev_2	277	283	PF00179	0.367
MOD_SUMO_rev_2	505	510	PF00179	0.396
MOD_SUMO_rev_2	537	544	PF00179	0.425
MOD_SUMO_rev_2	557	564	PF00179	0.493
MOD_SUMO_rev_2	93	101	PF00179	0.530
TRG_DiLeu_BaEn_1	29	34	PF01217	0.583
TRG_DiLeu_BaEn_2	359	365	PF01217	0.399
TRG_DiLeu_BaEn_3	490	496	PF01217	0.399
TRG_DiLeu_BaEn_4	491	497	PF01217	0.399
TRG_DiLeu_BaLyEn_6	223	228	PF01217	0.466
TRG_DiLeu_BaLyEn_6	562	567	PF01217	0.598
TRG_ENDOCYTIC_2	428	431	PF00928	0.397
TRG_ENDOCYTIC_2	433	436	PF00928	0.391
TRG_ER_diArg_1	146	148	PF00400	0.480
TRG_ER_diArg_1	270	273	PF00400	0.387
TRG_ER_diArg_1	346	348	PF00400	0.397
TRG_ER_diArg_1	357	359	PF00400	0.404
TRG_ER_diArg_1	563	566	PF00400	0.589
TRG_NLS_MonoExtC_3	268	273	PF00514	0.399
TRG_NLS_MonoExtN_4	266	273	PF00514	0.399
TRG_Pf-PMV_PEXEL_1	270	274	PF00026	0.364
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	346	350	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	372	376	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	445	449	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2I5	Leptomonas seymouri	96%	100%
A0A0N0P5J5	Leptomonas seymouri	23%	75%
A0A0N1IFZ5	Leptomonas seymouri	66%	100%
A0A0S4IZY8	Bodo saltans	67%	100%
A0A0S4J193	Bodo saltans	25%	96%
A0A0S4J561	Bodo saltans	28%	84%
A0A0S4JS20	Bodo saltans	87%	100%
A0A1X0NR57	Trypanosomatidae	23%	75%
A0A1X0NYU4	Trypanosomatidae	65%	99%
A0A1X0P0B7	Trypanosomatidae	88%	100%
A0A381MH18	Leishmania infantum	67%	99%
A0A381MN58	Leishmania infantum	99%	100%
A0A3Q8IAP5	Leishmania donovani	67%	99%
A0A3Q8IEH2	Leishmania donovani	99%	100%
A0A3R7KDB9	Trypanosoma rangeli	65%	99%
A0A3S5IRI8	Trypanosoma rangeli	87%	100%
A0A3S7WQV4	Leishmania donovani	21%	98%
A0A3S7X0V5	Leishmania donovani	24%	76%
A0A3S7X2K1	Leishmania donovani	99%	100%
A0A422NJR9	Trypanosoma rangeli	22%	80%
A4H8S1	Leishmania braziliensis	66%	99%
A4HFV9	Leishmania braziliensis	24%	77%
A4HIY0	Leishmania braziliensis	97%	100%
A4HU55	Leishmania infantum	21%	98%
A4HX40	Leishmania infantum	65%	100%
A4I2Z1	Leishmania infantum	24%	76%
C9ZJD8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	78%
C9ZLC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	86%	100%
C9ZLC2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	86%	100%
C9ZU76	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	86%
C9ZVV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	99%
E9ADG3	Leishmania major	25%	76%
E9AE37	Leishmania major	100%	100%
E9AHJ2	Leishmania infantum	99%	100%
E9ALP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9ALP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AMY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	98%
E9AQV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	89%
E9AZ87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	76%
P22225	Trypanosoma brucei brucei	66%	99%
Q26789	Trypanosoma brucei brucei	85%	100%
Q4QEM2	Leishmania major	66%	99%
Q4QHP3	Leishmania major	24%	100%
V5BDW8	Trypanosoma cruzi	88%	100%
V5BIN9	Trypanosoma cruzi	23%	80%