Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AE28_LEIMA

TriTrypDb:

LmjF.29.1660 , LMJLV39_290024200 , LMJSD75_290024500

Length:

269

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AE28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE28

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.535
CLV_C14_Caspase3-7	225	229	PF00656	0.381
CLV_NRD_NRD_1	186	188	PF00675	0.372
CLV_NRD_NRD_1	33	35	PF00675	0.531
CLV_NRD_NRD_1	48	50	PF00675	0.365
CLV_PCSK_KEX2_1	186	188	PF00082	0.371
CLV_PCSK_KEX2_1	33	35	PF00082	0.585
CLV_PCSK_KEX2_1	48	50	PF00082	0.377
CLV_PCSK_SKI1_1	187	191	PF00082	0.335
DEG_APCC_DBOX_1	186	194	PF00400	0.330
DOC_MAPK_gen_1	186	193	PF00069	0.351
DOC_MAPK_gen_1	48	56	PF00069	0.484
DOC_MAPK_MEF2A_6	186	195	PF00069	0.330
DOC_MAPK_MEF2A_6	48	56	PF00069	0.500
DOC_MAPK_NFAT4_5	49	57	PF00069	0.436
DOC_MIT_MIM_1	30	38	PF04212	0.334
LIG_APCC_ABBA_1	109	114	PF00400	0.556
LIG_BIR_II_1	1	5	PF00653	0.602
LIG_deltaCOP1_diTrp_1	252	260	PF00928	0.391
LIG_EVH1_2	146	150	PF00568	0.576
LIG_FHA_1	23	29	PF00498	0.468
LIG_FHA_2	1	7	PF00498	0.526
LIG_FHA_2	244	250	PF00498	0.435
LIG_FHA_2	45	51	PF00498	0.493
LIG_LIR_Gen_1	115	126	PF02991	0.403
LIG_LIR_Gen_1	204	212	PF02991	0.429
LIG_LIR_Gen_1	232	242	PF02991	0.383
LIG_LIR_Gen_1	80	90	PF02991	0.476
LIG_LIR_Nem_3	115	121	PF02991	0.399
LIG_LIR_Nem_3	204	209	PF02991	0.474
LIG_LIR_Nem_3	232	237	PF02991	0.375
LIG_LIR_Nem_3	252	256	PF02991	0.378
LIG_LIR_Nem_3	55	61	PF02991	0.462
LIG_LIR_Nem_3	80	85	PF02991	0.481
LIG_NRBOX	189	195	PF00104	0.409
LIG_Pex14_1	234	238	PF04695	0.445
LIG_Pex14_4	78	83	PF04695	0.405
LIG_SH2_NCK_1	265	269	PF00017	0.477
LIG_SH2_NCK_1	72	76	PF00017	0.492
LIG_SH2_STAT5	206	209	PF00017	0.468
LIG_SH2_STAT5	265	268	PF00017	0.518
LIG_SH2_STAT5	95	98	PF00017	0.604
LIG_SH3_3	165	171	PF00018	0.685
LIG_SUMO_SIM_par_1	192	197	PF11976	0.319
LIG_TRAF2_1	246	249	PF00917	0.529
MOD_CK1_1	161	167	PF00069	0.668
MOD_CK1_1	213	219	PF00069	0.611
MOD_CK2_1	119	125	PF00069	0.417
MOD_CK2_1	2	8	PF00069	0.613
MOD_CK2_1	218	224	PF00069	0.539
MOD_CK2_1	243	249	PF00069	0.438
MOD_CK2_1	44	50	PF00069	0.493
MOD_CK2_1	85	91	PF00069	0.484
MOD_GlcNHglycan	11	14	PF01048	0.586
MOD_GlcNHglycan	120	124	PF01048	0.493
MOD_GlcNHglycan	174	177	PF01048	0.601
MOD_GlcNHglycan	181	184	PF01048	0.395
MOD_GSK3_1	146	153	PF00069	0.673
MOD_GSK3_1	154	161	PF00069	0.681
MOD_NEK2_1	150	155	PF00069	0.764
MOD_NEK2_1	158	163	PF00069	0.547
MOD_NEK2_1	194	199	PF00069	0.334
MOD_NEK2_1	261	266	PF00069	0.495
MOD_NEK2_1	52	57	PF00069	0.457
MOD_NEK2_1	85	90	PF00069	0.392
MOD_PIKK_1	22	28	PF00454	0.521
MOD_PK_1	208	214	PF00069	0.431
MOD_PKA_2	150	156	PF00069	0.654
MOD_PKA_2	158	164	PF00069	0.645
MOD_PKA_2	85	91	PF00069	0.459
MOD_Plk_4	229	235	PF00069	0.392
MOD_Plk_4	85	91	PF00069	0.537
MOD_SUMO_rev_2	248	256	PF00179	0.418
TRG_ENDOCYTIC_2	118	121	PF00928	0.406
TRG_ENDOCYTIC_2	206	209	PF00928	0.468
TRG_ER_diArg_1	33	35	PF00400	0.533
TRG_NES_CRM1_1	188	204	PF08389	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMM1	Leptomonas seymouri	55%	100%
A0A0S4ING2	Bodo saltans	25%	100%
A0A1X0NZY4	Trypanosomatidae	33%	100%
A0A3Q8IIV0	Leishmania donovani	94%	100%
A0A3R7KCM5	Trypanosoma rangeli	37%	100%
A4HHI0	Leishmania braziliensis	73%	100%
A4I4K6	Leishmania infantum	94%	100%
C9ZLB6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ALQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5B997	Trypanosoma cruzi	35%	100%