LeishMANIAdb
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Thioredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Thioredoxin domain-containing protein
Gene product:
thioredoxin, putative
Species:
Leishmania major
UniProt:
E9AE27_LEIMA
TriTrypDb:
LmjF.29.1650 * , LMJLV39_290023900 * , LMJSD75_290024300 *
Length:
112

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 3
NetGPI no yes: 0, no: 3
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

E9AE27
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE27

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 107 109 PF00082 0.666
CLV_PCSK_PC1ET2_1 107 109 PF00082 0.666
DOC_USP7_MATH_1 80 84 PF00917 0.567
DOC_WW_Pin1_4 84 89 PF00397 0.702
DOC_WW_Pin1_4 91 96 PF00397 0.646
LIG_LIR_Nem_3 51 55 PF02991 0.448
LIG_NRBOX 74 80 PF00104 0.540
LIG_SH3_3 92 98 PF00018 0.623
LIG_SUMO_SIM_anti_2 26 31 PF11976 0.422
LIG_SUMO_SIM_par_1 26 31 PF11976 0.422
LIG_WRC_WIRS_1 49 54 PF05994 0.422
MOD_CK1_1 48 54 PF00069 0.422
MOD_CK1_1 87 93 PF00069 0.669
MOD_GlcNHglycan 109 112 PF01048 0.735
MOD_GSK3_1 103 110 PF00069 0.742
MOD_GSK3_1 80 87 PF00069 0.758
MOD_N-GLC_1 17 22 PF02516 0.263
MOD_N-GLC_1 81 86 PF02516 0.652
MOD_N-GLC_1 91 96 PF02516 0.657
MOD_N-GLC_2 57 59 PF02516 0.422
MOD_NEK2_1 23 28 PF00069 0.422
MOD_Plk_1 38 44 PF00069 0.422
MOD_Plk_4 23 29 PF00069 0.422
MOD_Plk_4 48 54 PF00069 0.422
MOD_ProDKin_1 84 90 PF00069 0.706
MOD_ProDKin_1 91 97 PF00069 0.644
MOD_SUMO_rev_2 4 8 PF00179 0.521
TRG_DiLeu_BaEn_1 71 76 PF01217 0.422

Homologs

Protein Taxonomy Sequence identity Coverage
A4I4K5 Leishmania infantum 90% 100%
E9ALQ6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS