Putative ABC transporter domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-binding cassette protein subfamily H, member 2, putative

Species:

Leishmania major

UniProt:

E9AE26_LEIMA

TriTrypDb:

LmjF.29.1640 , LMJLV39_290023600 , LMJSD75_290024100

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AE26

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE26

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0009987	cellular process	1	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055085	transmembrane transport	2	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0005215	transporter activity	1	2
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0015399	primary active transmembrane transporter activity	4	2
GO:0017076	purine nucleotide binding	4	9
GO:0022804	active transmembrane transporter activity	3	2
GO:0022857	transmembrane transporter activity	2	2
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0042626	ATPase-coupled transmembrane transporter activity	2	2
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:0140657	ATP-dependent activity	1	2
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.610
CLV_NRD_NRD_1	126	128	PF00675	0.391
CLV_NRD_NRD_1	288	290	PF00675	0.466
CLV_PCSK_KEX2_1	126	128	PF00082	0.391
CLV_PCSK_KEX2_1	288	290	PF00082	0.466
CLV_PCSK_SKI1_1	222	226	PF00082	0.335
CLV_PCSK_SKI1_1	317	321	PF00082	0.566
CLV_PCSK_SKI1_1	344	348	PF00082	0.582
CLV_PCSK_SKI1_1	88	92	PF00082	0.422
DEG_APCC_DBOX_1	221	229	PF00400	0.329
DOC_CYCLIN_RxL_1	218	226	PF00134	0.410
DOC_CYCLIN_yCln2_LP_2	118	124	PF00134	0.540
DOC_CYCLIN_yCln2_LP_2	414	420	PF00134	0.605
DOC_MAPK_gen_1	126	133	PF00069	0.388
DOC_MAPK_gen_1	218	227	PF00069	0.346
DOC_MAPK_gen_1	288	297	PF00069	0.385
DOC_PP1_RVXF_1	179	186	PF00149	0.329
DOC_PP2B_LxvP_1	118	121	PF13499	0.597
DOC_PP2B_LxvP_1	414	417	PF13499	0.600
DOC_PP4_FxxP_1	23	26	PF00568	0.561
DOC_USP7_MATH_1	403	407	PF00917	0.657
DOC_USP7_MATH_1	446	450	PF00917	0.719
DOC_WW_Pin1_4	14	19	PF00397	0.642
DOC_WW_Pin1_4	27	32	PF00397	0.575
DOC_WW_Pin1_4	381	386	PF00397	0.680
DOC_WW_Pin1_4	399	404	PF00397	0.765
DOC_WW_Pin1_4	6	11	PF00397	0.746
LIG_14-3-3_CanoR_1	222	228	PF00244	0.388
LIG_14-3-3_CanoR_1	288	297	PF00244	0.385
LIG_14-3-3_CanoR_1	55	59	PF00244	0.459
LIG_14-3-3_CanoR_1	8	14	PF00244	0.759
LIG_BIR_II_1	1	5	PF00653	0.604
LIG_BRCT_BRCA1_1	19	23	PF00533	0.590
LIG_FHA_1	108	114	PF00498	0.691
LIG_FHA_1	140	146	PF00498	0.329
LIG_FHA_1	187	193	PF00498	0.329
LIG_FHA_1	266	272	PF00498	0.420
LIG_FHA_1	274	280	PF00498	0.426
LIG_FHA_1	290	296	PF00498	0.315
LIG_FHA_1	334	340	PF00498	0.536
LIG_FHA_1	427	433	PF00498	0.536
LIG_FHA_2	195	201	PF00498	0.329
LIG_FHA_2	31	37	PF00498	0.687
LIG_FHA_2	429	435	PF00498	0.561
LIG_FHA_2	89	95	PF00498	0.531
LIG_Integrin_isoDGR_2	162	164	PF01839	0.349
LIG_LIR_Apic_2	20	26	PF02991	0.562
LIG_LIR_Gen_1	129	136	PF02991	0.359
LIG_LIR_Gen_1	189	198	PF02991	0.358
LIG_LIR_Gen_1	321	330	PF02991	0.446
LIG_LIR_Nem_3	129	133	PF02991	0.359
LIG_LIR_Nem_3	189	193	PF02991	0.358
LIG_LIR_Nem_3	321	326	PF02991	0.434
LIG_LIR_Nem_3	333	338	PF02991	0.505
LIG_LIR_Nem_3	347	352	PF02991	0.636
LIG_PTB_Apo_2	179	186	PF02174	0.324
LIG_SH2_STAP1	306	310	PF00017	0.343
LIG_SH2_STAP1	335	339	PF00017	0.419
LIG_SH2_STAT5	312	315	PF00017	0.402
LIG_SH2_STAT5	335	338	PF00017	0.460
LIG_SH3_2	121	126	PF14604	0.482
LIG_SH3_3	118	124	PF00018	0.545
LIG_SH3_3	199	205	PF00018	0.353
LIG_SH3_3	407	413	PF00018	0.569
LIG_SUMO_SIM_anti_2	260	266	PF11976	0.324
LIG_SUMO_SIM_anti_2	276	281	PF11976	0.303
LIG_SUMO_SIM_par_1	260	266	PF11976	0.329
LIG_SUMO_SIM_par_1	275	281	PF11976	0.394
LIG_SUMO_SIM_par_1	80	89	PF11976	0.512
LIG_TRAF2_1	33	36	PF00917	0.636
LIG_UBA3_1	208	215	PF00899	0.418
LIG_UBA3_1	282	291	PF00899	0.462
LIG_WRC_WIRS_1	187	192	PF05994	0.329
MOD_CK1_1	150	156	PF00069	0.370
MOD_CK1_1	17	23	PF00069	0.494
MOD_CK1_1	2	8	PF00069	0.693
MOD_CK1_1	239	245	PF00069	0.329
MOD_CK1_1	30	36	PF00069	0.580
MOD_CK1_1	396	402	PF00069	0.630
MOD_CK1_1	40	46	PF00069	0.604
MOD_CK1_1	447	453	PF00069	0.617
MOD_CK1_1	51	57	PF00069	0.625
MOD_CK1_1	95	101	PF00069	0.548
MOD_CK2_1	150	156	PF00069	0.376
MOD_CK2_1	194	200	PF00069	0.329
MOD_CK2_1	239	245	PF00069	0.294
MOD_CK2_1	30	36	PF00069	0.650
MOD_CK2_1	46	52	PF00069	0.458
MOD_CK2_1	88	94	PF00069	0.516
MOD_GlcNHglycan	136	139	PF01048	0.307
MOD_GlcNHglycan	19	22	PF01048	0.632
MOD_GlcNHglycan	240	244	PF01048	0.336
MOD_GlcNHglycan	395	398	PF01048	0.737
MOD_GlcNHglycan	407	410	PF01048	0.655
MOD_GlcNHglycan	439	442	PF01048	0.734
MOD_GlcNHglycan	446	449	PF01048	0.605
MOD_GSK3_1	17	24	PF00069	0.701
MOD_GSK3_1	2	9	PF00069	0.613
MOD_GSK3_1	204	211	PF00069	0.299
MOD_GSK3_1	247	254	PF00069	0.340
MOD_GSK3_1	389	396	PF00069	0.690
MOD_GSK3_1	399	406	PF00069	0.551
MOD_GSK3_1	428	435	PF00069	0.744
MOD_GSK3_1	54	61	PF00069	0.569
MOD_GSK3_1	88	95	PF00069	0.403
MOD_N-GLC_1	27	32	PF02516	0.616
MOD_N-GLC_1	333	338	PF02516	0.410
MOD_N-GLC_1	381	386	PF02516	0.716
MOD_NEK2_1	1	6	PF00069	0.655
MOD_NEK2_1	113	118	PF00069	0.705
MOD_NEK2_1	192	197	PF00069	0.333
MOD_NEK2_1	208	213	PF00069	0.284
MOD_NEK2_1	433	438	PF00069	0.557
MOD_NEK2_1	92	97	PF00069	0.402
MOD_PIKK_1	426	432	PF00454	0.637
MOD_PKA_2	247	253	PF00069	0.306
MOD_PKA_2	287	293	PF00069	0.393
MOD_PKA_2	361	367	PF00069	0.599
MOD_PKA_2	40	46	PF00069	0.730
MOD_PKA_2	54	60	PF00069	0.428
MOD_Plk_1	46	52	PF00069	0.682
MOD_Plk_1	88	94	PF00069	0.482
MOD_Plk_4	140	146	PF00069	0.318
MOD_Plk_4	170	176	PF00069	0.413
MOD_Plk_4	204	210	PF00069	0.388
MOD_Plk_4	223	229	PF00069	0.388
MOD_Plk_4	257	263	PF00069	0.294
MOD_Plk_4	396	402	PF00069	0.645
MOD_Plk_4	40	46	PF00069	0.526
MOD_Plk_4	428	434	PF00069	0.669
MOD_Plk_4	54	60	PF00069	0.583
MOD_ProDKin_1	14	20	PF00069	0.641
MOD_ProDKin_1	27	33	PF00069	0.576
MOD_ProDKin_1	381	387	PF00069	0.682
MOD_ProDKin_1	399	405	PF00069	0.763
MOD_ProDKin_1	6	12	PF00069	0.747
MOD_SUMO_rev_2	167	173	PF00179	0.374
MOD_SUMO_rev_2	89	98	PF00179	0.388
TRG_DiLeu_BaEn_1	278	283	PF01217	0.447
TRG_ER_diArg_1	125	127	PF00400	0.388
TRG_ER_diArg_1	217	220	PF00400	0.345
TRG_ER_diArg_1	230	233	PF00400	0.329

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8R4	Leptomonas seymouri	23%	89%
A0A0N1ICD4	Leptomonas seymouri	73%	99%
A0A0S4J9X9	Bodo saltans	57%	100%
A0A3S7X2I8	Leishmania donovani	89%	100%
A4HHH8	Leishmania braziliensis	68%	100%
A4I4M8	Leishmania infantum	89%	100%
E9ALQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%