Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Integral membrane protein S linking to the trans Golgi network, putative

Species:

Leishmania major

UniProt:

E9AE23_LEIMA

TriTrypDb:

LmjF.29.1610 , LMJLV39_290023200 , LMJSD75_290023700

Length:

352

Annotations

LeishMANIAdb annotations

Conserved eukaryotic protein, involved in protein trafficking.. Localization: Golgi (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005802	trans-Golgi network	4	2
GO:0005829	cytosol	2	2
GO:0031984	organelle subcompartment	2	2
GO:0098791	Golgi apparatus subcompartment	3	2
GO:0110165	cellular anatomical entity	1	10
GO:0016020	membrane	2	8

Expansion

Sequence features

E9AE23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE23

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006892	post-Golgi vesicle-mediated transport	6	2
GO:0006893	Golgi to plasma membrane transport	5	2
GO:0006895	Golgi to endosome transport	5	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016192	vesicle-mediated transport	4	2
GO:0016482	cytosolic transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0033365	protein localization to organelle	5	2
GO:0034067	protein localization to Golgi apparatus	6	2
GO:0043001	Golgi to plasma membrane protein transport	5	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0048193	Golgi vesicle transport	5	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0061951	establishment of protein localization to plasma membrane	5	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0072657	protein localization to membrane	4	2
GO:0072659	protein localization to plasma membrane	5	2
GO:0090150	establishment of protein localization to membrane	4	2
GO:0098876	vesicle-mediated transport to the plasma membrane	4	2
GO:1990778	protein localization to cell periphery	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.709
CLV_NRD_NRD_1	192	194	PF00675	0.290
CLV_NRD_NRD_1	216	218	PF00675	0.546
CLV_NRD_NRD_1	245	247	PF00675	0.311
CLV_PCSK_KEX2_1	192	194	PF00082	0.290
CLV_PCSK_KEX2_1	216	218	PF00082	0.509
CLV_PCSK_SKI1_1	194	198	PF00082	0.308
CLV_PCSK_SKI1_1	216	220	PF00082	0.485
CLV_PCSK_SKI1_1	34	38	PF00082	0.391
DEG_APCC_DBOX_1	169	177	PF00400	0.508
DEG_APCC_DBOX_1	245	253	PF00400	0.508
DEG_ODPH_VHL_1	90	101	PF01847	0.697
DEG_SPOP_SBC_1	267	271	PF00917	0.779
DOC_CYCLIN_RxL_1	190	198	PF00134	0.590
DOC_CYCLIN_RxL_1	31	41	PF00134	0.620
DOC_MAPK_gen_1	147	154	PF00069	0.604
DOC_MAPK_gen_1	192	199	PF00069	0.490
DOC_MAPK_gen_1	246	254	PF00069	0.490
DOC_MAPK_MEF2A_6	147	154	PF00069	0.604
DOC_MAPK_MEF2A_6	192	199	PF00069	0.561
DOC_MAPK_NFAT4_5	192	200	PF00069	0.590
DOC_PP4_FxxP_1	109	112	PF00568	0.630
DOC_USP7_MATH_1	112	116	PF00917	0.590
DOC_USP7_MATH_1	306	310	PF00917	0.757
DOC_USP7_MATH_1	316	320	PF00917	0.771
DOC_WW_Pin1_4	51	56	PF00397	0.767
DOC_WW_Pin1_4	8	13	PF00397	0.459
LIG_14-3-3_CanoR_1	124	130	PF00244	0.680
LIG_14-3-3_CanoR_1	151	155	PF00244	0.609
LIG_14-3-3_CanoR_1	340	347	PF00244	0.629
LIG_14-3-3_CanoR_1	7	12	PF00244	0.449
LIG_APCC_ABBA_1	75	80	PF00400	0.636
LIG_BIR_II_1	1	5	PF00653	0.520
LIG_BIR_III_4	305	309	PF00653	0.761
LIG_BIR_III_4	314	318	PF00653	0.762
LIG_BRCT_BRCA1_1	10	14	PF00533	0.438
LIG_BRCT_BRCA1_1	105	109	PF00533	0.638
LIG_BRCT_BRCA1_1	23	27	PF00533	0.332
LIG_eIF4E_1	184	190	PF01652	0.561
LIG_eIF4E_1	204	210	PF01652	0.484
LIG_FHA_1	118	124	PF00498	0.659
LIG_FHA_1	126	132	PF00498	0.652
LIG_FHA_1	200	206	PF00498	0.371
LIG_FHA_1	238	244	PF00498	0.369
LIG_FHA_1	269	275	PF00498	0.751
LIG_FHA_1	31	37	PF00498	0.632
LIG_FHA_1	44	50	PF00498	0.683
LIG_FHA_1	70	76	PF00498	0.643
LIG_FHA_1	85	91	PF00498	0.773
LIG_FHA_2	125	131	PF00498	0.637
LIG_FHA_2	45	51	PF00498	0.725
LIG_LIR_Apic_2	106	112	PF02991	0.699
LIG_LIR_Gen_1	100	109	PF02991	0.683
LIG_LIR_Gen_1	11	20	PF02991	0.290
LIG_LIR_Gen_1	24	35	PF02991	0.344
LIG_LIR_Nem_3	100	105	PF02991	0.680
LIG_LIR_Nem_3	11	17	PF02991	0.280
LIG_LIR_Nem_3	202	207	PF02991	0.352
LIG_LIR_Nem_3	24	30	PF02991	0.379
LIG_MLH1_MIPbox_1	23	27	PF16413	0.369
LIG_NRBOX	214	220	PF00104	0.402
LIG_REV1ctd_RIR_1	99	108	PF16727	0.662
LIG_SH2_STAT5	107	110	PF00017	0.647
LIG_SH2_STAT5	172	175	PF00017	0.561
LIG_SH2_STAT5	204	207	PF00017	0.349
LIG_SH2_STAT5	241	244	PF00017	0.431
LIG_SH3_3	89	95	PF00018	0.769
LIG_SUMO_SIM_par_1	127	133	PF11976	0.651
LIG_TRAF2_1	341	344	PF00917	0.729
LIG_TYR_ITIM	205	210	PF00017	0.443
MOD_CK1_1	292	298	PF00069	0.737
MOD_CK1_1	324	330	PF00069	0.698
MOD_CK1_1	339	345	PF00069	0.699
MOD_CK1_1	43	49	PF00069	0.718
MOD_CK1_1	84	90	PF00069	0.749
MOD_CK2_1	124	130	PF00069	0.636
MOD_CK2_1	44	50	PF00069	0.687
MOD_CK2_1	97	103	PF00069	0.701
MOD_GlcNHglycan	254	257	PF01048	0.516
MOD_GlcNHglycan	261	264	PF01048	0.511
MOD_GlcNHglycan	300	303	PF01048	0.567
MOD_GSK3_1	112	119	PF00069	0.694
MOD_GSK3_1	252	259	PF00069	0.732
MOD_GSK3_1	321	328	PF00069	0.775
MOD_GSK3_1	339	346	PF00069	0.720
MOD_GSK3_1	40	47	PF00069	0.636
MOD_GSK3_1	79	86	PF00069	0.740
MOD_N-GLC_1	298	303	PF02516	0.597
MOD_NEK2_1	116	121	PF00069	0.679
MOD_NEK2_1	180	185	PF00069	0.528
MOD_NEK2_1	199	204	PF00069	0.385
MOD_NEK2_1	231	236	PF00069	0.495
MOD_NEK2_1	30	35	PF00069	0.408
MOD_NEK2_1	42	47	PF00069	0.604
MOD_NEK2_1	5	10	PF00069	0.436
MOD_NEK2_1	79	84	PF00069	0.763
MOD_NEK2_2	112	117	PF00069	0.603
MOD_PIKK_1	292	298	PF00454	0.776
MOD_PIKK_1	322	328	PF00454	0.646
MOD_PKA_2	150	156	PF00069	0.682
MOD_PKA_2	252	258	PF00069	0.752
MOD_PKA_2	292	298	PF00069	0.776
MOD_PKA_2	339	345	PF00069	0.658
MOD_Plk_1	343	349	PF00069	0.630
MOD_Plk_1	40	46	PF00069	0.666
MOD_Plk_1	79	85	PF00069	0.787
MOD_Plk_4	112	118	PF00069	0.587
MOD_Plk_4	185	191	PF00069	0.600
MOD_Plk_4	199	205	PF00069	0.267
MOD_Plk_4	21	27	PF00069	0.369
MOD_Plk_4	231	237	PF00069	0.350
MOD_Plk_4	268	274	PF00069	0.753
MOD_Plk_4	97	103	PF00069	0.719
MOD_ProDKin_1	51	57	PF00069	0.767
MOD_ProDKin_1	8	14	PF00069	0.458
TRG_DiLeu_BaLyEn_6	214	219	PF01217	0.402
TRG_ENDOCYTIC_2	207	210	PF00928	0.344
TRG_ER_diArg_1	134	137	PF00400	0.706
TRG_ER_diArg_1	215	217	PF00400	0.426
TRG_ER_diArg_1	318	321	PF00400	0.782
TRG_ER_diLys_1	348	352	PF00400	0.765
TRG_Pf-PMV_PEXEL_1	193	198	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAN0	Leptomonas seymouri	42%	98%
A0A1X0NZV3	Trypanosomatidae	29%	100%
A0A3Q8IDS8	Leishmania donovani	85%	94%
A0A422NEB3	Trypanosoma rangeli	31%	100%
A4HHH5	Leishmania braziliensis	66%	93%
A4I4M5	Leishmania infantum	86%	94%
E9ALR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	94%
V5BDU0	Trypanosoma cruzi	30%	100%