Transmembrane 9 superfamily member

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endomembrane protein 70, putative

Species:

Leishmania major

UniProt:

E9AE21_LEIMA

TriTrypDb:

LmjF.29.1600 , LMJLV39_290023100 , LMJSD75_290023600

Length:

680

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 13, no: 1
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	15
GO:0110165	cellular anatomical entity	1	15

Expansion

Sequence features

E9AE21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE21

Function

Biological processes
Term	Name	Level	Count
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0033036	macromolecule localization	2	2
GO:0051179	localization	1	2
GO:0051641	cellular localization	2	2
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0072657	protein localization to membrane	4	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	137	139	PF00675	0.509
CLV_NRD_NRD_1	232	234	PF00675	0.458
CLV_NRD_NRD_1	413	415	PF00675	0.442
CLV_NRD_NRD_1	671	673	PF00675	0.280
CLV_PCSK_KEX2_1	137	139	PF00082	0.478
CLV_PCSK_KEX2_1	413	415	PF00082	0.471
CLV_PCSK_KEX2_1	671	673	PF00082	0.362
CLV_PCSK_SKI1_1	120	124	PF00082	0.464
CLV_PCSK_SKI1_1	142	146	PF00082	0.463
CLV_PCSK_SKI1_1	182	186	PF00082	0.493
CLV_PCSK_SKI1_1	204	208	PF00082	0.520
CLV_PCSK_SKI1_1	270	274	PF00082	0.426
CLV_PCSK_SKI1_1	299	303	PF00082	0.524
CLV_PCSK_SKI1_1	414	418	PF00082	0.459
CLV_PCSK_SKI1_1	449	453	PF00082	0.229
CLV_PCSK_SKI1_1	536	540	PF00082	0.223
DEG_APCC_DBOX_1	18	26	PF00400	0.423
DOC_CYCLIN_yCln2_LP_2	534	540	PF00134	0.425
DOC_MAPK_gen_1	150	158	PF00069	0.265
DOC_MAPK_gen_1	178	186	PF00069	0.305
DOC_MAPK_gen_1	233	240	PF00069	0.324
DOC_MAPK_gen_1	53	63	PF00069	0.379
DOC_MAPK_gen_1	671	679	PF00069	0.494
DOC_MAPK_MEF2A_6	19	28	PF00069	0.482
DOC_MAPK_MEF2A_6	233	242	PF00069	0.275
DOC_PP1_RVXF_1	243	250	PF00149	0.304
DOC_PP2B_LxvP_1	194	197	PF13499	0.273
DOC_PP4_FxxP_1	374	377	PF00568	0.406
DOC_PP4_FxxP_1	408	411	PF00568	0.206
DOC_PP4_FxxP_1	45	48	PF00568	0.360
DOC_PP4_FxxP_1	456	459	PF00568	0.417
DOC_PP4_FxxP_1	84	87	PF00568	0.221
DOC_USP7_MATH_1	51	55	PF00917	0.424
DOC_USP7_MATH_1	529	533	PF00917	0.461
DOC_USP7_MATH_2	252	258	PF00917	0.174
DOC_USP7_UBL2_3	116	120	PF12436	0.353
DOC_USP7_UBL2_3	142	146	PF12436	0.296
DOC_USP7_UBL2_3	178	182	PF12436	0.276
DOC_USP7_UBL2_3	53	57	PF12436	0.374
DOC_WW_Pin1_4	292	297	PF00397	0.157
DOC_WW_Pin1_4	37	42	PF00397	0.543
DOC_WW_Pin1_4	407	412	PF00397	0.206
LIG_14-3-3_CanoR_1	105	111	PF00244	0.251
LIG_14-3-3_CanoR_1	351	360	PF00244	0.495
LIG_14-3-3_CanoR_1	69	77	PF00244	0.313
LIG_APCC_ABBA_1	236	241	PF00400	0.261
LIG_BIR_II_1	1	5	PF00653	0.540
LIG_BRCT_BRCA1_1	506	510	PF00533	0.278
LIG_BRCT_BRCA1_1	570	574	PF00533	0.324
LIG_BRCT_BRCA1_1	623	627	PF00533	0.323
LIG_BRCT_BRCA1_1	665	669	PF00533	0.325
LIG_BRCT_BRCA1_1	71	75	PF00533	0.397
LIG_CaM_NSCaTE_8	304	311	PF13499	0.324
LIG_EH1_1	321	329	PF00400	0.393
LIG_eIF4E_1	434	440	PF01652	0.294
LIG_FHA_1	131	137	PF00498	0.258
LIG_FHA_1	143	149	PF00498	0.200
LIG_FHA_1	25	31	PF00498	0.442
LIG_FHA_1	285	291	PF00498	0.222
LIG_FHA_1	394	400	PF00498	0.277
LIG_FHA_1	417	423	PF00498	0.282
LIG_FHA_1	426	432	PF00498	0.254
LIG_FHA_1	477	483	PF00498	0.253
LIG_FHA_1	490	496	PF00498	0.268
LIG_FHA_1	576	582	PF00498	0.307
LIG_FHA_2	121	127	PF00498	0.169
LIG_FHA_2	164	170	PF00498	0.266
LIG_FHA_2	225	231	PF00498	0.261
LIG_FHA_2	300	306	PF00498	0.219
LIG_FHA_2	484	490	PF00498	0.261
LIG_GBD_Chelix_1	552	560	PF00786	0.283
LIG_LIR_Apic_2	246	252	PF02991	0.285
LIG_LIR_Apic_2	372	377	PF02991	0.406
LIG_LIR_Apic_2	43	48	PF02991	0.449
LIG_LIR_Apic_2	455	459	PF02991	0.261
LIG_LIR_Gen_1	232	242	PF02991	0.242
LIG_LIR_Gen_1	424	435	PF02991	0.368
LIG_LIR_Gen_1	492	501	PF02991	0.321
LIG_LIR_Gen_1	571	581	PF02991	0.300
LIG_LIR_Gen_1	78	87	PF02991	0.324
LIG_LIR_LC3C_4	546	551	PF02991	0.271
LIG_LIR_Nem_3	232	238	PF02991	0.222
LIG_LIR_Nem_3	282	288	PF02991	0.295
LIG_LIR_Nem_3	302	307	PF02991	0.241
LIG_LIR_Nem_3	348	352	PF02991	0.427
LIG_LIR_Nem_3	363	369	PF02991	0.406
LIG_LIR_Nem_3	424	430	PF02991	0.345
LIG_LIR_Nem_3	492	497	PF02991	0.321
LIG_LIR_Nem_3	571	577	PF02991	0.298
LIG_LIR_Nem_3	592	598	PF02991	0.299
LIG_NRBOX	24	30	PF00104	0.555
LIG_NRBOX	417	423	PF00104	0.348
LIG_Pex14_1	151	155	PF04695	0.261
LIG_Pex14_1	382	386	PF04695	0.524
LIG_Pex14_1	448	452	PF04695	0.406
LIG_Pex14_1	606	610	PF04695	0.406
LIG_Pex14_2	452	456	PF04695	0.358
LIG_Pex14_2	539	543	PF04695	0.324
LIG_PTB_Apo_2	105	112	PF02174	0.256
LIG_PTB_Apo_2	146	153	PF02174	0.295
LIG_PTB_Phospho_1	105	111	PF10480	0.256
LIG_PTB_Phospho_1	146	152	PF10480	0.295
LIG_SH2_CRK	674	678	PF00017	0.479
LIG_SH2_GRB2like	155	158	PF00017	0.324
LIG_SH2_GRB2like	379	382	PF00017	0.514
LIG_SH2_GRB2like	442	445	PF00017	0.456
LIG_SH2_GRB2like	600	603	PF00017	0.456
LIG_SH2_PTP2	235	238	PF00017	0.303
LIG_SH2_PTP2	466	469	PF00017	0.394
LIG_SH2_SRC	46	49	PF00017	0.361
LIG_SH2_SRC	600	603	PF00017	0.456
LIG_SH2_STAP1	111	115	PF00017	0.256
LIG_SH2_STAP1	288	292	PF00017	0.232
LIG_SH2_STAP1	379	383	PF00017	0.514
LIG_SH2_STAT3	288	291	PF00017	0.285
LIG_SH2_STAT3	558	561	PF00017	0.408
LIG_SH2_STAT5	111	114	PF00017	0.219
LIG_SH2_STAT5	235	238	PF00017	0.286
LIG_SH2_STAT5	307	310	PF00017	0.250
LIG_SH2_STAT5	434	437	PF00017	0.292
LIG_SH2_STAT5	442	445	PF00017	0.435
LIG_SH2_STAT5	46	49	PF00017	0.341
LIG_SH2_STAT5	466	469	PF00017	0.278
LIG_SH2_STAT5	558	561	PF00017	0.293
LIG_SH2_STAT5	596	599	PF00017	0.422
LIG_SH2_STAT5	610	613	PF00017	0.262
LIG_SH3_3	262	268	PF00018	0.325
LIG_SH3_3	370	376	PF00018	0.445
LIG_SH3_3	494	500	PF00018	0.334
LIG_SH3_3	539	545	PF00018	0.308
LIG_SUMO_SIM_anti_2	326	331	PF11976	0.247
LIG_SUMO_SIM_anti_2	486	492	PF11976	0.190
LIG_SUMO_SIM_par_1	21	27	PF11976	0.472
LIG_SUMO_SIM_par_1	419	424	PF11976	0.247
LIG_SUMO_SIM_par_1	486	492	PF11976	0.269
LIG_SUMO_SIM_par_1	549	555	PF11976	0.291
LIG_SUMO_SIM_par_1	587	592	PF11976	0.353
LIG_SxIP_EBH_1	474	488	PF03271	0.261
LIG_TRAF2_1	228	231	PF00917	0.318
LIG_TRAF2_1	88	91	PF00917	0.226
LIG_TYR_ITIM	464	469	PF00017	0.368
LIG_UBA3_1	341	347	PF00899	0.266
LIG_UBA3_1	467	474	PF00899	0.317
LIG_UBA3_1	74	81	PF00899	0.261
LIG_WRC_WIRS_1	453	458	PF05994	0.311
LIG_WRC_WIRS_1	569	574	PF05994	0.292
LIG_WRC_WIRS_1	634	639	PF05994	0.239
LIG_WW_1	376	379	PF00397	0.514
MOD_CDC14_SPxK_1	410	413	PF00782	0.242
MOD_CDK_SPxK_1	407	413	PF00069	0.242
MOD_CDK_SPxxK_3	292	299	PF00069	0.157
MOD_CDK_SPxxK_3	407	414	PF00069	0.206
MOD_CK1_1	10	16	PF00069	0.659
MOD_CK1_1	109	115	PF00069	0.229
MOD_CK1_1	2	8	PF00069	0.744
MOD_CK1_1	222	228	PF00069	0.302
MOD_CK1_1	429	435	PF00069	0.373
MOD_CK1_1	630	636	PF00069	0.259
MOD_CK1_1	67	73	PF00069	0.255
MOD_CK2_1	163	169	PF00069	0.266
MOD_CK2_1	224	230	PF00069	0.261
MOD_CK2_1	483	489	PF00069	0.261
MOD_CK2_1	67	73	PF00069	0.347
MOD_CK2_1	93	99	PF00069	0.311
MOD_GlcNHglycan	1	4	PF01048	0.596
MOD_GlcNHglycan	334	337	PF01048	0.319
MOD_GlcNHglycan	42	45	PF01048	0.673
MOD_GlcNHglycan	431	434	PF01048	0.379
MOD_GlcNHglycan	638	641	PF01048	0.532
MOD_GSK3_1	138	145	PF00069	0.226
MOD_GSK3_1	163	170	PF00069	0.226
MOD_GSK3_1	219	226	PF00069	0.318
MOD_GSK3_1	243	250	PF00069	0.280
MOD_GSK3_1	280	287	PF00069	0.255
MOD_GSK3_1	417	424	PF00069	0.405
MOD_GSK3_1	425	432	PF00069	0.346
MOD_GSK3_1	495	502	PF00069	0.337
MOD_GSK3_1	632	639	PF00069	0.236
MOD_GSK3_1	64	71	PF00069	0.383
MOD_GSK3_1	7	14	PF00069	0.698
MOD_N-GLC_1	142	147	PF02516	0.412
MOD_N-GLC_1	279	284	PF02516	0.433
MOD_NEK2_1	1	6	PF00069	0.694
MOD_NEK2_1	212	217	PF00069	0.262
MOD_NEK2_1	24	29	PF00069	0.437
MOD_NEK2_1	306	311	PF00069	0.258
MOD_NEK2_1	332	337	PF00069	0.266
MOD_NEK2_1	417	422	PF00069	0.347
MOD_NEK2_1	452	457	PF00069	0.377
MOD_NEK2_1	504	509	PF00069	0.288
MOD_NEK2_1	575	580	PF00069	0.375
MOD_NEK2_1	621	626	PF00069	0.288
MOD_NEK2_1	627	632	PF00069	0.268
MOD_NEK2_1	64	69	PF00069	0.317
MOD_OFUCOSY	586	593	PF10250	0.408
MOD_PIKK_1	168	174	PF00454	0.351
MOD_PIKK_1	2	8	PF00454	0.613
MOD_PIKK_1	527	533	PF00454	0.409
MOD_PK_1	243	249	PF00069	0.261
MOD_PK_1	93	99	PF00069	0.295
MOD_PKA_1	138	144	PF00069	0.226
MOD_PKA_2	219	225	PF00069	0.290
MOD_PKA_2	68	74	PF00069	0.368
MOD_Plk_1	168	174	PF00069	0.357
MOD_Plk_1	212	218	PF00069	0.261
MOD_Plk_1	279	285	PF00069	0.278
MOD_Plk_1	51	57	PF00069	0.383
MOD_Plk_1	93	99	PF00069	0.313
MOD_Plk_4	106	112	PF00069	0.231
MOD_Plk_4	24	30	PF00069	0.473
MOD_Plk_4	280	286	PF00069	0.282
MOD_Plk_4	323	329	PF00069	0.253
MOD_Plk_4	417	423	PF00069	0.344
MOD_Plk_4	426	432	PF00069	0.228
MOD_Plk_4	483	489	PF00069	0.251
MOD_Plk_4	499	505	PF00069	0.173
MOD_Plk_4	529	535	PF00069	0.458
MOD_Plk_4	621	627	PF00069	0.272
MOD_Plk_4	648	654	PF00069	0.294
MOD_ProDKin_1	292	298	PF00069	0.157
MOD_ProDKin_1	37	43	PF00069	0.547
MOD_ProDKin_1	407	413	PF00069	0.206
MOD_SUMO_for_1	92	95	PF00179	0.324
MOD_SUMO_rev_2	117	122	PF00179	0.244
MOD_SUMO_rev_2	134	144	PF00179	0.138
MOD_SUMO_rev_2	226	236	PF00179	0.174
MOD_SUMO_rev_2	254	262	PF00179	0.291
TRG_DiLeu_BaEn_2	58	64	PF01217	0.343
TRG_DiLeu_BaEn_3	231	237	PF01217	0.310
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.485
TRG_ENDOCYTIC_2	155	158	PF00928	0.250
TRG_ENDOCYTIC_2	235	238	PF00928	0.273
TRG_ENDOCYTIC_2	466	469	PF00928	0.337
TRG_ENDOCYTIC_2	557	560	PF00928	0.327
TRG_ENDOCYTIC_2	569	572	PF00928	0.164
TRG_ENDOCYTIC_2	595	598	PF00928	0.406
TRG_ENDOCYTIC_2	646	649	PF00928	0.232
TRG_ENDOCYTIC_2	674	677	PF00928	0.466
TRG_ENDOCYTIC_2	79	82	PF00928	0.260
TRG_ER_diArg_1	136	138	PF00400	0.314
TRG_ER_diArg_1	670	672	PF00400	0.558
TRG_NES_CRM1_1	264	276	PF08389	0.174
TRG_Pf-PMV_PEXEL_1	343	348	PF00026	0.206

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P948	Leptomonas seymouri	63%	100%
A0A0N1I2B1	Leptomonas seymouri	29%	100%
A0A0N1I6Y7	Leptomonas seymouri	30%	100%
A0A0N1IME8	Leptomonas seymouri	21%	100%
A0A0S4IV41	Bodo saltans	33%	100%
A0A0S4J9X2	Bodo saltans	40%	100%
A0A0S4JBB1	Bodo saltans	34%	100%
A0A0S4JCH7	Bodo saltans	33%	99%
A0A0S4JEU5	Bodo saltans	27%	100%
A0A0S4JIF4	Bodo saltans	36%	100%
A0A0S4JWZ9	Bodo saltans	21%	100%
A0A0S4JZ31	Bodo saltans	26%	100%
A0A1X0NJN3	Trypanosomatidae	23%	100%
A0A1X0NK64	Trypanosomatidae	28%	100%
A0A1X0NZX5	Trypanosomatidae	49%	100%
A0A1X0P2G3	Trypanosomatidae	32%	100%
A0A1X0P6M4	Trypanosomatidae	29%	89%
A0A1X0PA12	Trypanosomatidae	33%	100%
A0A3Q8IBT4	Leishmania donovani	25%	100%
A0A3Q8IFM1	Leishmania donovani	29%	100%
A0A3Q8IHT3	Leishmania donovani	29%	100%
A0A3R7MBZ3	Trypanosoma rangeli	30%	100%
A0A3S7X2L7	Leishmania donovani	93%	100%
A0A422NED2	Trypanosoma rangeli	49%	100%
A0A422NMS9	Trypanosoma rangeli	32%	100%
A0A422P482	Trypanosoma rangeli	22%	100%
A4H7C1	Leishmania braziliensis	24%	100%
A4HB85	Leishmania braziliensis	28%	100%
A4HHH4	Leishmania braziliensis	82%	100%
A4HHY3	Leishmania braziliensis	29%	100%
A4HVR6	Leishmania infantum	25%	100%
A4I4M3	Leishmania infantum	94%	100%
A4I563	Leishmania infantum	30%	100%
A4IAD3	Leishmania infantum	29%	100%
A4IFE9	Bos taurus	26%	100%
A5D7E2	Bos taurus	33%	100%
C9ZLB0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	93%
C9ZLW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZUX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9ALR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9APG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	90%
E9B0G0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B5F7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
F4HW17	Arabidopsis thaliana	25%	100%
F4JRE0	Arabidopsis thaliana	29%	100%
F4KIB2	Arabidopsis thaliana	32%	100%
O15321	Homo sapiens	26%	100%
P32802	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P40071	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	96%
P58021	Mus musculus	31%	100%
Q04562	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q4KLL4	Rattus norvegicus	33%	100%
Q4Q2H8	Leishmania major	28%	100%
Q4Q7S3	Leishmania major	30%	100%
Q4QG16	Leishmania major	21%	90%
Q54ZW0	Dictyostelium discoideum	25%	100%
Q55FP0	Dictyostelium discoideum	30%	100%
Q5R8F1	Pongo abelii	25%	100%
Q5R8Y6	Pongo abelii	30%	100%
Q5RDY2	Pongo abelii	33%	100%
Q66HF2	Rattus norvegicus	26%	100%
Q66HG5	Rattus norvegicus	30%	100%
Q7YTA6	Dictyostelium discoideum	21%	100%
Q8BH24	Mus musculus	33%	100%
Q8RWW1	Arabidopsis thaliana	32%	100%
Q92544	Homo sapiens	33%	100%
Q940G0	Arabidopsis thaliana	27%	100%
Q940S0	Arabidopsis thaliana	27%	100%
Q99805	Homo sapiens	30%	100%
Q9C5N2	Arabidopsis thaliana	33%	100%
Q9C720	Arabidopsis thaliana	33%	100%
Q9DBU0	Mus musculus	26%	100%
Q9FHT4	Arabidopsis thaliana	28%	100%
Q9FYQ8	Arabidopsis thaliana	29%	100%
Q9LIC2	Arabidopsis thaliana	32%	100%
Q9Y819	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q9ZPS7	Arabidopsis thaliana	27%	100%
V5BCD5	Trypanosoma cruzi	32%	100%
V5BHS7	Trypanosoma cruzi	29%	100%
V5D9U0	Trypanosoma cruzi	49%	100%
V5DII3	Trypanosoma cruzi	22%	100%