LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9AE19_LEIMA
TriTrypDb:
LmjF.29.1585 , LMJLV39_290022900 , LMJSD75_290023400
Length:
123

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AE19
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE19

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 27 29 PF00675 0.658
CLV_PCSK_KEX2_1 27 29 PF00082 0.658
DEG_Nend_UBRbox_3 1 3 PF02207 0.691
DOC_CKS1_1 47 52 PF01111 0.681
DOC_WW_Pin1_4 4 9 PF00397 0.702
DOC_WW_Pin1_4 46 51 PF00397 0.672
LIG_14-3-3_CanoR_1 19 23 PF00244 0.584
LIG_BIR_III_2 59 63 PF00653 0.668
LIG_FHA_1 18 24 PF00498 0.583
LIG_FHA_1 49 55 PF00498 0.722
LIG_FHA_2 19 25 PF00498 0.496
LIG_LIR_Apic_2 100 105 PF02991 0.591
LIG_LYPXL_S_1 68 72 PF13949 0.642
LIG_LYPXL_yS_3 69 72 PF13949 0.632
LIG_SH3_3 98 104 PF00018 0.546
LIG_SH3_CIN85_PxpxPR_1 58 63 PF14604 0.671
LIG_TRAF2_1 42 45 PF00917 0.785
LIG_TRAF2_1 78 81 PF00917 0.524
LIG_TRAF2_2 50 55 PF00917 0.675
MOD_CDK_SPxxK_3 46 53 PF00069 0.675
MOD_CK2_1 18 24 PF00069 0.562
MOD_GlcNHglycan 11 14 PF01048 0.616
MOD_N-GLC_1 34 39 PF02516 0.686
MOD_NEK2_1 34 39 PF00069 0.613
MOD_PIKK_1 48 54 PF00454 0.715
MOD_PKA_2 18 24 PF00069 0.579
MOD_Plk_4 18 24 PF00069 0.562
MOD_ProDKin_1 4 10 PF00069 0.698
MOD_ProDKin_1 46 52 PF00069 0.676
TRG_DiLeu_BaEn_4 80 86 PF01217 0.599
TRG_ENDOCYTIC_2 69 72 PF00928 0.632
TRG_ER_diArg_1 26 28 PF00400 0.683
TRG_Pf-PMV_PEXEL_1 63 67 PF00026 0.728

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PED8 Leptomonas seymouri 53% 100%
A0A3S7X2H6 Leishmania donovani 94% 100%
A0A422NEF5 Trypanosoma rangeli 39% 89%
A4HHH2 Leishmania braziliensis 80% 100%
A4I4M1 Leishmania infantum 94% 100%
E9ALR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS