UBA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

XPC-binding domain containing protein, putative

Species:

Leishmania major

UniProt:

E9AE18_LEIMA

TriTrypDb:

LmjF.29.1580 , LMJLV39_290022800 , LMJSD75_290023300

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	3
GO:0005730	nucleolus	5	2
GO:0005829	cytosol	2	3
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	4
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AE18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE18

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006259	DNA metabolic process	4	10
GO:0006281	DNA repair	5	10
GO:0006289	nucleotide-excision repair	6	10
GO:0006508	proteolysis	4	10
GO:0006511	ubiquitin-dependent protein catabolic process	7	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0006950	response to stress	2	10
GO:0006974	DNA damage response	4	10
GO:0008152	metabolic process	1	10
GO:0009056	catabolic process	2	10
GO:0009057	macromolecule catabolic process	4	10
GO:0009987	cellular process	1	10
GO:0010498	proteasomal protein catabolic process	5	10
GO:0019538	protein metabolic process	3	10
GO:0019941	modification-dependent protein catabolic process	6	10
GO:0030163	protein catabolic process	4	10
GO:0033554	cellular response to stress	3	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043632	modification-dependent macromolecule catabolic process	5	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044248	cellular catabolic process	3	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0044265	obsolete cellular macromolecule catabolic process	4	10
GO:0046483	heterocycle metabolic process	3	10
GO:0050896	response to stimulus	1	10
GO:0051603	proteolysis involved in protein catabolic process	5	10
GO:0051716	cellular response to stimulus	2	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901565	organonitrogen compound catabolic process	4	10
GO:1901575	organic substance catabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	10
GO:0003684	damaged DNA binding	5	10
GO:0005488	binding	1	10
GO:0005515	protein binding	2	3
GO:0031593	polyubiquitin modification-dependent protein binding	4	3
GO:0032182	ubiquitin-like protein binding	3	3
GO:0043130	ubiquitin binding	4	3
GO:0044877	protein-containing complex binding	2	2
GO:0070628	proteasome binding	3	2
GO:0097159	organic cyclic compound binding	2	10
GO:0140030	modification-dependent protein binding	3	3
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.728
CLV_C14_Caspase3-7	317	321	PF00656	0.659
CLV_PCSK_KEX2_1	131	133	PF00082	0.796
CLV_PCSK_KEX2_1	335	337	PF00082	0.548
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.796
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.548
CLV_PCSK_SKI1_1	25	29	PF00082	0.541
CLV_PCSK_SKI1_1	370	374	PF00082	0.296
CLV_PCSK_SKI1_1	85	89	PF00082	0.434
DEG_Nend_UBRbox_1	1	4	PF02207	0.393
DEG_SPOP_SBC_1	67	71	PF00917	0.676
DOC_MAPK_DCC_7	187	195	PF00069	0.378
DOC_MAPK_MEF2A_6	187	195	PF00069	0.386
DOC_MAPK_MEF2A_6	40	47	PF00069	0.365
DOC_PP1_RVXF_1	368	374	PF00149	0.296
DOC_PP1_RVXF_1	48	55	PF00149	0.425
DOC_PP4_FxxP_1	388	391	PF00568	0.449
DOC_USP7_MATH_1	122	126	PF00917	0.616
DOC_USP7_MATH_1	167	171	PF00917	0.711
DOC_USP7_MATH_1	241	245	PF00917	0.566
DOC_USP7_MATH_1	291	295	PF00917	0.639
DOC_USP7_MATH_1	325	329	PF00917	0.723
DOC_USP7_MATH_1	66	70	PF00917	0.648
DOC_WW_Pin1_4	120	125	PF00397	0.797
DOC_WW_Pin1_4	68	73	PF00397	0.684
LIG_14-3-3_CanoR_1	33	37	PF00244	0.502
LIG_14-3-3_CanoR_1	336	344	PF00244	0.501
LIG_14-3-3_CanoR_1	40	44	PF00244	0.458
LIG_Actin_WH2_2	36	52	PF00022	0.419
LIG_BIR_III_4	175	179	PF00653	0.581
LIG_BRCT_BRCA1_1	280	284	PF00533	0.484
LIG_BRCT_BRCA1_1	296	300	PF00533	0.589
LIG_EH1_1	2	10	PF00400	0.471
LIG_FHA_1	22	28	PF00498	0.320
LIG_FHA_1	4	10	PF00498	0.456
LIG_FHA_1	40	46	PF00498	0.369
LIG_FHA_2	145	151	PF00498	0.563
LIG_LIR_Gen_1	181	191	PF02991	0.555
LIG_LIR_Gen_1	217	223	PF02991	0.509
LIG_LIR_Gen_1	227	233	PF02991	0.428
LIG_LIR_Nem_3	181	186	PF02991	0.546
LIG_LIR_Nem_3	217	222	PF02991	0.493
LIG_LIR_Nem_3	227	232	PF02991	0.437
LIG_LIR_Nem_3	281	287	PF02991	0.541
LIG_Pex14_2	54	58	PF04695	0.485
LIG_SH2_CRK	106	110	PF00017	0.600
LIG_SH2_STAT5	287	290	PF00017	0.572
LIG_SH2_STAT5	374	377	PF00017	0.408
LIG_SH3_3	138	144	PF00018	0.764
LIG_SH3_3	26	32	PF00018	0.548
LIG_SUMO_SIM_anti_2	192	197	PF11976	0.538
LIG_SUMO_SIM_anti_2	227	234	PF11976	0.502
LIG_SUMO_SIM_anti_2	97	103	PF11976	0.412
LIG_TRAF2_1	348	351	PF00917	0.488
MOD_CK1_1	107	113	PF00069	0.667
MOD_CK1_1	11	17	PF00069	0.528
MOD_CK1_1	286	292	PF00069	0.564
MOD_CK1_1	294	300	PF00069	0.588
MOD_CK1_1	70	76	PF00069	0.679
MOD_CK2_1	120	126	PF00069	0.750
MOD_CK2_1	134	140	PF00069	0.600
MOD_CK2_1	144	150	PF00069	0.576
MOD_CK2_1	261	267	PF00069	0.735
MOD_CK2_1	335	341	PF00069	0.655
MOD_GlcNHglycan	109	112	PF01048	0.645
MOD_GlcNHglycan	280	283	PF01048	0.604
MOD_GlcNHglycan	289	292	PF01048	0.595
MOD_GlcNHglycan	293	296	PF01048	0.649
MOD_GlcNHglycan	309	313	PF01048	0.673
MOD_GlcNHglycan	325	328	PF01048	0.734
MOD_GlcNHglycan	64	67	PF01048	0.748
MOD_GlcNHglycan	72	75	PF01048	0.631
MOD_GSK3_1	17	24	PF00069	0.439
MOD_GSK3_1	257	264	PF00069	0.697
MOD_GSK3_1	283	290	PF00069	0.542
MOD_GSK3_1	3	10	PF00069	0.363
MOD_GSK3_1	342	349	PF00069	0.568
MOD_GSK3_1	62	69	PF00069	0.652
MOD_N-GLC_1	104	109	PF02516	0.671
MOD_N-GLC_1	12	17	PF02516	0.526
MOD_N-GLC_1	323	328	PF02516	0.587
MOD_NEK2_1	1	6	PF00069	0.383
MOD_NEK2_1	261	266	PF00069	0.751
MOD_NEK2_1	283	288	PF00069	0.555
MOD_NEK2_1	308	313	PF00069	0.654
MOD_NEK2_1	342	347	PF00069	0.567
MOD_NEK2_1	39	44	PF00069	0.458
MOD_NEK2_1	8	13	PF00069	0.439
MOD_PKA_1	335	341	PF00069	0.520
MOD_PKA_2	32	38	PF00069	0.515
MOD_PKA_2	335	341	PF00069	0.520
MOD_PKA_2	381	387	PF00069	0.411
MOD_PKA_2	39	45	PF00069	0.487
MOD_PKB_1	132	140	PF00069	0.601
MOD_Plk_1	104	110	PF00069	0.590
MOD_Plk_1	12	18	PF00069	0.536
MOD_Plk_1	191	197	PF00069	0.538
MOD_Plk_1	25	31	PF00069	0.431
MOD_Plk_2-3	156	162	PF00069	0.653
MOD_Plk_4	12	18	PF00069	0.559
MOD_Plk_4	191	197	PF00069	0.538
MOD_Plk_4	214	220	PF00069	0.534
MOD_Plk_4	225	231	PF00069	0.538
MOD_Plk_4	241	247	PF00069	0.468
MOD_Plk_4	257	263	PF00069	0.773
MOD_Plk_4	283	289	PF00069	0.505
MOD_Plk_4	97	103	PF00069	0.501
MOD_ProDKin_1	120	126	PF00069	0.798
MOD_ProDKin_1	68	74	PF00069	0.683
MOD_SUMO_rev_2	349	356	PF00179	0.295
MOD_SUMO_rev_2	80	88	PF00179	0.456
TRG_DiLeu_BaEn_1	257	262	PF01217	0.663
TRG_ENDOCYTIC_2	106	109	PF00928	0.546
TRG_ER_diArg_1	132	135	PF00400	0.696
TRG_NLS_MonoExtC_3	130	136	PF00514	0.712
TRG_NLS_MonoExtN_4	128	135	PF00514	0.714
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I958	Leptomonas seymouri	61%	99%
A0A1X0NZX2	Trypanosomatidae	29%	100%
A0A3Q8IFF1	Leishmania donovani	92%	98%
A0A422NEC4	Trypanosoma rangeli	30%	100%
A4HHH1	Leishmania braziliensis	75%	98%
A4I4M0	Leishmania infantum	93%	98%
C9ZLA7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	85%
E9ALR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%