WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AE17_LEIMA

TriTrypDb:

LmjF.29.1575 , LMJLV39_290022700 , LMJSD75_290023200

Length:

452

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	2
GO:0016020	membrane	2	2
GO:0019898	extrinsic component of membrane	2	2
GO:0034045	phagophore assembly site membrane	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AE17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE17

Function

Biological processes
Term	Name	Level	Count
GO:0000422	autophagy of mitochondrion	4	2
GO:0006497	protein lipidation	5	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006914	autophagy	3	2
GO:0006996	organelle organization	4	2
GO:0007005	mitochondrion organization	5	2
GO:0008104	protein localization	4	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0019538	protein metabolic process	3	2
GO:0022411	cellular component disassembly	4	2
GO:0033036	macromolecule localization	2	2
GO:0034497	protein localization to phagophore assembly site	5	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044804	autophagy of nucleus	4	2
GO:0051179	localization	1	2
GO:0051641	cellular localization	2	2
GO:0061726	mitochondrion disassembly	6	2
GO:0061919	process utilizing autophagic mechanism	2	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1903008	organelle disassembly	5	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005543	phospholipid binding	3	2
GO:0008289	lipid binding	2	2
GO:0032266	phosphatidylinositol-3-phosphate binding	6	2
GO:0035091	phosphatidylinositol binding	4	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	4	2
GO:1901981	phosphatidylinositol phosphate binding	5	2
GO:1902936	phosphatidylinositol bisphosphate binding	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.815
CLV_NRD_NRD_1	20	22	PF00675	0.504
CLV_NRD_NRD_1	331	333	PF00675	0.813
CLV_NRD_NRD_1	382	384	PF00675	0.508
CLV_NRD_NRD_1	96	98	PF00675	0.653
CLV_PCSK_KEX2_1	133	135	PF00082	0.836
CLV_PCSK_KEX2_1	20	22	PF00082	0.504
CLV_PCSK_KEX2_1	331	333	PF00082	0.816
CLV_PCSK_SKI1_1	275	279	PF00082	0.422
CLV_PCSK_SKI1_1	407	411	PF00082	0.790
CLV_PCSK_SKI1_1	85	89	PF00082	0.528
DEG_SPOP_SBC_1	318	322	PF00917	0.612
DOC_ANK_TNKS_1	196	203	PF00023	0.607
DOC_MAPK_gen_1	114	122	PF00069	0.429
DOC_MAPK_gen_1	231	241	PF00069	0.527
DOC_MAPK_MEF2A_6	234	243	PF00069	0.522
DOC_PP4_FxxP_1	423	426	PF00568	0.731
DOC_USP7_MATH_1	168	172	PF00917	0.721
DOC_USP7_MATH_1	206	210	PF00917	0.562
DOC_USP7_MATH_1	277	281	PF00917	0.658
DOC_USP7_MATH_1	298	302	PF00917	0.735
DOC_USP7_MATH_1	317	321	PF00917	0.497
DOC_USP7_MATH_1	341	345	PF00917	0.795
DOC_USP7_MATH_1	49	53	PF00917	0.521
DOC_USP7_MATH_1	7	11	PF00917	0.668
DOC_USP7_MATH_1	93	97	PF00917	0.680
DOC_WW_Pin1_4	155	160	PF00397	0.683
DOC_WW_Pin1_4	175	180	PF00397	0.588
DOC_WW_Pin1_4	287	292	PF00397	0.669
DOC_WW_Pin1_4	326	331	PF00397	0.716
DOC_WW_Pin1_4	39	44	PF00397	0.489
DOC_WW_Pin1_4	407	412	PF00397	0.782
DOC_WW_Pin1_4	424	429	PF00397	0.474
DOC_WW_Pin1_4	435	440	PF00397	0.623
LIG_14-3-3_CanoR_1	203	211	PF00244	0.473
LIG_14-3-3_CanoR_1	48	54	PF00244	0.476
LIG_14-3-3_CanoR_1	74	79	PF00244	0.472
LIG_Actin_WH2_2	57	73	PF00022	0.478
LIG_AP_GAE_1	375	381	PF02883	0.626
LIG_BRCT_BRCA1_1	170	174	PF00533	0.810
LIG_deltaCOP1_diTrp_1	369	378	PF00928	0.605
LIG_FHA_1	212	218	PF00498	0.464
LIG_FHA_1	220	226	PF00498	0.499
LIG_FHA_1	256	262	PF00498	0.434
LIG_FHA_2	205	211	PF00498	0.467
LIG_Integrin_RGD_1	117	119	PF01839	0.471
LIG_LIR_Apic_2	421	426	PF02991	0.645
LIG_LIR_Gen_1	60	70	PF02991	0.470
LIG_LIR_LC3C_4	51	56	PF02991	0.342
LIG_LIR_Nem_3	60	65	PF02991	0.446
LIG_PDZ_Class_2	447	452	PF00595	0.593
LIG_SH2_NCK_1	105	109	PF00017	0.483
LIG_SH2_PTP2	22	25	PF00017	0.462
LIG_SH2_PTP2	449	452	PF00017	0.691
LIG_SH2_SRC	353	356	PF00017	0.823
LIG_SH2_STAP1	105	109	PF00017	0.491
LIG_SH2_STAT3	72	75	PF00017	0.521
LIG_SH2_STAT5	22	25	PF00017	0.406
LIG_SH2_STAT5	449	452	PF00017	0.663
LIG_SH2_STAT5	72	75	PF00017	0.521
LIG_SH3_3	104	110	PF00018	0.487
LIG_SH3_3	78	84	PF00018	0.570
LIG_SUMO_SIM_anti_2	119	124	PF11976	0.422
LIG_SUMO_SIM_anti_2	51	57	PF11976	0.504
LIG_SUMO_SIM_par_1	63	69	PF11976	0.469
LIG_SUMO_SIM_par_1	86	91	PF11976	0.506
MOD_CDC14_SPxK_1	427	430	PF00782	0.765
MOD_CDK_SPK_2	326	331	PF00069	0.710
MOD_CDK_SPK_2	409	414	PF00069	0.781
MOD_CDK_SPxK_1	326	332	PF00069	0.710
MOD_CDK_SPxK_1	424	430	PF00069	0.753
MOD_CDK_SPxxK_3	407	414	PF00069	0.724
MOD_CDK_SPxxK_3	435	442	PF00069	0.738
MOD_CK1_1	146	152	PF00069	0.735
MOD_CK1_1	158	164	PF00069	0.703
MOD_CK1_1	270	276	PF00069	0.556
MOD_CK1_1	325	331	PF00069	0.728
MOD_CK2_1	204	210	PF00069	0.460
MOD_CK2_1	349	355	PF00069	0.786
MOD_Cter_Amidation	381	384	PF01082	0.507
MOD_GlcNHglycan	111	114	PF01048	0.549
MOD_GlcNHglycan	145	148	PF01048	0.725
MOD_GlcNHglycan	170	173	PF01048	0.803
MOD_GlcNHglycan	253	256	PF01048	0.490
MOD_GlcNHglycan	272	275	PF01048	0.494
MOD_GlcNHglycan	29	32	PF01048	0.539
MOD_GlcNHglycan	324	327	PF01048	0.768
MOD_GlcNHglycan	334	337	PF01048	0.587
MOD_GlcNHglycan	349	352	PF01048	0.587
MOD_GlcNHglycan	357	360	PF01048	0.751
MOD_GlcNHglycan	375	378	PF01048	0.618
MOD_GlcNHglycan	407	410	PF01048	0.790
MOD_GlcNHglycan	432	435	PF01048	0.804
MOD_GlcNHglycan	89	93	PF01048	0.534
MOD_GlcNHglycan	9	12	PF01048	0.667
MOD_GSK3_1	154	161	PF00069	0.689
MOD_GSK3_1	206	213	PF00069	0.486
MOD_GSK3_1	251	258	PF00069	0.491
MOD_GSK3_1	318	325	PF00069	0.787
MOD_GSK3_1	349	356	PF00069	0.784
MOD_GSK3_1	399	406	PF00069	0.691
MOD_N-GLC_1	166	171	PF02516	0.705
MOD_N-GLC_1	255	260	PF02516	0.491
MOD_N-GLC_1	347	352	PF02516	0.692
MOD_N-GLC_1	49	54	PF02516	0.515
MOD_N-GLC_1	7	12	PF02516	0.669
MOD_NEK2_1	204	209	PF00069	0.469
MOD_NEK2_1	211	216	PF00069	0.478
MOD_NEK2_1	217	222	PF00069	0.472
MOD_NEK2_1	26	31	PF00069	0.469
MOD_NEK2_1	405	410	PF00069	0.784
MOD_NEK2_1	88	93	PF00069	0.522
MOD_NEK2_2	255	260	PF00069	0.491
MOD_NEK2_2	418	423	PF00069	0.620
MOD_OFUCOSY	416	422	PF10250	0.634
MOD_Plk_1	118	124	PF00069	0.476
MOD_Plk_1	49	55	PF00069	0.510
MOD_Plk_1	7	13	PF00069	0.666
MOD_Plk_4	118	124	PF00069	0.426
MOD_Plk_4	279	285	PF00069	0.635
MOD_Plk_4	289	295	PF00069	0.739
MOD_Plk_4	49	55	PF00069	0.510
MOD_ProDKin_1	155	161	PF00069	0.683
MOD_ProDKin_1	175	181	PF00069	0.577
MOD_ProDKin_1	287	293	PF00069	0.671
MOD_ProDKin_1	326	332	PF00069	0.717
MOD_ProDKin_1	39	45	PF00069	0.487
MOD_ProDKin_1	407	413	PF00069	0.778
MOD_ProDKin_1	424	430	PF00069	0.479
MOD_ProDKin_1	435	441	PF00069	0.621
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.503
TRG_ENDOCYTIC_2	22	25	PF00928	0.409
TRG_ENDOCYTIC_2	449	452	PF00928	0.670
TRG_ER_diArg_1	20	22	PF00400	0.509
TRG_ER_diArg_1	330	332	PF00400	0.802
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PER0	Leptomonas seymouri	48%	71%
A0A3S7X2H0	Leishmania donovani	94%	100%
A4HHH0	Leishmania braziliensis	78%	100%
A4I4L9	Leishmania infantum	94%	100%
E9ALR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	78%