Putative GTPase activator protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GTPase activator protein, putative

Species:

Leishmania major

UniProt:

E9AE15_LEIMA

TriTrypDb:

LmjF.29.1560 , LMJLV39_290022500 , LMJSD75_290023000

Length:

529

Annotations

LeishMANIAdb annotations

Related to animal TBC proteins. Likely cytosolic.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AE15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE15

Function

Biological processes
Term	Name	Level	Count
GO:0043085	positive regulation of catalytic activity	4	2
GO:0043087	regulation of GTPase activity	5	2
GO:0043547	positive regulation of GTPase activity	6	2
GO:0044093	positive regulation of molecular function	3	2
GO:0050790	regulation of catalytic activity	3	2
GO:0051336	regulation of hydrolase activity	4	2
GO:0051345	positive regulation of hydrolase activity	5	2
GO:0065007	biological regulation	1	2
GO:0065009	regulation of molecular function	2	2
GO:0090630	activation of GTPase activity	7	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0003924	GTPase activity	7	5
GO:0003925	G protein activity	2	5
GO:0005096	GTPase activator activity	4	2
GO:0008047	enzyme activator activity	3	2
GO:0016462	pyrophosphatase activity	5	5
GO:0016787	hydrolase activity	2	5
GO:0016817	hydrolase activity, acting on acid anhydrides	3	5
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	5
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	5
GO:0030234	enzyme regulator activity	2	2
GO:0030695	GTPase regulator activity	4	2
GO:0060589	nucleoside-triphosphatase regulator activity	3	2
GO:0098772	molecular function regulator activity	1	5
GO:0140677	molecular function activator activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	7	11	PF00656	0.701
CLV_NRD_NRD_1	188	190	PF00675	0.439
CLV_NRD_NRD_1	256	258	PF00675	0.271
CLV_NRD_NRD_1	455	457	PF00675	0.398
CLV_NRD_NRD_1	485	487	PF00675	0.355
CLV_NRD_NRD_1	509	511	PF00675	0.423
CLV_NRD_NRD_1	92	94	PF00675	0.541
CLV_PCSK_KEX2_1	18	20	PF00082	0.488
CLV_PCSK_KEX2_1	190	192	PF00082	0.396
CLV_PCSK_KEX2_1	256	258	PF00082	0.246
CLV_PCSK_KEX2_1	455	457	PF00082	0.344
CLV_PCSK_KEX2_1	485	487	PF00082	0.354
CLV_PCSK_KEX2_1	509	511	PF00082	0.425
CLV_PCSK_KEX2_1	92	94	PF00082	0.587
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.472
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.385
CLV_PCSK_SKI1_1	371	375	PF00082	0.403
DEG_SCF_FBW7_2	73	79	PF00400	0.726
DOC_CKS1_1	142	147	PF01111	0.697
DOC_CKS1_1	165	170	PF01111	0.610
DOC_CKS1_1	73	78	PF01111	0.743
DOC_CYCLIN_yClb3_PxF_3	278	286	PF00134	0.514
DOC_MAPK_gen_1	194	204	PF00069	0.595
DOC_MAPK_gen_1	375	383	PF00069	0.370
DOC_MAPK_gen_1	485	493	PF00069	0.580
DOC_MAPK_MEF2A_6	230	237	PF00069	0.473
DOC_MAPK_MEF2A_6	329	337	PF00069	0.320
DOC_MAPK_MEF2A_6	421	430	PF00069	0.531
DOC_MAPK_NFAT4_5	230	238	PF00069	0.473
DOC_PP1_RVXF_1	160	166	PF00149	0.580
DOC_PP1_RVXF_1	228	235	PF00149	0.473
DOC_PP2B_LxvP_1	132	135	PF13499	0.620
DOC_PP4_FxxP_1	165	168	PF00568	0.586
DOC_USP7_MATH_1	109	113	PF00917	0.735
DOC_USP7_MATH_1	116	120	PF00917	0.688
DOC_USP7_MATH_1	12	16	PF00917	0.616
DOC_USP7_MATH_1	126	130	PF00917	0.665
DOC_USP7_MATH_1	147	151	PF00917	0.648
DOC_USP7_MATH_1	166	170	PF00917	0.473
DOC_USP7_MATH_1	522	526	PF00917	0.664
DOC_USP7_MATH_1	55	59	PF00917	0.748
DOC_USP7_MATH_1	61	65	PF00917	0.738
DOC_USP7_MATH_1	81	85	PF00917	0.606
DOC_USP7_MATH_1	98	102	PF00917	0.735
DOC_USP7_UBL2_3	190	194	PF12436	0.650
DOC_WW_Pin1_4	130	135	PF00397	0.705
DOC_WW_Pin1_4	141	146	PF00397	0.605
DOC_WW_Pin1_4	164	169	PF00397	0.588
DOC_WW_Pin1_4	206	211	PF00397	0.593
DOC_WW_Pin1_4	412	417	PF00397	0.547
DOC_WW_Pin1_4	419	424	PF00397	0.511
DOC_WW_Pin1_4	474	479	PF00397	0.542
DOC_WW_Pin1_4	69	74	PF00397	0.801
LIG_14-3-3_CanoR_1	200	205	PF00244	0.578
LIG_14-3-3_CanoR_1	455	462	PF00244	0.601
LIG_14-3-3_CanoR_1	469	475	PF00244	0.497
LIG_Actin_WH2_2	215	232	PF00022	0.556
LIG_BRCT_BRCA1_1	311	315	PF00533	0.410
LIG_Clathr_ClatBox_1	321	325	PF01394	0.329
LIG_eIF4E_1	249	255	PF01652	0.531
LIG_eIF4E_1	462	468	PF01652	0.544
LIG_FHA_1	29	35	PF00498	0.614
LIG_FHA_1	292	298	PF00498	0.525
LIG_FHA_1	328	334	PF00498	0.281
LIG_FHA_1	456	462	PF00498	0.526
LIG_FHA_2	165	171	PF00498	0.613
LIG_FHA_2	181	187	PF00498	0.483
LIG_FHA_2	5	11	PF00498	0.773
LIG_GBD_Chelix_1	316	324	PF00786	0.410
LIG_LIR_Gen_1	156	165	PF02991	0.659
LIG_LIR_Gen_1	312	321	PF02991	0.308
LIG_LIR_Gen_1	330	337	PF02991	0.273
LIG_LIR_Gen_1	393	402	PF02991	0.373
LIG_LIR_Nem_3	156	160	PF02991	0.590
LIG_LIR_Nem_3	192	198	PF02991	0.530
LIG_LIR_Nem_3	312	316	PF02991	0.308
LIG_LIR_Nem_3	328	334	PF02991	0.273
LIG_LIR_Nem_3	393	398	PF02991	0.373
LIG_PCNA_yPIPBox_3	358	371	PF02747	0.270
LIG_Pex14_1	408	412	PF04695	0.531
LIG_Pex14_2	315	319	PF04695	0.410
LIG_Pex14_2	395	399	PF04695	0.362
LIG_PTB_Apo_2	341	348	PF02174	0.273
LIG_PTB_Phospho_1	341	347	PF10480	0.273
LIG_SH2_NCK_1	462	466	PF00017	0.549
LIG_SH2_STAP1	462	466	PF00017	0.549
LIG_SH2_STAT5	249	252	PF00017	0.531
LIG_SH2_STAT5	260	263	PF00017	0.531
LIG_SH2_STAT5	282	285	PF00017	0.473
LIG_SH2_STAT5	309	312	PF00017	0.329
LIG_SH2_STAT5	410	413	PF00017	0.531
LIG_SH2_STAT5	435	438	PF00017	0.531
LIG_SH3_1	275	281	PF00018	0.497
LIG_SH3_1	70	76	PF00018	0.667
LIG_SH3_3	165	171	PF00018	0.611
LIG_SH3_3	17	23	PF00018	0.602
LIG_SH3_3	258	264	PF00018	0.515
LIG_SH3_3	275	281	PF00018	0.467
LIG_SH3_3	70	76	PF00018	0.774
LIG_Sin3_3	464	471	PF02671	0.556
LIG_SUMO_SIM_par_1	319	328	PF11976	0.329
LIG_SUMO_SIM_par_1	489	494	PF11976	0.637
LIG_TRAF2_1	38	41	PF00917	0.713
MOD_CDK_SPK_2	474	479	PF00069	0.575
MOD_CK1_1	150	156	PF00069	0.631
MOD_CK1_1	180	186	PF00069	0.598
MOD_CK1_1	4	10	PF00069	0.649
MOD_CK1_1	82	88	PF00069	0.808
MOD_CK2_1	180	186	PF00069	0.656
MOD_Cter_Amidation	136	139	PF01082	0.427
MOD_GlcNHglycan	106	109	PF01048	0.507
MOD_GlcNHglycan	111	114	PF01048	0.506
MOD_GlcNHglycan	149	152	PF01048	0.510
MOD_GlcNHglycan	206	209	PF01048	0.383
MOD_GlcNHglycan	46	51	PF01048	0.529
MOD_GlcNHglycan	524	527	PF01048	0.503
MOD_GlcNHglycan	63	66	PF01048	0.532
MOD_GlcNHglycan	89	92	PF01048	0.573
MOD_GlcNHglycan	94	97	PF01048	0.582
MOD_GSK3_1	1	8	PF00069	0.682
MOD_GSK3_1	126	133	PF00069	0.693
MOD_GSK3_1	146	153	PF00069	0.577
MOD_GSK3_1	200	207	PF00069	0.600
MOD_GSK3_1	233	240	PF00069	0.524
MOD_GSK3_1	305	312	PF00069	0.394
MOD_GSK3_1	470	477	PF00069	0.518
MOD_GSK3_1	522	529	PF00069	0.665
MOD_GSK3_1	71	78	PF00069	0.769
MOD_NEK2_1	204	209	PF00069	0.533
MOD_NEK2_1	233	238	PF00069	0.459
MOD_NEK2_1	426	431	PF00069	0.520
MOD_NEK2_1	450	455	PF00069	0.586
MOD_NEK2_1	470	475	PF00069	0.374
MOD_NEK2_1	54	59	PF00069	0.725
MOD_NEK2_2	390	395	PF00069	0.410
MOD_NEK2_2	98	103	PF00069	0.724
MOD_PIKK_1	177	183	PF00454	0.683
MOD_PIKK_1	82	88	PF00454	0.785
MOD_PKA_1	455	461	PF00069	0.581
MOD_PKA_1	92	98	PF00069	0.732
MOD_PKA_2	28	34	PF00069	0.590
MOD_PKA_2	455	461	PF00069	0.525
MOD_PKA_2	92	98	PF00069	0.778
MOD_Plk_1	155	161	PF00069	0.661
MOD_Plk_1	327	333	PF00069	0.272
MOD_Plk_1	426	432	PF00069	0.489
MOD_Plk_2-3	41	47	PF00069	0.577
MOD_Plk_4	1	7	PF00069	0.615
MOD_Plk_4	127	133	PF00069	0.737
MOD_Plk_4	200	206	PF00069	0.599
MOD_Plk_4	347	353	PF00069	0.273
MOD_Plk_4	382	388	PF00069	0.249
MOD_Plk_4	390	396	PF00069	0.317
MOD_ProDKin_1	130	136	PF00069	0.706
MOD_ProDKin_1	141	147	PF00069	0.599
MOD_ProDKin_1	164	170	PF00069	0.588
MOD_ProDKin_1	206	212	PF00069	0.591
MOD_ProDKin_1	412	418	PF00069	0.547
MOD_ProDKin_1	419	425	PF00069	0.511
MOD_ProDKin_1	474	480	PF00069	0.541
MOD_ProDKin_1	69	75	PF00069	0.804
MOD_SUMO_rev_2	362	370	PF00179	0.327
MOD_SUMO_rev_2	39	45	PF00179	0.729
TRG_DiLeu_BaLyEn_6	302	307	PF01217	0.455
TRG_ER_diArg_1	255	257	PF00400	0.471
TRG_ER_diArg_1	454	456	PF00400	0.540
TRG_ER_diArg_1	484	486	PF00400	0.526
TRG_ER_diArg_1	509	511	PF00400	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2C6	Leptomonas seymouri	76%	70%
A0A0S4II34	Bodo saltans	28%	100%
A0A1X0P1D7	Trypanosomatidae	46%	94%
A0A3Q8IEG1	Leishmania donovani	92%	100%
A4HHG8	Leishmania braziliensis	75%	90%
A4HQC7	Leishmania braziliensis	26%	100%
A4I4L7	Leishmania infantum	92%	100%
E9ALR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	74%
P87234	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	83%
V5BDT8	Trypanosoma cruzi	47%	94%