Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AE14_LEIMA

TriTrypDb:

LmjF.29.1550 , LMJLV39_290022400 , LMJSD75_290022900

Length:

475

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AE14

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	319	323	PF00656	0.614
CLV_NRD_NRD_1	175	177	PF00675	0.622
CLV_NRD_NRD_1	21	23	PF00675	0.455
CLV_NRD_NRD_1	360	362	PF00675	0.658
CLV_NRD_NRD_1	371	373	PF00675	0.712
CLV_PCSK_KEX2_1	15	17	PF00082	0.456
CLV_PCSK_KEX2_1	175	177	PF00082	0.606
CLV_PCSK_KEX2_1	21	23	PF00082	0.437
CLV_PCSK_KEX2_1	360	362	PF00082	0.602
CLV_PCSK_KEX2_1	371	373	PF00082	0.575
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.506
CLV_PCSK_SKI1_1	137	141	PF00082	0.590
CLV_PCSK_SKI1_1	175	179	PF00082	0.511
CLV_PCSK_SKI1_1	433	437	PF00082	0.551
CLV_PCSK_SKI1_1	47	51	PF00082	0.505
DEG_Nend_UBRbox_2	1	3	PF02207	0.443
DOC_CKS1_1	232	237	PF01111	0.529
DOC_CYCLIN_RxL_1	170	180	PF00134	0.465
DOC_CYCLIN_yCln2_LP_2	103	109	PF00134	0.510
DOC_CYCLIN_yCln2_LP_2	33	39	PF00134	0.391
DOC_MAPK_gen_1	21	28	PF00069	0.417
DOC_PP1_RVXF_1	45	52	PF00149	0.503
DOC_PP4_FxxP_1	232	235	PF00568	0.526
DOC_PP4_FxxP_1	243	246	PF00568	0.560
DOC_USP7_MATH_1	152	156	PF00917	0.596
DOC_USP7_MATH_1	201	205	PF00917	0.544
DOC_USP7_MATH_1	333	337	PF00917	0.752
DOC_USP7_MATH_1	79	83	PF00917	0.563
DOC_WW_Pin1_4	231	236	PF00397	0.555
DOC_WW_Pin1_4	3	8	PF00397	0.570
DOC_WW_Pin1_4	384	389	PF00397	0.779
DOC_WW_Pin1_4	403	408	PF00397	0.531
LIG_14-3-3_CanoR_1	222	227	PF00244	0.507
LIG_14-3-3_CanoR_1	38	44	PF00244	0.540
LIG_14-3-3_CanoR_1	433	441	PF00244	0.546
LIG_BRCT_BRCA1_1	201	205	PF00533	0.557
LIG_CaM_IQ_9	55	71	PF13499	0.431
LIG_EH1_1	463	471	PF00400	0.550
LIG_FHA_1	157	163	PF00498	0.715
LIG_FHA_1	354	360	PF00498	0.565
LIG_FHA_1	434	440	PF00498	0.709
LIG_FHA_1	441	447	PF00498	0.765
LIG_FHA_1	451	457	PF00498	0.442
LIG_FHA_2	133	139	PF00498	0.481
LIG_FHA_2	206	212	PF00498	0.555
LIG_FHA_2	317	323	PF00498	0.569
LIG_FHA_2	40	46	PF00498	0.443
LIG_FHA_2	420	426	PF00498	0.575
LIG_LIR_Apic_2	229	235	PF02991	0.529
LIG_LIR_Apic_2	241	246	PF02991	0.558
LIG_LIR_Gen_1	41	51	PF02991	0.414
LIG_LIR_Nem_3	146	150	PF02991	0.564
LIG_LIR_Nem_3	180	186	PF02991	0.462
LIG_LIR_Nem_3	41	46	PF02991	0.417
LIG_NRBOX	173	179	PF00104	0.467
LIG_PCNA_APIM_2	359	365	PF02747	0.482
LIG_PCNA_yPIPBox_3	87	99	PF02747	0.486
LIG_SH2_CRK	184	188	PF00017	0.496
LIG_SH2_CRK	416	420	PF00017	0.539
LIG_SH2_STAP1	227	231	PF00017	0.520
LIG_SH2_STAT3	227	230	PF00017	0.516
LIG_SH2_STAT5	163	166	PF00017	0.491
LIG_SH2_STAT5	19	22	PF00017	0.439
LIG_SH2_STAT5	362	365	PF00017	0.572
LIG_SH2_STAT5	464	467	PF00017	0.495
LIG_SH3_2	355	360	PF14604	0.520
LIG_SH3_3	1	7	PF00018	0.569
LIG_SH3_3	341	347	PF00018	0.621
LIG_SH3_3	349	355	PF00018	0.568
LIG_Sin3_3	268	275	PF02671	0.549
LIG_SUMO_SIM_anti_2	276	283	PF11976	0.551
LIG_SUMO_SIM_par_1	105	111	PF11976	0.520
LIG_SUMO_SIM_par_1	416	425	PF11976	0.730
LIG_SUMO_SIM_par_1	6	12	PF11976	0.472
LIG_TRAF2_1	123	126	PF00917	0.496
LIG_TRAF2_1	422	425	PF00917	0.577
LIG_TRFH_1	231	235	PF08558	0.532
LIG_TYR_ITIM	28	33	PF00017	0.412
LIG_TYR_ITIM	414	419	PF00017	0.562
LIG_WRC_WIRS_1	129	134	PF05994	0.446
MOD_CK1_1	199	205	PF00069	0.609
MOD_CK1_1	41	47	PF00069	0.446
MOD_CK2_1	137	143	PF00069	0.505
MOD_CK2_1	205	211	PF00069	0.518
MOD_CK2_1	39	45	PF00069	0.428
MOD_CK2_1	419	425	PF00069	0.573
MOD_CK2_1	79	85	PF00069	0.503
MOD_CMANNOS	293	296	PF00535	0.508
MOD_GlcNHglycan	334	338	PF01048	0.800
MOD_GlcNHglycan	339	342	PF01048	0.716
MOD_GlcNHglycan	379	382	PF01048	0.657
MOD_GlcNHglycan	80	84	PF01048	0.531
MOD_GSK3_1	128	135	PF00069	0.625
MOD_GSK3_1	152	159	PF00069	0.577
MOD_GSK3_1	196	203	PF00069	0.524
MOD_GSK3_1	323	330	PF00069	0.609
MOD_GSK3_1	333	340	PF00069	0.545
MOD_GSK3_1	377	384	PF00069	0.644
MOD_GSK3_1	399	406	PF00069	0.602
MOD_NEK2_1	128	133	PF00069	0.450
MOD_NEK2_1	189	194	PF00069	0.490
MOD_NEK2_1	196	201	PF00069	0.504
MOD_NEK2_1	205	210	PF00069	0.483
MOD_NEK2_1	376	381	PF00069	0.515
MOD_PIKK_1	241	247	PF00454	0.489
MOD_PKA_2	156	162	PF00069	0.547
MOD_PKB_1	351	359	PF00069	0.543
MOD_Plk_1	137	143	PF00069	0.505
MOD_Plk_2-3	327	333	PF00069	0.543
MOD_Plk_4	108	114	PF00069	0.529
MOD_Plk_4	128	134	PF00069	0.350
MOD_Plk_4	222	228	PF00069	0.576
MOD_Plk_4	277	283	PF00069	0.501
MOD_Plk_4	288	294	PF00069	0.546
MOD_ProDKin_1	231	237	PF00069	0.552
MOD_ProDKin_1	3	9	PF00069	0.567
MOD_ProDKin_1	384	390	PF00069	0.776
MOD_ProDKin_1	403	409	PF00069	0.526
MOD_SUMO_for_1	297	300	PF00179	0.607
MOD_SUMO_for_1	308	311	PF00179	0.516
TRG_DiLeu_BaEn_1	277	282	PF01217	0.496
TRG_DiLeu_BaEn_1	300	305	PF01217	0.522
TRG_DiLeu_BaEn_4	256	262	PF01217	0.485
TRG_DiLeu_BaLyEn_6	173	178	PF01217	0.565
TRG_ENDOCYTIC_2	30	33	PF00928	0.427
TRG_ENDOCYTIC_2	411	414	PF00928	0.528
TRG_ENDOCYTIC_2	416	419	PF00928	0.521
TRG_ER_diArg_1	174	176	PF00400	0.591
TRG_ER_diArg_1	20	22	PF00400	0.459
TRG_ER_diArg_1	350	353	PF00400	0.579
TRG_ER_diArg_1	359	361	PF00400	0.534
TRG_Pf-PMV_PEXEL_1	175	180	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P119	Trypanosomatidae	25%	79%
A4HHG7	Leishmania braziliensis	74%	100%
C9ZLA4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	85%
E9ALR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	71%
V5D9T6	Trypanosoma cruzi	29%	85%