Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AE13_LEIMA

TriTrypDb:

LmjF.29.1540 , LMJLV39_290022300 , LMJSD75_290022800

Length:

192

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AE13

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE13

PDB structure(s): 7ane_g

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.418
CLV_NRD_NRD_1	151	153	PF00675	0.425
CLV_NRD_NRD_1	159	161	PF00675	0.425
CLV_NRD_NRD_1	58	60	PF00675	0.386
CLV_NRD_NRD_1	97	99	PF00675	0.419
CLV_PCSK_KEX2_1	159	161	PF00082	0.448
CLV_PCSK_KEX2_1	58	60	PF00082	0.386
CLV_PCSK_KEX2_1	96	98	PF00082	0.421
CLV_PCSK_SKI1_1	114	118	PF00082	0.399
DEG_Nend_UBRbox_3	1	3	PF02207	0.673
DOC_MAPK_DCC_7	159	169	PF00069	0.463
DOC_MAPK_HePTP_8	157	169	PF00069	0.461
DOC_MAPK_MEF2A_6	160	169	PF00069	0.441
DOC_MAPK_MEF2A_6	46	55	PF00069	0.336
LIG_14-3-3_CanoR_1	159	165	PF00244	0.508
LIG_14-3-3_CanoR_1	16	24	PF00244	0.565
LIG_FHA_1	113	119	PF00498	0.385
LIG_FHA_1	2	8	PF00498	0.606
LIG_FHA_1	39	45	PF00498	0.494
LIG_LIR_Gen_1	106	113	PF02991	0.405
LIG_LIR_Gen_1	151	161	PF02991	0.460
LIG_LIR_Nem_3	106	110	PF02991	0.386
LIG_LIR_Nem_3	151	157	PF02991	0.482
LIG_Pex14_2	185	189	PF04695	0.409
LIG_PTB_Apo_2	179	186	PF02174	0.370
LIG_SH2_CRK	154	158	PF00017	0.451
LIG_SH2_STAT5	63	66	PF00017	0.381
LIG_SH3_3	46	52	PF00018	0.525
LIG_SUMO_SIM_par_1	51	57	PF11976	0.432
MOD_CK1_1	18	24	PF00069	0.543
MOD_CK1_1	82	88	PF00069	0.429
MOD_GSK3_1	18	25	PF00069	0.437
MOD_LATS_1	15	21	PF00433	0.516
MOD_LATS_1	158	164	PF00433	0.500
MOD_N-GLC_1	38	43	PF02516	0.543
MOD_N-GLC_1	82	87	PF02516	0.430
MOD_NEK2_1	1	6	PF00069	0.579
MOD_NEK2_1	103	108	PF00069	0.407
MOD_NEK2_1	22	27	PF00069	0.474
MOD_NEK2_1	74	79	PF00069	0.408
MOD_PIKK_1	124	130	PF00454	0.530
MOD_PKA_2	15	21	PF00069	0.498
MOD_PKA_2	22	28	PF00069	0.513
MOD_Plk_1	38	44	PF00069	0.544
MOD_Plk_4	103	109	PF00069	0.406
MOD_Plk_4	51	57	PF00069	0.429
MOD_SUMO_rev_2	147	155	PF00179	0.461
MOD_SUMO_rev_2	82	89	PF00179	0.414
TRG_DiLeu_BaEn_1	121	126	PF01217	0.522
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.641
TRG_ENDOCYTIC_2	154	157	PF00928	0.509
TRG_ER_diArg_1	159	161	PF00400	0.453
TRG_ER_diArg_1	58	60	PF00400	0.398
TRG_ER_diArg_1	66	69	PF00400	0.416
TRG_ER_diArg_1	95	98	PF00400	0.422
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P947	Leptomonas seymouri	85%	100%
A0A0S4KFE4	Bodo saltans	61%	100%
A0A1X0P098	Trypanosomatidae	75%	99%
A0A3S7X2N0	Leishmania donovani	97%	100%
A0A422NEG3	Trypanosoma rangeli	77%	100%
A4HHG6	Leishmania braziliensis	92%	100%
A4I4L5	Leishmania infantum	97%	100%
C9ZLA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	99%
E9ALS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%