LeishMANIAdb
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CPSF_A domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
CPSF_A domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9AE12_LEIMA
TriTrypDb:
LmjF.29.1530 , LMJLV39_290022200 , LMJSD75_290022700 *
Length:
708

Annotations

LeishMANIAdb annotations

A tail-anchored beta-barrel protein family, mostly unique to Kinetoplastids

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

E9AE12
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 145 149 PF00656 0.545
CLV_C14_Caspase3-7 276 280 PF00656 0.473
CLV_C14_Caspase3-7 677 681 PF00656 0.421
CLV_NRD_NRD_1 151 153 PF00675 0.364
CLV_NRD_NRD_1 207 209 PF00675 0.539
CLV_NRD_NRD_1 286 288 PF00675 0.658
CLV_NRD_NRD_1 362 364 PF00675 0.599
CLV_NRD_NRD_1 442 444 PF00675 0.569
CLV_NRD_NRD_1 58 60 PF00675 0.400
CLV_NRD_NRD_1 592 594 PF00675 0.672
CLV_PCSK_FUR_1 359 363 PF00082 0.649
CLV_PCSK_KEX2_1 151 153 PF00082 0.364
CLV_PCSK_KEX2_1 207 209 PF00082 0.544
CLV_PCSK_KEX2_1 286 288 PF00082 0.658
CLV_PCSK_KEX2_1 361 363 PF00082 0.598
CLV_PCSK_KEX2_1 441 443 PF00082 0.579
CLV_PCSK_KEX2_1 58 60 PF00082 0.400
CLV_PCSK_KEX2_1 592 594 PF00082 0.589
CLV_PCSK_SKI1_1 14 18 PF00082 0.417
CLV_PCSK_SKI1_1 151 155 PF00082 0.403
CLV_PCSK_SKI1_1 415 419 PF00082 0.558
CLV_PCSK_SKI1_1 442 446 PF00082 0.631
DEG_APCC_DBOX_1 150 158 PF00400 0.595
DEG_APCC_DBOX_1 206 214 PF00400 0.403
DEG_SCF_FBW7_1 482 489 PF00400 0.377
DEG_SPOP_SBC_1 486 490 PF00917 0.470
DEG_SPOP_SBC_1 655 659 PF00917 0.468
DEG_SPOP_SBC_1 87 91 PF00917 0.648
DOC_CYCLIN_RxL_1 348 357 PF00134 0.288
DOC_CYCLIN_yCln2_LP_2 410 416 PF00134 0.381
DOC_CYCLIN_yCln2_LP_2 663 669 PF00134 0.521
DOC_CYCLIN_yCln2_LP_2 695 701 PF00134 0.348
DOC_MAPK_DCC_7 4 13 PF00069 0.575
DOC_MAPK_gen_1 207 218 PF00069 0.324
DOC_MAPK_gen_1 335 344 PF00069 0.357
DOC_MAPK_MEF2A_6 58 67 PF00069 0.573
DOC_MAPK_MEF2A_6 690 699 PF00069 0.317
DOC_PP1_RVXF_1 440 447 PF00149 0.425
DOC_PP1_RVXF_1 504 510 PF00149 0.335
DOC_PP1_RVXF_1 688 694 PF00149 0.321
DOC_PP2B_LxvP_1 32 35 PF13499 0.579
DOC_PP2B_LxvP_1 410 413 PF13499 0.394
DOC_PP2B_LxvP_1 663 666 PF13499 0.464
DOC_PP2B_LxvP_1 695 698 PF13499 0.451
DOC_PP4_FxxP_1 175 178 PF00568 0.345
DOC_PP4_FxxP_1 60 63 PF00568 0.592
DOC_USP7_MATH_1 178 182 PF00917 0.538
DOC_USP7_MATH_1 188 192 PF00917 0.533
DOC_USP7_MATH_1 198 202 PF00917 0.525
DOC_USP7_MATH_1 297 301 PF00917 0.342
DOC_USP7_MATH_1 320 324 PF00917 0.435
DOC_USP7_MATH_1 397 401 PF00917 0.381
DOC_USP7_MATH_1 486 490 PF00917 0.486
DOC_USP7_MATH_1 521 525 PF00917 0.386
DOC_USP7_MATH_1 586 590 PF00917 0.436
DOC_USP7_MATH_1 606 610 PF00917 0.299
DOC_USP7_MATH_1 640 644 PF00917 0.528
DOC_USP7_MATH_1 674 678 PF00917 0.486
DOC_USP7_MATH_1 685 689 PF00917 0.432
DOC_USP7_MATH_1 87 91 PF00917 0.733
DOC_USP7_UBL2_3 223 227 PF12436 0.344
DOC_WW_Pin1_4 33 38 PF00397 0.486
DOC_WW_Pin1_4 482 487 PF00397 0.322
DOC_WW_Pin1_4 582 587 PF00397 0.457
DOC_WW_Pin1_4 6 11 PF00397 0.780
DOC_WW_Pin1_4 638 643 PF00397 0.541
DOC_WW_Pin1_4 658 663 PF00397 0.551
DOC_WW_Pin1_4 95 100 PF00397 0.685
LIG_14-3-3_CanoR_1 134 144 PF00244 0.606
LIG_14-3-3_CanoR_1 290 298 PF00244 0.418
LIG_14-3-3_CanoR_1 366 375 PF00244 0.485
LIG_14-3-3_CanoR_1 441 447 PF00244 0.430
LIG_14-3-3_CanoR_1 539 545 PF00244 0.399
LIG_14-3-3_CanoR_1 566 574 PF00244 0.468
LIG_14-3-3_CanoR_1 633 639 PF00244 0.480
LIG_14-3-3_CanoR_1 656 662 PF00244 0.521
LIG_14-3-3_CanoR_1 70 75 PF00244 0.608
LIG_Actin_WH2_2 335 352 PF00022 0.340
LIG_Actin_WH2_2 409 424 PF00022 0.381
LIG_Actin_WH2_2 551 568 PF00022 0.342
LIG_Actin_WH2_2 675 692 PF00022 0.409
LIG_APCC_ABBA_1 525 530 PF00400 0.347
LIG_BIR_II_1 1 5 PF00653 0.754
LIG_BRCT_BRCA1_1 660 664 PF00533 0.494
LIG_deltaCOP1_diTrp_1 112 121 PF00928 0.495
LIG_FHA_1 250 256 PF00498 0.392
LIG_FHA_1 350 356 PF00498 0.270
LIG_FHA_1 416 422 PF00498 0.399
LIG_FHA_1 486 492 PF00498 0.444
LIG_FHA_1 677 683 PF00498 0.428
LIG_FHA_2 274 280 PF00498 0.545
LIG_FHA_2 378 384 PF00498 0.538
LIG_FHA_2 402 408 PF00498 0.314
LIG_HP1_1 698 702 PF01393 0.301
LIG_LIR_Apic_2 300 304 PF02991 0.323
LIG_LIR_Apic_2 626 632 PF02991 0.424
LIG_LIR_Gen_1 168 175 PF02991 0.294
LIG_LIR_Gen_1 36 46 PF02991 0.598
LIG_LIR_Gen_1 445 454 PF02991 0.433
LIG_LIR_Gen_1 494 505 PF02991 0.366
LIG_LIR_LC3C_4 340 344 PF02991 0.276
LIG_LIR_Nem_3 118 124 PF02991 0.604
LIG_LIR_Nem_3 168 172 PF02991 0.294
LIG_LIR_Nem_3 261 267 PF02991 0.324
LIG_LIR_Nem_3 36 42 PF02991 0.596
LIG_LIR_Nem_3 445 449 PF02991 0.428
LIG_LIR_Nem_3 494 500 PF02991 0.397
LIG_LYPXL_yS_3 594 597 PF13949 0.386
LIG_PTB_Apo_2 470 477 PF02174 0.303
LIG_PTB_Phospho_1 470 476 PF10480 0.306
LIG_SH2_CRK 39 43 PF00017 0.536
LIG_SH2_CRK 468 472 PF00017 0.331
LIG_SH2_CRK 629 633 PF00017 0.466
LIG_SH2_NCK_1 39 43 PF00017 0.591
LIG_SH2_NCK_1 468 472 PF00017 0.309
LIG_SH2_SRC 476 479 PF00017 0.326
LIG_SH2_STAP1 39 43 PF00017 0.566
LIG_SH2_STAP1 536 540 PF00017 0.450
LIG_SH2_STAT3 209 212 PF00017 0.385
LIG_SH2_STAT3 271 274 PF00017 0.445
LIG_SH2_STAT5 209 212 PF00017 0.402
LIG_SH2_STAT5 364 367 PF00017 0.438
LIG_SH2_STAT5 39 42 PF00017 0.471
LIG_SH2_STAT5 476 479 PF00017 0.326
LIG_SH2_STAT5 528 531 PF00017 0.391
LIG_SH3_1 629 635 PF00018 0.435
LIG_SH3_3 31 37 PF00018 0.594
LIG_SH3_3 629 635 PF00018 0.458
LIG_SH3_3 649 655 PF00018 0.571
LIG_SH3_3 659 665 PF00018 0.411
LIG_SH3_5 532 536 PF00018 0.332
LIG_SH3_CIN85_PxpxPR_1 628 633 PF14604 0.421
LIG_SUMO_SIM_par_1 235 240 PF11976 0.387
LIG_SUMO_SIM_par_1 351 357 PF11976 0.313
LIG_TRFH_1 694 698 PF08558 0.399
LIG_TYR_ITIM 466 471 PF00017 0.307
LIG_UBA3_1 409 415 PF00899 0.429
LIG_WRC_WIRS_1 100 105 PF05994 0.512
LIG_WRC_WIRS_1 166 171 PF05994 0.399
MOD_CDC14_SPxK_1 585 588 PF00782 0.574
MOD_CDK_SPxK_1 582 588 PF00069 0.559
MOD_CDK_SPxxK_3 638 645 PF00069 0.610
MOD_CK1_1 135 141 PF00069 0.682
MOD_CK1_1 183 189 PF00069 0.793
MOD_CK1_1 192 198 PF00069 0.573
MOD_CK1_1 327 333 PF00069 0.670
MOD_CK1_1 490 496 PF00069 0.606
MOD_CK1_1 499 505 PF00069 0.462
MOD_CK1_1 538 544 PF00069 0.486
MOD_CK1_1 568 574 PF00069 0.631
MOD_CK1_1 641 647 PF00069 0.551
MOD_CK1_1 657 663 PF00069 0.650
MOD_CK1_1 73 79 PF00069 0.493
MOD_CK2_1 377 383 PF00069 0.666
MOD_CK2_1 401 407 PF00069 0.513
MOD_Cter_Amidation 56 59 PF01082 0.454
MOD_GlcNHglycan 125 129 PF01048 0.670
MOD_GlcNHglycan 134 137 PF01048 0.761
MOD_GlcNHglycan 187 191 PF01048 0.669
MOD_GlcNHglycan 194 197 PF01048 0.528
MOD_GlcNHglycan 200 203 PF01048 0.534
MOD_GlcNHglycan 279 282 PF01048 0.692
MOD_GlcNHglycan 540 543 PF01048 0.595
MOD_GlcNHglycan 570 573 PF01048 0.419
MOD_GlcNHglycan 614 617 PF01048 0.455
MOD_GlcNHglycan 670 673 PF01048 0.640
MOD_GlcNHglycan 75 78 PF01048 0.531
MOD_GlcNHglycan 90 93 PF01048 0.721
MOD_GSK3_1 132 139 PF00069 0.692
MOD_GSK3_1 161 168 PF00069 0.395
MOD_GSK3_1 179 186 PF00069 0.499
MOD_GSK3_1 188 195 PF00069 0.708
MOD_GSK3_1 273 280 PF00069 0.573
MOD_GSK3_1 320 327 PF00069 0.610
MOD_GSK3_1 33 40 PF00069 0.476
MOD_GSK3_1 349 356 PF00069 0.348
MOD_GSK3_1 366 373 PF00069 0.620
MOD_GSK3_1 384 391 PF00069 0.797
MOD_GSK3_1 397 404 PF00069 0.550
MOD_GSK3_1 478 485 PF00069 0.405
MOD_GSK3_1 486 493 PF00069 0.588
MOD_GSK3_1 516 523 PF00069 0.487
MOD_GSK3_1 561 568 PF00069 0.502
MOD_GSK3_1 582 589 PF00069 0.528
MOD_GSK3_1 634 641 PF00069 0.578
MOD_GSK3_1 654 661 PF00069 0.640
MOD_GSK3_1 95 102 PF00069 0.461
MOD_N-GLC_1 198 203 PF02516 0.470
MOD_N-GLC_1 349 354 PF02516 0.440
MOD_N-GLC_1 472 477 PF02516 0.346
MOD_N-GLC_1 586 591 PF02516 0.539
MOD_NEK2_1 124 129 PF00069 0.510
MOD_NEK2_1 310 315 PF00069 0.266
MOD_NEK2_1 349 354 PF00069 0.438
MOD_NEK2_1 416 421 PF00069 0.390
MOD_NEK2_1 487 492 PF00069 0.674
MOD_NEK2_2 561 566 PF00069 0.486
MOD_PIKK_1 180 186 PF00454 0.607
MOD_PIKK_1 327 333 PF00454 0.615
MOD_PKA_1 442 448 PF00069 0.474
MOD_PKA_2 442 448 PF00069 0.531
MOD_PKA_2 538 544 PF00069 0.614
MOD_PKA_2 565 571 PF00069 0.480
MOD_PKA_2 655 661 PF00069 0.591
MOD_Plk_1 308 314 PF00069 0.439
MOD_Plk_1 349 355 PF00069 0.322
MOD_Plk_1 472 478 PF00069 0.351
MOD_Plk_1 586 592 PF00069 0.535
MOD_Plk_2-3 108 114 PF00069 0.298
MOD_Plk_4 117 123 PF00069 0.379
MOD_Plk_4 349 355 PF00069 0.435
MOD_Plk_4 370 376 PF00069 0.693
MOD_Plk_4 472 478 PF00069 0.428
MOD_ProDKin_1 33 39 PF00069 0.339
MOD_ProDKin_1 482 488 PF00069 0.406
MOD_ProDKin_1 582 588 PF00069 0.585
MOD_ProDKin_1 6 12 PF00069 0.750
MOD_ProDKin_1 638 644 PF00069 0.699
MOD_ProDKin_1 658 664 PF00069 0.703
MOD_ProDKin_1 95 101 PF00069 0.604
MOD_SUMO_rev_2 125 133 PF00179 0.608
MOD_SUMO_rev_2 217 225 PF00179 0.429
MOD_SUMO_rev_2 383 391 PF00179 0.721
TRG_ENDOCYTIC_2 39 42 PF00928 0.410
TRG_ENDOCYTIC_2 468 471 PF00928 0.400
TRG_ENDOCYTIC_2 594 597 PF00928 0.481
TRG_ER_diArg_1 151 153 PF00400 0.449
TRG_ER_diArg_1 206 208 PF00400 0.449
TRG_ER_diArg_1 267 270 PF00400 0.450
TRG_ER_diArg_1 286 288 PF00400 0.582
TRG_ER_diArg_1 289 292 PF00400 0.529
TRG_ER_diArg_1 358 361 PF00400 0.432
TRG_ER_diArg_1 362 364 PF00400 0.512
TRG_ER_diArg_1 365 368 PF00400 0.537
TRG_ER_diArg_1 440 443 PF00400 0.456
TRG_ER_diArg_1 58 60 PF00400 0.500
TRG_ER_diArg_1 592 594 PF00400 0.524
TRG_Pf-PMV_PEXEL_1 208 212 PF00026 0.483
TRG_Pf-PMV_PEXEL_1 442 447 PF00026 0.437

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P9G4 Leptomonas seymouri 54% 98%
A0A1X0NZU7 Trypanosomatidae 30% 93%
A0A3S7X2G1 Leishmania donovani 90% 100%
A0A422NEG1 Trypanosoma rangeli 32% 100%
A4HHG5 Leishmania braziliensis 78% 100%
A4I4L4 Leishmania infantum 90% 100%
C9ZLA2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
E9ALS1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
V5ATS3 Trypanosoma cruzi 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS