Nodulin-like domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

major facilitator superfamily, putative

Species:

Leishmania major

UniProt:

E9AE11_LEIMA

TriTrypDb:

LmjF.29.1520 , LMJLV39_290022100 , LMJSD75_290022500

Length:

648

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 106
NetGPI	no	yes: 0, no: 106

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	100
GO:0110165	cellular anatomical entity	1	100
GO:0005737	cytoplasm	2	3

Expansion

Sequence features

E9AE11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE11

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	49
GO:0022857	transmembrane transporter activity	2	49

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	642	646	PF00656	0.701
CLV_NRD_NRD_1	216	218	PF00675	0.259
CLV_NRD_NRD_1	437	439	PF00675	0.642
CLV_NRD_NRD_1	617	619	PF00675	0.346
CLV_PCSK_FUR_1	615	619	PF00082	0.433
CLV_PCSK_KEX2_1	215	217	PF00082	0.253
CLV_PCSK_KEX2_1	316	318	PF00082	0.403
CLV_PCSK_KEX2_1	399	401	PF00082	0.360
CLV_PCSK_KEX2_1	617	619	PF00082	0.345
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.403
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.424
CLV_PCSK_SKI1_1	149	153	PF00082	0.366
CLV_PCSK_SKI1_1	216	220	PF00082	0.328
CLV_PCSK_SKI1_1	316	320	PF00082	0.413
CLV_PCSK_SKI1_1	528	532	PF00082	0.278
CLV_PCSK_SKI1_1	564	568	PF00082	0.564
CLV_PCSK_SKI1_1	618	622	PF00082	0.352
CLV_PCSK_SKI1_1	634	638	PF00082	0.363
DEG_Nend_Nbox_1	1	3	PF02207	0.668
DOC_CYCLIN_RxL_1	525	534	PF00134	0.375
DOC_MAPK_DCC_7	105	113	PF00069	0.183
DOC_MAPK_gen_1	205	214	PF00069	0.457
DOC_MAPK_gen_1	399	405	PF00069	0.479
DOC_MAPK_MEF2A_6	105	113	PF00069	0.321
DOC_MAPK_MEF2A_6	264	273	PF00069	0.291
DOC_PP1_RVXF_1	361	368	PF00149	0.543
DOC_PP2B_LxvP_1	496	499	PF13499	0.412
DOC_PP2B_PxIxI_1	474	480	PF00149	0.390
DOC_SPAK_OSR1_1	14	18	PF12202	0.524
DOC_USP7_MATH_1	257	261	PF00917	0.312
DOC_USP7_MATH_1	353	357	PF00917	0.772
DOC_USP7_MATH_1	421	425	PF00917	0.536
DOC_USP7_MATH_1	482	486	PF00917	0.365
DOC_USP7_MATH_1	499	503	PF00917	0.374
DOC_USP7_UBL2_3	293	297	PF12436	0.700
DOC_USP7_UBL2_3	347	351	PF12436	0.597
DOC_USP7_UBL2_3	435	439	PF12436	0.274
DOC_USP7_UBL2_3	533	537	PF12436	0.484
LIG_14-3-3_CanoR_1	168	176	PF00244	0.365
LIG_14-3-3_CanoR_1	215	224	PF00244	0.486
LIG_14-3-3_CanoR_1	264	270	PF00244	0.354
LIG_14-3-3_CanoR_1	380	390	PF00244	0.670
LIG_14-3-3_CanoR_1	438	444	PF00244	0.393
LIG_14-3-3_CanoR_1	456	460	PF00244	0.286
LIG_14-3-3_CanoR_1	8	16	PF00244	0.535
LIG_AP2alpha_1	510	514	PF02296	0.199
LIG_deltaCOP1_diTrp_1	402	408	PF00928	0.364
LIG_EH1_1	175	183	PF00400	0.442
LIG_FHA_1	108	114	PF00498	0.335
LIG_FHA_1	125	131	PF00498	0.319
LIG_FHA_1	185	191	PF00498	0.383
LIG_FHA_1	266	272	PF00498	0.345
LIG_FHA_1	4	10	PF00498	0.577
LIG_FHA_1	471	477	PF00498	0.587
LIG_FHA_1	55	61	PF00498	0.341
LIG_FHA_1	602	608	PF00498	0.391
LIG_HCF-1_HBM_1	4	7	PF13415	0.434
LIG_LIR_Apic_2	74	78	PF02991	0.462
LIG_LIR_Gen_1	13	22	PF02991	0.484
LIG_LIR_Gen_1	171	182	PF02991	0.293
LIG_LIR_Gen_1	392	403	PF02991	0.517
LIG_LIR_Gen_1	442	451	PF02991	0.327
LIG_LIR_Gen_1	594	603	PF02991	0.308
LIG_LIR_Gen_1	609	619	PF02991	0.339
LIG_LIR_Nem_3	13	18	PF02991	0.503
LIG_LIR_Nem_3	150	154	PF02991	0.346
LIG_LIR_Nem_3	171	177	PF02991	0.267
LIG_LIR_Nem_3	392	398	PF02991	0.526
LIG_LIR_Nem_3	442	447	PF02991	0.352
LIG_LIR_Nem_3	594	598	PF02991	0.307
LIG_LIR_Nem_3	609	614	PF02991	0.320
LIG_LYPXL_yS_3	227	230	PF13949	0.390
LIG_NRBOX	491	497	PF00104	0.395
LIG_Pex14_2	233	237	PF04695	0.335
LIG_Pex14_2	510	514	PF04695	0.351
LIG_PTB_Apo_2	160	167	PF02174	0.304
LIG_PTB_Apo_2	430	437	PF02174	0.346
LIG_PTB_Apo_2	537	544	PF02174	0.542
LIG_PTB_Phospho_1	430	436	PF10480	0.392
LIG_PTB_Phospho_1	537	543	PF10480	0.373
LIG_REV1ctd_RIR_1	164	172	PF16727	0.283
LIG_SH2_CRK	256	260	PF00017	0.335
LIG_SH2_CRK	428	432	PF00017	0.296
LIG_SH2_CRK	444	448	PF00017	0.407
LIG_SH2_CRK	75	79	PF00017	0.431
LIG_SH2_GRB2like	256	259	PF00017	0.382
LIG_SH2_GRB2like	538	541	PF00017	0.303
LIG_SH2_NCK_1	256	260	PF00017	0.320
LIG_SH2_SRC	256	259	PF00017	0.366
LIG_SH2_STAP1	444	448	PF00017	0.382
LIG_SH2_STAP1	562	566	PF00017	0.308
LIG_SH2_STAT3	223	226	PF00017	0.450
LIG_SH2_STAT3	562	565	PF00017	0.363
LIG_SH2_STAT5	223	226	PF00017	0.464
LIG_SH2_STAT5	234	237	PF00017	0.323
LIG_SH2_STAT5	246	249	PF00017	0.315
LIG_SH2_STAT5	337	340	PF00017	0.556
LIG_SH2_STAT5	543	546	PF00017	0.371
LIG_SH3_1	297	303	PF00018	0.637
LIG_SH3_3	297	303	PF00018	0.634
LIG_SH3_3	315	321	PF00018	0.790
LIG_SH3_3	577	583	PF00018	0.368
LIG_SUMO_SIM_anti_2	157	163	PF11976	0.423
LIG_SUMO_SIM_anti_2	187	192	PF11976	0.372
LIG_SUMO_SIM_anti_2	268	273	PF11976	0.306
LIG_SUMO_SIM_anti_2	48	57	PF11976	0.337
LIG_SUMO_SIM_anti_2	594	600	PF11976	0.383
LIG_SUMO_SIM_par_1	445	452	PF11976	0.343
LIG_TYR_ITIM	244	249	PF00017	0.354
LIG_TYR_ITSM	440	447	PF00017	0.347
LIG_UBA3_1	495	503	PF00899	0.398
LIG_WRC_WIRS_1	148	153	PF05994	0.365
LIG_WRC_WIRS_1	249	254	PF05994	0.384
LIG_WRC_WIRS_1	307	312	PF05994	0.480
LIG_WRC_WIRS_1	511	516	PF05994	0.402
MOD_CK1_1	10	16	PF00069	0.426
MOD_CK1_1	124	130	PF00069	0.350
MOD_CK1_1	449	455	PF00069	0.352
MOD_CK1_1	50	56	PF00069	0.347
MOD_CK2_1	352	358	PF00069	0.712
MOD_CMANNOS	404	407	PF00535	0.355
MOD_Cter_Amidation	348	351	PF01082	0.500
MOD_Cter_Amidation	586	589	PF01082	0.465
MOD_GlcNHglycan	24	27	PF01048	0.251
MOD_GlcNHglycan	423	426	PF01048	0.383
MOD_GlcNHglycan	444	447	PF01048	0.332
MOD_GlcNHglycan	451	454	PF01048	0.301
MOD_GSK3_1	120	127	PF00069	0.365
MOD_GSK3_1	133	140	PF00069	0.363
MOD_GSK3_1	22	29	PF00069	0.337
MOD_GSK3_1	3	10	PF00069	0.439
MOD_GSK3_1	390	397	PF00069	0.438
MOD_GSK3_1	442	449	PF00069	0.355
MOD_GSK3_1	46	53	PF00069	0.329
MOD_GSK3_1	516	523	PF00069	0.344
MOD_GSK3_1	635	642	PF00069	0.525
MOD_GSK3_1	83	90	PF00069	0.394
MOD_N-GLC_1	162	167	PF02516	0.347
MOD_N-GLC_1	45	50	PF02516	0.396
MOD_N-GLC_1	601	606	PF02516	0.288
MOD_NEK2_1	120	125	PF00069	0.342
MOD_NEK2_1	154	159	PF00069	0.370
MOD_NEK2_1	22	27	PF00069	0.307
MOD_NEK2_1	265	270	PF00069	0.295
MOD_NEK2_1	394	399	PF00069	0.384
MOD_NEK2_1	45	50	PF00069	0.342
MOD_NEK2_1	510	515	PF00069	0.351
MOD_NEK2_1	87	92	PF00069	0.273
MOD_NEK2_2	27	32	PF00069	0.323
MOD_PIKK_1	222	228	PF00454	0.346
MOD_PKA_1	216	222	PF00069	0.410
MOD_PKA_2	167	173	PF00069	0.428
MOD_PKA_2	216	222	PF00069	0.325
MOD_PKA_2	437	443	PF00069	0.535
MOD_PKA_2	455	461	PF00069	0.312
MOD_PKA_2	7	13	PF00069	0.401
MOD_Plk_1	10	16	PF00069	0.528
MOD_Plk_1	162	168	PF00069	0.388
MOD_Plk_1	203	209	PF00069	0.465
MOD_Plk_1	3	9	PF00069	0.565
MOD_Plk_1	50	56	PF00069	0.311
MOD_Plk_1	601	607	PF00069	0.327
MOD_Plk_2-3	306	312	PF00069	0.677
MOD_Plk_2-3	635	641	PF00069	0.505
MOD_Plk_4	126	132	PF00069	0.328
MOD_Plk_4	154	160	PF00069	0.367
MOD_Plk_4	162	168	PF00069	0.372
MOD_Plk_4	265	271	PF00069	0.374
MOD_Plk_4	27	33	PF00069	0.314
MOD_Plk_4	390	396	PF00069	0.410
MOD_Plk_4	439	445	PF00069	0.313
MOD_Plk_4	50	56	PF00069	0.382
MOD_Plk_4	591	597	PF00069	0.316
MOD_Plk_4	607	613	PF00069	0.292
MOD_Plk_4	83	89	PF00069	0.306
MOD_SUMO_rev_2	309	318	PF00179	0.727
MOD_SUMO_rev_2	374	379	PF00179	0.609
MOD_SUMO_rev_2	432	440	PF00179	0.507
MOD_SUMO_rev_2	633	639	PF00179	0.509
TRG_DiLeu_BaEn_2	10	16	PF01217	0.460
TRG_ENDOCYTIC_2	164	167	PF00928	0.351
TRG_ENDOCYTIC_2	174	177	PF00928	0.303
TRG_ENDOCYTIC_2	198	201	PF00928	0.370
TRG_ENDOCYTIC_2	227	230	PF00928	0.389
TRG_ENDOCYTIC_2	234	237	PF00928	0.353
TRG_ENDOCYTIC_2	246	249	PF00928	0.296
TRG_ENDOCYTIC_2	428	431	PF00928	0.363
TRG_ENDOCYTIC_2	444	447	PF00928	0.319
TRG_ENDOCYTIC_2	538	541	PF00928	0.321
TRG_ENDOCYTIC_2	558	561	PF00928	0.447
TRG_ENDOCYTIC_2	616	619	PF00928	0.387
TRG_ER_diArg_1	214	217	PF00400	0.349
TRG_ER_diArg_1	616	618	PF00400	0.443
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G0	Leptomonas seymouri	29%	100%
A0A0N1HZC2	Leptomonas seymouri	32%	100%
A0A0N1IKC5	Leptomonas seymouri	32%	100%
A0A0N1PB63	Leptomonas seymouri	27%	98%
A0A0N1PD04	Leptomonas seymouri	26%	100%
A0A0N1PFR4	Leptomonas seymouri	33%	98%
A0A0S4JR45	Bodo saltans	29%	100%
A0A1X0NKK0	Trypanosomatidae	31%	100%
A0A1X0NM09	Trypanosomatidae	29%	100%
A0A1X0NV19	Trypanosomatidae	33%	100%
A0A1X0NV27	Trypanosomatidae	32%	100%
A0A1X0NVF9	Trypanosomatidae	23%	97%
A0A1X0NVH8	Trypanosomatidae	29%	98%
A0A1X0NVM7	Trypanosomatidae	30%	100%
A0A1X0NWQ1	Trypanosomatidae	34%	100%
A0A1X0NZE6	Trypanosomatidae	30%	100%
A0A1X0NZU2	Trypanosomatidae	33%	100%
A0A1X0NZU5	Trypanosomatidae	53%	100%
A0A1X0NZW1	Trypanosomatidae	32%	100%
A0A1X0P0M7	Trypanosomatidae	29%	100%
A0A381MMW5	Leishmania infantum	89%	99%
A0A3Q8IEC4	Leishmania donovani	88%	100%
A0A3Q8IF95	Leishmania donovani	27%	100%
A0A3Q8IIT5	Leishmania donovani	31%	96%
A0A3Q8ISY9	Leishmania donovani	28%	100%
A0A3R7KKN8	Trypanosoma rangeli	33%	100%
A0A3R7MAQ7	Trypanosoma rangeli	27%	92%
A0A3R7N3S6	Trypanosoma rangeli	26%	100%
A0A3R7N415	Trypanosoma rangeli	31%	100%
A0A3R7N921	Trypanosoma rangeli	28%	100%
A0A3R7R443	Trypanosoma rangeli	31%	100%
A0A3S7WRJ4	Leishmania donovani	31%	100%
A0A3S7WRJ5	Leishmania donovani	31%	93%
A0A3S7WRS3	Leishmania donovani	25%	100%
A0A3S7WSR4	Leishmania donovani	31%	100%
A0A3S7WWU1	Leishmania donovani	26%	98%
A0A3S7X2G0	Leishmania donovani	89%	99%
A0A3S7X2K5	Leishmania donovani	94%	100%
A0A3S7XB11	Leishmania donovani	30%	100%
A0A422MSE4	Trypanosoma rangeli	34%	100%
A0A422MSP6	Trypanosoma rangeli	48%	100%
A0A422MST9	Trypanosoma rangeli	31%	100%
A0A422MU68	Trypanosoma rangeli	31%	100%
A4H6J0	Leishmania braziliensis	31%	100%
A4H6J1	Leishmania braziliensis	32%	99%
A4H6Q5	Leishmania braziliensis	26%	100%
A4HC19	Leishmania braziliensis	28%	100%
A4HHG2	Leishmania braziliensis	31%	96%
A4HHG3	Leishmania braziliensis	76%	100%
A4HHG4	Leishmania braziliensis	74%	99%
A4HJW3	Leishmania braziliensis	28%	100%
A4HPE2	Leishmania braziliensis	31%	100%
A4HUX5	Leishmania infantum	31%	100%
A4HUX6	Leishmania infantum	32%	93%
A4HV40	Leishmania infantum	25%	100%
A4HZF5	Leishmania infantum	27%	100%
A4HZJ4	Leishmania infantum	26%	98%
A4I4L2	Leishmania infantum	30%	96%
A4I7C5	Leishmania infantum	28%	100%
A4ICI3	Leishmania infantum	30%	100%
C9ZL97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZL98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZL99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZLA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZLA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZTR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZTR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZTR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZTR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZTR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZTS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZUT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
D0A7B1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A7H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E8NHE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AE01	Leishmania major	94%	100%
E9AE09	Leishmania major	30%	100%
E9AE10	Leishmania major	30%	100%
E9AGK5	Leishmania infantum	31%	100%
E9AHJ0	Leishmania infantum	88%	100%
E9AHJ1	Leishmania infantum	94%	100%
E9ALS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
E9ALS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	96%
E9ANL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9ANL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	99%
E9ANS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9APJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AT53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AVF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AVF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	98%
E9B2B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
Q4Q1E4	Leishmania major	30%	100%
Q4Q5T8	Leishmania major	28%	100%
Q4QC27	Leishmania major	27%	100%
Q4QC28	Leishmania major	27%	100%
Q4QFY5	Leishmania major	31%	100%
Q4QGU8	Leishmania major	26%	100%
Q4QH14	Leishmania major	31%	99%
Q4QH15	Leishmania major	31%	100%
V5B647	Trypanosoma cruzi	30%	100%
V5B983	Trypanosoma cruzi	46%	100%
V5BFV8	Trypanosoma cruzi	31%	97%
V5BQY6	Trypanosoma cruzi	29%	92%
V5BVP0	Trypanosoma cruzi	31%	100%
V5DT25	Trypanosoma cruzi	31%	100%