Nodulin-like domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nodulin-like, putative

Species:

Leishmania major

UniProt:

E9AE09_LEIMA

TriTrypDb:

LmjF.29.1500 , LMJLV39_290021800 , LMJSD75_290021300 , LMJSD75_290022400

Length:

672

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 77
NetGPI	no	yes: 0, no: 77

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	4
GO:0016020	membrane	2	71
GO:0110165	cellular anatomical entity	1	71

Expansion

Sequence features

E9AE09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE09

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	36
GO:0022857	transmembrane transporter activity	2	36

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	341	345	PF00656	0.787
CLV_NRD_NRD_1	223	225	PF00675	0.435
CLV_NRD_NRD_1	239	241	PF00675	0.379
CLV_NRD_NRD_1	405	407	PF00675	0.601
CLV_NRD_NRD_1	509	511	PF00675	0.465
CLV_NRD_NRD_1	648	650	PF00675	0.507
CLV_PCSK_FUR_1	646	650	PF00082	0.345
CLV_PCSK_KEX2_1	239	241	PF00082	0.386
CLV_PCSK_KEX2_1	304	306	PF00082	0.510
CLV_PCSK_KEX2_1	509	511	PF00082	0.447
CLV_PCSK_KEX2_1	648	650	PF00082	0.510
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.481
CLV_PCSK_SKI1_1	224	228	PF00082	0.466
CLV_PCSK_SKI1_1	437	441	PF00082	0.484
CLV_PCSK_SKI1_1	596	600	PF00082	0.376
CLV_PCSK_SKI1_1	75	79	PF00082	0.337
DEG_Nend_UBRbox_1	1	4	PF02207	0.722
DEG_SPOP_SBC_1	23	27	PF00917	0.435
DOC_CKS1_1	205	210	PF01111	0.668
DOC_CYCLIN_RxL_1	432	443	PF00134	0.687
DOC_CYCLIN_yCln2_LP_2	546	552	PF00134	0.354
DOC_MAPK_gen_1	103	112	PF00069	0.418
DOC_MAPK_gen_1	224	230	PF00069	0.570
DOC_MAPK_gen_1	268	275	PF00069	0.435
DOC_MAPK_MEF2A_6	268	277	PF00069	0.457
DOC_MAPK_MEF2A_6	437	446	PF00069	0.664
DOC_MAPK_MEF2A_6	481	488	PF00069	0.339
DOC_MAPK_MEF2A_6	623	630	PF00069	0.342
DOC_MAPK_RevD_3	255	269	PF00069	0.569
DOC_MAPK_RevD_3	291	305	PF00069	0.378
DOC_PP1_RVXF_1	73	79	PF00149	0.616
DOC_PP2B_LxvP_1	546	549	PF13499	0.358
DOC_PP4_FxxP_1	121	124	PF00568	0.489
DOC_PP4_FxxP_1	71	74	PF00568	0.565
DOC_USP7_MATH_1	23	27	PF00917	0.360
DOC_USP7_MATH_1	256	260	PF00917	0.463
DOC_USP7_MATH_1	405	409	PF00917	0.852
DOC_WW_Pin1_4	204	209	PF00397	0.638
DOC_WW_Pin1_4	401	406	PF00397	0.823
LIG_14-3-3_CanoR_1	224	229	PF00244	0.623
LIG_14-3-3_CanoR_1	349	353	PF00244	0.833
LIG_14-3-3_CanoR_1	38	44	PF00244	0.447
LIG_14-3-3_CanoR_1	406	412	PF00244	0.798
LIG_14-3-3_CanoR_1	481	485	PF00244	0.414
LIG_14-3-3_CanoR_1	509	519	PF00244	0.693
LIG_APCC_ABBA_1	30	35	PF00400	0.434
LIG_BRCT_BRCA1_1	470	474	PF00533	0.431
LIG_BRCT_BRCA1_1	584	588	PF00533	0.431
LIG_Clathr_ClatBox_1	439	443	PF01394	0.616
LIG_deltaCOP1_diTrp_1	443	452	PF00928	0.424
LIG_eIF4E_1	9	15	PF01652	0.616
LIG_FHA_1	155	161	PF00498	0.361
LIG_FHA_1	225	231	PF00498	0.623
LIG_FHA_1	260	266	PF00498	0.512
LIG_FHA_1	272	278	PF00498	0.396
LIG_FHA_1	32	38	PF00498	0.357
LIG_FHA_1	439	445	PF00498	0.556
LIG_FHA_1	455	461	PF00498	0.385
LIG_FHA_1	513	519	PF00498	0.706
LIG_FHA_1	589	595	PF00498	0.361
LIG_FHA_2	394	400	PF00498	0.876
LIG_FHA_2	408	414	PF00498	0.816
LIG_IRF3_LxIS_1	18	25	PF10401	0.439
LIG_IRF3_LxIS_1	252	258	PF10401	0.266
LIG_LIR_Apic_2	70	74	PF02991	0.542
LIG_LIR_Gen_1	141	152	PF02991	0.546
LIG_LIR_Gen_1	180	190	PF02991	0.373
LIG_LIR_Gen_1	27	37	PF02991	0.445
LIG_LIR_Gen_1	270	280	PF02991	0.353
LIG_LIR_Gen_1	483	491	PF02991	0.397
LIG_LIR_Gen_1	534	543	PF02991	0.479
LIG_LIR_Nem_3	141	147	PF02991	0.553
LIG_LIR_Nem_3	151	155	PF02991	0.452
LIG_LIR_Nem_3	177	182	PF02991	0.380
LIG_LIR_Nem_3	27	33	PF02991	0.452
LIG_LIR_Nem_3	270	275	PF02991	0.381
LIG_LIR_Nem_3	434	439	PF02991	0.584
LIG_LIR_Nem_3	471	477	PF02991	0.398
LIG_LIR_Nem_3	483	488	PF02991	0.403
LIG_LIR_Nem_3	520	526	PF02991	0.358
LIG_LIR_Nem_3	534	538	PF02991	0.354
LIG_LYPXL_yS_3	299	302	PF13949	0.676
LIG_LYPXL_yS_3	309	312	PF13949	0.514
LIG_NRBOX	86	92	PF00104	0.439
LIG_PALB2_WD40_1	163	171	PF16756	0.307
LIG_Pex14_1	448	452	PF04695	0.401
LIG_Pex14_2	164	168	PF04695	0.363
LIG_Pex14_2	447	451	PF04695	0.379
LIG_Pex14_2	584	588	PF04695	0.381
LIG_Pex14_2	599	603	PF04695	0.360
LIG_Pex14_2	92	96	PF04695	0.329
LIG_PTB_Apo_2	162	169	PF02174	0.422
LIG_SH2_CRK	144	148	PF00017	0.616
LIG_SH2_GRB2like	163	166	PF00017	0.400
LIG_SH2_GRB2like	572	575	PF00017	0.585
LIG_SH2_PTP2	19	22	PF00017	0.424
LIG_SH2_PTP2	485	488	PF00017	0.322
LIG_SH2_STAP1	182	186	PF00017	0.341
LIG_SH2_STAP1	314	318	PF00017	0.571
LIG_SH2_STAP1	572	576	PF00017	0.579
LIG_SH2_STAT3	231	234	PF00017	0.617
LIG_SH2_STAT5	120	123	PF00017	0.406
LIG_SH2_STAT5	163	166	PF00017	0.365
LIG_SH2_STAT5	184	187	PF00017	0.407
LIG_SH2_STAT5	19	22	PF00017	0.429
LIG_SH2_STAT5	199	202	PF00017	0.396
LIG_SH2_STAT5	206	209	PF00017	0.573
LIG_SH2_STAT5	242	245	PF00017	0.390
LIG_SH2_STAT5	264	267	PF00017	0.442
LIG_SH2_STAT5	272	275	PF00017	0.234
LIG_SH2_STAT5	485	488	PF00017	0.353
LIG_SH2_STAT5	535	538	PF00017	0.346
LIG_SH2_STAT5	60	63	PF00017	0.385
LIG_SH3_1	304	310	PF00018	0.728
LIG_SH3_3	133	139	PF00018	0.589
LIG_SH3_3	202	208	PF00018	0.553
LIG_SH3_3	304	310	PF00018	0.706
LIG_SH3_3	356	362	PF00018	0.795
LIG_SH3_3	73	79	PF00018	0.594
LIG_SUMO_SIM_anti_2	106	111	PF11976	0.299
LIG_SUMO_SIM_anti_2	274	279	PF11976	0.458
LIG_SUMO_SIM_par_1	281	287	PF11976	0.471
LIG_SUMO_SIM_par_1	438	443	PF11976	0.578
LIG_TRAF2_1	396	399	PF00917	0.830
LIG_UBA3_1	598	605	PF00899	0.516
MOD_CDC14_SPxK_1	404	407	PF00782	0.831
MOD_CDK_SPK_2	401	406	PF00069	0.692
MOD_CDK_SPxK_1	401	407	PF00069	0.827
MOD_CK1_1	177	183	PF00069	0.420
MOD_CK1_1	259	265	PF00069	0.493
MOD_CK1_1	31	37	PF00069	0.340
MOD_CK1_1	350	356	PF00069	0.844
MOD_CK1_1	480	486	PF00069	0.388
MOD_CK1_1	554	560	PF00069	0.439
MOD_CK2_1	393	399	PF00069	0.847
MOD_CK2_1	407	413	PF00069	0.808
MOD_CK2_1	511	517	PF00069	0.730
MOD_CMANNOS	445	448	PF00535	0.427
MOD_GlcNHglycan	152	155	PF01048	0.425
MOD_GlcNHglycan	179	182	PF01048	0.553
MOD_GlcNHglycan	269	272	PF01048	0.688
MOD_GlcNHglycan	368	371	PF01048	0.604
MOD_GlcNHglycan	372	375	PF01048	0.601
MOD_GlcNHglycan	391	394	PF01048	0.624
MOD_GlcNHglycan	492	495	PF01048	0.417
MOD_GlcNHglycan	499	502	PF01048	0.413
MOD_GlcNHglycan	585	588	PF01048	0.436
MOD_GSK3_1	150	157	PF00069	0.452
MOD_GSK3_1	24	31	PF00069	0.431
MOD_GSK3_1	255	262	PF00069	0.421
MOD_GSK3_1	267	274	PF00069	0.391
MOD_GSK3_1	308	315	PF00069	0.643
MOD_GSK3_1	350	357	PF00069	0.852
MOD_GSK3_1	366	373	PF00069	0.730
MOD_GSK3_1	389	396	PF00069	0.770
MOD_GSK3_1	401	408	PF00069	0.819
MOD_GSK3_1	46	53	PF00069	0.366
MOD_GSK3_1	583	590	PF00069	0.409
MOD_GSK3_1	605	612	PF00069	0.448
MOD_N-GLC_1	177	182	PF02516	0.569
MOD_N-GLC_2	56	58	PF02516	0.441
MOD_NEK2_1	155	160	PF00069	0.415
MOD_NEK2_1	22	27	PF00069	0.390
MOD_NEK2_1	255	260	PF00069	0.408
MOD_NEK2_1	273	278	PF00069	0.475
MOD_NEK2_1	447	452	PF00069	0.402
MOD_NEK2_1	454	459	PF00069	0.372
MOD_NEK2_1	519	524	PF00069	0.406
MOD_NEK2_1	531	536	PF00069	0.370
MOD_NEK2_1	551	556	PF00069	0.445
MOD_NEK2_1	582	587	PF00069	0.410
MOD_NEK2_1	588	593	PF00069	0.412
MOD_NEK2_1	8	13	PF00069	0.575
MOD_NEK2_2	28	33	PF00069	0.411
MOD_NEK2_2	564	569	PF00069	0.288
MOD_OFUCOSY	616	621	PF10250	0.611
MOD_PKA_1	224	230	PF00069	0.694
MOD_PKA_1	509	515	PF00069	0.711
MOD_PKA_2	214	220	PF00069	0.618
MOD_PKA_2	325	331	PF00069	0.791
MOD_PKA_2	348	354	PF00069	0.869
MOD_PKA_2	366	372	PF00069	0.881
MOD_PKA_2	405	411	PF00069	0.836
MOD_PKA_2	480	486	PF00069	0.417
MOD_PKA_2	509	515	PF00069	0.547
MOD_Plk_1	46	52	PF00069	0.363
MOD_Plk_1	477	483	PF00069	0.406
MOD_Plk_1	605	611	PF00069	0.535
MOD_Plk_4	127	133	PF00069	0.430
MOD_Plk_4	155	161	PF00069	0.404
MOD_Plk_4	243	249	PF00069	0.422
MOD_Plk_4	256	262	PF00069	0.409
MOD_Plk_4	407	413	PF00069	0.834
MOD_Plk_4	431	437	PF00069	0.620
MOD_Plk_4	447	453	PF00069	0.435
MOD_Plk_4	456	462	PF00069	0.409
MOD_Plk_4	480	486	PF00069	0.347
MOD_Plk_4	519	525	PF00069	0.385
MOD_Plk_4	531	537	PF00069	0.388
MOD_ProDKin_1	204	210	PF00069	0.641
MOD_ProDKin_1	401	407	PF00069	0.825
MOD_SUMO_rev_2	218	227	PF00179	0.676
TRG_ENDOCYTIC_2	144	147	PF00928	0.540
TRG_ENDOCYTIC_2	182	185	PF00928	0.391
TRG_ENDOCYTIC_2	19	22	PF00928	0.418
TRG_ENDOCYTIC_2	272	275	PF00928	0.297
TRG_ENDOCYTIC_2	299	302	PF00928	0.621
TRG_ENDOCYTIC_2	309	312	PF00928	0.514
TRG_ENDOCYTIC_2	485	488	PF00928	0.387
TRG_ENDOCYTIC_2	535	538	PF00928	0.353
TRG_ENDOCYTIC_2	580	583	PF00928	0.392
TRG_ENDOCYTIC_2	60	63	PF00928	0.367
TRG_ER_diArg_1	213	216	PF00400	0.683
TRG_ER_diArg_1	239	241	PF00400	0.580
TRG_ER_diArg_1	508	510	PF00400	0.658
TRG_ER_diArg_1	647	649	PF00400	0.721
TRG_ER_diArg_1	9	12	PF00400	0.539
TRG_ER_diLys_1	668	672	PF00400	0.570
TRG_NLS_MonoExtC_3	302	307	PF00514	0.537
TRG_NLS_MonoExtN_4	300	307	PF00514	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G0	Leptomonas seymouri	28%	100%
A0A0N1HZC2	Leptomonas seymouri	30%	100%
A0A0N1IKC5	Leptomonas seymouri	27%	100%
A0A0N1PB63	Leptomonas seymouri	25%	100%
A0A0N1PD04	Leptomonas seymouri	25%	100%
A0A0N1PFR4	Leptomonas seymouri	66%	100%
A0A1X0NKK0	Trypanosomatidae	28%	100%
A0A1X0NM09	Trypanosomatidae	27%	100%
A0A1X0NVF9	Trypanosomatidae	23%	100%
A0A1X0NVM7	Trypanosomatidae	28%	100%
A0A1X0NWQ1	Trypanosomatidae	25%	100%
A0A1X0NZE6	Trypanosomatidae	26%	100%
A0A1X0NZT1	Trypanosomatidae	23%	81%
A0A1X0NZU2	Trypanosomatidae	32%	100%
A0A1X0NZW1	Trypanosomatidae	50%	100%
A0A381MMW5	Leishmania infantum	31%	100%
A0A3Q8IEC4	Leishmania donovani	31%	100%
A0A3Q8IF95	Leishmania donovani	24%	100%
A0A3Q8IIT5	Leishmania donovani	93%	100%
A0A3Q8ISY9	Leishmania donovani	27%	97%
A0A3R7KKN8	Trypanosoma rangeli	53%	100%
A0A3R7N3S6	Trypanosoma rangeli	23%	100%
A0A3R7N921	Trypanosoma rangeli	24%	100%
A0A3S7WRJ4	Leishmania donovani	26%	100%
A0A3S7WRJ5	Leishmania donovani	26%	96%
A0A3S7WRS3	Leishmania donovani	25%	100%
A0A3S7WWU1	Leishmania donovani	25%	100%
A0A3S7X2G0	Leishmania donovani	31%	100%
A0A3S7X2K5	Leishmania donovani	30%	100%
A0A3S7XB11	Leishmania donovani	29%	100%
A0A422MU68	Trypanosoma rangeli	25%	100%
A0A422NL17	Trypanosoma rangeli	23%	83%
A4H6J0	Leishmania braziliensis	25%	100%
A4H6J1	Leishmania braziliensis	27%	100%
A4H6Q5	Leishmania braziliensis	24%	100%
A4HC19	Leishmania braziliensis	25%	100%
A4HHG2	Leishmania braziliensis	82%	99%
A4HHG3	Leishmania braziliensis	30%	100%
A4HHG4	Leishmania braziliensis	31%	100%
A4HJW3	Leishmania braziliensis	26%	100%
A4HPE2	Leishmania braziliensis	27%	100%
A4HUX5	Leishmania infantum	26%	100%
A4HUX6	Leishmania infantum	26%	96%
A4HV40	Leishmania infantum	25%	100%
A4HZF5	Leishmania infantum	24%	100%
A4HZJ4	Leishmania infantum	26%	100%
A4I4L2	Leishmania infantum	93%	100%
A4I7C5	Leishmania infantum	27%	97%
A4ICI3	Leishmania infantum	29%	100%
D0A7B1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E8NHE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AE01	Leishmania major	30%	100%
E9AE10	Leishmania major	100%	100%
E9AE11	Leishmania major	30%	100%
E9AHJ0	Leishmania infantum	31%	100%
E9AHJ1	Leishmania infantum	30%	100%
E9ALS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9ALS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9ANL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9ANL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9ANS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9APJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AT53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AVF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	92%
E9AVF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B2B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4Q1E4	Leishmania major	28%	100%
Q4Q5T8	Leishmania major	27%	100%
Q4QC27	Leishmania major	25%	100%
Q4QGU8	Leishmania major	24%	100%
Q4QH14	Leishmania major	26%	100%
Q4QH15	Leishmania major	26%	100%
V5BFV8	Trypanosoma cruzi	26%	100%
V5BLR7	Trypanosoma cruzi	23%	81%
V5BWJ7	Trypanosoma cruzi	23%	100%
V5DT25	Trypanosoma cruzi	27%	100%