Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AE07_LEIMA

TriTrypDb:

LmjF.29.1480 , LMJLV39_290021600 , LMJSD75_290022100

Length:

290

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AE07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE07

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	272	276	PF00656	0.476
CLV_NRD_NRD_1	122	124	PF00675	0.438
CLV_PCSK_KEX2_1	122	124	PF00082	0.438
CLV_PCSK_SKI1_1	13	17	PF00082	0.432
CLV_PCSK_SKI1_1	41	45	PF00082	0.445
DEG_SPOP_SBC_1	24	28	PF00917	0.612
DOC_CYCLIN_RxL_1	38	46	PF00134	0.636
DOC_CYCLIN_yClb1_LxF_4	39	44	PF00134	0.602
DOC_MAPK_FxFP_2	45	48	PF00069	0.703
DOC_MAPK_gen_1	190	198	PF00069	0.795
DOC_MAPK_MEF2A_6	109	118	PF00069	0.768
DOC_PP1_RVXF_1	39	46	PF00149	0.637
DOC_PP2B_LxvP_1	128	131	PF13499	0.772
DOC_PP2B_PxIxI_1	113	119	PF00149	0.764
DOC_PP4_FxxP_1	247	250	PF00568	0.623
DOC_PP4_FxxP_1	45	48	PF00568	0.704
DOC_USP7_MATH_1	131	135	PF00917	0.768
DOC_USP7_MATH_1	136	140	PF00917	0.781
DOC_USP7_MATH_1	274	278	PF00917	0.471
DOC_USP7_MATH_1	63	67	PF00917	0.626
DOC_USP7_MATH_1	86	90	PF00917	0.644
DOC_WW_Pin1_4	110	115	PF00397	0.818
DOC_WW_Pin1_4	250	255	PF00397	0.556
DOC_WW_Pin1_4	67	72	PF00397	0.699
LIG_14-3-3_CanoR_1	122	130	PF00244	0.694
LIG_14-3-3_CanoR_1	132	140	PF00244	0.683
LIG_14-3-3_CanoR_1	19	24	PF00244	0.700
LIG_14-3-3_CanoR_1	31	39	PF00244	0.657
LIG_BRCT_BRCA1_1	51	55	PF00533	0.728
LIG_FHA_1	158	164	PF00498	0.740
LIG_FHA_1	232	238	PF00498	0.339
LIG_FHA_1	258	264	PF00498	0.556
LIG_FHA_1	86	92	PF00498	0.727
LIG_FHA_2	270	276	PF00498	0.573
LIG_LIR_Apic_2	66	71	PF02991	0.646
LIG_LIR_Nem_3	222	227	PF02991	0.726
LIG_LIR_Nem_3	253	259	PF02991	0.561
LIG_LIR_Nem_3	51	56	PF02991	0.735
LIG_Pex14_1	224	228	PF04695	0.633
LIG_SH2_CRK	53	57	PF00017	0.712
LIG_SH2_PTP2	68	71	PF00017	0.616
LIG_SH2_STAP1	259	263	PF00017	0.561
LIG_SH2_STAT5	256	259	PF00017	0.565
LIG_SH2_STAT5	68	71	PF00017	0.616
LIG_SH3_3	135	141	PF00018	0.667
LIG_SUMO_SIM_anti_2	115	121	PF11976	0.764
LIG_SUMO_SIM_anti_2	234	240	PF11976	0.336
LIG_WW_3	38	42	PF00397	0.633
MOD_CK1_1	143	149	PF00069	0.735
MOD_CK1_1	157	163	PF00069	0.623
MOD_CK1_1	231	237	PF00069	0.269
MOD_CK1_1	267	273	PF00069	0.605
MOD_CK1_1	33	39	PF00069	0.646
MOD_CK1_1	57	63	PF00069	0.740
MOD_GlcNHglycan	101	104	PF01048	0.508
MOD_GlcNHglycan	133	136	PF01048	0.586
MOD_GlcNHglycan	160	163	PF01048	0.500
MOD_GlcNHglycan	32	35	PF01048	0.413
MOD_GlcNHglycan	71	74	PF01048	0.450
MOD_GlcNHglycan	88	91	PF01048	0.433
MOD_GSK3_1	108	115	PF00069	0.816
MOD_GSK3_1	136	143	PF00069	0.766
MOD_GSK3_1	154	161	PF00069	0.614
MOD_GSK3_1	19	26	PF00069	0.633
MOD_GSK3_1	269	276	PF00069	0.618
MOD_GSK3_1	63	70	PF00069	0.635
MOD_GSK3_1	86	93	PF00069	0.818
MOD_N-GLC_1	228	233	PF02516	0.410
MOD_N-GLC_1	267	272	PF02516	0.765
MOD_NEK2_1	273	278	PF00069	0.591
MOD_NEK2_1	30	35	PF00069	0.698
MOD_NEK2_1	43	48	PF00069	0.647
MOD_PIKK_1	143	149	PF00454	0.750
MOD_PIKK_1	274	280	PF00454	0.443
MOD_PIKK_1	33	39	PF00454	0.647
MOD_PK_1	19	25	PF00069	0.663
MOD_PKA_2	108	114	PF00069	0.704
MOD_PKA_2	121	127	PF00069	0.659
MOD_PKA_2	131	137	PF00069	0.701
MOD_PKA_2	30	36	PF00069	0.622
MOD_PKA_2	99	105	PF00069	0.764
MOD_PKB_1	83	91	PF00069	0.694
MOD_Plk_1	228	234	PF00069	0.410
MOD_Plk_4	19	25	PF00069	0.729
MOD_Plk_4	259	265	PF00069	0.497
MOD_Plk_4	64	70	PF00069	0.622
MOD_ProDKin_1	110	116	PF00069	0.818
MOD_ProDKin_1	250	256	PF00069	0.557
MOD_ProDKin_1	67	73	PF00069	0.699
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.650
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.633
TRG_ENDOCYTIC_2	53	56	PF00928	0.703
TRG_ER_diArg_1	82	85	PF00400	0.724
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7L3	Leishmania donovani	80%	96%
A4HHG0	Leishmania braziliensis	53%	78%
A4I4L0	Leishmania infantum	80%	96%
E9ALS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	96%