ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AE06_LEIMA

TriTrypDb:

LmjF.29.1470 , LMJLV39_290021500 , LMJSD75_290022000

Length:

708

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AE06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE06

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.533
CLV_C14_Caspase3-7	328	332	PF00656	0.635
CLV_C14_Caspase3-7	373	377	PF00656	0.615
CLV_NRD_NRD_1	476	478	PF00675	0.412
CLV_NRD_NRD_1	571	573	PF00675	0.573
CLV_NRD_NRD_1	603	605	PF00675	0.650
CLV_NRD_NRD_1	687	689	PF00675	0.700
CLV_PCSK_KEX2_1	227	229	PF00082	0.566
CLV_PCSK_KEX2_1	476	478	PF00082	0.396
CLV_PCSK_KEX2_1	571	573	PF00082	0.573
CLV_PCSK_KEX2_1	687	689	PF00082	0.700
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.566
CLV_PCSK_SKI1_1	11	15	PF00082	0.540
CLV_PCSK_SKI1_1	166	170	PF00082	0.479
CLV_PCSK_SKI1_1	196	200	PF00082	0.409
CLV_PCSK_SKI1_1	227	231	PF00082	0.414
CLV_PCSK_SKI1_1	358	362	PF00082	0.607
CLV_PCSK_SKI1_1	476	480	PF00082	0.434
CLV_PCSK_SKI1_1	649	653	PF00082	0.469
CLV_Separin_Metazoa	502	506	PF03568	0.598
DEG_SPOP_SBC_1	383	387	PF00917	0.545
DOC_ANK_TNKS_1	686	693	PF00023	0.625
DOC_CYCLIN_yCln2_LP_2	218	224	PF00134	0.560
DOC_MAPK_gen_1	227	234	PF00069	0.460
DOC_MAPK_gen_1	632	641	PF00069	0.426
DOC_MAPK_MEF2A_6	227	236	PF00069	0.473
DOC_MAPK_MEF2A_6	511	518	PF00069	0.360
DOC_PP1_RVXF_1	347	353	PF00149	0.660
DOC_PP2B_LxvP_1	218	221	PF13499	0.562
DOC_PP2B_LxvP_1	651	654	PF13499	0.454
DOC_USP7_MATH_1	120	124	PF00917	0.741
DOC_USP7_MATH_1	132	136	PF00917	0.654
DOC_USP7_MATH_1	256	260	PF00917	0.591
DOC_USP7_MATH_1	26	30	PF00917	0.680
DOC_USP7_MATH_1	340	344	PF00917	0.566
DOC_USP7_MATH_1	370	374	PF00917	0.496
DOC_USP7_MATH_1	420	424	PF00917	0.507
DOC_USP7_MATH_1	486	490	PF00917	0.532
DOC_USP7_MATH_1	699	703	PF00917	0.399
DOC_USP7_UBL2_3	294	298	PF12436	0.734
DOC_WW_Pin1_4	227	232	PF00397	0.416
DOC_WW_Pin1_4	680	685	PF00397	0.503
LIG_14-3-3_CanoR_1	334	344	PF00244	0.617
LIG_14-3-3_CanoR_1	571	575	PF00244	0.561
LIG_AP2alpha_1	101	105	PF02296	0.714
LIG_BH_BH3_1	159	175	PF00452	0.623
LIG_BIR_II_1	1	5	PF00653	0.754
LIG_CtBP_PxDLS_1	515	519	PF00389	0.430
LIG_EVH1_2	286	290	PF00568	0.646
LIG_FHA_1	312	318	PF00498	0.698
LIG_FHA_1	384	390	PF00498	0.523
LIG_FHA_1	410	416	PF00498	0.610
LIG_FHA_1	591	597	PF00498	0.410
LIG_FHA_2	187	193	PF00498	0.596
LIG_FHA_2	228	234	PF00498	0.449
LIG_FHA_2	328	334	PF00498	0.645
LIG_FHA_2	533	539	PF00498	0.458
LIG_FHA_2	658	664	PF00498	0.495
LIG_FHA_2	684	690	PF00498	0.619
LIG_GBD_Chelix_1	430	438	PF00786	0.517
LIG_LIR_Gen_1	102	110	PF02991	0.643
LIG_LIR_Gen_1	161	170	PF02991	0.470
LIG_LIR_Gen_1	246	256	PF02991	0.581
LIG_LIR_Gen_1	488	498	PF02991	0.577
LIG_LIR_Gen_1	528	534	PF02991	0.480
LIG_LIR_Gen_1	620	630	PF02991	0.470
LIG_LIR_LC3C_4	593	597	PF02991	0.422
LIG_LIR_Nem_3	102	108	PF02991	0.719
LIG_LIR_Nem_3	161	165	PF02991	0.474
LIG_LIR_Nem_3	246	252	PF02991	0.585
LIG_LIR_Nem_3	488	494	PF02991	0.478
LIG_LIR_Nem_3	496	500	PF02991	0.431
LIG_LIR_Nem_3	528	532	PF02991	0.442
LIG_LIR_Nem_3	620	626	PF02991	0.448
LIG_PCNA_yPIPBox_3	585	596	PF02747	0.546
LIG_PDZ_Class_2	703	708	PF00595	0.513
LIG_Pex14_2	101	105	PF04695	0.687
LIG_SH2_CRK	249	253	PF00017	0.575
LIG_SH2_SRC	483	486	PF00017	0.501
LIG_SH2_SRC	500	503	PF00017	0.419
LIG_SH2_SRC	678	681	PF00017	0.459
LIG_SH2_STAP1	201	205	PF00017	0.515
LIG_SH2_STAP1	249	253	PF00017	0.575
LIG_SH2_STAP1	500	504	PF00017	0.524
LIG_SH2_STAT5	222	225	PF00017	0.483
LIG_SH2_STAT5	48	51	PF00017	0.554
LIG_SH2_STAT5	483	486	PF00017	0.560
LIG_SH2_STAT5	574	577	PF00017	0.500
LIG_SH2_STAT5	583	586	PF00017	0.452
LIG_SH2_STAT5	678	681	PF00017	0.440
LIG_SH3_3	282	288	PF00018	0.592
LIG_SH3_3	59	65	PF00018	0.623
LIG_SH3_3	69	75	PF00018	0.755
LIG_SH3_3	698	704	PF00018	0.444
LIG_SH3_4	294	301	PF00018	0.726
LIG_SH3_CIN85_PxpxPR_1	63	68	PF14604	0.739
LIG_Sin3_3	506	513	PF02671	0.525
LIG_SUMO_SIM_anti_2	233	238	PF11976	0.479
LIG_SUMO_SIM_par_1	649	655	PF11976	0.503
LIG_UBA3_1	638	644	PF00899	0.524
LIG_WRC_WIRS_1	543	548	PF05994	0.524
MOD_CDK_SPxxK_3	680	687	PF00069	0.564
MOD_CK1_1	135	141	PF00069	0.658
MOD_CK1_1	311	317	PF00069	0.649
MOD_CK1_1	409	415	PF00069	0.607
MOD_CK1_1	425	431	PF00069	0.528
MOD_CK1_1	553	559	PF00069	0.620
MOD_CK1_1	606	612	PF00069	0.743
MOD_CK1_1	683	689	PF00069	0.616
MOD_CK2_1	119	125	PF00069	0.739
MOD_CK2_1	238	244	PF00069	0.570
MOD_CK2_1	264	270	PF00069	0.665
MOD_CK2_1	275	281	PF00069	0.571
MOD_CK2_1	28	34	PF00069	0.725
MOD_CK2_1	327	333	PF00069	0.587
MOD_CK2_1	532	538	PF00069	0.499
MOD_CK2_1	657	663	PF00069	0.573
MOD_CK2_1	683	689	PF00069	0.575
MOD_GlcNHglycan	1	4	PF01048	0.760
MOD_GlcNHglycan	134	137	PF01048	0.675
MOD_GlcNHglycan	150	154	PF01048	0.662
MOD_GlcNHglycan	206	209	PF01048	0.454
MOD_GlcNHglycan	240	243	PF01048	0.653
MOD_GlcNHglycan	258	261	PF01048	0.491
MOD_GlcNHglycan	266	269	PF01048	0.666
MOD_GlcNHglycan	28	31	PF01048	0.627
MOD_GlcNHglycan	324	327	PF01048	0.568
MOD_GlcNHglycan	408	411	PF01048	0.557
MOD_GlcNHglycan	457	460	PF01048	0.573
MOD_GlcNHglycan	488	491	PF01048	0.538
MOD_GlcNHglycan	605	608	PF01048	0.699
MOD_GlcNHglycan	646	649	PF01048	0.546
MOD_GlcNHglycan	68	71	PF01048	0.656
MOD_GlcNHglycan	95	98	PF01048	0.759
MOD_GSK3_1	238	245	PF00069	0.622
MOD_GSK3_1	290	297	PF00069	0.701
MOD_GSK3_1	300	307	PF00069	0.593
MOD_GSK3_1	309	316	PF00069	0.498
MOD_GSK3_1	375	382	PF00069	0.677
MOD_GSK3_1	579	586	PF00069	0.506
MOD_GSK3_1	640	647	PF00069	0.365
MOD_NEK2_1	170	175	PF00069	0.588
MOD_NEK2_1	290	295	PF00069	0.616
MOD_NEK2_1	308	313	PF00069	0.562
MOD_NEK2_1	455	460	PF00069	0.579
MOD_NEK2_1	542	547	PF00069	0.469
MOD_NEK2_1	570	575	PF00069	0.502
MOD_NEK2_1	625	630	PF00069	0.473
MOD_NEK2_1	640	645	PF00069	0.407
MOD_NEK2_2	468	473	PF00069	0.557
MOD_PIKK_1	370	376	PF00454	0.521
MOD_PIKK_1	457	463	PF00454	0.648
MOD_PKA_1	406	412	PF00069	0.570
MOD_PKA_2	275	281	PF00069	0.674
MOD_PKA_2	570	576	PF00069	0.562
MOD_PKA_2	600	606	PF00069	0.578
MOD_Plk_2-3	172	178	PF00069	0.488
MOD_Plk_2-3	533	539	PF00069	0.548
MOD_Plk_4	275	281	PF00069	0.633
MOD_Plk_4	514	520	PF00069	0.539
MOD_Plk_4	542	548	PF00069	0.528
MOD_Plk_4	652	658	PF00069	0.476
MOD_ProDKin_1	227	233	PF00069	0.414
MOD_ProDKin_1	680	686	PF00069	0.505
TRG_DiLeu_BaEn_1	104	109	PF01217	0.706
TRG_DiLeu_BaEn_1	538	543	PF01217	0.493
TRG_DiLeu_BaEn_4	89	95	PF01217	0.763
TRG_DiLeu_LyEn_5	104	109	PF01217	0.589
TRG_ENDOCYTIC_2	249	252	PF00928	0.567
TRG_ENDOCYTIC_2	491	494	PF00928	0.498
TRG_ENDOCYTIC_2	500	503	PF00928	0.464
TRG_ENDOCYTIC_2	623	626	PF00928	0.405
TRG_ER_diArg_1	475	477	PF00400	0.414
TRG_ER_diArg_1	570	572	PF00400	0.558
TRG_ER_diArg_1	598	601	PF00400	0.422
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.611
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICE2	Leptomonas seymouri	58%	100%
A0A0S4KH65	Bodo saltans	27%	96%
A0A1X0P032	Trypanosomatidae	33%	100%
A0A3Q8IF68	Leishmania donovani	93%	99%
A0A3R7NCZ3	Trypanosoma rangeli	33%	100%
A4HHF9	Leishmania braziliensis	77%	100%
A4I4K9	Leishmania infantum	92%	99%
C9ZL94	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9ALS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BH81	Trypanosoma cruzi	33%	100%