AP complex subunit sigma

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

clathrin coat assembly protein ap19, putative

Species:

Leishmania major

UniProt:

E9AE03_LEIMA

TriTrypDb:

LmjF.29.1440 , LMJLV39_290020900 , LMJSD75_290021500

Length:

165

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	4
GO:0030119	AP-type membrane coat adaptor complex	3	7
GO:0030121	AP-1 adaptor complex	5	7
GO:0030131	clathrin adaptor complex	4	7
GO:0032991	protein-containing complex	1	7
GO:0098796	membrane protein complex	2	7

Expansion

Sequence features

E9AE03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE03

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006886	intracellular protein transport	4	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0016192	vesicle-mediated transport	4	2
GO:0033036	macromolecule localization	2	11
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0005515	protein binding	2	7
GO:0030276	clathrin binding	3	7
GO:0030674	protein-macromolecule adaptor activity	2	7
GO:0035615	clathrin adaptor activity	4	7
GO:0060090	molecular adaptor activity	1	7
GO:0140312	cargo adaptor activity	3	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	72	76	PF00656	0.323
CLV_NRD_NRD_1	54	56	PF00675	0.308
CLV_NRD_NRD_1	60	62	PF00675	0.266
CLV_PCSK_KEX2_1	128	130	PF00082	0.288
CLV_PCSK_KEX2_1	60	62	PF00082	0.263
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.323
CLV_PCSK_SKI1_1	128	132	PF00082	0.268
DEG_APCC_DBOX_1	128	136	PF00400	0.288
DEG_Nend_Nbox_1	1	3	PF02207	0.235
DOC_MAPK_gen_1	15	23	PF00069	0.275
DOC_MAPK_gen_1	60	67	PF00069	0.263
DOC_USP7_MATH_1	142	146	PF00917	0.408
DOC_USP7_UBL2_3	26	30	PF12436	0.263
LIG_14-3-3_CanoR_1	129	133	PF00244	0.314
LIG_14-3-3_CanoR_1	45	50	PF00244	0.340
LIG_14-3-3_CanoR_1	60	66	PF00244	0.224
LIG_BRCT_BRCA1_1	46	50	PF00533	0.276
LIG_BRCT_BRCA1_1	63	67	PF00533	0.132
LIG_Clathr_ClatBox_1	78	82	PF01394	0.263
LIG_FHA_1	157	163	PF00498	0.547
LIG_FHA_1	78	84	PF00498	0.293
LIG_FHA_2	72	78	PF00498	0.377
LIG_LIR_Gen_1	17	27	PF02991	0.347
LIG_LIR_Nem_3	17	23	PF02991	0.347
LIG_LIR_Nem_3	92	98	PF02991	0.279
LIG_MLH1_MIPbox_1	63	67	PF16413	0.245
LIG_SH2_CRK	62	66	PF00017	0.245
LIG_SH2_PTP2	20	23	PF00017	0.323
LIG_SH2_STAP1	62	66	PF00017	0.245
LIG_SH2_STAT5	111	114	PF00017	0.384
LIG_SH2_STAT5	134	137	PF00017	0.263
LIG_SH2_STAT5	20	23	PF00017	0.332
LIG_SH2_STAT5	57	60	PF00017	0.290
LIG_SH2_STAT5	66	69	PF00017	0.248
LIG_SH2_STAT5	94	97	PF00017	0.247
LIG_SUMO_SIM_anti_2	100	105	PF11976	0.155
LIG_SUMO_SIM_anti_2	80	85	PF11976	0.282
LIG_SUMO_SIM_par_1	77	82	PF11976	0.239
LIG_UBA3_1	5	13	PF00899	0.253
MOD_CK2_1	21	27	PF00069	0.263
MOD_CK2_1	45	51	PF00069	0.177
MOD_CK2_1	71	77	PF00069	0.377
MOD_Cter_Amidation	53	56	PF01082	0.377
MOD_Cter_Amidation	58	61	PF01082	0.377
MOD_GlcNHglycan	42	45	PF01048	0.300
MOD_GSK3_1	40	47	PF00069	0.282
MOD_N-GLC_2	97	99	PF02516	0.245
MOD_NEK2_1	123	128	PF00069	0.245
MOD_NEK2_1	149	154	PF00069	0.549
MOD_NEK2_1	40	45	PF00069	0.271
MOD_NEK2_1	6	11	PF00069	0.235
MOD_PIKK_1	21	27	PF00454	0.352
MOD_PKA_1	128	134	PF00069	0.358
MOD_PKA_2	128	134	PF00069	0.358
MOD_PKA_2	14	20	PF00069	0.313
MOD_PKA_2	44	50	PF00069	0.302
MOD_Plk_2-3	150	156	PF00069	0.518
MOD_Plk_2-3	77	83	PF00069	0.288
MOD_Plk_4	150	156	PF00069	0.493
MOD_Plk_4	45	51	PF00069	0.383
MOD_Plk_4	61	67	PF00069	0.221
TRG_DiLeu_BaEn_2	149	155	PF01217	0.432
TRG_ENDOCYTIC_2	111	114	PF00928	0.245
TRG_ENDOCYTIC_2	20	23	PF00928	0.343
TRG_ENDOCYTIC_2	62	65	PF00928	0.245
TRG_ER_diArg_1	60	62	PF00400	0.288

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7V4	Leptomonas seymouri	34%	99%
A0A0N1I965	Leptomonas seymouri	84%	100%
A0A0N1PDE8	Leptomonas seymouri	34%	100%
A0A0N1PDX0	Leptomonas seymouri	40%	100%
A0A0S4J0F7	Bodo saltans	29%	99%
A0A0S4J161	Bodo saltans	58%	98%
A0A0S4JCD4	Bodo saltans	44%	100%
A0A0S4JQI5	Bodo saltans	43%	100%
A0A1X0NVQ0	Trypanosomatidae	32%	100%
A0A1X0P093	Trypanosomatidae	72%	99%
A0A1X0P9M2	Trypanosomatidae	45%	100%
A0A3Q8IMU4	Leishmania donovani	33%	99%
A0A3Q8INE3	Leishmania donovani	43%	100%
A0A3R7MTZ7	Trypanosoma rangeli	42%	100%
A0A3R7N944	Trypanosoma rangeli	34%	100%
A0A3R7NTN2	Trypanosoma rangeli	32%	88%
A0A3S7X2E9	Leishmania donovani	97%	100%
A0A422N1J3	Trypanosoma rangeli	69%	99%
A4HAU5	Leishmania braziliensis	43%	100%
A4HDI7	Leishmania braziliensis	35%	99%
A4HHF6	Leishmania braziliensis	92%	100%
A4I4K2	Leishmania infantum	97%	100%
A4IA12	Leishmania infantum	43%	100%
B0G185	Dictyostelium discoideum	55%	100%
C9ZL88	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
C9ZWF3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
D0A005	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	93%
E9AH61	Leishmania infantum	33%	99%
E9ALS9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AWZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	99%
E9B519	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
O23685	Arabidopsis thaliana	53%	100%
O50016	Zea mays	52%	100%
O82201	Arabidopsis thaliana	39%	100%
P35181	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	48%	100%
P47064	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	85%
P53680	Homo sapiens	50%	100%
P56377	Homo sapiens	56%	100%
P59780	Homo sapiens	38%	85%
P61966	Homo sapiens	52%	100%
P61967	Mus musculus	52%	100%
P62743	Mus musculus	50%	100%
P62744	Rattus norvegicus	50%	100%
Q00381	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	100%
Q09905	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	100%
Q17QC5	Bos taurus	50%	100%
Q1JQ98	Bos taurus	51%	100%
Q1JQA3	Bos taurus	38%	85%
Q2YDH6	Bos taurus	40%	85%
Q3ZBB6	Bos taurus	40%	100%
Q3ZBS3	Bos taurus	57%	100%
Q4ICG5	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	51%	100%
Q4Q2W7	Leishmania major	43%	100%
Q4QAH7	Leishmania major	33%	99%
Q4WS49	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	51%	100%
Q54H39	Dictyostelium discoideum	50%	100%
Q54NZ4	Dictyostelium discoideum	37%	100%
Q54WW3	Dictyostelium discoideum	45%	100%
Q553S2	Dictyostelium discoideum	40%	96%
Q59QC5	Candida albicans (strain SC5314 / ATCC MYA-2876)	32%	94%
Q5BFF8	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	52%	100%
Q5R940	Pongo abelii	50%	100%
Q5RDP9	Pongo abelii	38%	85%
Q75F71	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	28%	89%
Q7SAQ1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	51%	100%
Q7TN05	Mus musculus	51%	100%
Q84WL9	Arabidopsis thaliana	51%	100%
Q8BSZ2	Mus musculus	38%	85%
Q8LEZ8	Arabidopsis thaliana	53%	100%
Q8VZ37	Arabidopsis thaliana	33%	99%
Q92572	Homo sapiens	40%	85%
Q96PC3	Homo sapiens	54%	100%
Q9DB50	Mus musculus	57%	100%
Q9DCR2	Mus musculus	40%	85%
Q9P7N2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	54%	100%
Q9WVL1	Mus musculus	40%	100%
Q9Y587	Homo sapiens	39%	100%
Q9Y7L6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	51%	100%
V5DBK5	Trypanosoma cruzi	33%	100%