Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AE02_LEIMA

TriTrypDb:

LmjF.29.1430 , LMJLV39_290021000 , LMJSD75_290021400

Length:

506

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0020023	kinetoplast	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AE02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE02

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	188	190	PF00675	0.405
CLV_NRD_NRD_1	20	22	PF00675	0.717
CLV_NRD_NRD_1	436	438	PF00675	0.751
CLV_NRD_NRD_1	479	481	PF00675	0.584
CLV_NRD_NRD_1	487	489	PF00675	0.566
CLV_PCSK_KEX2_1	105	107	PF00082	0.495
CLV_PCSK_KEX2_1	143	145	PF00082	0.595
CLV_PCSK_KEX2_1	157	159	PF00082	0.620
CLV_PCSK_KEX2_1	188	190	PF00082	0.419
CLV_PCSK_KEX2_1	20	22	PF00082	0.731
CLV_PCSK_KEX2_1	368	370	PF00082	0.594
CLV_PCSK_KEX2_1	487	489	PF00082	0.599
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.499
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.716
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.685
CLV_PCSK_PC1ET2_1	368	370	PF00082	0.594
CLV_PCSK_PC7_1	483	489	PF00082	0.544
CLV_PCSK_SKI1_1	12	16	PF00082	0.496
CLV_PCSK_SKI1_1	157	161	PF00082	0.624
CLV_PCSK_SKI1_1	21	25	PF00082	0.678
CLV_PCSK_SKI1_1	342	346	PF00082	0.343
CLV_PCSK_SKI1_1	349	353	PF00082	0.413
CLV_PCSK_SKI1_1	4	8	PF00082	0.478
DEG_APCC_DBOX_1	188	196	PF00400	0.455
DEG_APCC_DBOX_1	341	349	PF00400	0.381
DEG_ODPH_VHL_1	352	364	PF01847	0.413
DEG_SCF_FBW7_1	441	446	PF00400	0.537
DEG_SCF_FBW7_1	61	68	PF00400	0.517
DOC_ANK_TNKS_1	232	239	PF00023	0.606
DOC_CKS1_1	149	154	PF01111	0.684
DOC_CKS1_1	45	50	PF01111	0.557
DOC_CKS1_1	62	67	PF01111	0.487
DOC_CYCLIN_RxL_1	154	162	PF00134	0.419
DOC_MAPK_gen_1	105	111	PF00069	0.499
DOC_MAPK_gen_1	157	166	PF00069	0.651
DOC_MAPK_gen_1	188	196	PF00069	0.520
DOC_MAPK_MEF2A_6	105	113	PF00069	0.447
DOC_MAPK_MEF2A_6	188	196	PF00069	0.520
DOC_MAPK_NFAT4_5	106	114	PF00069	0.447
DOC_MAPK_NFAT4_5	189	197	PF00069	0.520
DOC_PP1_RVXF_1	499	506	PF00149	0.537
DOC_PP2B_LxvP_1	164	167	PF13499	0.543
DOC_USP7_MATH_1	332	336	PF00917	0.605
DOC_USP7_MATH_1	65	69	PF00917	0.742
DOC_USP7_MATH_1	95	99	PF00917	0.518
DOC_USP7_UBL2_3	157	161	PF12436	0.417
DOC_WW_Pin1_4	148	153	PF00397	0.642
DOC_WW_Pin1_4	355	360	PF00397	0.554
DOC_WW_Pin1_4	439	444	PF00397	0.544
DOC_WW_Pin1_4	44	49	PF00397	0.686
DOC_WW_Pin1_4	494	499	PF00397	0.715
DOC_WW_Pin1_4	51	56	PF00397	0.612
DOC_WW_Pin1_4	61	66	PF00397	0.519
LIG_14-3-3_CanoR_1	20	26	PF00244	0.667
LIG_14-3-3_CanoR_1	241	250	PF00244	0.377
LIG_14-3-3_CanoR_1	33	40	PF00244	0.538
LIG_14-3-3_CanoR_1	334	341	PF00244	0.535
LIG_14-3-3_CanoR_1	382	390	PF00244	0.436
LIG_14-3-3_CanoR_1	392	400	PF00244	0.367
LIG_14-3-3_CanoR_1	429	436	PF00244	0.734
LIG_14-3-3_CanoR_1	66	70	PF00244	0.788
LIG_Actin_WH2_2	333	351	PF00022	0.502
LIG_AP2alpha_1	176	180	PF02296	0.486
LIG_APCC_ABBA_1	173	178	PF00400	0.634
LIG_APCC_ABBA_1	221	226	PF00400	0.510
LIG_APCC_ABBA_1	473	478	PF00400	0.470
LIG_BIR_III_4	301	305	PF00653	0.588
LIG_BRCT_BRCA1_1	501	505	PF00533	0.482
LIG_deltaCOP1_diTrp_1	128	137	PF00928	0.614
LIG_deltaCOP1_diTrp_1	79	88	PF00928	0.466
LIG_EVH1_2	10	14	PF00568	0.525
LIG_EVH1_2	213	217	PF00568	0.337
LIG_EVH1_2	360	364	PF00568	0.456
LIG_FHA_1	440	446	PF00498	0.708
LIG_FHA_1	69	75	PF00498	0.711
LIG_FHA_2	304	310	PF00498	0.822
LIG_Integrin_RGD_1	182	184	PF01839	0.464
LIG_LIR_Gen_1	128	137	PF02991	0.610
LIG_LIR_Gen_1	79	86	PF02991	0.466
LIG_LIR_Nem_3	128	134	PF02991	0.641
LIG_LIR_Nem_3	291	296	PF02991	0.530
LIG_LIR_Nem_3	387	393	PF02991	0.411
LIG_LIR_Nem_3	79	85	PF02991	0.467
LIG_NRBOX	191	197	PF00104	0.514
LIG_NRP_CendR_1	504	506	PF00754	0.544
LIG_PCNA_yPIPBox_3	277	287	PF02747	0.336
LIG_Pex14_2	176	180	PF04695	0.639
LIG_SH2_SRC	165	168	PF00017	0.596
LIG_SH2_SRC	412	415	PF00017	0.431
LIG_SH2_STAT5	141	144	PF00017	0.691
LIG_SH2_STAT5	165	168	PF00017	0.527
LIG_SH2_STAT5	198	201	PF00017	0.450
LIG_SH2_STAT5	372	375	PF00017	0.498
LIG_SH2_STAT5	396	399	PF00017	0.427
LIG_SH2_STAT5	402	405	PF00017	0.437
LIG_SH2_STAT5	412	415	PF00017	0.473
LIG_SH2_STAT5	453	456	PF00017	0.690
LIG_SH3_1	488	494	PF00018	0.533
LIG_SH3_3	146	152	PF00018	0.691
LIG_SH3_3	163	169	PF00018	0.548
LIG_SH3_3	208	214	PF00018	0.306
LIG_SH3_3	45	51	PF00018	0.701
LIG_SH3_3	488	494	PF00018	0.589
LIG_SH3_3	59	65	PF00018	0.756
LIG_SH3_CIN85_PxpxPR_1	61	66	PF14604	0.564
LIG_SUMO_SIM_anti_2	282	289	PF11976	0.428
LIG_SUMO_SIM_par_1	282	289	PF11976	0.426
LIG_TRAF2_1	289	292	PF00917	0.709
LIG_UBA3_1	194	200	PF00899	0.368
LIG_WW_3	9	13	PF00397	0.473
MOD_CDK_SPK_2	53	58	PF00069	0.611
MOD_CDK_SPK_2	61	66	PF00069	0.558
MOD_CDK_SPxxK_3	150	157	PF00069	0.427
MOD_CDK_SPxxK_3	494	501	PF00069	0.549
MOD_CDK_SPxxK_3	51	58	PF00069	0.611
MOD_CK1_1	139	145	PF00069	0.664
MOD_CK1_1	244	250	PF00069	0.371
MOD_CK1_1	285	291	PF00069	0.541
MOD_CK1_1	50	56	PF00069	0.701
MOD_CK1_1	68	74	PF00069	0.623
MOD_CK2_1	285	291	PF00069	0.589
MOD_CK2_1	303	309	PF00069	0.743
MOD_CK2_1	77	83	PF00069	0.658
MOD_Cter_Amidation	103	106	PF01082	0.466
MOD_GlcNHglycan	243	246	PF01048	0.438
MOD_GlcNHglycan	28	31	PF01048	0.667
MOD_GlcNHglycan	336	339	PF01048	0.488
MOD_GlcNHglycan	426	429	PF01048	0.498
MOD_GSK3_1	114	121	PF00069	0.549
MOD_GSK3_1	244	251	PF00069	0.453
MOD_GSK3_1	282	289	PF00069	0.559
MOD_GSK3_1	296	303	PF00069	0.679
MOD_GSK3_1	323	330	PF00069	0.598
MOD_GSK3_1	39	46	PF00069	0.639
MOD_GSK3_1	439	446	PF00069	0.724
MOD_GSK3_1	447	454	PF00069	0.686
MOD_GSK3_1	47	54	PF00069	0.592
MOD_GSK3_1	61	68	PF00069	0.621
MOD_GSK3_1	70	77	PF00069	0.706
MOD_N-GLC_1	463	468	PF02516	0.682
MOD_NEK2_1	136	141	PF00069	0.617
MOD_NEK2_1	463	468	PF00069	0.718
MOD_NEK2_1	499	504	PF00069	0.713
MOD_PIKK_1	244	250	PF00454	0.390
MOD_PIKK_1	429	435	PF00454	0.738
MOD_PKA_2	391	397	PF00069	0.435
MOD_PKA_2	65	71	PF00069	0.684
MOD_Plk_1	308	314	PF00069	0.688
MOD_Plk_1	327	333	PF00069	0.544
MOD_Plk_4	114	120	PF00069	0.547
MOD_Plk_4	269	275	PF00069	0.463
MOD_Plk_4	77	83	PF00069	0.590
MOD_ProDKin_1	148	154	PF00069	0.641
MOD_ProDKin_1	355	361	PF00069	0.560
MOD_ProDKin_1	439	445	PF00069	0.541
MOD_ProDKin_1	44	50	PF00069	0.687
MOD_ProDKin_1	494	500	PF00069	0.715
MOD_ProDKin_1	51	57	PF00069	0.609
MOD_ProDKin_1	61	67	PF00069	0.519
TRG_DiLeu_BaEn_1	190	195	PF01217	0.531
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.656
TRG_DiLeu_BaLyEn_6	379	384	PF01217	0.502
TRG_ENDOCYTIC_2	177	180	PF00928	0.592
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	277	282	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	382	387	PF00026	0.374
TRG_Pf-PMV_PEXEL_1	434	439	PF00026	0.758

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P950	Leptomonas seymouri	39%	91%
A0A0N1ILX4	Leptomonas seymouri	25%	100%
A0A0S4JKE9	Bodo saltans	27%	100%
A0A1X0NTZ8	Trypanosomatidae	27%	100%
A0A1X0NZT5	Trypanosomatidae	31%	100%
A0A3Q8IAB6	Leishmania donovani	25%	93%
A0A3R7KFA4	Trypanosoma rangeli	31%	100%
A0A3S5IRP3	Trypanosoma rangeli	27%	100%
A0A3S7X2J5	Leishmania donovani	94%	94%
A4H889	Leishmania braziliensis	25%	100%
A4HHF5	Leishmania braziliensis	81%	100%
A4HWL2	Leishmania infantum	25%	93%
A4I4K3	Leishmania infantum	94%	94%
C9ZL87	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZXS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9ALT0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9AQB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q4QF55	Leishmania major	25%	95%
V5B4N1	Trypanosoma cruzi	27%	100%
V5D9T1	Trypanosoma cruzi	30%	100%