Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AE00_LEIMA

TriTrypDb:

LmjF.29.1410 , LMJLV39_290020800 , LMJSD75_290021000

Length:

903

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AE00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE00

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.686
CLV_C14_Caspase3-7	62	66	PF00656	0.644
CLV_C14_Caspase3-7	620	624	PF00656	0.635
CLV_C14_Caspase3-7	706	710	PF00656	0.639
CLV_C14_Caspase3-7	71	75	PF00656	0.614
CLV_C14_Caspase3-7	863	867	PF00656	0.610
CLV_NRD_NRD_1	144	146	PF00675	0.723
CLV_NRD_NRD_1	179	181	PF00675	0.672
CLV_NRD_NRD_1	292	294	PF00675	0.831
CLV_NRD_NRD_1	300	302	PF00675	0.699
CLV_NRD_NRD_1	422	424	PF00675	0.554
CLV_NRD_NRD_1	519	521	PF00675	0.643
CLV_NRD_NRD_1	604	606	PF00675	0.535
CLV_PCSK_FUR_1	142	146	PF00082	0.576
CLV_PCSK_KEX2_1	144	146	PF00082	0.723
CLV_PCSK_KEX2_1	179	181	PF00082	0.672
CLV_PCSK_KEX2_1	292	294	PF00082	0.831
CLV_PCSK_KEX2_1	604	606	PF00082	0.535
CLV_PCSK_KEX2_1	889	891	PF00082	0.637
CLV_PCSK_KEX2_1	898	900	PF00082	0.545
CLV_PCSK_PC1ET2_1	889	891	PF00082	0.637
CLV_PCSK_PC1ET2_1	898	900	PF00082	0.545
CLV_PCSK_PC7_1	140	146	PF00082	0.664
CLV_PCSK_PC7_1	894	900	PF00082	0.613
CLV_PCSK_SKI1_1	111	115	PF00082	0.620
CLV_PCSK_SKI1_1	125	129	PF00082	0.511
CLV_PCSK_SKI1_1	415	419	PF00082	0.564
CLV_PCSK_SKI1_1	605	609	PF00082	0.565
CLV_PCSK_SKI1_1	832	836	PF00082	0.607
CLV_PCSK_SKI1_1	849	853	PF00082	0.509
CLV_PCSK_SKI1_1	898	902	PF00082	0.654
DEG_APCC_DBOX_1	110	118	PF00400	0.621
DEG_APCC_DBOX_1	414	422	PF00400	0.632
DEG_APCC_DBOX_1	823	831	PF00400	0.636
DEG_Kelch_actinfilin_1	755	759	PF01344	0.620
DEG_SCF_FBW7_1	340	347	PF00400	0.688
DEG_SCF_FBW7_2	798	805	PF00400	0.650
DEG_SPOP_SBC_1	161	165	PF00917	0.660
DEG_SPOP_SBC_1	390	394	PF00917	0.673
DEG_SPOP_SBC_1	609	613	PF00917	0.555
DEG_SPOP_SBC_1	779	783	PF00917	0.564
DOC_CDC14_PxL_1	472	480	PF14671	0.675
DOC_CKS1_1	157	162	PF01111	0.719
DOC_CKS1_1	256	261	PF01111	0.731
DOC_CKS1_1	399	404	PF01111	0.681
DOC_CKS1_1	582	587	PF01111	0.680
DOC_CYCLIN_RxL_1	412	422	PF00134	0.559
DOC_MAPK_gen_1	70	79	PF00069	0.618
DOC_MAPK_RevD_3	590	605	PF00069	0.554
DOC_PP1_SILK_1	553	558	PF00149	0.595
DOC_PP2B_LxvP_1	191	194	PF13499	0.681
DOC_PP2B_LxvP_1	42	45	PF13499	0.610
DOC_PP4_FxxP_1	119	122	PF00568	0.566
DOC_PP4_FxxP_1	157	160	PF00568	0.719
DOC_PP4_FxxP_1	272	275	PF00568	0.566
DOC_PP4_FxxP_1	650	653	PF00568	0.555
DOC_SPAK_OSR1_1	894	898	PF12202	0.610
DOC_USP7_MATH_1	195	199	PF00917	0.784
DOC_USP7_MATH_1	210	214	PF00917	0.697
DOC_USP7_MATH_1	3	7	PF00917	0.668
DOC_USP7_MATH_1	336	340	PF00917	0.574
DOC_USP7_MATH_1	454	458	PF00917	0.573
DOC_USP7_MATH_1	529	533	PF00917	0.688
DOC_USP7_MATH_1	558	562	PF00917	0.642
DOC_USP7_MATH_1	573	577	PF00917	0.573
DOC_USP7_MATH_1	638	642	PF00917	0.665
DOC_USP7_MATH_1	685	689	PF00917	0.566
DOC_USP7_MATH_1	779	783	PF00917	0.636
DOC_USP7_MATH_1	867	871	PF00917	0.607
DOC_WW_Pin1_4	156	161	PF00397	0.720
DOC_WW_Pin1_4	16	21	PF00397	0.694
DOC_WW_Pin1_4	255	260	PF00397	0.790
DOC_WW_Pin1_4	328	333	PF00397	0.735
DOC_WW_Pin1_4	340	345	PF00397	0.615
DOC_WW_Pin1_4	348	353	PF00397	0.540
DOC_WW_Pin1_4	354	359	PF00397	0.560
DOC_WW_Pin1_4	379	384	PF00397	0.691
DOC_WW_Pin1_4	395	400	PF00397	0.675
DOC_WW_Pin1_4	53	58	PF00397	0.579
DOC_WW_Pin1_4	581	586	PF00397	0.733
DOC_WW_Pin1_4	649	654	PF00397	0.646
DOC_WW_Pin1_4	722	727	PF00397	0.577
DOC_WW_Pin1_4	737	742	PF00397	0.635
DOC_WW_Pin1_4	769	774	PF00397	0.537
DOC_WW_Pin1_4	798	803	PF00397	0.676
LIG_14-3-3_CanoR_1	102	108	PF00244	0.643
LIG_14-3-3_CanoR_1	147	157	PF00244	0.619
LIG_14-3-3_CanoR_1	187	192	PF00244	0.636
LIG_14-3-3_CanoR_1	197	207	PF00244	0.570
LIG_14-3-3_CanoR_1	292	297	PF00244	0.671
LIG_14-3-3_CanoR_1	305	311	PF00244	0.598
LIG_14-3-3_CanoR_1	413	418	PF00244	0.647
LIG_14-3-3_CanoR_1	431	438	PF00244	0.511
LIG_14-3-3_CanoR_1	439	444	PF00244	0.589
LIG_14-3-3_CanoR_1	445	449	PF00244	0.560
LIG_14-3-3_CanoR_1	520	526	PF00244	0.637
LIG_14-3-3_CanoR_1	557	563	PF00244	0.665
LIG_Actin_WH2_2	506	522	PF00022	0.651
LIG_AP2alpha_1	119	123	PF02296	0.627
LIG_AP2alpha_2	121	123	PF02296	0.582
LIG_APCC_ABBA_1	116	121	PF00400	0.635
LIG_BIR_III_2	709	713	PF00653	0.636
LIG_BRCT_BRCA1_1	89	93	PF00533	0.541
LIG_CtBP_PxDLS_1	224	228	PF00389	0.686
LIG_CtBP_PxDLS_1	813	819	PF00389	0.544
LIG_DLG_GKlike_1	413	421	PF00625	0.560
LIG_EH_1	426	430	PF12763	0.613
LIG_EH1_1	894	902	PF00400	0.608
LIG_FHA_1	204	210	PF00498	0.673
LIG_FHA_1	29	35	PF00498	0.649
LIG_FHA_1	431	437	PF00498	0.546
LIG_FHA_1	604	610	PF00498	0.598
LIG_FHA_1	611	617	PF00498	0.547
LIG_FHA_1	684	690	PF00498	0.660
LIG_FHA_1	760	766	PF00498	0.673
LIG_FHA_1	80	86	PF00498	0.618
LIG_FHA_1	838	844	PF00498	0.686
LIG_FHA_2	391	397	PF00498	0.681
LIG_FHA_2	799	805	PF00498	0.673
LIG_FHA_2	874	880	PF00498	0.680
LIG_LIR_Apic_2	156	160	PF02991	0.715
LIG_LIR_Apic_2	269	275	PF02991	0.569
LIG_LIR_Apic_2	725	730	PF02991	0.622
LIG_LIR_Gen_1	471	478	PF02991	0.682
LIG_LIR_Gen_1	486	495	PF02991	0.513
LIG_LIR_Nem_3	471	475	PF02991	0.692
LIG_LIR_Nem_3	486	490	PF02991	0.511
LIG_NRBOX	13	19	PF00104	0.652
LIG_NRBOX	514	520	PF00104	0.597
LIG_PDZ_Class_2	898	903	PF00595	0.654
LIG_Pex14_2	119	123	PF04695	0.627
LIG_SH2_CRK	727	731	PF00017	0.589
LIG_SH2_STAP1	105	109	PF00017	0.660
LIG_SH2_STAT3	833	836	PF00017	0.631
LIG_SH3_3	124	130	PF00018	0.566
LIG_SH3_3	17	23	PF00018	0.641
LIG_SH3_3	217	223	PF00018	0.666
LIG_SH3_3	256	262	PF00018	0.718
LIG_SH3_3	278	284	PF00018	0.542
LIG_SH3_3	396	402	PF00018	0.676
LIG_SH3_3	41	47	PF00018	0.678
LIG_SH3_3	470	476	PF00018	0.643
LIG_SH3_3	501	507	PF00018	0.651
LIG_SH3_3	582	588	PF00018	0.726
LIG_SH3_3	705	711	PF00018	0.635
LIG_SH3_3	877	883	PF00018	0.663
LIG_SH3_3	885	891	PF00018	0.623
LIG_SUMO_SIM_anti_2	812	818	PF11976	0.546
LIG_SUMO_SIM_par_1	370	375	PF11976	0.608
LIG_SUMO_SIM_par_1	840	847	PF11976	0.642
LIG_TRAF2_1	230	233	PF00917	0.705
LIG_UBA3_1	116	125	PF00899	0.583
LIG_UBA3_1	417	424	PF00899	0.558
LIG_WRC_WIRS_1	594	599	PF05994	0.560
MOD_CDK_SPxK_1	354	360	PF00069	0.656
MOD_CDK_SPxxK_3	398	405	PF00069	0.586
MOD_CK1_1	103	109	PF00069	0.564
MOD_CK1_1	148	154	PF00069	0.683
MOD_CK1_1	156	162	PF00069	0.728
MOD_CK1_1	166	172	PF00069	0.681
MOD_CK1_1	183	189	PF00069	0.581
MOD_CK1_1	198	204	PF00069	0.637
MOD_CK1_1	226	232	PF00069	0.724
MOD_CK1_1	244	250	PF00069	0.603
MOD_CK1_1	324	330	PF00069	0.667
MOD_CK1_1	339	345	PF00069	0.615
MOD_CK1_1	363	369	PF00069	0.714
MOD_CK1_1	370	376	PF00069	0.684
MOD_CK1_1	395	401	PF00069	0.679
MOD_CK1_1	434	440	PF00069	0.602
MOD_CK1_1	446	452	PF00069	0.571
MOD_CK1_1	486	492	PF00069	0.629
MOD_CK1_1	576	582	PF00069	0.684
MOD_CK1_1	6	12	PF00069	0.624
MOD_CK1_1	612	618	PF00069	0.642
MOD_CK1_1	626	632	PF00069	0.556
MOD_CK1_1	734	740	PF00069	0.636
MOD_CK1_1	764	770	PF00069	0.672
MOD_CK1_1	812	818	PF00069	0.546
MOD_CK1_1	847	853	PF00069	0.589
MOD_CK1_1	94	100	PF00069	0.621
MOD_CK2_1	166	172	PF00069	0.715
MOD_CK2_1	186	192	PF00069	0.519
MOD_CK2_1	226	232	PF00069	0.807
MOD_CK2_1	390	396	PF00069	0.680
MOD_CK2_1	85	91	PF00069	0.620
MOD_CK2_1	873	879	PF00069	0.679
MOD_Cter_Amidation	142	145	PF01082	0.721
MOD_GlcNHglycan	102	105	PF01048	0.635
MOD_GlcNHglycan	130	133	PF01048	0.642
MOD_GlcNHglycan	147	150	PF01048	0.728
MOD_GlcNHglycan	165	168	PF01048	0.539
MOD_GlcNHglycan	181	185	PF01048	0.650
MOD_GlcNHglycan	200	203	PF01048	0.626
MOD_GlcNHglycan	228	231	PF01048	0.663
MOD_GlcNHglycan	319	322	PF01048	0.573
MOD_GlcNHglycan	456	459	PF01048	0.725
MOD_GlcNHglycan	492	495	PF01048	0.659
MOD_GlcNHglycan	5	8	PF01048	0.586
MOD_GlcNHglycan	575	578	PF01048	0.720
MOD_GlcNHglycan	657	660	PF01048	0.675
MOD_GlcNHglycan	782	785	PF01048	0.679
MOD_GlcNHglycan	798	801	PF01048	0.569
MOD_GlcNHglycan	811	814	PF01048	0.598
MOD_GSK3_1	156	163	PF00069	0.746
MOD_GSK3_1	183	190	PF00069	0.685
MOD_GSK3_1	196	203	PF00069	0.673
MOD_GSK3_1	254	261	PF00069	0.812
MOD_GSK3_1	317	324	PF00069	0.683
MOD_GSK3_1	331	338	PF00069	0.618
MOD_GSK3_1	340	347	PF00069	0.560
MOD_GSK3_1	363	370	PF00069	0.646
MOD_GSK3_1	390	397	PF00069	0.662
MOD_GSK3_1	413	420	PF00069	0.690
MOD_GSK3_1	430	437	PF00069	0.508
MOD_GSK3_1	439	446	PF00069	0.602
MOD_GSK3_1	464	471	PF00069	0.656
MOD_GSK3_1	486	493	PF00069	0.666
MOD_GSK3_1	521	528	PF00069	0.607
MOD_GSK3_1	55	62	PF00069	0.652
MOD_GSK3_1	558	565	PF00069	0.666
MOD_GSK3_1	573	580	PF00069	0.560
MOD_GSK3_1	599	606	PF00069	0.629
MOD_GSK3_1	608	615	PF00069	0.597
MOD_GSK3_1	623	630	PF00069	0.560
MOD_GSK3_1	634	641	PF00069	0.591
MOD_GSK3_1	64	71	PF00069	0.544
MOD_GSK3_1	683	690	PF00069	0.658
MOD_GSK3_1	757	764	PF00069	0.645
MOD_GSK3_1	87	94	PF00069	0.574
MOD_GSK3_1	96	103	PF00069	0.590
MOD_N-GLC_1	107	112	PF02516	0.655
MOD_N-GLC_1	354	359	PF02516	0.656
MOD_N-GLC_1	592	597	PF02516	0.702
MOD_N-GLC_1	599	604	PF02516	0.623
MOD_N-GLC_1	609	614	PF02516	0.530
MOD_N-GLC_2	362	364	PF02516	0.623
MOD_NEK2_1	304	309	PF00069	0.737
MOD_NEK2_1	346	351	PF00069	0.721
MOD_NEK2_1	367	372	PF00069	0.759
MOD_NEK2_1	374	379	PF00069	0.714
MOD_NEK2_1	429	434	PF00069	0.657
MOD_NEK2_1	438	443	PF00069	0.606
MOD_NEK2_1	490	495	PF00069	0.670
MOD_NEK2_1	513	518	PF00069	0.519
MOD_NEK2_1	562	567	PF00069	0.672
MOD_NEK2_1	603	608	PF00069	0.670
MOD_NEK2_1	634	639	PF00069	0.689
MOD_NEK2_1	743	748	PF00069	0.660
MOD_NEK2_1	757	762	PF00069	0.525
MOD_NEK2_1	844	849	PF00069	0.651
MOD_NEK2_1	93	98	PF00069	0.570
MOD_NEK2_2	893	898	PF00069	0.537
MOD_PIKK_1	244	250	PF00454	0.686
MOD_PIKK_1	464	470	PF00454	0.561
MOD_PIKK_1	521	527	PF00454	0.687
MOD_PIKK_1	729	735	PF00454	0.665
MOD_PIKK_1	79	85	PF00454	0.627
MOD_PIKK_1	791	797	PF00454	0.682
MOD_PIKK_1	850	856	PF00454	0.549
MOD_PK_1	431	437	PF00069	0.643
MOD_PKA_1	292	298	PF00069	0.716
MOD_PKA_2	143	149	PF00069	0.685
MOD_PKA_2	186	192	PF00069	0.664
MOD_PKA_2	196	202	PF00069	0.623
MOD_PKA_2	244	250	PF00069	0.684
MOD_PKA_2	292	298	PF00069	0.668
MOD_PKA_2	304	310	PF00069	0.608
MOD_PKA_2	430	436	PF00069	0.565
MOD_PKA_2	438	444	PF00069	0.614
MOD_PKA_2	519	525	PF00069	0.635
MOD_PKA_2	558	564	PF00069	0.618
MOD_PKA_2	603	609	PF00069	0.538
MOD_PKA_2	893	899	PF00069	0.612
MOD_Plk_1	374	380	PF00069	0.639
MOD_Plk_1	529	535	PF00069	0.689
MOD_Plk_1	592	598	PF00069	0.631
MOD_Plk_1	599	605	PF00069	0.610
MOD_Plk_1	680	686	PF00069	0.644
MOD_Plk_4	166	172	PF00069	0.715
MOD_Plk_4	367	373	PF00069	0.630
MOD_Plk_4	374	380	PF00069	0.585
MOD_Plk_4	431	437	PF00069	0.643
MOD_Plk_4	468	474	PF00069	0.701
MOD_Plk_4	514	520	PF00069	0.670
MOD_Plk_4	55	61	PF00069	0.564
MOD_Plk_4	812	818	PF00069	0.594
MOD_Plk_4	839	845	PF00069	0.685
MOD_ProDKin_1	156	162	PF00069	0.719
MOD_ProDKin_1	16	22	PF00069	0.691
MOD_ProDKin_1	255	261	PF00069	0.787
MOD_ProDKin_1	328	334	PF00069	0.735
MOD_ProDKin_1	340	346	PF00069	0.617
MOD_ProDKin_1	348	354	PF00069	0.539
MOD_ProDKin_1	379	385	PF00069	0.694
MOD_ProDKin_1	395	401	PF00069	0.678
MOD_ProDKin_1	53	59	PF00069	0.585
MOD_ProDKin_1	581	587	PF00069	0.731
MOD_ProDKin_1	649	655	PF00069	0.647
MOD_ProDKin_1	722	728	PF00069	0.582
MOD_ProDKin_1	737	743	PF00069	0.636
MOD_ProDKin_1	769	775	PF00069	0.537
MOD_ProDKin_1	798	804	PF00069	0.674
MOD_SUMO_for_1	404	407	PF00179	0.595
MOD_SUMO_rev_2	416	426	PF00179	0.555
MOD_SUMO_rev_2	62	71	PF00179	0.668
TRG_DiLeu_BaEn_1	10	15	PF01217	0.688
TRG_DiLeu_BaEn_2	114	120	PF01217	0.525
TRG_DiLeu_BaLyEn_6	538	543	PF01217	0.628
TRG_DiLeu_BaLyEn_6	896	901	PF01217	0.604
TRG_ER_diArg_1	141	144	PF00400	0.623
TRG_ER_diArg_1	178	180	PF00400	0.674
TRG_ER_diArg_1	556	559	PF00400	0.644
TRG_ER_diArg_1	603	605	PF00400	0.534
TRG_NLS_Bipartite_1	292	306	PF00514	0.577
TRG_NLS_MonoExtC_3	300	305	PF00514	0.583
TRG_NLS_MonoExtN_4	301	306	PF00514	0.589
TRG_Pf-PMV_PEXEL_1	27	32	PF00026	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBH8	Leishmania donovani	88%	100%
A4HHF2	Leishmania braziliensis	51%	73%
A4I4K1	Leishmania infantum	88%	72%
E9ALT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	75%