Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

LYAR-type C2HC zinc finger, putative

Species:

Leishmania major

UniProt:

E9ADZ9_LEIMA

TriTrypDb:

LmjF.29.1400 , LMJLV39_290020700 , LMJSD75_290020900

Length:

316

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	9
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	9
GO:0005634	nucleus	5	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7

Expansion

Sequence features

E9ADZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADZ9

Function

Biological processes
Term	Name	Level	Count
GO:0000122	negative regulation of transcription by RNA polymerase II	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0006357	regulation of transcription by RNA polymerase II	7	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009890	negative regulation of biosynthetic process	5	2
GO:0009892	negative regulation of metabolic process	4	2
GO:0009987	cellular process	1	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010558	negative regulation of macromolecule biosynthetic process	6	2
GO:0010605	negative regulation of macromolecule metabolic process	5	2
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031324	negative regulation of cellular metabolic process	5	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0031327	negative regulation of cellular biosynthetic process	6	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0045892	negative regulation of DNA-templated transcription	7	2
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	2
GO:0046483	heterocycle metabolic process	3	2
GO:0048519	negative regulation of biological process	3	2
GO:0048523	negative regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051172	negative regulation of nitrogen compound metabolic process	5	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0051253	negative regulation of RNA metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	2
GO:0080090	regulation of primary metabolic process	4	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1902679	negative regulation of RNA biosynthetic process	7	2
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:1903507	negative regulation of nucleic acid-templated transcription	8	2
GO:2001141	regulation of RNA biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003677	DNA binding	4	9
GO:0005488	binding	1	10
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	98	102	PF00656	0.699
CLV_NRD_NRD_1	127	129	PF00675	0.723
CLV_NRD_NRD_1	208	210	PF00675	0.833
CLV_PCSK_KEX2_1	208	210	PF00082	0.833
CLV_PCSK_KEX2_1	286	288	PF00082	0.542
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.559
CLV_PCSK_SKI1_1	159	163	PF00082	0.699
CLV_PCSK_SKI1_1	211	215	PF00082	0.787
CLV_PCSK_SKI1_1	283	287	PF00082	0.497
CLV_PCSK_SKI1_1	70	74	PF00082	0.611
DEG_COP1_1	239	247	PF00400	0.529
DOC_MAPK_gen_1	128	137	PF00069	0.745
DOC_MAPK_gen_1	226	233	PF00069	0.567
DOC_MAPK_MEF2A_6	128	137	PF00069	0.745
DOC_PP2B_LxvP_1	231	234	PF13499	0.605
DOC_USP7_MATH_1	201	205	PF00917	0.702
DOC_USP7_MATH_1	299	303	PF00917	0.542
DOC_USP7_MATH_1	71	75	PF00917	0.781
DOC_USP7_UBL2_3	191	195	PF12436	0.690
DOC_USP7_UBL2_3	274	278	PF12436	0.597
DOC_USP7_UBL2_3	286	290	PF12436	0.481
DOC_USP7_UBL2_3	56	60	PF12436	0.515
DOC_WW_Pin1_4	149	154	PF00397	0.785
DOC_WW_Pin1_4	167	172	PF00397	0.647
DOC_WW_Pin1_4	183	188	PF00397	0.756
DOC_WW_Pin1_4	197	202	PF00397	0.713
DOC_WW_Pin1_4	226	231	PF00397	0.686
LIG_14-3-3_CanoR_1	147	153	PF00244	0.762
LIG_14-3-3_CanoR_1	235	239	PF00244	0.603
LIG_14-3-3_CanoR_1	287	293	PF00244	0.561
LIG_Actin_WH2_2	251	266	PF00022	0.481
LIG_FHA_1	149	155	PF00498	0.666
LIG_FHA_1	227	233	PF00498	0.673
LIG_FHA_1	244	250	PF00498	0.577
LIG_FHA_1	271	277	PF00498	0.570
LIG_FHA_1	46	52	PF00498	0.289
LIG_FHA_2	249	255	PF00498	0.612
LIG_FHA_2	29	35	PF00498	0.404
LIG_FHA_2	296	302	PF00498	0.481
LIG_FHA_2	50	56	PF00498	0.356
LIG_LIR_Gen_1	29	38	PF02991	0.312
LIG_LIR_Nem_3	29	33	PF02991	0.312
LIG_MYND_1	230	234	PF01753	0.672
LIG_PDZ_Class_1	311	316	PF00595	0.472
LIG_SH2_STAP1	284	288	PF00017	0.489
LIG_SH2_STAT5	8	11	PF00017	0.518
LIG_SH3_3	10	16	PF00018	0.408
LIG_SH3_3	150	156	PF00018	0.735
LIG_SH3_3	218	224	PF00018	0.780
LIG_SH3_3	83	89	PF00018	0.614
LIG_SH3_4	15	22	PF00018	0.487
LIG_SH3_4	191	198	PF00018	0.693
LIG_TRAF2_1	251	254	PF00917	0.546
LIG_TRAF2_1	52	55	PF00917	0.443
LIG_WRC_WIRS_1	1	6	PF05994	0.363
LIG_WRC_WIRS_1	244	249	PF05994	0.518
LIG_WW_3	84	88	PF00397	0.550
MOD_CK1_1	113	119	PF00069	0.727
MOD_CK1_1	148	154	PF00069	0.708
MOD_CK1_1	166	172	PF00069	0.540
MOD_CK1_1	236	242	PF00069	0.551
MOD_CK1_1	270	276	PF00069	0.541
MOD_CK1_1	49	55	PF00069	0.365
MOD_CK1_1	96	102	PF00069	0.687
MOD_CK2_1	137	143	PF00069	0.690
MOD_CK2_1	248	254	PF00069	0.502
MOD_CK2_1	295	301	PF00069	0.476
MOD_CK2_1	49	55	PF00069	0.356
MOD_CK2_1	77	83	PF00069	0.538
MOD_Cter_Amidation	224	227	PF01082	0.665
MOD_GlcNHglycan	108	111	PF01048	0.796
MOD_GlcNHglycan	112	115	PF01048	0.780
MOD_GlcNHglycan	122	125	PF01048	0.713
MOD_GlcNHglycan	165	168	PF01048	0.724
MOD_GlcNHglycan	265	268	PF01048	0.619
MOD_GlcNHglycan	301	304	PF01048	0.556
MOD_GlcNHglycan	66	69	PF01048	0.562
MOD_GlcNHglycan	73	76	PF01048	0.633
MOD_GlcNHglycan	79	82	PF01048	0.598
MOD_GSK3_1	106	113	PF00069	0.773
MOD_GSK3_1	145	152	PF00069	0.725
MOD_GSK3_1	163	170	PF00069	0.676
MOD_GSK3_1	197	204	PF00069	0.794
MOD_GSK3_1	263	270	PF00069	0.533
MOD_GSK3_1	295	302	PF00069	0.469
MOD_GSK3_1	45	52	PF00069	0.331
MOD_GSK3_1	92	99	PF00069	0.650
MOD_N-GLC_1	311	316	PF02516	0.537
MOD_N-GLC_2	23	25	PF02516	0.421
MOD_NEK2_1	145	150	PF00069	0.620
MOD_NEK2_1	263	268	PF00069	0.555
MOD_NEK2_1	4	9	PF00069	0.362
MOD_OFUCOSY	25	32	PF10250	0.463
MOD_PIKK_1	103	109	PF00454	0.612
MOD_PKA_1	195	201	PF00069	0.778
MOD_PKA_2	234	240	PF00069	0.659
MOD_PKA_2	263	269	PF00069	0.504
MOD_Plk_2-3	97	103	PF00069	0.723
MOD_Plk_4	243	249	PF00069	0.523
MOD_ProDKin_1	149	155	PF00069	0.782
MOD_ProDKin_1	167	173	PF00069	0.645
MOD_ProDKin_1	183	189	PF00069	0.759
MOD_ProDKin_1	197	203	PF00069	0.713
MOD_ProDKin_1	226	232	PF00069	0.686
MOD_SUMO_for_1	213	216	PF00179	0.764
MOD_SUMO_rev_2	212	222	PF00179	0.662
TRG_DiLeu_BaEn_3	253	259	PF01217	0.566
TRG_DiLeu_BaLyEn_6	227	232	PF01217	0.639
TRG_ER_diArg_1	208	210	PF00400	0.822
TRG_NLS_MonoCore_2	13	18	PF00514	0.396
TRG_NLS_MonoExtN_4	156	163	PF00514	0.706
TRG_Pf-PMV_PEXEL_1	278	282	PF00026	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGN4	Leptomonas seymouri	55%	100%
A0A1X0P0F5	Trypanosomatidae	35%	100%
A0A3Q8IRD2	Leishmania donovani	90%	100%
A4HHF0	Leishmania braziliensis	72%	98%
A4HHF1	Leishmania braziliensis	69%	100%
A4I4K0	Leishmania infantum	90%	100%
C9ZL83	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9ALT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%