Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein, putative

Species:

Leishmania major

UniProt:

E9ADZ8_LEIMA

TriTrypDb:

LmjF.29.1390 , LMJLV39_290020600 , LMJSD75_290020800

Length:

777

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

E9ADZ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADZ8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.512
CLV_C14_Caspase3-7	149	153	PF00656	0.494
CLV_NRD_NRD_1	197	199	PF00675	0.472
CLV_NRD_NRD_1	246	248	PF00675	0.683
CLV_NRD_NRD_1	324	326	PF00675	0.668
CLV_NRD_NRD_1	443	445	PF00675	0.710
CLV_NRD_NRD_1	549	551	PF00675	0.607
CLV_NRD_NRD_1	582	584	PF00675	0.679
CLV_NRD_NRD_1	656	658	PF00675	0.687
CLV_PCSK_FUR_1	244	248	PF00082	0.680
CLV_PCSK_KEX2_1	246	248	PF00082	0.683
CLV_PCSK_KEX2_1	324	326	PF00082	0.668
CLV_PCSK_KEX2_1	443	445	PF00082	0.710
CLV_PCSK_KEX2_1	548	550	PF00082	0.606
CLV_PCSK_KEX2_1	582	584	PF00082	0.679
CLV_PCSK_KEX2_1	656	658	PF00082	0.687
CLV_PCSK_SKI1_1	129	133	PF00082	0.346
CLV_PCSK_SKI1_1	151	155	PF00082	0.346
CLV_PCSK_SKI1_1	157	161	PF00082	0.413
CLV_PCSK_SKI1_1	198	202	PF00082	0.538
CLV_PCSK_SKI1_1	246	250	PF00082	0.687
CLV_PCSK_SKI1_1	99	103	PF00082	0.405
DEG_COP1_1	713	725	PF00400	0.544
DEG_SPOP_SBC_1	514	518	PF00917	0.675
DEG_SPOP_SBC_1	617	621	PF00917	0.663
DOC_CDC14_PxL_1	674	682	PF14671	0.499
DOC_CKS1_1	168	173	PF01111	0.604
DOC_CKS1_1	422	427	PF01111	0.675
DOC_CKS1_1	464	469	PF01111	0.780
DOC_CKS1_1	544	549	PF01111	0.668
DOC_CKS1_1	570	575	PF01111	0.688
DOC_CYCLIN_yCln2_LP_2	728	734	PF00134	0.523
DOC_MAPK_DCC_7	491	501	PF00069	0.717
DOC_MAPK_gen_1	155	164	PF00069	0.605
DOC_PP2B_LxvP_1	728	731	PF13499	0.510
DOC_PP4_FxxP_1	437	440	PF00568	0.653
DOC_PP4_MxPP_1	397	400	PF00568	0.558
DOC_USP7_MATH_1	124	128	PF00917	0.518
DOC_USP7_MATH_1	24	28	PF00917	0.741
DOC_USP7_MATH_1	262	266	PF00917	0.732
DOC_USP7_MATH_1	301	305	PF00917	0.647
DOC_USP7_MATH_1	355	359	PF00917	0.671
DOC_USP7_MATH_1	428	432	PF00917	0.643
DOC_USP7_MATH_1	503	507	PF00917	0.750
DOC_USP7_MATH_1	617	621	PF00917	0.694
DOC_USP7_MATH_1	691	695	PF00917	0.578
DOC_USP7_MATH_1	768	772	PF00917	0.625
DOC_USP7_MATH_1	94	98	PF00917	0.577
DOC_WW_Pin1_4	164	169	PF00397	0.611
DOC_WW_Pin1_4	20	25	PF00397	0.770
DOC_WW_Pin1_4	237	242	PF00397	0.750
DOC_WW_Pin1_4	249	254	PF00397	0.654
DOC_WW_Pin1_4	297	302	PF00397	0.515
DOC_WW_Pin1_4	359	364	PF00397	0.681
DOC_WW_Pin1_4	412	417	PF00397	0.660
DOC_WW_Pin1_4	421	426	PF00397	0.663
DOC_WW_Pin1_4	451	456	PF00397	0.805
DOC_WW_Pin1_4	463	468	PF00397	0.655
DOC_WW_Pin1_4	475	480	PF00397	0.686
DOC_WW_Pin1_4	517	522	PF00397	0.765
DOC_WW_Pin1_4	531	536	PF00397	0.586
DOC_WW_Pin1_4	539	544	PF00397	0.666
DOC_WW_Pin1_4	549	554	PF00397	0.585
DOC_WW_Pin1_4	569	574	PF00397	0.793
DOC_WW_Pin1_4	678	683	PF00397	0.573
DOC_WW_Pin1_4	712	717	PF00397	0.618
DOC_WW_Pin1_4	721	726	PF00397	0.638
DOC_WW_Pin1_4	740	745	PF00397	0.613
DOC_WW_Pin1_4	769	774	PF00397	0.669
LIG_14-3-3_CanoR_1	163	168	PF00244	0.652
LIG_14-3-3_CanoR_1	208	216	PF00244	0.465
LIG_14-3-3_CanoR_1	372	376	PF00244	0.753
LIG_14-3-3_CanoR_1	443	447	PF00244	0.661
LIG_14-3-3_CanoR_1	762	768	PF00244	0.632
LIG_APCC_ABBA_1	227	232	PF00400	0.646
LIG_BIR_III_2	235	239	PF00653	0.632
LIG_CaM_IQ_9	207	222	PF13499	0.425
LIG_FHA_1	140	146	PF00498	0.632
LIG_FHA_1	3	9	PF00498	0.666
LIG_FHA_1	33	39	PF00498	0.746
LIG_FHA_1	363	369	PF00498	0.612
LIG_FHA_1	488	494	PF00498	0.678
LIG_FHA_1	764	770	PF00498	0.631
LIG_FHA_2	107	113	PF00498	0.546
LIG_FHA_2	208	214	PF00498	0.619
LIG_FHA_2	255	261	PF00498	0.693
LIG_FHA_2	280	286	PF00498	0.414
LIG_FHA_2	298	304	PF00498	0.346
LIG_IBAR_NPY_1	757	759	PF08397	0.778
LIG_LIR_Apic_2	231	237	PF02991	0.475
LIG_LIR_Apic_2	436	440	PF02991	0.579
LIG_LIR_Apic_2	604	610	PF02991	0.635
LIG_LIR_Gen_1	117	126	PF02991	0.546
LIG_LIR_Gen_1	141	150	PF02991	0.628
LIG_LIR_Gen_1	367	376	PF02991	0.543
LIG_LIR_Gen_1	564	574	PF02991	0.607
LIG_LIR_Gen_1	72	80	PF02991	0.516
LIG_LIR_Nem_3	117	122	PF02991	0.532
LIG_LIR_Nem_3	141	147	PF02991	0.546
LIG_LIR_Nem_3	219	224	PF02991	0.592
LIG_LIR_Nem_3	367	373	PF02991	0.544
LIG_LIR_Nem_3	564	570	PF02991	0.652
LIG_LIR_Nem_3	600	605	PF02991	0.684
LIG_LIR_Nem_3	72	76	PF02991	0.519
LIG_LIR_Nem_3	724	729	PF02991	0.548
LIG_LYPXL_SIV_4	691	699	PF13949	0.612
LIG_MYND_1	678	682	PF01753	0.609
LIG_Pex14_2	217	221	PF04695	0.490
LIG_PTAP_UEV_1	478	483	PF05743	0.660
LIG_PTB_Apo_2	42	49	PF02174	0.574
LIG_PTB_Apo_2	753	760	PF02174	0.680
LIG_PTB_Phospho_1	753	759	PF10480	0.681
LIG_REV1ctd_RIR_1	157	167	PF16727	0.532
LIG_SH2_CRK	234	238	PF00017	0.604
LIG_SH2_CRK	370	374	PF00017	0.615
LIG_SH2_CRK	567	571	PF00017	0.721
LIG_SH2_CRK	686	690	PF00017	0.517
LIG_SH2_GRB2like	409	412	PF00017	0.646
LIG_SH2_NCK_1	234	238	PF00017	0.615
LIG_SH2_NCK_1	352	356	PF00017	0.642
LIG_SH2_NCK_1	389	393	PF00017	0.660
LIG_SH2_NCK_1	692	696	PF00017	0.610
LIG_SH2_STAP1	352	356	PF00017	0.678
LIG_SH2_STAP1	759	763	PF00017	0.675
LIG_SH2_STAT3	427	430	PF00017	0.644
LIG_SH2_STAT5	409	412	PF00017	0.653
LIG_SH2_STAT5	562	565	PF00017	0.670
LIG_SH2_STAT5	567	570	PF00017	0.680
LIG_SH2_STAT5	574	577	PF00017	0.635
LIG_SH2_STAT5	726	729	PF00017	0.604
LIG_SH3_1	419	425	PF00018	0.672
LIG_SH3_1	491	497	PF00018	0.666
LIG_SH3_3	165	171	PF00018	0.627
LIG_SH3_3	235	241	PF00018	0.589
LIG_SH3_3	393	399	PF00018	0.652
LIG_SH3_3	419	425	PF00018	0.711
LIG_SH3_3	461	467	PF00018	0.751
LIG_SH3_3	476	482	PF00018	0.613
LIG_SH3_3	490	496	PF00018	0.697
LIG_SH3_3	508	514	PF00018	0.676
LIG_SH3_3	518	524	PF00018	0.679
LIG_SH3_3	541	547	PF00018	0.720
LIG_SH3_3	567	573	PF00018	0.663
LIG_SH3_3	719	725	PF00018	0.750
LIG_SUMO_SIM_par_1	765	772	PF11976	0.629
LIG_TRFH_1	726	730	PF08558	0.593
LIG_TYR_ITIM	368	373	PF00017	0.638
LIG_WRC_WIRS_1	280	285	PF05994	0.473
MOD_CDK_SPK_2	543	548	PF00069	0.684
MOD_CDK_SPK_2	740	745	PF00069	0.617
MOD_CDK_SPxK_1	531	537	PF00069	0.668
MOD_CDK_SPxK_1	543	549	PF00069	0.593
MOD_CDK_SPxxK_3	237	244	PF00069	0.560
MOD_CDK_SPxxK_3	412	419	PF00069	0.635
MOD_CDK_SPxxK_3	543	550	PF00069	0.688
MOD_CDK_SPxxK_3	712	719	PF00069	0.606
MOD_CK1_1	139	145	PF00069	0.632
MOD_CK1_1	166	172	PF00069	0.633
MOD_CK1_1	225	231	PF00069	0.474
MOD_CK1_1	254	260	PF00069	0.722
MOD_CK1_1	27	33	PF00069	0.701
MOD_CK1_1	350	356	PF00069	0.727
MOD_CK1_1	374	380	PF00069	0.646
MOD_CK1_1	390	396	PF00069	0.714
MOD_CK1_1	420	426	PF00069	0.739
MOD_CK1_1	454	460	PF00069	0.672
MOD_CK1_1	46	52	PF00069	0.784
MOD_CK1_1	468	474	PF00069	0.581
MOD_CK1_1	487	493	PF00069	0.566
MOD_CK1_1	519	525	PF00069	0.703
MOD_CK1_1	54	60	PF00069	0.656
MOD_CK1_1	552	558	PF00069	0.678
MOD_CK1_1	620	626	PF00069	0.709
MOD_CK1_1	715	721	PF00069	0.640
MOD_CK1_1	746	752	PF00069	0.657
MOD_CK2_1	249	255	PF00069	0.708
MOD_CK2_1	279	285	PF00069	0.358
MOD_CK2_1	44	50	PF00069	0.647
MOD_CK2_1	78	84	PF00069	0.540
MOD_Cter_Amidation	244	247	PF01082	0.680
MOD_GlcNHglycan	126	129	PF01048	0.428
MOD_GlcNHglycan	29	32	PF01048	0.708
MOD_GlcNHglycan	353	356	PF01048	0.677
MOD_GlcNHglycan	389	392	PF01048	0.770
MOD_GlcNHglycan	405	408	PF01048	0.630
MOD_GlcNHglycan	430	433	PF01048	0.791
MOD_GlcNHglycan	449	452	PF01048	0.553
MOD_GlcNHglycan	456	459	PF01048	0.626
MOD_GlcNHglycan	505	508	PF01048	0.668
MOD_GlcNHglycan	55	59	PF01048	0.684
MOD_GlcNHglycan	554	557	PF01048	0.725
MOD_GlcNHglycan	620	623	PF01048	0.651
MOD_GlcNHglycan	637	641	PF01048	0.525
MOD_GlcNHglycan	66	69	PF01048	0.456
MOD_GlcNHglycan	667	670	PF01048	0.688
MOD_GlcNHglycan	693	696	PF01048	0.584
MOD_GlcNHglycan	719	722	PF01048	0.697
MOD_GlcNHglycan	736	739	PF01048	0.525
MOD_GlcNHglycan	745	748	PF01048	0.626
MOD_GSK3_1	163	170	PF00069	0.690
MOD_GSK3_1	20	27	PF00069	0.727
MOD_GSK3_1	297	304	PF00069	0.526
MOD_GSK3_1	346	353	PF00069	0.654
MOD_GSK3_1	355	362	PF00069	0.613
MOD_GSK3_1	37	44	PF00069	0.581
MOD_GSK3_1	401	408	PF00069	0.735
MOD_GSK3_1	417	424	PF00069	0.577
MOD_GSK3_1	447	454	PF00069	0.673
MOD_GSK3_1	468	475	PF00069	0.773
MOD_GSK3_1	497	504	PF00069	0.721
MOD_GSK3_1	512	519	PF00069	0.715
MOD_GSK3_1	539	546	PF00069	0.747
MOD_GSK3_1	561	568	PF00069	0.769
MOD_GSK3_1	616	623	PF00069	0.711
MOD_GSK3_1	661	668	PF00069	0.675
MOD_GSK3_1	711	718	PF00069	0.616
MOD_GSK3_1	734	741	PF00069	0.614
MOD_N-GLC_1	222	227	PF02516	0.447
MOD_N-GLC_1	297	302	PF02516	0.515
MOD_N-GLC_1	317	322	PF02516	0.435
MOD_N-GLC_1	44	49	PF02516	0.655
MOD_N-GLC_2	7	9	PF02516	0.654
MOD_NEK2_1	364	369	PF00069	0.547
MOD_NEK2_1	405	410	PF00069	0.760
MOD_NEK2_1	43	48	PF00069	0.761
MOD_NEK2_1	473	478	PF00069	0.681
MOD_NEK2_1	53	58	PF00069	0.646
MOD_NEK2_1	763	768	PF00069	0.632
MOD_PIKK_1	175	181	PF00454	0.528
MOD_PIKK_1	207	213	PF00454	0.505
MOD_PIKK_1	216	222	PF00454	0.400
MOD_PIKK_1	374	380	PF00454	0.808
MOD_PIKK_1	426	432	PF00454	0.650
MOD_PIKK_1	554	560	PF00454	0.721
MOD_PKA_2	207	213	PF00069	0.433
MOD_PKA_2	371	377	PF00069	0.754
MOD_PKA_2	442	448	PF00069	0.654
MOD_PKB_1	161	169	PF00069	0.591
MOD_Plk_1	225	231	PF00069	0.509
MOD_Plk_1	44	50	PF00069	0.647
MOD_Plk_1	603	609	PF00069	0.655
MOD_Plk_1	636	642	PF00069	0.641
MOD_Plk_4	273	279	PF00069	0.534
MOD_Plk_4	405	411	PF00069	0.684
MOD_Plk_4	468	474	PF00069	0.683
MOD_ProDKin_1	164	170	PF00069	0.611
MOD_ProDKin_1	20	26	PF00069	0.771
MOD_ProDKin_1	237	243	PF00069	0.752
MOD_ProDKin_1	249	255	PF00069	0.655
MOD_ProDKin_1	297	303	PF00069	0.525
MOD_ProDKin_1	359	365	PF00069	0.682
MOD_ProDKin_1	412	418	PF00069	0.662
MOD_ProDKin_1	421	427	PF00069	0.664
MOD_ProDKin_1	451	457	PF00069	0.805
MOD_ProDKin_1	463	469	PF00069	0.656
MOD_ProDKin_1	475	481	PF00069	0.686
MOD_ProDKin_1	517	523	PF00069	0.766
MOD_ProDKin_1	531	537	PF00069	0.590
MOD_ProDKin_1	539	545	PF00069	0.669
MOD_ProDKin_1	549	555	PF00069	0.586
MOD_ProDKin_1	569	575	PF00069	0.796
MOD_ProDKin_1	678	684	PF00069	0.576
MOD_ProDKin_1	712	718	PF00069	0.617
MOD_ProDKin_1	721	727	PF00069	0.637
MOD_ProDKin_1	740	746	PF00069	0.613
MOD_ProDKin_1	769	775	PF00069	0.671
TRG_DiLeu_BaEn_3	272	278	PF01217	0.513
TRG_ENDOCYTIC_2	370	373	PF00928	0.611
TRG_ENDOCYTIC_2	567	570	PF00928	0.641
TRG_ER_diArg_1	154	157	PF00400	0.546
TRG_ER_diArg_1	160	163	PF00400	0.454
TRG_ER_diArg_1	244	247	PF00400	0.680
TRG_ER_diArg_1	442	444	PF00400	0.696
TRG_ER_diArg_1	547	550	PF00400	0.692
TRG_ER_diArg_1	582	584	PF00400	0.679
TRG_ER_diArg_1	656	658	PF00400	0.687
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.687

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEF2	Leishmania donovani	90%	99%
A4HHE9	Leishmania braziliensis	63%	99%
A4I4J9	Leishmania infantum	90%	99%
E9ALT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%