Protein KRI1 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADZ7_LEIMA

TriTrypDb:

LmjF.29.1380 , LMJLV39_290020500 , LMJSD75_290020700

Length:

658

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005829	cytosol	2	2
GO:0030684	preribosome	3	2
GO:0030688	preribosome, small subunit precursor	4	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

E9ADZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADZ7

Function

Biological processes
Term	Name	Level	Count
GO:0000054	ribosomal subunit export from nucleus	3	2
GO:0000056	ribosomal small subunit export from nucleus	4	2
GO:0006810	transport	3	2
GO:0006913	nucleocytoplasmic transport	5	2
GO:0009987	cellular process	1	8
GO:0022613	ribonucleoprotein complex biogenesis	4	8
GO:0031503	protein-containing complex localization	2	2
GO:0033750	ribosome localization	3	2
GO:0042274	ribosomal small subunit biogenesis	5	8
GO:0044085	cellular component biogenesis	3	8
GO:0046907	intracellular transport	3	2
GO:0051168	nuclear export	6	2
GO:0051169	nuclear transport	4	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051640	organelle localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051656	establishment of organelle localization	3	2
GO:0071840	cellular component organization or biogenesis	2	8

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.644
CLV_C14_Caspase3-7	20	24	PF00656	0.596
CLV_C14_Caspase3-7	442	446	PF00656	0.599
CLV_C14_Caspase3-7	509	513	PF00656	0.544
CLV_C14_Caspase3-7	516	520	PF00656	0.544
CLV_NRD_NRD_1	255	257	PF00675	0.551
CLV_NRD_NRD_1	262	264	PF00675	0.607
CLV_NRD_NRD_1	405	407	PF00675	0.508
CLV_NRD_NRD_1	41	43	PF00675	0.535
CLV_NRD_NRD_1	490	492	PF00675	0.604
CLV_NRD_NRD_1	496	498	PF00675	0.582
CLV_NRD_NRD_1	56	58	PF00675	0.653
CLV_NRD_NRD_1	600	602	PF00675	0.620
CLV_NRD_NRD_1	612	614	PF00675	0.427
CLV_NRD_NRD_1	623	625	PF00675	0.439
CLV_NRD_NRD_1	643	645	PF00675	0.535
CLV_NRD_NRD_1	652	654	PF00675	0.577
CLV_NRD_NRD_1	77	79	PF00675	0.503
CLV_PCSK_FUR_1	260	264	PF00082	0.619
CLV_PCSK_FUR_1	621	625	PF00082	0.536
CLV_PCSK_FUR_1	74	78	PF00082	0.508
CLV_PCSK_KEX2_1	254	256	PF00082	0.552
CLV_PCSK_KEX2_1	260	262	PF00082	0.599
CLV_PCSK_KEX2_1	405	407	PF00082	0.518
CLV_PCSK_KEX2_1	41	43	PF00082	0.522
CLV_PCSK_KEX2_1	490	492	PF00082	0.583
CLV_PCSK_KEX2_1	496	498	PF00082	0.550
CLV_PCSK_KEX2_1	56	58	PF00082	0.626
CLV_PCSK_KEX2_1	600	602	PF00082	0.605
CLV_PCSK_KEX2_1	612	614	PF00082	0.427
CLV_PCSK_KEX2_1	623	625	PF00082	0.439
CLV_PCSK_KEX2_1	643	645	PF00082	0.459
CLV_PCSK_KEX2_1	652	654	PF00082	0.577
CLV_PCSK_KEX2_1	74	76	PF00082	0.440
CLV_PCSK_KEX2_1	77	79	PF00082	0.507
CLV_PCSK_PC7_1	256	262	PF00082	0.575
CLV_PCSK_SKI1_1	10	14	PF00082	0.445
CLV_PCSK_SKI1_1	146	150	PF00082	0.723
CLV_PCSK_SKI1_1	240	244	PF00082	0.523
CLV_PCSK_SKI1_1	298	302	PF00082	0.458
CLV_PCSK_SKI1_1	331	335	PF00082	0.533
CLV_PCSK_SKI1_1	496	500	PF00082	0.660
CLV_PCSK_SKI1_1	624	628	PF00082	0.493
CLV_PCSK_SKI1_1	644	648	PF00082	0.456
DEG_SPOP_SBC_1	526	530	PF00917	0.540
DOC_CYCLIN_RxL_1	206	215	PF00134	0.532
DOC_MAPK_gen_1	405	414	PF00069	0.469
DOC_MAPK_gen_1	563	571	PF00069	0.613
DOC_MAPK_gen_1	588	597	PF00069	0.601
DOC_MAPK_MEF2A_6	405	414	PF00069	0.372
DOC_MAPK_MEF2A_6	588	597	PF00069	0.574
DOC_PP1_RVXF_1	207	214	PF00149	0.478
DOC_PP1_RVXF_1	651	658	PF00149	0.558
DOC_PP2B_LxvP_1	140	143	PF13499	0.553
DOC_USP7_MATH_1	158	162	PF00917	0.686
DOC_USP7_MATH_1	372	376	PF00917	0.552
DOC_USP7_MATH_1	429	433	PF00917	0.642
DOC_USP7_MATH_1	489	493	PF00917	0.649
DOC_USP7_MATH_1	543	547	PF00917	0.675
DOC_USP7_MATH_1	577	581	PF00917	0.593
DOC_USP7_UBL2_3	247	251	PF12436	0.476
DOC_USP7_UBL2_3	6	10	PF12436	0.514
DOC_USP7_UBL2_3	602	606	PF12436	0.531
DOC_USP7_UBL2_3	627	631	PF12436	0.463
DOC_WW_Pin1_4	427	432	PF00397	0.601
DOC_WW_Pin1_4	437	442	PF00397	0.703
DOC_WW_Pin1_4	541	546	PF00397	0.670
LIG_14-3-3_CanoR_1	298	307	PF00244	0.447
LIG_14-3-3_CanoR_1	490	498	PF00244	0.661
LIG_14-3-3_CanoR_1	624	634	PF00244	0.522
LIG_14-3-3_CanoR_1	652	656	PF00244	0.586
LIG_BIR_III_4	23	27	PF00653	0.615
LIG_BIR_III_4	376	380	PF00653	0.579
LIG_BIR_III_4	85	89	PF00653	0.604
LIG_Clathr_ClatBox_1	455	459	PF01394	0.659
LIG_deltaCOP1_diTrp_1	119	129	PF00928	0.670
LIG_FHA_1	11	17	PF00498	0.429
LIG_FHA_1	381	387	PF00498	0.536
LIG_FHA_1	399	405	PF00498	0.514
LIG_FHA_1	528	534	PF00498	0.638
LIG_FHA_1	553	559	PF00498	0.621
LIG_FHA_2	241	247	PF00498	0.531
LIG_FHA_2	332	338	PF00498	0.529
LIG_FHA_2	445	451	PF00498	0.636
LIG_FHA_2	509	515	PF00498	0.694
LIG_FHA_2	603	609	PF00498	0.464
LIG_FHA_2	631	637	PF00498	0.531
LIG_Integrin_RGD_1	535	537	PF01839	0.619
LIG_LIR_Apic_2	477	483	PF02991	0.537
LIG_LIR_Gen_1	297	307	PF02991	0.467
LIG_LIR_Nem_3	13	17	PF02991	0.424
LIG_LIR_Nem_3	226	231	PF02991	0.646
LIG_LIR_Nem_3	236	242	PF02991	0.537
LIG_LIR_Nem_3	633	637	PF02991	0.516
LIG_Pex14_2	393	397	PF04695	0.464
LIG_RPA_C_Fungi	251	263	PF08784	0.570
LIG_SH2_CRK	14	18	PF00017	0.493
LIG_SH2_CRK	480	484	PF00017	0.588
LIG_SH2_GRB2like	479	482	PF00017	0.521
LIG_SH2_NCK_1	480	484	PF00017	0.588
LIG_SH2_NCK_1	62	66	PF00017	0.508
LIG_SH2_SRC	90	93	PF00017	0.616
LIG_SH2_STAP1	102	106	PF00017	0.569
LIG_SH2_STAP1	62	66	PF00017	0.508
LIG_SH2_STAT3	479	482	PF00017	0.543
LIG_SH2_STAT5	317	320	PF00017	0.523
LIG_SH2_STAT5	332	335	PF00017	0.454
LIG_SH2_STAT5	365	368	PF00017	0.522
LIG_SH3_3	132	138	PF00018	0.637
LIG_SH3_3	425	431	PF00018	0.503
LIG_SH3_3	568	574	PF00018	0.614
LIG_SH3_4	6	13	PF00018	0.512
LIG_SUMO_SIM_anti_2	432	440	PF11976	0.500
LIG_SUMO_SIM_anti_2	450	459	PF11976	0.657
LIG_TRAF2_1	101	104	PF00917	0.639
LIG_TRAF2_1	185	188	PF00917	0.700
LIG_TRAF2_1	335	338	PF00917	0.450
LIG_TRAF2_1	448	451	PF00917	0.659
LIG_TRAF2_1	605	608	PF00917	0.475
LIG_TRFH_1	14	18	PF08558	0.489
LIG_TYR_ITIM	12	17	PF00017	0.484
LIG_UBA3_1	359	364	PF00899	0.534
LIG_UBA3_1	455	463	PF00899	0.629
MOD_CK1_1	215	221	PF00069	0.605
MOD_CK1_1	439	445	PF00069	0.646
MOD_CK1_1	474	480	PF00069	0.497
MOD_CK1_1	550	556	PF00069	0.683
MOD_CK1_1	580	586	PF00069	0.656
MOD_CK1_1	645	651	PF00069	0.529
MOD_CK2_1	240	246	PF00069	0.521
MOD_CK2_1	32	38	PF00069	0.487
MOD_CK2_1	331	337	PF00069	0.532
MOD_CK2_1	437	443	PF00069	0.663
MOD_CK2_1	444	450	PF00069	0.800
MOD_CK2_1	508	514	PF00069	0.684
MOD_CK2_1	575	581	PF00069	0.652
MOD_CK2_1	602	608	PF00069	0.472
MOD_CK2_1	630	636	PF00069	0.534
MOD_GlcNHglycan	152	155	PF01048	0.720
MOD_GlcNHglycan	214	217	PF01048	0.585
MOD_GlcNHglycan	44	47	PF01048	0.627
MOD_GlcNHglycan	473	476	PF01048	0.508
MOD_GlcNHglycan	491	494	PF01048	0.710
MOD_GlcNHglycan	539	542	PF01048	0.687
MOD_GlcNHglycan	547	550	PF01048	0.746
MOD_GlcNHglycan	560	563	PF01048	0.596
MOD_GlcNHglycan	627	630	PF01048	0.534
MOD_GlcNHglycan	644	647	PF01048	0.555
MOD_GSK3_1	281	288	PF00069	0.601
MOD_GSK3_1	417	424	PF00069	0.521
MOD_GSK3_1	471	478	PF00069	0.489
MOD_GSK3_1	508	515	PF00069	0.581
MOD_GSK3_1	525	532	PF00069	0.692
MOD_GSK3_1	537	544	PF00069	0.728
MOD_GSK3_1	552	559	PF00069	0.676
MOD_LATS_1	139	145	PF00433	0.556
MOD_NEK2_1	159	164	PF00069	0.631
MOD_NEK2_1	275	280	PF00069	0.630
MOD_NEK2_1	339	344	PF00069	0.531
MOD_NEK2_1	630	635	PF00069	0.535
MOD_NEK2_1	642	647	PF00069	0.657
MOD_NEK2_2	651	656	PF00069	0.482
MOD_PIKK_1	141	147	PF00454	0.584
MOD_PIKK_1	289	295	PF00454	0.593
MOD_PIKK_1	645	651	PF00454	0.513
MOD_PKA_1	255	261	PF00069	0.566
MOD_PKA_2	255	261	PF00069	0.606
MOD_PKA_2	489	495	PF00069	0.642
MOD_PKA_2	642	648	PF00069	0.534
MOD_PKA_2	651	657	PF00069	0.548
MOD_Plk_2-3	315	321	PF00069	0.526
MOD_Plk_2-3	636	642	PF00069	0.528
MOD_Plk_4	381	387	PF00069	0.510
MOD_Plk_4	475	481	PF00069	0.505
MOD_Plk_4	529	535	PF00069	0.681
MOD_Plk_4	553	559	PF00069	0.586
MOD_ProDKin_1	427	433	PF00069	0.605
MOD_ProDKin_1	437	443	PF00069	0.702
MOD_ProDKin_1	541	547	PF00069	0.671
MOD_SUMO_rev_2	126	135	PF00179	0.681
MOD_SUMO_rev_2	186	195	PF00179	0.593
MOD_SUMO_rev_2	244	249	PF00179	0.482
MOD_SUMO_rev_2	453	462	PF00179	0.637
MOD_SUMO_rev_2	603	611	PF00179	0.472
TRG_DiLeu_BaEn_1	237	242	PF01217	0.539
TRG_DiLeu_BaEn_1	451	456	PF01217	0.666
TRG_DiLeu_BaEn_3	451	457	PF01217	0.633
TRG_DiLeu_LyEn_5	237	242	PF01217	0.539
TRG_ENDOCYTIC_2	14	17	PF00928	0.479
TRG_ENDOCYTIC_2	634	637	PF00928	0.493
TRG_ER_diArg_1	254	256	PF00400	0.552
TRG_ER_diArg_1	260	263	PF00400	0.602
TRG_ER_diArg_1	40	42	PF00400	0.502
TRG_ER_diArg_1	404	406	PF00400	0.528
TRG_ER_diArg_1	409	412	PF00400	0.482
TRG_ER_diArg_1	489	491	PF00400	0.643
TRG_ER_diArg_1	496	498	PF00400	0.601
TRG_ER_diArg_1	599	601	PF00400	0.657
TRG_ER_diArg_1	642	644	PF00400	0.543
TRG_ER_diArg_1	74	77	PF00400	0.494
TRG_NLS_MonoCore_2	4	9	PF00514	0.513
TRG_NLS_MonoExtN_4	2	9	PF00514	0.528
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	294	299	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2D0	Leptomonas seymouri	50%	93%
A0A3Q8IHA2	Leishmania donovani	87%	100%
A4HHE8	Leishmania braziliensis	67%	100%
A4I4J8	Leishmania infantum	87%	100%
E9ALT4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BH77	Trypanosoma cruzi	37%	100%