Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein, putative

Species:

Leishmania major

UniProt:

E9ADZ5_LEIMA

TriTrypDb:

LmjF.29.1360 , LMJLV39_290020300 , LMJSD75_290020500

Length:

664

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADZ5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	401	405	PF00656	0.579
CLV_C14_Caspase3-7	576	580	PF00656	0.614
CLV_C14_Caspase3-7	600	604	PF00656	0.552
CLV_MEL_PAP_1	150	156	PF00089	0.294
CLV_NRD_NRD_1	118	120	PF00675	0.711
CLV_NRD_NRD_1	12	14	PF00675	0.576
CLV_NRD_NRD_1	124	126	PF00675	0.625
CLV_NRD_NRD_1	220	222	PF00675	0.655
CLV_NRD_NRD_1	230	232	PF00675	0.551
CLV_NRD_NRD_1	352	354	PF00675	0.715
CLV_PCSK_FUR_1	122	126	PF00082	0.638
CLV_PCSK_FUR_1	350	354	PF00082	0.671
CLV_PCSK_KEX2_1	12	14	PF00082	0.576
CLV_PCSK_KEX2_1	124	126	PF00082	0.639
CLV_PCSK_KEX2_1	220	222	PF00082	0.727
CLV_PCSK_KEX2_1	352	354	PF00082	0.713
CLV_PCSK_SKI1_1	233	237	PF00082	0.596
CLV_PCSK_SKI1_1	262	266	PF00082	0.389
CLV_PCSK_SKI1_1	496	500	PF00082	0.561
DEG_APCC_DBOX_1	357	365	PF00400	0.672
DEG_APCC_DBOX_1	508	516	PF00400	0.538
DOC_CKS1_1	424	429	PF01111	0.624
DOC_CKS1_1	435	440	PF01111	0.560
DOC_CKS1_1	560	565	PF01111	0.611
DOC_CYCLIN_yClb1_LxF_4	470	476	PF00134	0.636
DOC_CYCLIN_yCln2_LP_2	435	441	PF00134	0.549
DOC_MAPK_gen_1	231	239	PF00069	0.620
DOC_MAPK_MEF2A_6	231	239	PF00069	0.499
DOC_MAPK_NFAT4_5	232	240	PF00069	0.492
DOC_PP1_RVXF_1	278	285	PF00149	0.632
DOC_PP2B_LxvP_1	34	37	PF13499	0.653
DOC_PP2B_LxvP_1	425	428	PF13499	0.668
DOC_PP2B_LxvP_1	547	550	PF13499	0.671
DOC_USP7_MATH_1	152	156	PF00917	0.442
DOC_USP7_MATH_1	219	223	PF00917	0.594
DOC_USP7_MATH_1	29	33	PF00917	0.720
DOC_USP7_MATH_1	305	309	PF00917	0.649
DOC_USP7_MATH_1	374	378	PF00917	0.564
DOC_USP7_MATH_1	397	401	PF00917	0.639
DOC_USP7_MATH_1	403	407	PF00917	0.593
DOC_USP7_MATH_1	414	418	PF00917	0.511
DOC_USP7_MATH_1	441	445	PF00917	0.624
DOC_USP7_MATH_1	488	492	PF00917	0.676
DOC_USP7_MATH_1	520	524	PF00917	0.644
DOC_USP7_MATH_1	595	599	PF00917	0.551
DOC_USP7_MATH_1	654	658	PF00917	0.578
DOC_USP7_MATH_1	67	71	PF00917	0.647
DOC_USP7_MATH_1	81	85	PF00917	0.538
DOC_USP7_MATH_2	51	57	PF00917	0.571
DOC_USP7_UBL2_3	232	236	PF12436	0.518
DOC_WW_Pin1_4	20	25	PF00397	0.760
DOC_WW_Pin1_4	268	273	PF00397	0.546
DOC_WW_Pin1_4	338	343	PF00397	0.639
DOC_WW_Pin1_4	365	370	PF00397	0.830
DOC_WW_Pin1_4	40	45	PF00397	0.544
DOC_WW_Pin1_4	423	428	PF00397	0.700
DOC_WW_Pin1_4	434	439	PF00397	0.583
DOC_WW_Pin1_4	465	470	PF00397	0.699
DOC_WW_Pin1_4	476	481	PF00397	0.670
DOC_WW_Pin1_4	527	532	PF00397	0.631
DOC_WW_Pin1_4	559	564	PF00397	0.646
DOC_WW_Pin1_4	58	63	PF00397	0.677
DOC_WW_Pin1_4	640	645	PF00397	0.588
LIG_14-3-3_CanoR_1	110	114	PF00244	0.690
LIG_14-3-3_CanoR_1	124	132	PF00244	0.572
LIG_14-3-3_CanoR_1	153	159	PF00244	0.494
LIG_14-3-3_CanoR_1	190	199	PF00244	0.505
LIG_14-3-3_CanoR_1	212	217	PF00244	0.544
LIG_14-3-3_CanoR_1	220	227	PF00244	0.532
LIG_14-3-3_CanoR_1	262	267	PF00244	0.546
LIG_14-3-3_CanoR_1	3	11	PF00244	0.686
LIG_14-3-3_CanoR_1	352	361	PF00244	0.694
LIG_14-3-3_CanoR_1	86	92	PF00244	0.693
LIG_APCC_ABBA_1	264	269	PF00400	0.632
LIG_APCC_ABBA_1	284	289	PF00400	0.632
LIG_BRCT_BRCA1_1	142	146	PF00533	0.494
LIG_BRCT_BRCA1_1	522	526	PF00533	0.733
LIG_BRCT_BRCA1_1	656	660	PF00533	0.601
LIG_CtBP_PxDLS_1	630	634	PF00389	0.592
LIG_FHA_1	184	190	PF00498	0.632
LIG_FHA_1	268	274	PF00498	0.546
LIG_FHA_1	390	396	PF00498	0.660
LIG_FHA_1	528	534	PF00498	0.654
LIG_FHA_1	560	566	PF00498	0.665
LIG_FHA_1	622	628	PF00498	0.678
LIG_FHA_1	75	81	PF00498	0.627
LIG_FHA_2	131	137	PF00498	0.589
LIG_FHA_2	245	251	PF00498	0.546
LIG_FHA_2	424	430	PF00498	0.528
LIG_IBAR_NPY_1	653	655	PF08397	0.648
LIG_LIR_Apic_2	534	539	PF02991	0.651
LIG_LIR_Gen_1	186	195	PF02991	0.568
LIG_LIR_Gen_1	468	477	PF02991	0.569
LIG_LIR_Nem_3	252	258	PF02991	0.615
LIG_LIR_Nem_3	468	473	PF02991	0.587
LIG_LIR_Nem_3	657	663	PF02991	0.667
LIG_LYPXL_yS_3	422	425	PF13949	0.623
LIG_MLH1_MIPbox_1	522	526	PF16413	0.624
LIG_MYND_1	423	427	PF01753	0.663
LIG_REV1ctd_RIR_1	522	530	PF16727	0.532
LIG_SH2_CRK	258	262	PF00017	0.529
LIG_SH2_CRK	536	540	PF00017	0.720
LIG_SH2_CRK	566	570	PF00017	0.666
LIG_SH2_NCK_1	48	52	PF00017	0.580
LIG_SH2_NCK_1	536	540	PF00017	0.708
LIG_SH2_SRC	536	539	PF00017	0.651
LIG_SH2_STAP1	199	203	PF00017	0.442
LIG_SH2_STAT5	199	202	PF00017	0.442
LIG_SH2_STAT5	287	290	PF00017	0.546
LIG_SH2_STAT5	655	658	PF00017	0.655
LIG_SH3_3	463	469	PF00018	0.682
LIG_SH3_3	487	493	PF00018	0.631
LIG_SH3_3	557	563	PF00018	0.704
LIG_SH3_3	581	587	PF00018	0.611
LIG_SH3_3	624	630	PF00018	0.612
LIG_SH3_3	641	647	PF00018	0.565
LIG_TRAF2_1	134	137	PF00917	0.551
LIG_WRC_WIRS_1	68	73	PF05994	0.646
MOD_CDK_SPK_2	559	564	PF00069	0.610
MOD_CDK_SPK_2	640	645	PF00069	0.629
MOD_CDK_SPxxK_3	365	372	PF00069	0.707
MOD_CK1_1	135	141	PF00069	0.557
MOD_CK1_1	183	189	PF00069	0.632
MOD_CK1_1	20	26	PF00069	0.614
MOD_CK1_1	340	346	PF00069	0.734
MOD_CK1_1	377	383	PF00069	0.742
MOD_CK1_1	385	391	PF00069	0.660
MOD_CK1_1	7	13	PF00069	0.691
MOD_CK1_1	74	80	PF00069	0.649
MOD_CK1_1	82	88	PF00069	0.654
MOD_CK1_1	90	96	PF00069	0.590
MOD_CK2_1	130	136	PF00069	0.594
MOD_CK2_1	152	158	PF00069	0.529
MOD_CK2_1	190	196	PF00069	0.632
MOD_CK2_1	423	429	PF00069	0.523
MOD_GlcNHglycan	126	129	PF01048	0.644
MOD_GlcNHglycan	171	174	PF01048	0.346
MOD_GlcNHglycan	19	22	PF01048	0.684
MOD_GlcNHglycan	29	32	PF01048	0.618
MOD_GlcNHglycan	376	379	PF01048	0.817
MOD_GlcNHglycan	400	403	PF01048	0.645
MOD_GlcNHglycan	412	415	PF01048	0.525
MOD_GlcNHglycan	443	446	PF01048	0.630
MOD_GlcNHglycan	462	465	PF01048	0.644
MOD_GlcNHglycan	73	76	PF01048	0.729
MOD_GSK3_1	104	111	PF00069	0.723
MOD_GSK3_1	120	127	PF00069	0.597
MOD_GSK3_1	165	172	PF00069	0.546
MOD_GSK3_1	208	215	PF00069	0.546
MOD_GSK3_1	3	10	PF00069	0.687
MOD_GSK3_1	359	366	PF00069	0.725
MOD_GSK3_1	373	380	PF00069	0.575
MOD_GSK3_1	382	389	PF00069	0.564
MOD_GSK3_1	410	417	PF00069	0.677
MOD_GSK3_1	504	511	PF00069	0.686
MOD_GSK3_1	527	534	PF00069	0.666
MOD_GSK3_1	597	604	PF00069	0.686
MOD_GSK3_1	67	74	PF00069	0.693
MOD_GSK3_1	81	88	PF00069	0.688
MOD_LATS_1	351	357	PF00433	0.640
MOD_N-GLC_1	359	364	PF02516	0.590
MOD_N-GLC_1	4	9	PF02516	0.650
MOD_N-GLC_1	526	531	PF02516	0.628
MOD_N-GLC_1	58	63	PF02516	0.651
MOD_N-GLC_1	601	606	PF02516	0.616
MOD_N-GLC_1	90	95	PF02516	0.682
MOD_N-GLC_2	588	590	PF02516	0.510
MOD_NEK2_1	140	145	PF00069	0.503
MOD_NEK2_1	244	249	PF00069	0.632
MOD_NEK2_1	382	387	PF00069	0.577
MOD_NEK2_1	4	9	PF00069	0.686
MOD_NEK2_1	475	480	PF00069	0.640
MOD_NEK2_1	526	531	PF00069	0.661
MOD_NEK2_1	601	606	PF00069	0.669
MOD_NEK2_1	71	76	PF00069	0.707
MOD_NEK2_2	520	525	PF00069	0.600
MOD_PIKK_1	152	158	PF00454	0.554
MOD_PIKK_1	353	359	PF00454	0.665
MOD_PIKK_1	504	510	PF00454	0.721
MOD_PIKK_1	515	521	PF00454	0.649
MOD_PIKK_1	531	537	PF00454	0.603
MOD_PIKK_1	601	607	PF00454	0.651
MOD_PIKK_1	90	96	PF00454	0.601
MOD_PK_1	212	218	PF00069	0.703
MOD_PKA_1	124	130	PF00069	0.636
MOD_PKA_2	109	115	PF00069	0.690
MOD_PKA_2	124	130	PF00069	0.560
MOD_PKA_2	152	158	PF00069	0.494
MOD_PKA_2	189	195	PF00069	0.632
MOD_PKA_2	197	203	PF00069	0.539
MOD_PKA_2	219	225	PF00069	0.602
MOD_PKA_2	351	357	PF00069	0.713
MOD_PKA_2	451	457	PF00069	0.637
MOD_PKA_2	508	514	PF00069	0.641
MOD_PKA_2	85	91	PF00069	0.690
MOD_PKB_1	122	130	PF00069	0.637
MOD_Plk_1	359	365	PF00069	0.581
MOD_Plk_1	403	409	PF00069	0.679
MOD_Plk_1	414	420	PF00069	0.574
MOD_Plk_1	496	502	PF00069	0.556
MOD_Plk_4	165	171	PF00069	0.632
MOD_Plk_4	29	35	PF00069	0.701
MOD_Plk_4	377	383	PF00069	0.591
MOD_Plk_4	508	514	PF00069	0.697
MOD_Plk_4	520	526	PF00069	0.553
MOD_Plk_4	656	662	PF00069	0.725
MOD_Plk_4	67	73	PF00069	0.645
MOD_ProDKin_1	20	26	PF00069	0.759
MOD_ProDKin_1	268	274	PF00069	0.546
MOD_ProDKin_1	338	344	PF00069	0.639
MOD_ProDKin_1	365	371	PF00069	0.829
MOD_ProDKin_1	40	46	PF00069	0.547
MOD_ProDKin_1	423	429	PF00069	0.704
MOD_ProDKin_1	434	440	PF00069	0.582
MOD_ProDKin_1	465	471	PF00069	0.701
MOD_ProDKin_1	476	482	PF00069	0.672
MOD_ProDKin_1	527	533	PF00069	0.634
MOD_ProDKin_1	559	565	PF00069	0.647
MOD_ProDKin_1	58	64	PF00069	0.675
MOD_ProDKin_1	640	646	PF00069	0.589
TRG_DiLeu_BaLyEn_6	277	282	PF01217	0.546
TRG_DiLeu_BaLyEn_6	430	435	PF01217	0.542
TRG_ENDOCYTIC_2	258	261	PF00928	0.529
TRG_ENDOCYTIC_2	422	425	PF00928	0.672
TRG_ER_diArg_1	11	13	PF00400	0.571
TRG_ER_diArg_1	122	125	PF00400	0.661
TRG_ER_diArg_1	350	353	PF00400	0.719
TRG_NES_CRM1_1	276	290	PF08389	0.546
TRG_NLS_Bipartite_1	220	235	PF00514	0.687
TRG_NLS_MonoExtN_4	118	123	PF00514	0.701
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIS4	Leishmania donovani	88%	100%
A4HHF3	Leishmania braziliensis	63%	100%
A4I4J6	Leishmania infantum	88%	100%
E9ALT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%