Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein, putative

Species:

Leishmania major

UniProt:

E9ADZ4_LEIMA

TriTrypDb:

LmjF.29.1350 , LMJLV39_290020200 , LMJSD75_290020300

Length:

920

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005829	cytosol	2	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

E9ADZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADZ4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0003727	single-stranded RNA binding	5	2
GO:0003729	mRNA binding	5	2
GO:0003730	mRNA 3'-UTR binding	6	2
GO:0005488	binding	1	6
GO:0008143	poly(A) binding	7	2
GO:0008187	poly-pyrimidine tract binding	6	2
GO:0008266	poly(U) RNA binding	7	2
GO:0070717	poly-purine tract binding	6	2
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.580
CLV_NRD_NRD_1	29	31	PF00675	0.750
CLV_NRD_NRD_1	300	302	PF00675	0.671
CLV_NRD_NRD_1	312	314	PF00675	0.468
CLV_NRD_NRD_1	407	409	PF00675	0.755
CLV_NRD_NRD_1	674	676	PF00675	0.706
CLV_NRD_NRD_1	808	810	PF00675	0.849
CLV_NRD_NRD_1	854	856	PF00675	0.734
CLV_PCSK_KEX2_1	29	31	PF00082	0.756
CLV_PCSK_KEX2_1	406	408	PF00082	0.746
CLV_PCSK_KEX2_1	808	810	PF00082	0.849
CLV_PCSK_KEX2_1	819	821	PF00082	0.805
CLV_PCSK_PC1ET2_1	819	821	PF00082	0.870
CLV_PCSK_SKI1_1	315	319	PF00082	0.610
CLV_PCSK_SKI1_1	344	348	PF00082	0.397
CLV_PCSK_SKI1_1	408	412	PF00082	0.752
DEG_COP1_1	203	210	PF00400	0.707
DEG_Nend_UBRbox_1	1	4	PF02207	0.647
DEG_SCF_FBW7_1	178	184	PF00400	0.829
DEG_SCF_FBW7_1	36	42	PF00400	0.807
DEG_SCF_FBW7_1	527	532	PF00400	0.748
DEG_SCF_FBW7_1	870	877	PF00400	0.721
DEG_SPOP_SBC_1	181	185	PF00917	0.678
DEG_SPOP_SBC_1	54	58	PF00917	0.744
DEG_SPOP_SBC_1	705	709	PF00917	0.797
DOC_CKS1_1	1	6	PF01111	0.587
DOC_CKS1_1	167	172	PF01111	0.792
DOC_CKS1_1	175	180	PF01111	0.701
DOC_CKS1_1	207	212	PF01111	0.808
DOC_CKS1_1	36	41	PF01111	0.806
DOC_CKS1_1	435	440	PF01111	0.776
DOC_CYCLIN_yCln2_LP_2	238	244	PF00134	0.469
DOC_MAPK_gen_1	313	321	PF00069	0.613
DOC_MAPK_gen_1	45	54	PF00069	0.765
DOC_MAPK_gen_1	819	827	PF00069	0.635
DOC_MAPK_gen_1	855	862	PF00069	0.720
DOC_MAPK_MEF2A_6	135	142	PF00069	0.813
DOC_MAPK_MEF2A_6	313	321	PF00069	0.613
DOC_MAPK_NFAT4_5	314	322	PF00069	0.606
DOC_PP1_RVXF_1	360	367	PF00149	0.636
DOC_PP2B_LxvP_1	592	595	PF13499	0.727
DOC_PP4_FxxP_1	167	170	PF00568	0.783
DOC_PP4_FxxP_1	564	567	PF00568	0.576
DOC_USP7_MATH_1	244	248	PF00917	0.469
DOC_USP7_MATH_1	387	391	PF00917	0.565
DOC_USP7_MATH_1	401	405	PF00917	0.687
DOC_USP7_MATH_1	418	422	PF00917	0.509
DOC_USP7_MATH_1	478	482	PF00917	0.702
DOC_USP7_MATH_1	529	533	PF00917	0.742
DOC_USP7_MATH_1	55	59	PF00917	0.685
DOC_USP7_MATH_1	595	599	PF00917	0.607
DOC_USP7_MATH_1	617	621	PF00917	0.627
DOC_USP7_MATH_1	686	690	PF00917	0.783
DOC_USP7_MATH_1	705	709	PF00917	0.695
DOC_USP7_MATH_1	713	717	PF00917	0.772
DOC_USP7_MATH_1	803	807	PF00917	0.779
DOC_USP7_MATH_1	835	839	PF00917	0.747
DOC_USP7_MATH_1	910	914	PF00917	0.638
DOC_USP7_MATH_2	213	219	PF00917	0.712
DOC_USP7_UBL2_3	314	318	PF12436	0.630
DOC_WW_Pin1_4	10	15	PF00397	0.665
DOC_WW_Pin1_4	166	171	PF00397	0.787
DOC_WW_Pin1_4	174	179	PF00397	0.698
DOC_WW_Pin1_4	184	189	PF00397	0.550
DOC_WW_Pin1_4	202	207	PF00397	0.812
DOC_WW_Pin1_4	209	214	PF00397	0.704
DOC_WW_Pin1_4	32	37	PF00397	0.861
DOC_WW_Pin1_4	350	355	PF00397	0.636
DOC_WW_Pin1_4	431	436	PF00397	0.810
DOC_WW_Pin1_4	440	445	PF00397	0.651
DOC_WW_Pin1_4	476	481	PF00397	0.766
DOC_WW_Pin1_4	520	525	PF00397	0.778
DOC_WW_Pin1_4	535	540	PF00397	0.589
DOC_WW_Pin1_4	555	560	PF00397	0.497
DOC_WW_Pin1_4	57	62	PF00397	0.665
DOC_WW_Pin1_4	624	629	PF00397	0.766
DOC_WW_Pin1_4	641	646	PF00397	0.583
DOC_WW_Pin1_4	680	685	PF00397	0.704
DOC_WW_Pin1_4	698	703	PF00397	0.746
DOC_WW_Pin1_4	709	714	PF00397	0.658
DOC_WW_Pin1_4	720	725	PF00397	0.718
DOC_WW_Pin1_4	782	787	PF00397	0.709
DOC_WW_Pin1_4	793	798	PF00397	0.664
DOC_WW_Pin1_4	827	832	PF00397	0.773
DOC_WW_Pin1_4	846	851	PF00397	0.812
DOC_WW_Pin1_4	870	875	PF00397	0.685
DOC_WW_Pin1_4	895	900	PF00397	0.854
LIG_14-3-3_CanoR_1	105	112	PF00244	0.667
LIG_14-3-3_CanoR_1	118	125	PF00244	0.651
LIG_14-3-3_CanoR_1	29	39	PF00244	0.786
LIG_14-3-3_CanoR_1	344	349	PF00244	0.636
LIG_14-3-3_CanoR_1	47	55	PF00244	0.679
LIG_14-3-3_CanoR_1	513	519	PF00244	0.764
LIG_14-3-3_CanoR_1	574	580	PF00244	0.737
LIG_14-3-3_CanoR_1	697	702	PF00244	0.671
LIG_14-3-3_CanoR_1	759	763	PF00244	0.632
LIG_AP2alpha_2	240	242	PF02296	0.636
LIG_APCC_ABBA_1	346	351	PF00400	0.636
LIG_APCC_ABBA_1	366	371	PF00400	0.400
LIG_BRCT_BRCA1_1	441	445	PF00533	0.735
LIG_BRCT_BRCA1_1	557	561	PF00533	0.590
LIG_BRCT_BRCA1_1	617	621	PF00533	0.772
LIG_BRCT_BRCA1_1	702	706	PF00533	0.827
LIG_BRCT_BRCA1_1	739	743	PF00533	0.586
LIG_BRCT_BRCA1_1	776	780	PF00533	0.842
LIG_BRCT_BRCA1_1	864	868	PF00533	0.596
LIG_FHA_1	112	118	PF00498	0.678
LIG_FHA_1	202	208	PF00498	0.732
LIG_FHA_1	217	223	PF00498	0.467
LIG_FHA_1	260	266	PF00498	0.637
LIG_FHA_1	282	288	PF00498	0.651
LIG_FHA_1	350	356	PF00498	0.636
LIG_FHA_1	414	420	PF00498	0.697
LIG_FHA_1	782	788	PF00498	0.845
LIG_FHA_1	874	880	PF00498	0.831
LIG_FHA_2	210	216	PF00498	0.786
LIG_FHA_2	235	241	PF00498	0.580
LIG_FHA_2	654	660	PF00498	0.764
LIG_GSK3_LRP6_1	874	880	PF00069	0.754
LIG_IBAR_NPY_1	909	911	PF08397	0.812
LIG_LIR_Apic_2	481	486	PF02991	0.738
LIG_LIR_Apic_2	491	497	PF02991	0.827
LIG_LIR_Apic_2	562	567	PF02991	0.577
LIG_LIR_Gen_1	558	569	PF02991	0.581
LIG_LIR_Gen_1	618	628	PF02991	0.720
LIG_LIR_LC3C_4	292	297	PF02991	0.627
LIG_LIR_Nem_3	237	242	PF02991	0.627
LIG_LIR_Nem_3	262	267	PF02991	0.636
LIG_LIR_Nem_3	334	340	PF02991	0.636
LIG_LIR_Nem_3	558	564	PF02991	0.588
LIG_LIR_Nem_3	618	624	PF02991	0.692
LIG_LIR_Nem_3	740	746	PF02991	0.600
LIG_PDZ_Class_2	915	920	PF00595	0.795
LIG_PTB_Apo_2	905	912	PF02174	0.827
LIG_PTB_Phospho_1	905	911	PF10480	0.831
LIG_Rb_LxCxE_1	858	877	PF01857	0.743
LIG_Rb_pABgroove_1	233	241	PF01858	0.636
LIG_SH2_CRK	340	344	PF00017	0.608
LIG_SH2_CRK	483	487	PF00017	0.701
LIG_SH2_CRK	907	911	PF00017	0.824
LIG_SH2_GRB2like	906	909	PF00017	0.840
LIG_SH2_NCK_1	494	498	PF00017	0.831
LIG_SH2_NCK_1	907	911	PF00017	0.824
LIG_SH2_SRC	494	497	PF00017	0.788
LIG_SH2_STAP1	267	271	PF00017	0.636
LIG_SH2_STAT3	107	110	PF00017	0.839
LIG_SH2_STAT5	107	110	PF00017	0.840
LIG_SH2_STAT5	369	372	PF00017	0.569
LIG_SH2_STAT5	623	626	PF00017	0.699
LIG_SH2_STAT5	84	87	PF00017	0.620
LIG_SH3_1	432	438	PF00018	0.808
LIG_SH3_3	146	152	PF00018	0.782
LIG_SH3_3	175	181	PF00018	0.824
LIG_SH3_3	204	210	PF00018	0.809
LIG_SH3_3	33	39	PF00018	0.813
LIG_SH3_3	419	425	PF00018	0.639
LIG_SH3_3	432	438	PF00018	0.745
LIG_SH3_3	49	55	PF00018	0.683
LIG_SH3_3	493	499	PF00018	0.784
LIG_SH3_3	61	67	PF00018	0.669
LIG_SH3_3	840	846	PF00018	0.687
LIG_SH3_3	872	878	PF00018	0.755
LIG_SH3_3	92	98	PF00018	0.606
LIG_Sin3_3	242	249	PF02671	0.469
LIG_SUMO_SIM_par_1	15	20	PF11976	0.682
LIG_SUMO_SIM_par_1	8	13	PF11976	0.640
LIG_SUMO_SIM_par_1	858	863	PF11976	0.811
LIG_WRC_WIRS_1	561	566	PF05994	0.587
MOD_CDC14_SPxK_1	538	541	PF00782	0.836
MOD_CDK_SPxK_1	535	541	PF00069	0.839
MOD_CDK_SPxxK_3	184	191	PF00069	0.611
MOD_CDK_SPxxK_3	793	800	PF00069	0.858
MOD_CK1_1	183	189	PF00069	0.838
MOD_CK1_1	281	287	PF00069	0.605
MOD_CK1_1	32	38	PF00069	0.752
MOD_CK1_1	434	440	PF00069	0.763
MOD_CK1_1	479	485	PF00069	0.763
MOD_CK1_1	503	509	PF00069	0.784
MOD_CK1_1	57	63	PF00069	0.673
MOD_CK1_1	593	599	PF00069	0.679
MOD_CK1_1	670	676	PF00069	0.652
MOD_CK1_1	700	706	PF00069	0.826
MOD_CK1_1	723	729	PF00069	0.852
MOD_CK1_1	761	767	PF00069	0.691
MOD_CK1_1	782	788	PF00069	0.689
MOD_CK1_1	8	14	PF00069	0.647
MOD_CK1_1	830	836	PF00069	0.833
MOD_CK1_1	849	855	PF00069	0.707
MOD_CK1_1	858	864	PF00069	0.569
MOD_CK1_1	877	883	PF00069	0.764
MOD_CK1_1	912	918	PF00069	0.791
MOD_CK2_1	191	197	PF00069	0.826
MOD_CK2_1	209	215	PF00069	0.803
MOD_CK2_1	860	866	PF00069	0.817
MOD_GlcNHglycan	171	174	PF01048	0.777
MOD_GlcNHglycan	41	44	PF01048	0.733
MOD_GlcNHglycan	49	52	PF01048	0.641
MOD_GlcNHglycan	518	521	PF01048	0.849
MOD_GlcNHglycan	592	595	PF01048	0.717
MOD_GlcNHglycan	598	601	PF01048	0.768
MOD_GlcNHglycan	617	620	PF01048	0.711
MOD_GlcNHglycan	647	650	PF01048	0.821
MOD_GlcNHglycan	688	691	PF01048	0.836
MOD_GlcNHglycan	739	742	PF01048	0.667
MOD_GlcNHglycan	755	758	PF01048	0.746
MOD_GlcNHglycan	764	767	PF01048	0.842
MOD_GlcNHglycan	781	784	PF01048	0.566
MOD_GlcNHglycan	787	790	PF01048	0.759
MOD_GlcNHglycan	827	830	PF01048	0.810
MOD_GlcNHglycan	837	840	PF01048	0.651
MOD_GlcNHglycan	86	89	PF01048	0.682
MOD_GlcNHglycan	884	887	PF01048	0.849
MOD_GlcNHglycan	900	903	PF01048	0.848
MOD_GSK3_1	120	127	PF00069	0.680
MOD_GSK3_1	176	183	PF00069	0.829
MOD_GSK3_1	202	209	PF00069	0.658
MOD_GSK3_1	211	218	PF00069	0.583
MOD_GSK3_1	28	35	PF00069	0.750
MOD_GSK3_1	430	437	PF00069	0.770
MOD_GSK3_1	503	510	PF00069	0.729
MOD_GSK3_1	516	523	PF00069	0.759
MOD_GSK3_1	525	532	PF00069	0.708
MOD_GSK3_1	53	60	PF00069	0.679
MOD_GSK3_1	555	562	PF00069	0.827
MOD_GSK3_1	624	631	PF00069	0.715
MOD_GSK3_1	637	644	PF00069	0.639
MOD_GSK3_1	663	670	PF00069	0.723
MOD_GSK3_1	671	678	PF00069	0.642
MOD_GSK3_1	700	707	PF00069	0.747
MOD_GSK3_1	709	716	PF00069	0.702
MOD_GSK3_1	719	726	PF00069	0.607
MOD_GSK3_1	758	765	PF00069	0.696
MOD_GSK3_1	766	773	PF00069	0.799
MOD_GSK3_1	781	788	PF00069	0.544
MOD_GSK3_1	791	798	PF00069	0.730
MOD_GSK3_1	825	832	PF00069	0.745
MOD_GSK3_1	833	840	PF00069	0.670
MOD_GSK3_1	858	865	PF00069	0.617
MOD_GSK3_1	869	876	PF00069	0.698
MOD_GSK3_1	891	898	PF00069	0.806
MOD_GSK3_1	909	916	PF00069	0.797
MOD_LATS_1	27	33	PF00433	0.826
MOD_N-GLC_1	191	196	PF02516	0.797
MOD_N-GLC_1	601	606	PF02516	0.679
MOD_N-GLC_1	663	668	PF02516	0.824
MOD_N-GLC_1	771	776	PF02516	0.766
MOD_N-GLC_1	825	830	PF02516	0.710
MOD_N-GLC_1	880	885	PF02516	0.812
MOD_NEK2_1	131	136	PF00069	0.717
MOD_NEK2_1	201	206	PF00069	0.639
MOD_NEK2_1	400	405	PF00069	0.589
MOD_NEK2_1	41	46	PF00069	0.714
MOD_NEK2_1	463	468	PF00069	0.701
MOD_NEK2_1	470	475	PF00069	0.719
MOD_NEK2_1	488	493	PF00069	0.669
MOD_NEK2_1	514	519	PF00069	0.841
MOD_NEK2_1	569	574	PF00069	0.645
MOD_NEK2_1	622	627	PF00069	0.801
MOD_NEK2_1	667	672	PF00069	0.854
MOD_NEK2_1	704	709	PF00069	0.674
MOD_NEK2_1	719	724	PF00069	0.770
MOD_NEK2_1	771	776	PF00069	0.745
MOD_NEK2_1	825	830	PF00069	0.788
MOD_NEK2_1	837	842	PF00069	0.618
MOD_NEK2_1	860	865	PF00069	0.813
MOD_NEK2_1	91	96	PF00069	0.567
MOD_NEK2_2	234	239	PF00069	0.580
MOD_PIKK_1	105	111	PF00454	0.762
MOD_PIKK_1	118	124	PF00454	0.590
MOD_PIKK_1	401	407	PF00454	0.541
MOD_PIKK_1	463	469	PF00454	0.663
MOD_PIKK_1	508	514	PF00454	0.613
MOD_PIKK_1	55	61	PF00454	0.743
MOD_PIKK_1	668	674	PF00454	0.717
MOD_PKA_1	29	35	PF00069	0.752
MOD_PKA_1	675	681	PF00069	0.617
MOD_PKA_1	855	861	PF00069	0.719
MOD_PKA_2	265	271	PF00069	0.636
MOD_PKA_2	28	34	PF00069	0.819
MOD_PKA_2	46	52	PF00069	0.688
MOD_PKA_2	758	764	PF00069	0.603
MOD_PKB_1	118	126	PF00069	0.757
MOD_Plk_1	191	197	PF00069	0.796
MOD_Plk_1	326	332	PF00069	0.608
MOD_Plk_1	663	669	PF00069	0.650
MOD_Plk_1	771	777	PF00069	0.797
MOD_Plk_1	880	886	PF00069	0.811
MOD_Plk_4	234	240	PF00069	0.504
MOD_Plk_4	5	11	PF00069	0.673
MOD_Plk_4	617	623	PF00069	0.632
MOD_Plk_4	663	669	PF00069	0.732
MOD_Plk_4	855	861	PF00069	0.633
MOD_Plk_4	91	97	PF00069	0.723
MOD_ProDKin_1	10	16	PF00069	0.659
MOD_ProDKin_1	166	172	PF00069	0.790
MOD_ProDKin_1	174	180	PF00069	0.701
MOD_ProDKin_1	184	190	PF00069	0.549
MOD_ProDKin_1	202	208	PF00069	0.812
MOD_ProDKin_1	209	215	PF00069	0.695
MOD_ProDKin_1	32	38	PF00069	0.862
MOD_ProDKin_1	350	356	PF00069	0.636
MOD_ProDKin_1	431	437	PF00069	0.810
MOD_ProDKin_1	440	446	PF00069	0.653
MOD_ProDKin_1	476	482	PF00069	0.767
MOD_ProDKin_1	520	526	PF00069	0.777
MOD_ProDKin_1	535	541	PF00069	0.591
MOD_ProDKin_1	555	561	PF00069	0.498
MOD_ProDKin_1	57	63	PF00069	0.666
MOD_ProDKin_1	624	630	PF00069	0.769
MOD_ProDKin_1	641	647	PF00069	0.583
MOD_ProDKin_1	680	686	PF00069	0.704
MOD_ProDKin_1	698	704	PF00069	0.748
MOD_ProDKin_1	709	715	PF00069	0.660
MOD_ProDKin_1	720	726	PF00069	0.718
MOD_ProDKin_1	782	788	PF00069	0.710
MOD_ProDKin_1	793	799	PF00069	0.664
MOD_ProDKin_1	827	833	PF00069	0.772
MOD_ProDKin_1	846	852	PF00069	0.815
MOD_ProDKin_1	870	876	PF00069	0.691
MOD_ProDKin_1	895	901	PF00069	0.853
MOD_SUMO_rev_2	625	634	PF00179	0.737
TRG_DiLeu_BaEn_1	197	202	PF01217	0.735
TRG_DiLeu_BaLyEn_6	359	364	PF01217	0.636
TRG_ENDOCYTIC_2	340	343	PF00928	0.611
TRG_ER_diArg_1	117	120	PF00400	0.762
TRG_ER_diArg_1	28	30	PF00400	0.745
TRG_ER_diArg_1	406	408	PF00400	0.746
TRG_ER_diArg_1	807	809	PF00400	0.857
TRG_ER_diArg_1	903	906	PF00400	0.697
TRG_NES_CRM1_1	358	372	PF08389	0.636
TRG_NLS_Bipartite_1	301	317	PF00514	0.689

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X2K7	Leishmania donovani	92%	100%
A4HHU3	Leishmania braziliensis	71%	100%
A4I4J5	Leishmania infantum	92%	100%
E9ALT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%