Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania major

UniProt:

E9ADZ3_LEIMA

TriTrypDb:

LmjF.29.1340 , LMJLV39_290019800 , LMJSD75_290019900

Length:

639

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0005815	microtubule organizing center	2	2
GO:0032991	protein-containing complex	1	2
GO:0036064	ciliary basal body	3	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

E9ADZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADZ3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.777
CLV_C14_Caspase3-7	359	363	PF00656	0.579
CLV_C14_Caspase3-7	543	547	PF00656	0.748
CLV_NRD_NRD_1	155	157	PF00675	0.653
CLV_NRD_NRD_1	158	160	PF00675	0.567
CLV_NRD_NRD_1	260	262	PF00675	0.585
CLV_NRD_NRD_1	70	72	PF00675	0.435
CLV_NRD_NRD_1	82	84	PF00675	0.223
CLV_PCSK_KEX2_1	143	145	PF00082	0.687
CLV_PCSK_KEX2_1	155	157	PF00082	0.599
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.687
CLV_PCSK_SKI1_1	159	163	PF00082	0.457
CLV_PCSK_SKI1_1	176	180	PF00082	0.242
CLV_PCSK_SKI1_1	83	87	PF00082	0.348
DEG_Nend_Nbox_1	1	3	PF02207	0.785
DOC_CKS1_1	25	30	PF01111	0.791
DOC_CKS1_1	301	306	PF01111	0.817
DOC_CKS1_1	470	475	PF01111	0.761
DOC_CYCLIN_yCln2_LP_2	301	307	PF00134	0.740
DOC_CYCLIN_yCln2_LP_2	563	569	PF00134	0.729
DOC_MAPK_gen_1	155	163	PF00069	0.616
DOC_MAPK_gen_1	60	70	PF00069	0.653
DOC_PP1_RVXF_1	211	218	PF00149	0.614
DOC_PP2B_LxvP_1	297	300	PF13499	0.723
DOC_PP2B_LxvP_1	309	312	PF13499	0.576
DOC_PP2B_LxvP_1	563	566	PF13499	0.728
DOC_PP4_FxxP_1	25	28	PF00568	0.713
DOC_PP4_FxxP_1	370	373	PF00568	0.527
DOC_USP7_MATH_1	238	242	PF00917	0.627
DOC_USP7_MATH_1	552	556	PF00917	0.594
DOC_USP7_MATH_1	607	611	PF00917	0.701
DOC_USP7_MATH_1	633	637	PF00917	0.698
DOC_WW_Pin1_4	146	151	PF00397	0.686
DOC_WW_Pin1_4	24	29	PF00397	0.520
DOC_WW_Pin1_4	292	297	PF00397	0.797
DOC_WW_Pin1_4	300	305	PF00397	0.737
DOC_WW_Pin1_4	307	312	PF00397	0.587
DOC_WW_Pin1_4	351	356	PF00397	0.802
DOC_WW_Pin1_4	372	377	PF00397	0.652
DOC_WW_Pin1_4	460	465	PF00397	0.793
DOC_WW_Pin1_4	466	471	PF00397	0.750
DOC_WW_Pin1_4	505	510	PF00397	0.763
DOC_WW_Pin1_4	521	526	PF00397	0.616
DOC_WW_Pin1_4	544	549	PF00397	0.778
DOC_WW_Pin1_4	6	11	PF00397	0.742
DOC_WW_Pin1_4	626	631	PF00397	0.694
LIG_14-3-3_CanoR_1	207	215	PF00244	0.666
LIG_14-3-3_CanoR_1	409	414	PF00244	0.606
LIG_14-3-3_CanoR_1	585	592	PF00244	0.749
LIG_Actin_WH2_2	163	178	PF00022	0.636
LIG_APCC_ABBA_1	188	193	PF00400	0.636
LIG_APCC_ABBA_1	217	222	PF00400	0.609
LIG_BIR_III_4	362	366	PF00653	0.635
LIG_BIR_III_4	442	446	PF00653	0.737
LIG_BRCT_BRCA1_1	32	36	PF00533	0.726
LIG_BRCT_BRCA1_1	414	418	PF00533	0.713
LIG_BRCT_BRCA1_1	451	455	PF00533	0.681
LIG_BRCT_BRCA1_1	500	504	PF00533	0.639
LIG_FHA_1	107	113	PF00498	0.636
LIG_FHA_1	296	302	PF00498	0.803
LIG_FHA_1	352	358	PF00498	0.793
LIG_FHA_1	431	437	PF00498	0.750
LIG_FHA_1	485	491	PF00498	0.811
LIG_FHA_1	554	560	PF00498	0.694
LIG_FHA_2	114	120	PF00498	0.636
LIG_FHA_2	357	363	PF00498	0.671
LIG_FHA_2	76	82	PF00498	0.636
LIG_LIR_Apic_2	131	136	PF02991	0.636
LIG_LIR_Apic_2	367	373	PF02991	0.510
LIG_LIR_Gen_1	51	59	PF02991	0.699
LIG_LIR_Gen_1	94	101	PF02991	0.528
LIG_LIR_Nem_3	109	114	PF02991	0.615
LIG_LIR_Nem_3	180	185	PF02991	0.636
LIG_LIR_Nem_3	367	372	PF02991	0.739
LIG_LIR_Nem_3	457	462	PF02991	0.654
LIG_LIR_Nem_3	51	55	PF02991	0.711
LIG_LIR_Nem_3	619	625	PF02991	0.736
LIG_LIR_Nem_3	87	92	PF02991	0.576
LIG_MAD2	409	417	PF02301	0.564
LIG_PTB_Apo_2	211	218	PF02174	0.614
LIG_PTB_Apo_2	319	326	PF02174	0.563
LIG_SH2_CRK	133	137	PF00017	0.636
LIG_SH2_CRK	431	435	PF00017	0.797
LIG_SH2_CRK	89	93	PF00017	0.636
LIG_SH2_NCK_1	419	423	PF00017	0.812
LIG_SH2_NCK_1	52	56	PF00017	0.781
LIG_SH2_PTP2	371	374	PF00017	0.752
LIG_SH2_PTP2	394	397	PF00017	0.612
LIG_SH2_SRC	371	374	PF00017	0.752
LIG_SH2_SRC	394	397	PF00017	0.690
LIG_SH2_STAP1	419	423	PF00017	0.812
LIG_SH2_STAP1	52	56	PF00017	0.781
LIG_SH2_STAT5	2	5	PF00017	0.786
LIG_SH2_STAT5	369	372	PF00017	0.751
LIG_SH2_STAT5	394	397	PF00017	0.690
LIG_SH3_3	343	349	PF00018	0.662
LIG_SH3_3	370	376	PF00018	0.640
LIG_SH3_3	408	414	PF00018	0.673
LIG_SH3_3	422	428	PF00018	0.600
LIG_SH3_3	431	437	PF00018	0.658
LIG_SH3_3	444	450	PF00018	0.757
LIG_SH3_3	467	473	PF00018	0.648
LIG_SH3_3	530	536	PF00018	0.685
LIG_SH3_3	56	62	PF00018	0.742
LIG_SH3_3	603	609	PF00018	0.671
LIG_SH3_3	7	13	PF00018	0.685
LIG_SUMO_SIM_par_1	166	171	PF11976	0.636
LIG_TYR_ITSM	365	372	PF00017	0.737
LIG_WRC_WIRS_1	92	97	PF05994	0.636
LIG_WW_1	49	52	PF00397	0.778
MOD_CDK_SPxK_1	24	30	PF00069	0.784
MOD_CK1_1	106	112	PF00069	0.557
MOD_CK1_1	186	192	PF00069	0.608
MOD_CK1_1	295	301	PF00069	0.798
MOD_CK1_1	310	316	PF00069	0.559
MOD_CK1_1	347	353	PF00069	0.759
MOD_CK1_1	39	45	PF00069	0.662
MOD_CK1_1	412	418	PF00069	0.660
MOD_CK1_1	469	475	PF00069	0.771
MOD_CK1_1	555	561	PF00069	0.575
MOD_CK1_1	626	632	PF00069	0.710
MOD_CK1_1	75	81	PF00069	0.636
MOD_CK2_1	113	119	PF00069	0.605
MOD_GlcNHglycan	118	123	PF01048	0.292
MOD_GlcNHglycan	19	22	PF01048	0.723
MOD_GlcNHglycan	305	308	PF01048	0.695
MOD_GlcNHglycan	336	339	PF01048	0.658
MOD_GlcNHglycan	346	349	PF01048	0.666
MOD_GlcNHglycan	387	390	PF01048	0.806
MOD_GlcNHglycan	398	401	PF01048	0.610
MOD_GlcNHglycan	45	48	PF01048	0.807
MOD_GlcNHglycan	456	459	PF01048	0.650
MOD_GlcNHglycan	494	497	PF01048	0.658
MOD_GlcNHglycan	542	545	PF01048	0.779
MOD_GlcNHglycan	572	575	PF01048	0.725
MOD_GlcNHglycan	578	581	PF01048	0.702
MOD_GlcNHglycan	625	628	PF01048	0.703
MOD_GlcNHglycan	74	77	PF01048	0.435
MOD_GSK3_1	177	184	PF00069	0.636
MOD_GSK3_1	203	210	PF00069	0.743
MOD_GSK3_1	266	273	PF00069	0.725
MOD_GSK3_1	295	302	PF00069	0.625
MOD_GSK3_1	30	37	PF00069	0.762
MOD_GSK3_1	303	310	PF00069	0.610
MOD_GSK3_1	312	319	PF00069	0.561
MOD_GSK3_1	330	337	PF00069	0.562
MOD_GSK3_1	338	345	PF00069	0.677
MOD_GSK3_1	347	354	PF00069	0.683
MOD_GSK3_1	39	46	PF00069	0.681
MOD_GSK3_1	454	461	PF00069	0.737
MOD_GSK3_1	465	472	PF00069	0.721
MOD_GSK3_1	521	528	PF00069	0.716
MOD_GSK3_1	536	543	PF00069	0.589
MOD_N-GLC_1	186	191	PF02516	0.435
MOD_N-GLC_1	271	276	PF02516	0.724
MOD_N-GLC_1	39	44	PF02516	0.685
MOD_N-GLC_1	505	510	PF02516	0.826
MOD_N-GLC_1	553	558	PF02516	0.684
MOD_N-GLC_1	623	628	PF02516	0.704
MOD_N-GLC_2	235	237	PF02516	0.633
MOD_NEK2_1	168	173	PF00069	0.626
MOD_NEK2_1	233	238	PF00069	0.624
MOD_NEK2_1	282	287	PF00069	0.589
MOD_NEK2_1	316	321	PF00069	0.720
MOD_NEK2_1	32	37	PF00069	0.726
MOD_NEK2_1	344	349	PF00069	0.784
MOD_NEK2_1	356	361	PF00069	0.643
MOD_OFUCOSY	237	242	PF10250	0.629
MOD_PIKK_1	207	213	PF00454	0.684
MOD_PIKK_1	409	415	PF00454	0.713
MOD_PIKK_1	61	67	PF00454	0.657
MOD_PK_1	135	141	PF00069	0.702
MOD_PK_1	181	187	PF00069	0.636
MOD_PK_1	30	36	PF00069	0.724
MOD_PKA_2	112	118	PF00069	0.521
MOD_Plk_1	186	192	PF00069	0.636
MOD_Plk_1	30	36	PF00069	0.801
MOD_Plk_1	618	624	PF00069	0.697
MOD_Plk_4	537	543	PF00069	0.828
MOD_Plk_4	565	571	PF00069	0.677
MOD_Plk_4	607	613	PF00069	0.711
MOD_Plk_4	88	94	PF00069	0.636
MOD_ProDKin_1	146	152	PF00069	0.684
MOD_ProDKin_1	24	30	PF00069	0.522
MOD_ProDKin_1	292	298	PF00069	0.798
MOD_ProDKin_1	300	306	PF00069	0.740
MOD_ProDKin_1	307	313	PF00069	0.588
MOD_ProDKin_1	351	357	PF00069	0.800
MOD_ProDKin_1	372	378	PF00069	0.656
MOD_ProDKin_1	460	466	PF00069	0.792
MOD_ProDKin_1	469	475	PF00069	0.708
MOD_ProDKin_1	505	511	PF00069	0.762
MOD_ProDKin_1	521	527	PF00069	0.618
MOD_ProDKin_1	544	550	PF00069	0.780
MOD_ProDKin_1	6	12	PF00069	0.744
MOD_ProDKin_1	626	632	PF00069	0.695
MOD_SUMO_for_1	142	145	PF00179	0.612
MOD_SUMO_rev_2	53	62	PF00179	0.757
TRG_ENDOCYTIC_2	369	372	PF00928	0.751
TRG_ENDOCYTIC_2	394	397	PF00928	0.612
TRG_ENDOCYTIC_2	431	434	PF00928	0.805
TRG_ENDOCYTIC_2	52	55	PF00928	0.781
TRG_ENDOCYTIC_2	89	92	PF00928	0.589
TRG_NLS_Bipartite_1	143	160	PF00514	0.630
TRG_NLS_MonoExtC_3	155	160	PF00514	0.596
TRG_NLS_MonoExtN_4	155	160	PF00514	0.596
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IF58	Leishmania donovani	92%	100%
A4HHE7	Leishmania braziliensis	71%	100%
A4I4J0	Leishmania infantum	93%	100%
E9ALT8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%