Aurora kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Aurora kinase

Gene product:

Aurora kinase 2, putative

Species:

Leishmania major

UniProt:

E9ADZ1_LEIMA

TriTrypDb:

LmjF.29.1330 , LMJLV39_290019700 , LMJSD75_290019800

Length:

592

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	4
GO:0005737	cytoplasm	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9ADZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADZ1

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	16
GO:0006793	phosphorus metabolic process	3	16
GO:0006796	phosphate-containing compound metabolic process	4	16
GO:0006807	nitrogen compound metabolic process	2	16
GO:0007165	signal transduction	2	4
GO:0008152	metabolic process	1	16
GO:0009987	cellular process	1	16
GO:0016310	phosphorylation	5	16
GO:0018105	peptidyl-serine phosphorylation	6	3
GO:0018193	peptidyl-amino acid modification	5	3
GO:0018209	peptidyl-serine modification	6	3
GO:0019538	protein metabolic process	3	16
GO:0035556	intracellular signal transduction	3	4
GO:0036211	protein modification process	4	16
GO:0043170	macromolecule metabolic process	3	16
GO:0043412	macromolecule modification	4	16
GO:0044237	cellular metabolic process	2	16
GO:0044238	primary metabolic process	2	16
GO:0046777	protein autophosphorylation	6	3
GO:0050789	regulation of biological process	2	4
GO:0050794	regulation of cellular process	3	4
GO:0065007	biological regulation	1	4
GO:0071704	organic substance metabolic process	2	16
GO:1901564	organonitrogen compound metabolic process	3	16
GO:0000075	cell cycle checkpoint signaling	4	1
GO:0000077	DNA damage checkpoint signaling	5	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0007093	mitotic cell cycle checkpoint signaling	4	1
GO:0007346	regulation of mitotic cell cycle	5	1
GO:0010564	regulation of cell cycle process	5	1
GO:0010948	negative regulation of cell cycle process	6	1
GO:0022402	cell cycle process	2	1
GO:0031570	DNA integrity checkpoint signaling	5	1
GO:0033554	cellular response to stress	3	1
GO:0042770	signal transduction in response to DNA damage	4	1
GO:0044773	mitotic DNA damage checkpoint signaling	6	1
GO:0044774	mitotic DNA integrity checkpoint signaling	5	1
GO:0045786	negative regulation of cell cycle	5	1
GO:0045930	negative regulation of mitotic cell cycle	6	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0051726	regulation of cell cycle	4	1
GO:1901987	regulation of cell cycle phase transition	6	1
GO:1901988	negative regulation of cell cycle phase transition	7	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0003824	catalytic activity	1	16
GO:0004672	protein kinase activity	3	16
GO:0004674	protein serine/threonine kinase activity	4	16
GO:0004683	calmodulin-dependent protein kinase activity	5	3
GO:0005488	binding	1	16
GO:0005515	protein binding	2	3
GO:0005516	calmodulin binding	3	3
GO:0005524	ATP binding	5	16
GO:0009931	calcium-dependent protein serine/threonine kinase activity	5	3
GO:0010857	calcium-dependent protein kinase activity	4	3
GO:0016301	kinase activity	4	16
GO:0016740	transferase activity	2	16
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	16
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	16
GO:0017076	purine nucleotide binding	4	16
GO:0030554	adenyl nucleotide binding	5	16
GO:0032553	ribonucleotide binding	3	16
GO:0032555	purine ribonucleotide binding	4	16
GO:0032559	adenyl ribonucleotide binding	5	16
GO:0035639	purine ribonucleoside triphosphate binding	4	16
GO:0036094	small molecule binding	2	16
GO:0043167	ion binding	2	16
GO:0043168	anion binding	3	16
GO:0097159	organic cyclic compound binding	2	16
GO:0097367	carbohydrate derivative binding	2	16
GO:0106310	protein serine kinase activity	4	5
GO:0140096	catalytic activity, acting on a protein	2	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	431	435	PF00656	0.260
CLV_NRD_NRD_1	264	266	PF00675	0.299
CLV_NRD_NRD_1	457	459	PF00675	0.316
CLV_NRD_NRD_1	589	591	PF00675	0.497
CLV_PCSK_KEX2_1	264	266	PF00082	0.288
CLV_PCSK_KEX2_1	457	459	PF00082	0.316
CLV_PCSK_KEX2_1	86	88	PF00082	0.646
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.605
CLV_PCSK_SKI1_1	387	391	PF00082	0.481
DEG_SPOP_SBC_1	6	10	PF00917	0.549
DOC_CKS1_1	330	335	PF01111	0.413
DOC_CYCLIN_yCln2_LP_2	546	552	PF00134	0.274
DOC_MAPK_gen_1	316	326	PF00069	0.283
DOC_MAPK_gen_1	387	396	PF00069	0.337
DOC_MAPK_MEF2A_6	37	45	PF00069	0.493
DOC_PP1_RVXF_1	296	302	PF00149	0.274
DOC_PP2B_LxvP_1	121	124	PF13499	0.505
DOC_PP4_FxxP_1	330	333	PF00568	0.274
DOC_USP7_MATH_1	124	128	PF00917	0.504
DOC_USP7_MATH_1	158	162	PF00917	0.558
DOC_USP7_MATH_1	193	197	PF00917	0.578
DOC_USP7_MATH_1	228	232	PF00917	0.539
DOC_USP7_MATH_1	4	8	PF00917	0.568
DOC_USP7_MATH_1	416	420	PF00917	0.260
DOC_USP7_MATH_1	436	440	PF00917	0.262
DOC_USP7_MATH_1	536	540	PF00917	0.235
DOC_USP7_MATH_1	55	59	PF00917	0.565
DOC_USP7_MATH_1	71	75	PF00917	0.556
DOC_USP7_MATH_1	90	94	PF00917	0.576
DOC_USP7_UBL2_3	587	591	PF12436	0.476
DOC_WW_Pin1_4	130	135	PF00397	0.550
DOC_WW_Pin1_4	19	24	PF00397	0.588
DOC_WW_Pin1_4	191	196	PF00397	0.590
DOC_WW_Pin1_4	198	203	PF00397	0.559
DOC_WW_Pin1_4	241	246	PF00397	0.679
DOC_WW_Pin1_4	329	334	PF00397	0.332
DOC_WW_Pin1_4	465	470	PF00397	0.332
DOC_WW_Pin1_4	494	499	PF00397	0.313
DOC_WW_Pin1_4	7	12	PF00397	0.566
LIG_14-3-3_CanoR_1	136	146	PF00244	0.583
LIG_14-3-3_CanoR_1	219	225	PF00244	0.606
LIG_14-3-3_CanoR_1	325	330	PF00244	0.281
LIG_14-3-3_CanoR_1	37	42	PF00244	0.515
LIG_14-3-3_CanoR_1	457	461	PF00244	0.288
LIG_14-3-3_CterR_2	590	592	PF00244	0.493
LIG_APCC_ABBA_1	43	48	PF00400	0.487
LIG_APCC_ABBAyCdc20_2	42	48	PF00400	0.490
LIG_BIR_II_1	1	5	PF00653	0.528
LIG_BIR_III_4	397	401	PF00653	0.274
LIG_CtBP_PxDLS_1	516	520	PF00389	0.274
LIG_FHA_1	15	21	PF00498	0.623
LIG_FHA_1	185	191	PF00498	0.607
LIG_FHA_1	367	373	PF00498	0.276
LIG_FHA_1	448	454	PF00498	0.255
LIG_FHA_2	426	432	PF00498	0.356
LIG_FHA_2	442	448	PF00498	0.274
LIG_FHA_2	571	577	PF00498	0.287
LIG_LIR_Apic_2	328	333	PF02991	0.274
LIG_LIR_Apic_2	463	469	PF02991	0.345
LIG_LIR_Gen_1	271	280	PF02991	0.323
LIG_LIR_Nem_3	133	138	PF02991	0.546
LIG_LIR_Nem_3	205	211	PF02991	0.536
LIG_LIR_Nem_3	271	277	PF02991	0.295
LIG_LYPXL_yS_3	208	211	PF13949	0.525
LIG_SH2_CRK	274	278	PF00017	0.288
LIG_SH2_NCK_1	274	278	PF00017	0.274
LIG_SH2_STAP1	327	331	PF00017	0.311
LIG_SH2_STAP1	368	372	PF00017	0.274
LIG_SH2_STAT3	510	513	PF00017	0.255
LIG_SH2_STAT5	329	332	PF00017	0.424
LIG_SH2_STAT5	342	345	PF00017	0.304
LIG_SH2_STAT5	368	371	PF00017	0.368
LIG_SH2_STAT5	466	469	PF00017	0.340
LIG_SH2_STAT5	501	504	PF00017	0.405
LIG_SH3_2	247	252	PF14604	0.526
LIG_SH3_3	152	158	PF00018	0.577
LIG_SH3_3	17	23	PF00018	0.557
LIG_SH3_3	196	202	PF00018	0.562
LIG_SH3_3	243	249	PF00018	0.602
LIG_SH3_3	410	416	PF00018	0.294
LIG_SH3_3	569	575	PF00018	0.311
LIG_SH3_3	65	71	PF00018	0.563
LIG_SUMO_SIM_anti_2	334	341	PF11976	0.255
LIG_SUMO_SIM_par_1	275	281	PF11976	0.274
LIG_SUMO_SIM_par_1	547	553	PF11976	0.273
LIG_TRAF2_1	504	507	PF00917	0.217
LIG_UBA3_1	559	566	PF00899	0.274
LIG_WW_1	498	501	PF00397	0.274
LIG_WW_2	68	71	PF00397	0.522
MOD_CDC14_SPxK_1	133	136	PF00782	0.518
MOD_CDC14_SPxK_1	22	25	PF00782	0.598
MOD_CDK_SPxK_1	130	136	PF00069	0.520
MOD_CDK_SPxK_1	19	25	PF00069	0.600
MOD_CDK_SPxxK_3	245	252	PF00069	0.509
MOD_CK1_1	15	21	PF00069	0.567
MOD_CK1_1	176	182	PF00069	0.568
MOD_CK1_1	194	200	PF00069	0.571
MOD_CK1_1	210	216	PF00069	0.554
MOD_CK1_1	229	235	PF00069	0.701
MOD_CK1_1	241	247	PF00069	0.518
MOD_CK1_1	275	281	PF00069	0.274
MOD_CK1_1	285	291	PF00069	0.233
MOD_CK1_1	344	350	PF00069	0.321
MOD_CK1_1	366	372	PF00069	0.274
MOD_CK1_1	419	425	PF00069	0.264
MOD_CK1_1	478	484	PF00069	0.274
MOD_CK1_1	534	540	PF00069	0.260
MOD_CK1_1	7	13	PF00069	0.566
MOD_CK2_1	435	441	PF00069	0.245
MOD_CK2_1	501	507	PF00069	0.268
MOD_CK2_1	570	576	PF00069	0.287
MOD_Cter_Amidation	455	458	PF01082	0.279
MOD_GlcNHglycan	106	110	PF01048	0.647
MOD_GlcNHglycan	159	163	PF01048	0.567
MOD_GlcNHglycan	165	169	PF01048	0.560
MOD_GlcNHglycan	17	20	PF01048	0.602
MOD_GlcNHglycan	178	181	PF01048	0.561
MOD_GlcNHglycan	196	199	PF01048	0.560
MOD_GlcNHglycan	204	207	PF01048	0.562
MOD_GlcNHglycan	212	215	PF01048	0.505
MOD_GlcNHglycan	226	229	PF01048	0.572
MOD_GlcNHglycan	239	243	PF01048	0.520
MOD_GlcNHglycan	284	287	PF01048	0.301
MOD_GlcNHglycan	343	346	PF01048	0.307
MOD_GlcNHglycan	421	424	PF01048	0.308
MOD_GlcNHglycan	438	441	PF01048	0.252
MOD_GlcNHglycan	472	475	PF01048	0.310
MOD_GlcNHglycan	477	480	PF01048	0.346
MOD_GlcNHglycan	533	536	PF01048	0.267
MOD_GlcNHglycan	538	541	PF01048	0.281
MOD_GlcNHglycan	552	555	PF01048	0.362
MOD_GlcNHglycan	56	60	PF01048	0.531
MOD_GlcNHglycan	567	571	PF01048	0.294
MOD_GlcNHglycan	73	76	PF01048	0.613
MOD_GlcNHglycan	81	86	PF01048	0.529
MOD_GSK3_1	101	108	PF00069	0.570
MOD_GSK3_1	15	22	PF00069	0.637
MOD_GSK3_1	175	182	PF00069	0.574
MOD_GSK3_1	194	201	PF00069	0.601
MOD_GSK3_1	220	227	PF00069	0.545
MOD_GSK3_1	234	241	PF00069	0.549
MOD_GSK3_1	278	285	PF00069	0.283
MOD_GSK3_1	325	332	PF00069	0.274
MOD_GSK3_1	456	463	PF00069	0.332
MOD_GSK3_1	478	485	PF00069	0.441
MOD_GSK3_1	501	508	PF00069	0.481
MOD_GSK3_1	531	538	PF00069	0.236
MOD_GSK3_1	566	573	PF00069	0.347
MOD_LATS_1	181	187	PF00433	0.563
MOD_LATS_1	35	41	PF00433	0.530
MOD_N-GLC_1	442	447	PF02516	0.257
MOD_N-GLC_1	517	522	PF02516	0.301
MOD_NEK2_1	12	17	PF00069	0.647
MOD_NEK2_1	137	142	PF00069	0.518
MOD_NEK2_1	175	180	PF00069	0.566
MOD_NEK2_1	204	209	PF00069	0.573
MOD_NEK2_1	314	319	PF00069	0.425
MOD_NEK2_1	407	412	PF00069	0.387
MOD_NEK2_1	531	536	PF00069	0.310
MOD_PIKK_1	502	508	PF00454	0.257
MOD_PIKK_1	60	66	PF00454	0.562
MOD_PK_1	47	53	PF00069	0.450
MOD_PKA_2	282	288	PF00069	0.344
MOD_PKA_2	358	364	PF00069	0.274
MOD_PKA_2	366	372	PF00069	0.225
MOD_PKA_2	456	462	PF00069	0.297
MOD_PKA_2	570	576	PF00069	0.310
MOD_Plk_1	100	106	PF00069	0.553
MOD_Plk_1	294	300	PF00069	0.334
MOD_Plk_2-3	101	107	PF00069	0.522
MOD_Plk_4	109	115	PF00069	0.494
MOD_Plk_4	207	213	PF00069	0.563
MOD_Plk_4	272	278	PF00069	0.310
MOD_Plk_4	325	331	PF00069	0.314
MOD_Plk_4	344	350	PF00069	0.337
MOD_Plk_4	505	511	PF00069	0.329
MOD_Plk_4	555	561	PF00069	0.368
MOD_ProDKin_1	130	136	PF00069	0.549
MOD_ProDKin_1	19	25	PF00069	0.589
MOD_ProDKin_1	191	197	PF00069	0.590
MOD_ProDKin_1	198	204	PF00069	0.560
MOD_ProDKin_1	241	247	PF00069	0.680
MOD_ProDKin_1	329	335	PF00069	0.332
MOD_ProDKin_1	465	471	PF00069	0.332
MOD_ProDKin_1	494	500	PF00069	0.313
MOD_ProDKin_1	7	13	PF00069	0.568
MOD_SUMO_for_1	389	392	PF00179	0.457
TRG_DiLeu_BaLyEn_6	116	121	PF01217	0.589
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.569
TRG_ENDOCYTIC_2	208	211	PF00928	0.525
TRG_ENDOCYTIC_2	274	277	PF00928	0.288
TRG_ENDOCYTIC_2	327	330	PF00928	0.375
TRG_ER_diArg_1	263	265	PF00400	0.281
TRG_ER_diArg_1	296	299	PF00400	0.322
TRG_ER_diArg_1	41	44	PF00400	0.514
TRG_Pf-PMV_PEXEL_1	302	307	PF00026	0.323
TRG_Pf-PMV_PEXEL_1	387	392	PF00026	0.272

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H5G0	Leishmania donovani	27%	100%
A0A3S7X2F1	Leishmania donovani	92%	100%
A4H459	Leishmania braziliensis	26%	100%
A4HHE4	Leishmania braziliensis	74%	100%
A4HSE2	Leishmania infantum	27%	100%
A4IB02	Leishmania infantum	26%	100%
E9AET0	Leishmania major	27%	100%
E9AHI7	Leishmania infantum	92%	100%
E9AKB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9ALU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
E9B5Y5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4QAV8	Leishmania major	27%	100%
Q4QJJ0	Leishmania major	26%	100%
V5BFI8	Trypanosoma cruzi	25%	100%