TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Hsp70 protein/TPR repeat, putative

Species:

Leishmania major

UniProt:

E9ADY2_LEIMA

TriTrypDb:

LmjF.29.1240 , LMJLV39_290018800 , LMJSD75_290018900

Length:

722

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	yes	yes: 3
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9ADY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADY2

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	2
GO:0006457	protein folding	2	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018208	peptidyl-proline modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0061077	chaperone-mediated protein folding	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	2
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016853	isomerase activity	2	2
GO:0016859	cis-trans isomerase activity	3	2
GO:0017076	purine nucleotide binding	4	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0044183	protein folding chaperone	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:0140096	catalytic activity, acting on a protein	2	2
GO:0140657	ATP-dependent activity	1	9
GO:0140662	ATP-dependent protein folding chaperone	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.328
CLV_C14_Caspase3-7	421	425	PF00656	0.604
CLV_C14_Caspase3-7	452	456	PF00656	0.512
CLV_C14_Caspase3-7	497	501	PF00656	0.390
CLV_NRD_NRD_1	258	260	PF00675	0.382
CLV_NRD_NRD_1	265	267	PF00675	0.338
CLV_NRD_NRD_1	545	547	PF00675	0.490
CLV_NRD_NRD_1	578	580	PF00675	0.465
CLV_NRD_NRD_1	664	666	PF00675	0.343
CLV_PCSK_KEX2_1	545	547	PF00082	0.506
CLV_PCSK_KEX2_1	577	579	PF00082	0.513
CLV_PCSK_KEX2_1	620	622	PF00082	0.474
CLV_PCSK_KEX2_1	664	666	PF00082	0.377
CLV_PCSK_PC1ET2_1	545	547	PF00082	0.506
CLV_PCSK_PC1ET2_1	577	579	PF00082	0.565
CLV_PCSK_PC1ET2_1	620	622	PF00082	0.473
CLV_PCSK_PC7_1	541	547	PF00082	0.546
CLV_PCSK_PC7_1	573	579	PF00082	0.548
CLV_PCSK_SKI1_1	112	116	PF00082	0.336
CLV_PCSK_SKI1_1	12	16	PF00082	0.418
CLV_PCSK_SKI1_1	146	150	PF00082	0.454
CLV_PCSK_SKI1_1	259	263	PF00082	0.384
CLV_PCSK_SKI1_1	266	270	PF00082	0.347
CLV_PCSK_SKI1_1	312	316	PF00082	0.366
CLV_PCSK_SKI1_1	358	362	PF00082	0.330
CLV_PCSK_SKI1_1	387	391	PF00082	0.522
CLV_PCSK_SKI1_1	41	45	PF00082	0.359
CLV_PCSK_SKI1_1	439	443	PF00082	0.466
CLV_PCSK_SKI1_1	660	664	PF00082	0.340
CLV_PCSK_SKI1_1	703	707	PF00082	0.507
CLV_PCSK_SKI1_1	714	718	PF00082	0.503
DEG_APCC_DBOX_1	311	319	PF00400	0.418
DEG_Nend_UBRbox_2	1	3	PF02207	0.505
DEG_SPOP_SBC_1	271	275	PF00917	0.424
DOC_ANK_TNKS_1	339	346	PF00023	0.418
DOC_CYCLIN_yCln2_LP_2	100	106	PF00134	0.400
DOC_MAPK_gen_1	545	554	PF00069	0.524
DOC_MAPK_gen_1	617	625	PF00069	0.464
DOC_MAPK_MEF2A_6	125	133	PF00069	0.400
DOC_MAPK_MEF2A_6	68	76	PF00069	0.400
DOC_PP2B_LxvP_1	131	134	PF13499	0.418
DOC_PP2B_LxvP_1	322	325	PF13499	0.304
DOC_USP7_MATH_1	132	136	PF00917	0.393
DOC_USP7_MATH_1	323	327	PF00917	0.257
DOC_USP7_MATH_1	377	381	PF00917	0.418
DOC_USP7_MATH_1	483	487	PF00917	0.643
DOC_USP7_MATH_1	632	636	PF00917	0.450
DOC_USP7_UBL2_3	256	260	PF12436	0.359
DOC_USP7_UBL2_3	710	714	PF12436	0.477
DOC_USP7_UBL2_3	715	719	PF12436	0.568
DOC_WW_Pin1_4	124	129	PF00397	0.422
DOC_WW_Pin1_4	424	429	PF00397	0.541
DOC_WW_Pin1_4	75	80	PF00397	0.418
LIG_14-3-3_CanoR_1	146	151	PF00244	0.328
LIG_14-3-3_CanoR_1	312	322	PF00244	0.366
LIG_14-3-3_CanoR_1	365	371	PF00244	0.351
LIG_14-3-3_CanoR_1	431	438	PF00244	0.560
LIG_14-3-3_CanoR_1	439	447	PF00244	0.620
LIG_Actin_WH2_2	209	224	PF00022	0.418
LIG_Clathr_ClatBox_1	417	421	PF01394	0.496
LIG_deltaCOP1_diTrp_1	588	598	PF00928	0.471
LIG_EH1_1	108	116	PF00400	0.396
LIG_FHA_1	124	130	PF00498	0.446
LIG_FHA_1	18	24	PF00498	0.420
LIG_FHA_1	440	446	PF00498	0.453
LIG_FHA_1	594	600	PF00498	0.428
LIG_FHA_1	647	653	PF00498	0.479
LIG_FHA_1	82	88	PF00498	0.473
LIG_FHA_2	272	278	PF00498	0.378
LIG_FHA_2	47	53	PF00498	0.362
LIG_FHA_2	59	65	PF00498	0.364
LIG_FHA_2	609	615	PF00498	0.517
LIG_FHA_2	678	684	PF00498	0.267
LIG_Integrin_RGD_1	252	254	PF01839	0.418
LIG_LIR_Gen_1	141	150	PF02991	0.427
LIG_LIR_Gen_1	234	244	PF02991	0.396
LIG_LIR_Gen_1	442	451	PF02991	0.593
LIG_LIR_Gen_1	527	537	PF02991	0.578
LIG_LIR_Gen_1	626	636	PF02991	0.454
LIG_LIR_Nem_3	141	145	PF02991	0.427
LIG_LIR_Nem_3	234	240	PF02991	0.418
LIG_LIR_Nem_3	257	261	PF02991	0.382
LIG_LIR_Nem_3	442	447	PF02991	0.600
LIG_LIR_Nem_3	527	533	PF02991	0.472
LIG_LIR_Nem_3	534	540	PF02991	0.479
LIG_LIR_Nem_3	626	631	PF02991	0.458
LIG_Pex14_1	56	60	PF04695	0.418
LIG_Pex14_2	717	721	PF04695	0.522
LIG_Rb_pABgroove_1	603	611	PF01858	0.499
LIG_RPA_C_Fungi	462	474	PF08784	0.430
LIG_RPA_C_Fungi	660	672	PF08784	0.418
LIG_SH2_CRK	177	181	PF00017	0.418
LIG_SH2_CRK	669	673	PF00017	0.400
LIG_SH2_GRB2like	628	631	PF00017	0.456
LIG_SH2_SRC	227	230	PF00017	0.328
LIG_SH2_SRC	628	631	PF00017	0.456
LIG_SH2_SRC	675	678	PF00017	0.352
LIG_SH2_STAP1	138	142	PF00017	0.256
LIG_SH2_STAP1	675	679	PF00017	0.352
LIG_SH2_STAT3	471	474	PF00017	0.437
LIG_SH2_STAT5	110	113	PF00017	0.383
LIG_SH2_STAT5	171	174	PF00017	0.453
LIG_SH2_STAT5	227	230	PF00017	0.378
LIG_SH2_STAT5	471	474	PF00017	0.437
LIG_SH2_STAT5	495	498	PF00017	0.551
LIG_SH2_STAT5	502	505	PF00017	0.581
LIG_SH2_STAT5	60	63	PF00017	0.418
LIG_SH2_STAT5	628	631	PF00017	0.456
LIG_SH3_3	653	659	PF00018	0.487
LIG_SH3_3	73	79	PF00018	0.419
LIG_SUMO_SIM_anti_2	288	294	PF11976	0.418
LIG_SUMO_SIM_par_1	189	195	PF11976	0.356
LIG_SUMO_SIM_par_1	290	296	PF11976	0.400
LIG_SUMO_SIM_par_1	691	698	PF11976	0.368
LIG_TRAF2_1	612	615	PF00917	0.592
LIG_TYR_ITIM	175	180	PF00017	0.400
LIG_UBA3_1	114	121	PF00899	0.352
LIG_UBA3_1	314	321	PF00899	0.412
LIG_WRC_WIRS_1	23	28	PF05994	0.418
LIG_WRC_WIRS_1	255	260	PF05994	0.418
LIG_WW_3	337	341	PF00397	0.352
MOD_CDK_SPxxK_3	424	431	PF00069	0.473
MOD_CK1_1	201	207	PF00069	0.454
MOD_CK1_1	78	84	PF00069	0.491
MOD_CK2_1	271	277	PF00069	0.363
MOD_CK2_1	30	36	PF00069	0.446
MOD_CK2_1	323	329	PF00069	0.301
MOD_CK2_1	372	378	PF00069	0.487
MOD_CK2_1	405	411	PF00069	0.716
MOD_CK2_1	508	514	PF00069	0.518
MOD_CK2_1	528	534	PF00069	0.468
MOD_CK2_1	58	64	PF00069	0.418
MOD_CK2_1	608	614	PF00069	0.591
MOD_CK2_1	677	683	PF00069	0.314
MOD_Cter_Amidation	240	243	PF01082	0.352
MOD_GlcNHglycan	134	137	PF01048	0.391
MOD_GlcNHglycan	177	180	PF01048	0.310
MOD_GlcNHglycan	285	288	PF01048	0.434
MOD_GlcNHglycan	325	328	PF01048	0.350
MOD_GlcNHglycan	378	382	PF01048	0.387
MOD_GlcNHglycan	61	64	PF01048	0.400
MOD_GlcNHglycan	669	672	PF01048	0.368
MOD_GSK3_1	161	168	PF00069	0.475
MOD_GSK3_1	18	25	PF00069	0.429
MOD_GSK3_1	231	238	PF00069	0.392
MOD_GSK3_1	271	278	PF00069	0.349
MOD_GSK3_1	325	332	PF00069	0.347
MOD_GSK3_1	397	404	PF00069	0.739
MOD_GSK3_1	483	490	PF00069	0.485
MOD_GSK3_1	524	531	PF00069	0.595
MOD_GSK3_1	560	567	PF00069	0.702
MOD_N-GLC_1	372	377	PF02516	0.400
MOD_N-GLC_1	615	620	PF02516	0.539
MOD_N-GLC_1	646	651	PF02516	0.499
MOD_N-GLC_2	646	648	PF02516	0.498
MOD_NEK2_1	123	128	PF00069	0.414
MOD_NEK2_1	175	180	PF00069	0.335
MOD_NEK2_1	231	236	PF00069	0.418
MOD_NEK2_1	361	366	PF00069	0.371
MOD_NEK2_1	58	63	PF00069	0.418
MOD_NEK2_1	608	613	PF00069	0.555
MOD_NEK2_2	536	541	PF00069	0.529
MOD_NEK2_2	632	637	PF00069	0.462
MOD_OFUCOSY	627	634	PF10250	0.391
MOD_PIKK_1	206	212	PF00454	0.407
MOD_PIKK_1	275	281	PF00454	0.352
MOD_PIKK_1	329	335	PF00454	0.352
MOD_PIKK_1	686	692	PF00454	0.608
MOD_Plk_1	156	162	PF00069	0.403
MOD_Plk_1	165	171	PF00069	0.338
MOD_Plk_1	275	281	PF00069	0.418
MOD_Plk_1	372	378	PF00069	0.502
MOD_Plk_1	508	514	PF00069	0.409
MOD_Plk_1	621	627	PF00069	0.492
MOD_Plk_2-3	30	36	PF00069	0.400
MOD_Plk_2-3	509	515	PF00069	0.376
MOD_Plk_2-3	528	534	PF00069	0.532
MOD_Plk_2-3	610	616	PF00069	0.552
MOD_Plk_2-3	677	683	PF00069	0.267
MOD_Plk_4	110	116	PF00069	0.400
MOD_Plk_4	146	152	PF00069	0.480
MOD_Plk_4	156	162	PF00069	0.429
MOD_Plk_4	19	25	PF00069	0.444
MOD_Plk_4	201	207	PF00069	0.363
MOD_Plk_4	46	52	PF00069	0.418
MOD_Plk_4	467	473	PF00069	0.428
MOD_Plk_4	6	12	PF00069	0.411
MOD_Plk_4	600	606	PF00069	0.456
MOD_ProDKin_1	124	130	PF00069	0.422
MOD_ProDKin_1	424	430	PF00069	0.534
MOD_ProDKin_1	75	81	PF00069	0.418
MOD_SUMO_rev_2	249	258	PF00179	0.461
MOD_SUMO_rev_2	485	490	PF00179	0.513
MOD_SUMO_rev_2	560	567	PF00179	0.632
MOD_SUMO_rev_2	610	618	PF00179	0.526
TRG_DiLeu_BaEn_4	549	555	PF01217	0.563
TRG_ENDOCYTIC_2	177	180	PF00928	0.418
TRG_ENDOCYTIC_2	237	240	PF00928	0.418
TRG_ENDOCYTIC_2	537	540	PF00928	0.566
TRG_ENDOCYTIC_2	628	631	PF00928	0.456
TRG_ENDOCYTIC_2	669	672	PF00928	0.400
TRG_ER_diArg_1	571	574	PF00400	0.567
TRG_ER_diArg_1	663	665	PF00400	0.377
TRG_ER_FFAT_1	670	681	PF00635	0.418
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.359
TRG_Pf-PMV_PEXEL_1	431	435	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	92	97	PF00026	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6E2	Leptomonas seymouri	71%	93%
A0A0S4JRE7	Bodo saltans	41%	100%
A0A3S7X2D2	Leishmania donovani	94%	100%
A4HHD6	Leishmania braziliensis	85%	100%
A4I4I1	Leishmania infantum	94%	100%
E9ALU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BI61	Trypanosoma cruzi	24%	100%