Splicing factor YJU2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Family of unknown function (DUF572), putative

Species:

Leishmania major

UniProt:

E9ADY0_LEIMA

TriTrypDb:

LmjF.29.1220 , LMJLV39_290018600 , LMJSD75_290018700

Length:

477

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005681	spliceosomal complex	3	2
GO:0005684	U2-type spliceosomal complex	4	2
GO:0005737	cytoplasm	2	2
GO:0032991	protein-containing complex	1	2
GO:0071006	U2-type catalytic step 1 spliceosome	4	2
GO:0071012	catalytic step 1 spliceosome	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

E9ADY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADY0

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	7
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	7
GO:0000398	mRNA splicing, via spliceosome	8	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006397	mRNA processing	7	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0008380	RNA splicing	7	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0016071	mRNA metabolic process	6	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	387	391	PF00656	0.694
CLV_C14_Caspase3-7	394	398	PF00656	0.771
CLV_NRD_NRD_1	20	22	PF00675	0.411
CLV_NRD_NRD_1	203	205	PF00675	0.381
CLV_NRD_NRD_1	286	288	PF00675	0.411
CLV_NRD_NRD_1	321	323	PF00675	0.386
CLV_NRD_NRD_1	331	333	PF00675	0.396
CLV_NRD_NRD_1	34	36	PF00675	0.411
CLV_NRD_NRD_1	455	457	PF00675	0.792
CLV_NRD_NRD_1	464	466	PF00675	0.695
CLV_NRD_NRD_1	66	68	PF00675	0.411
CLV_NRD_NRD_1	78	80	PF00675	0.411
CLV_PCSK_FUR_1	201	205	PF00082	0.381
CLV_PCSK_FUR_1	32	36	PF00082	0.411
CLV_PCSK_KEX2_1	127	129	PF00082	0.372
CLV_PCSK_KEX2_1	203	205	PF00082	0.381
CLV_PCSK_KEX2_1	286	288	PF00082	0.411
CLV_PCSK_KEX2_1	321	323	PF00082	0.409
CLV_PCSK_KEX2_1	331	333	PF00082	0.416
CLV_PCSK_KEX2_1	34	36	PF00082	0.411
CLV_PCSK_KEX2_1	464	466	PF00082	0.768
CLV_PCSK_KEX2_1	49	51	PF00082	0.411
CLV_PCSK_KEX2_1	66	68	PF00082	0.411
CLV_PCSK_KEX2_1	78	80	PF00082	0.411
CLV_PCSK_KEX2_1	83	85	PF00082	0.411
CLV_PCSK_PC1ET2_1	127	129	PF00082	0.385
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.411
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.411
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.513
CLV_PCSK_PC7_1	199	205	PF00082	0.363
CLV_PCSK_PC7_1	79	85	PF00082	0.513
CLV_PCSK_SKI1_1	321	325	PF00082	0.411
CLV_PCSK_SKI1_1	78	82	PF00082	0.375
DEG_SCF_FBW7_1	111	117	PF00400	0.411
DEG_SCF_FBW7_1	360	365	PF00400	0.705
DEG_SPOP_SBC_1	227	231	PF00917	0.513
DEG_SPOP_SBC_1	239	243	PF00917	0.183
DEG_SPOP_SBC_1	309	313	PF00917	0.280
DEG_SPOP_SBC_1	362	366	PF00917	0.728
DOC_CKS1_1	111	116	PF01111	0.411
DOC_CYCLIN_yCln2_LP_2	351	357	PF00134	0.397
DOC_MAPK_gen_1	405	412	PF00069	0.560
DOC_MAPK_gen_1	49	57	PF00069	0.411
DOC_MAPK_gen_1	83	91	PF00069	0.513
DOC_PP2B_LxvP_1	351	354	PF13499	0.397
DOC_PP4_FxxP_1	247	250	PF00568	0.411
DOC_PP4_FxxP_1	442	445	PF00568	0.809
DOC_PP4_FxxP_1	53	56	PF00568	0.367
DOC_USP7_MATH_1	218	222	PF00917	0.496
DOC_USP7_MATH_1	240	244	PF00917	0.436
DOC_USP7_MATH_1	355	359	PF00917	0.411
DOC_USP7_MATH_1	372	376	PF00917	0.710
DOC_USP7_MATH_1	398	402	PF00917	0.769
DOC_USP7_MATH_1	446	450	PF00917	0.716
DOC_USP7_MATH_1	69	73	PF00917	0.353
DOC_USP7_UBL2_3	374	378	PF12436	0.702
DOC_WW_Pin1_4	110	115	PF00397	0.411
DOC_WW_Pin1_4	235	240	PF00397	0.471
DOC_WW_Pin1_4	310	315	PF00397	0.280
DOC_WW_Pin1_4	358	363	PF00397	0.765
LIG_14-3-3_CanoR_1	286	292	PF00244	0.474
LIG_14-3-3_CanoR_1	421	428	PF00244	0.736
LIG_14-3-3_CanoR_1	50	54	PF00244	0.390
LIG_14-3-3_CanoR_1	78	86	PF00244	0.375
LIG_BIR_II_1	1	5	PF00653	0.624
LIG_BRCT_BRCA1_1	243	247	PF00533	0.513
LIG_FHA_1	337	343	PF00498	0.459
LIG_FHA_1	421	427	PF00498	0.742
LIG_FHA_1	50	56	PF00498	0.353
LIG_FHA_2	107	113	PF00498	0.411
LIG_FHA_2	229	235	PF00498	0.513
LIG_FHA_2	305	311	PF00498	0.319
LIG_LIR_Apic_2	10	16	PF02991	0.355
LIG_LIR_Apic_2	244	250	PF02991	0.513
LIG_LIR_Apic_2	440	445	PF02991	0.805
LIG_LIR_Apic_2	52	56	PF02991	0.411
LIG_LIR_Nem_3	130	136	PF02991	0.411
LIG_LIR_Nem_3	17	23	PF02991	0.411
LIG_LIR_Nem_3	274	280	PF02991	0.411
LIG_LIR_Nem_3	285	291	PF02991	0.411
LIG_PCNA_yPIPBox_3	317	331	PF02747	0.261
LIG_Pex14_2	53	57	PF04695	0.411
LIG_SH2_GRB2like	75	78	PF00017	0.411
LIG_SH2_PTP2	13	16	PF00017	0.411
LIG_SH2_SRC	85	88	PF00017	0.375
LIG_SH2_STAT5	106	109	PF00017	0.416
LIG_SH2_STAT5	120	123	PF00017	0.411
LIG_SH2_STAT5	13	16	PF00017	0.411
LIG_SH2_STAT5	85	88	PF00017	0.411
LIG_SH3_1	108	114	PF00018	0.411
LIG_SH3_2	451	456	PF14604	0.690
LIG_SH3_3	108	114	PF00018	0.411
LIG_SH3_3	342	348	PF00018	0.311
LIG_SH3_3	403	409	PF00018	0.808
LIG_SH3_3	448	454	PF00018	0.762
LIG_SH3_CIN85_PxpxPR_1	451	456	PF14604	0.768
LIG_SUMO_SIM_anti_2	399	404	PF11976	0.576
LIG_SUMO_SIM_anti_2	93	98	PF11976	0.411
LIG_TRAF2_1	143	146	PF00917	0.407
LIG_TRAF2_1	182	185	PF00917	0.513
LIG_WW_3	453	457	PF00397	0.686
MOD_CDK_SPK_2	110	115	PF00069	0.411
MOD_CK1_1	221	227	PF00069	0.468
MOD_CK1_1	238	244	PF00069	0.315
MOD_CK1_1	358	364	PF00069	0.775
MOD_CK1_1	401	407	PF00069	0.777
MOD_CK1_1	424	430	PF00069	0.699
MOD_CK2_1	106	112	PF00069	0.411
MOD_CK2_1	228	234	PF00069	0.513
MOD_CK2_1	261	267	PF00069	0.449
MOD_CK2_1	304	310	PF00069	0.397
MOD_Cter_Amidation	32	35	PF01082	0.411
MOD_GlcNHglycan	219	223	PF01048	0.429
MOD_GlcNHglycan	263	266	PF01048	0.482
MOD_GlcNHglycan	355	358	PF01048	0.490
MOD_GlcNHglycan	365	368	PF01048	0.673
MOD_GlcNHglycan	423	426	PF01048	0.759
MOD_GlcNHglycan	9	12	PF01048	0.559
MOD_GSK3_1	106	113	PF00069	0.411
MOD_GSK3_1	193	200	PF00069	0.411
MOD_GSK3_1	234	241	PF00069	0.378
MOD_GSK3_1	304	311	PF00069	0.397
MOD_GSK3_1	334	341	PF00069	0.312
MOD_GSK3_1	358	365	PF00069	0.777
MOD_GSK3_1	420	427	PF00069	0.777
MOD_N-GLC_1	4	9	PF02516	0.583
MOD_NEK2_1	100	105	PF00069	0.280
MOD_NEK2_1	197	202	PF00069	0.411
MOD_NEK2_2	85	90	PF00069	0.402
MOD_PIKK_1	446	452	PF00454	0.828
MOD_PK_1	373	379	PF00069	0.706
MOD_PKA_1	373	379	PF00069	0.706
MOD_PKA_1	49	55	PF00069	0.411
MOD_PKA_1	78	84	PF00069	0.402
MOD_PKA_2	202	208	PF00069	0.436
MOD_PKA_2	420	426	PF00069	0.657
MOD_PKA_2	49	55	PF00069	0.390
MOD_PKA_2	69	75	PF00069	0.378
MOD_PKA_2	78	84	PF00069	0.318
MOD_Plk_1	398	404	PF00069	0.733
MOD_Plk_1	4	10	PF00069	0.584
MOD_Plk_4	193	199	PF00069	0.411
MOD_Plk_4	338	344	PF00069	0.397
MOD_Plk_4	398	404	PF00069	0.756
MOD_Plk_4	458	464	PF00069	0.723
MOD_ProDKin_1	110	116	PF00069	0.411
MOD_ProDKin_1	235	241	PF00069	0.471
MOD_ProDKin_1	310	316	PF00069	0.280
MOD_ProDKin_1	358	364	PF00069	0.767
MOD_SUMO_for_1	150	153	PF00179	0.411
TRG_ER_diArg_1	198	201	PF00400	0.397
TRG_ER_diArg_1	202	204	PF00400	0.411
TRG_ER_diArg_1	286	288	PF00400	0.411
TRG_ER_diArg_1	320	322	PF00400	0.386
TRG_ER_diArg_1	331	333	PF00400	0.397
TRG_ER_diArg_1	463	465	PF00400	0.720
TRG_ER_diArg_1	66	68	PF00400	0.411
TRG_NLS_Bipartite_1	21	38	PF00514	0.411
TRG_NLS_MonoExtN_4	32	38	PF00514	0.411
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	289	294	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	464	468	PF00026	0.715

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY11	Leptomonas seymouri	55%	100%
A0A3Q8IF48	Leishmania donovani	90%	100%
A4HHD4	Leishmania braziliensis	75%	100%
A4I4H9	Leishmania infantum	90%	100%
E9ALV1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%