Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADX9_LEIMA

TriTrypDb:

LmjF.29.1210 , LMJLV39_290018500 , LMJSD75_290018600

Length:

379

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ADX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADX9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.516
CLV_NRD_NRD_1	142	144	PF00675	0.489
CLV_NRD_NRD_1	285	287	PF00675	0.634
CLV_NRD_NRD_1	352	354	PF00675	0.644
CLV_PCSK_KEX2_1	142	144	PF00082	0.537
CLV_PCSK_KEX2_1	183	185	PF00082	0.494
CLV_PCSK_KEX2_1	284	286	PF00082	0.632
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.494
CLV_PCSK_SKI1_1	189	193	PF00082	0.467
CLV_PCSK_SKI1_1	303	307	PF00082	0.578
CLV_Separin_Metazoa	281	285	PF03568	0.634
DEG_MDM2_SWIB_1	118	126	PF02201	0.530
DEG_MDM2_SWIB_1	365	372	PF02201	0.576
DOC_CKS1_1	252	257	PF01111	0.594
DOC_CYCLIN_yCln2_LP_2	257	260	PF00134	0.652
DOC_MAPK_FxFP_2	191	194	PF00069	0.403
DOC_MAPK_gen_1	142	150	PF00069	0.456
DOC_MAPK_gen_1	183	190	PF00069	0.352
DOC_MAPK_gen_1	334	343	PF00069	0.532
DOC_MAPK_gen_1	9	19	PF00069	0.490
DOC_MAPK_HePTP_8	140	152	PF00069	0.512
DOC_MAPK_MEF2A_6	142	150	PF00069	0.399
DOC_MAPK_MEF2A_6	9	17	PF00069	0.490
DOC_PP2B_LxvP_1	257	260	PF13499	0.663
DOC_PP2B_LxvP_1	370	373	PF13499	0.562
DOC_PP4_FxxP_1	191	194	PF00568	0.403
DOC_USP7_MATH_1	155	159	PF00917	0.648
DOC_USP7_MATH_1	204	208	PF00917	0.695
DOC_USP7_MATH_1	223	227	PF00917	0.696
DOC_USP7_MATH_1	69	73	PF00917	0.726
DOC_WW_Pin1_4	158	163	PF00397	0.590
DOC_WW_Pin1_4	22	27	PF00397	0.479
DOC_WW_Pin1_4	251	256	PF00397	0.668
DOC_WW_Pin1_4	71	76	PF00397	0.657
LIG_14-3-3_CanoR_1	12	16	PF00244	0.497
LIG_14-3-3_CanoR_1	160	170	PF00244	0.605
LIG_14-3-3_CanoR_1	189	194	PF00244	0.453
LIG_14-3-3_CanoR_1	216	222	PF00244	0.740
LIG_APCC_ABBA_1	13	18	PF00400	0.381
LIG_APCC_ABBAyCdc20_2	12	18	PF00400	0.492
LIG_BIR_II_1	1	5	PF00653	0.598
LIG_Clathr_ClatBox_1	54	58	PF01394	0.508
LIG_CSL_BTD_1	252	255	PF09270	0.585
LIG_CtBP_PxDLS_1	194	198	PF00389	0.490
LIG_eIF4E_1	300	306	PF01652	0.579
LIG_EVH1_1	258	262	PF00568	0.636
LIG_EVH1_2	261	265	PF00568	0.608
LIG_FHA_1	107	113	PF00498	0.643
LIG_FHA_1	12	18	PF00498	0.459
LIG_FHA_1	135	141	PF00498	0.532
LIG_FHA_1	252	258	PF00498	0.648
LIG_FHA_1	49	55	PF00498	0.423
LIG_FHA_1	91	97	PF00498	0.531
LIG_FHA_2	177	183	PF00498	0.535
LIG_FHA_2	23	29	PF00498	0.711
LIG_FHA_2	366	372	PF00498	0.705
LIG_FHA_2	79	85	PF00498	0.661
LIG_Integrin_RGD_1	30	32	PF01839	0.541
LIG_LIR_Gen_1	168	178	PF02991	0.551
LIG_LIR_Gen_1	366	377	PF02991	0.638
LIG_LIR_Gen_1	8	17	PF02991	0.496
LIG_LIR_LC3C_4	51	56	PF02991	0.452
LIG_LIR_Nem_3	14	19	PF02991	0.431
LIG_LIR_Nem_3	168	174	PF02991	0.499
LIG_LIR_Nem_3	366	372	PF02991	0.589
LIG_LIR_Nem_3	8	13	PF02991	0.506
LIG_MYND_1	255	259	PF01753	0.575
LIG_MYND_1	71	75	PF01753	0.686
LIG_Pex14_2	118	122	PF04695	0.566
LIG_Pex14_2	365	369	PF04695	0.562
LIG_SH2_CRK	171	175	PF00017	0.556
LIG_SH2_GRB2like	300	303	PF00017	0.498
LIG_SH2_NCK_1	171	175	PF00017	0.549
LIG_SH2_NCK_1	217	221	PF00017	0.631
LIG_SH2_PTP2	16	19	PF00017	0.480
LIG_SH2_SRC	16	19	PF00017	0.427
LIG_SH2_STAP1	108	112	PF00017	0.647
LIG_SH2_STAT5	108	111	PF00017	0.599
LIG_SH2_STAT5	16	19	PF00017	0.465
LIG_SH2_STAT5	171	174	PF00017	0.464
LIG_SH2_STAT5	200	203	PF00017	0.613
LIG_SH3_1	285	291	PF00018	0.623
LIG_SH3_2	259	264	PF14604	0.617
LIG_SH3_3	198	204	PF00018	0.655
LIG_SH3_3	246	252	PF00018	0.616
LIG_SH3_3	256	262	PF00018	0.383
LIG_SH3_3	285	291	PF00018	0.623
LIG_SUMO_SIM_par_1	53	59	PF11976	0.513
LIG_TRAF2_1	165	168	PF00917	0.627
LIG_TRAF2_1	178	181	PF00917	0.476
LIG_TRAF2_1	25	28	PF00917	0.622
LIG_TRAF2_1	64	67	PF00917	0.567
LIG_TYR_ITIM	169	174	PF00017	0.539
LIG_TYR_ITSM	12	19	PF00017	0.479
LIG_WW_1	214	217	PF00397	0.538
LIG_WW_3	213	217	PF00397	0.537
MOD_CDK_SPK_2	158	163	PF00069	0.549
MOD_CK1_1	128	134	PF00069	0.474
MOD_CK1_1	158	164	PF00069	0.596
MOD_CK1_1	176	182	PF00069	0.523
MOD_CK1_1	2	8	PF00069	0.516
MOD_CK1_1	224	230	PF00069	0.692
MOD_CK1_1	61	67	PF00069	0.542
MOD_CK1_1	83	89	PF00069	0.644
MOD_CK2_1	161	167	PF00069	0.618
MOD_CK2_1	176	182	PF00069	0.394
MOD_CK2_1	2	8	PF00069	0.573
MOD_CK2_1	22	28	PF00069	0.715
MOD_CK2_1	61	67	PF00069	0.643
MOD_CK2_1	78	84	PF00069	0.498
MOD_GlcNHglycan	1	4	PF01048	0.584
MOD_GlcNHglycan	163	166	PF01048	0.627
MOD_GlcNHglycan	175	178	PF01048	0.592
MOD_GlcNHglycan	206	209	PF01048	0.604
MOD_GlcNHglycan	223	226	PF01048	0.725
MOD_GlcNHglycan	276	279	PF01048	0.631
MOD_GlcNHglycan	307	310	PF01048	0.565
MOD_GlcNHglycan	329	332	PF01048	0.626
MOD_GlcNHglycan	45	48	PF01048	0.502
MOD_GlcNHglycan	63	66	PF01048	0.426
MOD_GSK3_1	124	131	PF00069	0.503
MOD_GSK3_1	169	176	PF00069	0.599
MOD_GSK3_1	76	83	PF00069	0.715
MOD_GSK3_1	84	91	PF00069	0.571
MOD_N-GLC_1	112	117	PF02516	0.665
MOD_NEK2_1	125	130	PF00069	0.484
MOD_NEK2_1	169	174	PF00069	0.504
MOD_NEK2_1	274	279	PF00069	0.590
MOD_NEK2_1	305	310	PF00069	0.616
MOD_NEK2_1	341	346	PF00069	0.701
MOD_NEK2_1	365	370	PF00069	0.681
MOD_NEK2_1	88	93	PF00069	0.499
MOD_NEK2_2	358	363	PF00069	0.639
MOD_PIKK_1	176	182	PF00454	0.365
MOD_PIKK_1	348	354	PF00454	0.636
MOD_PKA_2	11	17	PF00069	0.507
MOD_PKA_2	215	221	PF00069	0.664
MOD_PKA_2	69	75	PF00069	0.707
MOD_Plk_1	112	118	PF00069	0.653
MOD_Plk_1	339	345	PF00069	0.725
MOD_Plk_1	365	371	PF00069	0.663
MOD_Plk_1	83	89	PF00069	0.441
MOD_Plk_4	11	17	PF00069	0.502
MOD_Plk_4	253	259	PF00069	0.730
MOD_Plk_4	365	371	PF00069	0.678
MOD_ProDKin_1	158	164	PF00069	0.579
MOD_ProDKin_1	22	28	PF00069	0.482
MOD_ProDKin_1	251	257	PF00069	0.669
MOD_ProDKin_1	71	77	PF00069	0.655
MOD_SUMO_rev_2	205	215	PF00179	0.695
TRG_DiLeu_BaEn_1	301	306	PF01217	0.440
TRG_DiLeu_BaEn_1	35	40	PF01217	0.519
TRG_DiLeu_BaLyEn_6	285	290	PF01217	0.620
TRG_ENDOCYTIC_2	16	19	PF00928	0.391
TRG_ENDOCYTIC_2	171	174	PF00928	0.546
TRG_ER_diArg_1	283	286	PF00400	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6E7	Leptomonas seymouri	41%	100%
A0A0S4KK84	Bodo saltans	26%	100%
A0A1X0NZS1	Trypanosomatidae	29%	92%
A0A3Q8IFC4	Leishmania donovani	89%	100%
A0A3R7LZ67	Trypanosoma rangeli	30%	94%
A4HHD3	Leishmania braziliensis	73%	100%
A4I4H8	Leishmania infantum	90%	100%
E9ALV2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BR99	Trypanosoma cruzi	28%	94%