Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADX8_LEIMA

TriTrypDb:

LmjF.29.1200 , LMJLV39_290018400 , LMJSD75_290018500

Length:

607

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 4, no: 1
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9ADX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADX8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.474
CLV_C14_Caspase3-7	239	243	PF00656	0.490
CLV_NRD_NRD_1	127	129	PF00675	0.691
CLV_NRD_NRD_1	195	197	PF00675	0.708
CLV_NRD_NRD_1	214	216	PF00675	0.647
CLV_NRD_NRD_1	291	293	PF00675	0.711
CLV_NRD_NRD_1	313	315	PF00675	0.677
CLV_NRD_NRD_1	453	455	PF00675	0.486
CLV_NRD_NRD_1	484	486	PF00675	0.480
CLV_NRD_NRD_1	491	493	PF00675	0.425
CLV_NRD_NRD_1	53	55	PF00675	0.628
CLV_PCSK_FUR_1	289	293	PF00082	0.612
CLV_PCSK_FUR_1	51	55	PF00082	0.597
CLV_PCSK_KEX2_1	127	129	PF00082	0.686
CLV_PCSK_KEX2_1	197	199	PF00082	0.667
CLV_PCSK_KEX2_1	214	216	PF00082	0.600
CLV_PCSK_KEX2_1	291	293	PF00082	0.711
CLV_PCSK_KEX2_1	453	455	PF00082	0.486
CLV_PCSK_KEX2_1	484	486	PF00082	0.480
CLV_PCSK_KEX2_1	490	492	PF00082	0.443
CLV_PCSK_KEX2_1	53	55	PF00082	0.628
CLV_PCSK_PC1ET2_1	127	129	PF00082	0.686
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.667
CLV_PCSK_SKI1_1	18	22	PF00082	0.620
CLV_PCSK_SKI1_1	485	489	PF00082	0.528
CLV_PCSK_SKI1_1	510	514	PF00082	0.380
CLV_PCSK_SKI1_1	573	577	PF00082	0.418
CLV_PCSK_SKI1_1	59	63	PF00082	0.621
CLV_PCSK_SKI1_1	594	598	PF00082	0.441
DEG_APCC_DBOX_1	17	25	PF00400	0.475
DEG_APCC_DBOX_1	195	203	PF00400	0.469
DEG_APCC_DBOX_1	509	517	PF00400	0.366
DEG_Nend_UBRbox_3	1	3	PF02207	0.490
DOC_CYCLIN_yClb5_NLxxxL_5	198	206	PF00134	0.542
DOC_CYCLIN_yCln2_LP_2	183	189	PF00134	0.501
DOC_CYCLIN_yCln2_LP_2	559	565	PF00134	0.385
DOC_MAPK_gen_1	196	205	PF00069	0.550
DOC_MAPK_gen_1	314	322	PF00069	0.413
DOC_MAPK_gen_1	508	517	PF00069	0.385
DOC_MAPK_MEF2A_6	18	26	PF00069	0.473
DOC_MAPK_MEF2A_6	508	517	PF00069	0.385
DOC_MAPK_NFAT4_5	508	516	PF00069	0.385
DOC_PP2B_LxvP_1	183	186	PF13499	0.501
DOC_PP2B_LxvP_1	559	562	PF13499	0.385
DOC_PP4_FxxP_1	545	548	PF00568	0.332
DOC_SPAK_OSR1_1	492	496	PF12202	0.600
DOC_USP7_MATH_1	171	175	PF00917	0.473
DOC_USP7_MATH_1	254	258	PF00917	0.475
DOC_USP7_MATH_1	304	308	PF00917	0.495
DOC_USP7_MATH_1	350	354	PF00917	0.385
DOC_USP7_MATH_1	398	402	PF00917	0.774
DOC_USP7_MATH_1	437	441	PF00917	0.734
DOC_USP7_MATH_1	443	447	PF00917	0.742
DOC_WW_Pin1_4	302	307	PF00397	0.449
DOC_WW_Pin1_4	402	407	PF00397	0.758
DOC_WW_Pin1_4	419	424	PF00397	0.803
DOC_WW_Pin1_4	439	444	PF00397	0.604
DOC_WW_Pin1_4	453	458	PF00397	0.654
DOC_WW_Pin1_4	498	503	PF00397	0.619
LIG_14-3-3_CanoR_1	12	19	PF00244	0.560
LIG_14-3-3_CanoR_1	149	154	PF00244	0.486
LIG_14-3-3_CanoR_1	248	255	PF00244	0.456
LIG_14-3-3_CanoR_1	492	502	PF00244	0.707
LIG_Actin_WH2_2	558	575	PF00022	0.385
LIG_BIR_III_4	386	390	PF00653	0.685
LIG_deltaCOP1_diTrp_1	344	347	PF00928	0.254
LIG_deltaCOP1_diTrp_1	367	376	PF00928	0.778
LIG_EH1_1	354	362	PF00400	0.342
LIG_EVH1_1	73	77	PF00568	0.403
LIG_FAT_LD_1	199	207	PF03623	0.445
LIG_FHA_1	244	250	PF00498	0.446
LIG_FHA_1	297	303	PF00498	0.533
LIG_FHA_1	324	330	PF00498	0.527
LIG_FHA_1	501	507	PF00498	0.457
LIG_FHA_2	407	413	PF00498	0.766
LIG_GBD_Chelix_1	517	525	PF00786	0.363
LIG_LIR_Gen_1	326	335	PF02991	0.558
LIG_LIR_Gen_1	346	356	PF02991	0.320
LIG_LIR_Gen_1	549	558	PF02991	0.418
LIG_LIR_Gen_1	95	105	PF02991	0.405
LIG_LIR_LC3C_4	556	561	PF02991	0.385
LIG_LIR_Nem_3	326	331	PF02991	0.559
LIG_LIR_Nem_3	344	348	PF02991	0.313
LIG_LIR_Nem_3	524	529	PF02991	0.505
LIG_LIR_Nem_3	549	553	PF02991	0.418
LIG_LIR_Nem_3	556	561	PF02991	0.394
LIG_LIR_Nem_3	95	100	PF02991	0.511
LIG_MYND_1	439	443	PF01753	0.637
LIG_NBox_RRM_1	347	357	PF00076	0.342
LIG_NRBOX	103	109	PF00104	0.352
LIG_NRBOX	198	204	PF00104	0.565
LIG_NRBOX	508	514	PF00104	0.385
LIG_Pex14_1	273	277	PF04695	0.464
LIG_Pex14_1	343	347	PF04695	0.441
LIG_Pex14_2	546	550	PF04695	0.363
LIG_REV1ctd_RIR_1	8	16	PF16727	0.532
LIG_RPA_C_Fungi	486	498	PF08784	0.510
LIG_SH2_CRK	227	231	PF00017	0.753
LIG_SH2_CRK	348	352	PF00017	0.396
LIG_SH2_CRK	461	465	PF00017	0.627
LIG_SH2_NCK_1	348	352	PF00017	0.254
LIG_SH2_STAP1	533	537	PF00017	0.492
LIG_SH2_STAT5	318	321	PF00017	0.514
LIG_SH2_STAT5	328	331	PF00017	0.574
LIG_SH2_STAT5	348	351	PF00017	0.412
LIG_SH2_STAT5	558	561	PF00017	0.385
LIG_SH2_STAT5	97	100	PF00017	0.478
LIG_SH3_3	151	157	PF00018	0.631
LIG_SH3_3	307	313	PF00018	0.570
LIG_SH3_3	33	39	PF00018	0.531
LIG_SH3_3	71	77	PF00018	0.522
LIG_SUMO_SIM_anti_2	102	109	PF11976	0.373
LIG_SUMO_SIM_par_1	102	109	PF11976	0.487
LIG_SUMO_SIM_par_1	204	212	PF11976	0.460
LIG_TRAF2_1	578	581	PF00917	0.499
LIG_TYR_ITSM	344	351	PF00017	0.320
LIG_UBA3_1	504	508	PF00899	0.385
LIG_UBA3_1	565	573	PF00899	0.469
LIG_WRC_WIRS_1	582	587	PF05994	0.507
MOD_CK1_1	257	263	PF00069	0.674
MOD_CK1_1	305	311	PF00069	0.553
MOD_CK1_1	381	387	PF00069	0.608
MOD_CK1_1	401	407	PF00069	0.628
MOD_CK1_1	417	423	PF00069	0.702
MOD_CK1_1	424	430	PF00069	0.637
MOD_CK2_1	149	155	PF00069	0.630
MOD_CK2_1	406	412	PF00069	0.694
MOD_CMANNOS	523	526	PF00535	0.385
MOD_Cter_Amidation	451	454	PF01082	0.599
MOD_GlcNHglycan	230	233	PF01048	0.563
MOD_GlcNHglycan	256	259	PF01048	0.636
MOD_GlcNHglycan	260	263	PF01048	0.588
MOD_GlcNHglycan	352	355	PF01048	0.359
MOD_GlcNHglycan	380	383	PF01048	0.637
MOD_GlcNHglycan	397	401	PF01048	0.652
MOD_GlcNHglycan	406	409	PF01048	0.651
MOD_GlcNHglycan	41	44	PF01048	0.597
MOD_GlcNHglycan	416	419	PF01048	0.579
MOD_GlcNHglycan	429	432	PF01048	0.616
MOD_GlcNHglycan	495	498	PF01048	0.527
MOD_GlcNHglycan	537	540	PF01048	0.556
MOD_GlcNHglycan	555	558	PF01048	0.259
MOD_GSK3_1	141	148	PF00069	0.612
MOD_GSK3_1	254	261	PF00069	0.637
MOD_GSK3_1	292	299	PF00069	0.742
MOD_GSK3_1	346	353	PF00069	0.278
MOD_GSK3_1	37	44	PF00069	0.599
MOD_GSK3_1	398	405	PF00069	0.697
MOD_GSK3_1	417	424	PF00069	0.734
MOD_GSK3_1	439	446	PF00069	0.726
MOD_GSK3_1	529	536	PF00069	0.600
MOD_N-GLC_1	378	383	PF02516	0.611
MOD_NEK2_1	11	16	PF00069	0.559
MOD_NEK2_1	187	192	PF00069	0.716
MOD_NEK2_1	296	301	PF00069	0.599
MOD_NEK2_1	41	46	PF00069	0.575
MOD_NEK2_1	426	431	PF00069	0.617
MOD_NEK2_1	493	498	PF00069	0.569
MOD_NEK2_1	521	526	PF00069	0.379
MOD_NEK2_2	343	348	PF00069	0.320
MOD_PK_1	149	155	PF00069	0.586
MOD_PKA_2	11	17	PF00069	0.525
MOD_PKA_2	208	214	PF00069	0.554
MOD_PKA_2	401	407	PF00069	0.660
MOD_Plk_1	292	298	PF00069	0.618
MOD_Plk_1	343	349	PF00069	0.254
MOD_Plk_1	378	384	PF00069	0.614
MOD_Plk_4	149	155	PF00069	0.604
MOD_Plk_4	187	193	PF00069	0.529
MOD_Plk_4	297	303	PF00069	0.616
MOD_Plk_4	305	311	PF00069	0.597
MOD_Plk_4	323	329	PF00069	0.532
MOD_Plk_4	500	506	PF00069	0.517
MOD_Plk_4	546	552	PF00069	0.474
MOD_Plk_4	93	99	PF00069	0.453
MOD_ProDKin_1	302	308	PF00069	0.547
MOD_ProDKin_1	402	408	PF00069	0.700
MOD_ProDKin_1	419	425	PF00069	0.765
MOD_ProDKin_1	439	445	PF00069	0.488
MOD_ProDKin_1	453	459	PF00069	0.557
MOD_ProDKin_1	498	504	PF00069	0.502
TRG_DiLeu_BaEn_1	103	108	PF01217	0.369
TRG_DiLeu_BaEn_1	233	238	PF01217	0.632
TRG_DiLeu_BaEn_1	592	597	PF01217	0.533
TRG_DiLeu_BaLyEn_6	507	512	PF01217	0.385
TRG_ENDOCYTIC_2	328	331	PF00928	0.573
TRG_ENDOCYTIC_2	348	351	PF00928	0.462
TRG_ENDOCYTIC_2	461	464	PF00928	0.630
TRG_ENDOCYTIC_2	558	561	PF00928	0.385
TRG_ENDOCYTIC_2	7	10	PF00928	0.547
TRG_ENDOCYTIC_2	97	100	PF00928	0.478
TRG_ER_diArg_1	196	199	PF00400	0.574
TRG_ER_diArg_1	213	215	PF00400	0.469
TRG_ER_diArg_1	289	292	PF00400	0.496
TRG_ER_diArg_1	489	492	PF00400	0.539
TRG_ER_diArg_1	53	55	PF00400	0.519
TRG_NLS_MonoExtC_3	126	132	PF00514	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBG2	Leishmania donovani	92%	100%
A4HHD2	Leishmania braziliensis	68%	100%
A4I4H7	Leishmania infantum	92%	100%
E9ALV3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%