EXS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Etoposide-induced protein 2.4 (EI24), putative

Species:

Leishmania major

UniProt:

E9ADX7_LEIMA

TriTrypDb:

LmjF.29.1190 , LMJLV39_290018300 , LMJSD75_290018400

Length:

598

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	7
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9ADX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADX7

Function

Biological processes
Term	Name	Level	Count
GO:0006914	autophagy	3	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009987	cellular process	1	2
GO:0016236	macroautophagy	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0061919	process utilizing autophagic mechanism	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.409
CLV_NRD_NRD_1	239	241	PF00675	0.459
CLV_NRD_NRD_1	38	40	PF00675	0.515
CLV_PCSK_KEX2_1	37	39	PF00082	0.452
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.452
CLV_PCSK_SKI1_1	128	132	PF00082	0.385
CLV_PCSK_SKI1_1	166	170	PF00082	0.315
CLV_PCSK_SKI1_1	187	191	PF00082	0.275
CLV_PCSK_SKI1_1	354	358	PF00082	0.513
DEG_APCC_DBOX_1	202	210	PF00400	0.444
DEG_SPOP_SBC_1	57	61	PF00917	0.705
DOC_AGCK_PIF_2	466	471	PF00069	0.404
DOC_ANK_TNKS_1	68	75	PF00023	0.655
DOC_CKS1_1	282	287	PF01111	0.654
DOC_CKS1_1	451	456	PF01111	0.312
DOC_CKS1_1	77	82	PF01111	0.681
DOC_CYCLIN_yClb5_NLxxxL_5	125	134	PF00134	0.529
DOC_MAPK_gen_1	118	126	PF00069	0.644
DOC_MAPK_MEF2A_6	575	583	PF00069	0.388
DOC_MAPK_RevD_3	25	39	PF00069	0.687
DOC_PP2B_LxvP_1	583	586	PF13499	0.312
DOC_PP4_FxxP_1	108	111	PF00568	0.684
DOC_PP4_FxxP_1	543	546	PF00568	0.570
DOC_USP7_MATH_1	185	189	PF00917	0.665
DOC_USP7_MATH_1	255	259	PF00917	0.737
DOC_USP7_MATH_1	309	313	PF00917	0.784
DOC_USP7_MATH_1	381	385	PF00917	0.675
DOC_USP7_MATH_1	394	398	PF00917	0.644
DOC_USP7_MATH_1	402	406	PF00917	0.694
DOC_USP7_MATH_1	434	438	PF00917	0.343
DOC_USP7_MATH_1	546	550	PF00917	0.577
DOC_USP7_MATH_1	57	61	PF00917	0.711
DOC_WW_Pin1_4	151	156	PF00397	0.447
DOC_WW_Pin1_4	250	255	PF00397	0.614
DOC_WW_Pin1_4	281	286	PF00397	0.785
DOC_WW_Pin1_4	316	321	PF00397	0.656
DOC_WW_Pin1_4	398	403	PF00397	0.752
DOC_WW_Pin1_4	408	413	PF00397	0.640
DOC_WW_Pin1_4	450	455	PF00397	0.312
DOC_WW_Pin1_4	52	57	PF00397	0.722
DOC_WW_Pin1_4	58	63	PF00397	0.726
DOC_WW_Pin1_4	76	81	PF00397	0.720
LIG_14-3-3_CanoR_1	103	109	PF00244	0.791
LIG_14-3-3_CanoR_1	166	173	PF00244	0.353
LIG_14-3-3_CanoR_1	187	197	PF00244	0.529
LIG_14-3-3_CanoR_1	324	333	PF00244	0.666
LIG_14-3-3_CanoR_1	346	353	PF00244	0.694
LIG_14-3-3_CanoR_1	354	361	PF00244	0.669
LIG_14-3-3_CanoR_1	407	412	PF00244	0.626
LIG_14-3-3_CanoR_1	52	56	PF00244	0.642
LIG_Actin_WH2_2	195	212	PF00022	0.388
LIG_Actin_WH2_2	323	341	PF00022	0.679
LIG_AP2alpha_2	413	415	PF02296	0.699
LIG_BRCT_BRCA1_1	191	195	PF00533	0.340
LIG_BRCT_BRCA1_1	54	58	PF00533	0.637
LIG_BRCT_BRCA1_1	556	560	PF00533	0.572
LIG_CtBP_PxDLS_1	2	6	PF00389	0.711
LIG_deltaCOP1_diTrp_1	235	243	PF00928	0.623
LIG_eIF4E_1	233	239	PF01652	0.603
LIG_FHA_1	168	174	PF00498	0.340
LIG_FHA_1	184	190	PF00498	0.762
LIG_FHA_1	234	240	PF00498	0.614
LIG_FHA_1	333	339	PF00498	0.643
LIG_FHA_1	346	352	PF00498	0.611
LIG_FHA_1	360	366	PF00498	0.638
LIG_FHA_1	415	421	PF00498	0.642
LIG_FHA_1	488	494	PF00498	0.578
LIG_FHA_1	5	11	PF00498	0.692
LIG_FHA_1	516	522	PF00498	0.431
LIG_FHA_1	89	95	PF00498	0.784
LIG_FHA_2	317	323	PF00498	0.705
LIG_FHA_2	408	414	PF00498	0.662
LIG_GBD_Chelix_1	577	585	PF00786	0.340
LIG_LIR_Apic_2	107	111	PF02991	0.686
LIG_LIR_Apic_2	541	546	PF02991	0.564
LIG_LIR_Gen_1	112	120	PF02991	0.683
LIG_LIR_Gen_1	192	202	PF02991	0.388
LIG_LIR_Gen_1	413	422	PF02991	0.629
LIG_LIR_Gen_1	435	445	PF02991	0.312
LIG_LIR_Gen_1	535	544	PF02991	0.413
LIG_LIR_Nem_3	112	116	PF02991	0.678
LIG_LIR_Nem_3	140	146	PF02991	0.312
LIG_LIR_Nem_3	192	198	PF02991	0.388
LIG_LIR_Nem_3	23	28	PF02991	0.675
LIG_LIR_Nem_3	413	418	PF02991	0.634
LIG_LIR_Nem_3	427	433	PF02991	0.493
LIG_LIR_Nem_3	435	441	PF02991	0.183
LIG_LIR_Nem_3	500	506	PF02991	0.529
LIG_LIR_Nem_3	535	539	PF02991	0.324
LIG_LIR_Nem_3	557	563	PF02991	0.580
LIG_NRBOX	121	127	PF00104	0.636
LIG_NRBOX	192	198	PF00104	0.388
LIG_PALB2_WD40_1	224	232	PF16756	0.388
LIG_PDZ_Class_1	593	598	PF00595	0.582
LIG_Pex14_1	207	211	PF04695	0.414
LIG_Pex14_2	556	560	PF04695	0.572
LIG_SH2_CRK	143	147	PF00017	0.312
LIG_SH2_CRK	218	222	PF00017	0.312
LIG_SH2_STAP1	534	538	PF00017	0.312
LIG_SH2_STAP1	570	574	PF00017	0.609
LIG_SH2_STAT3	211	214	PF00017	0.399
LIG_SH2_STAT3	473	476	PF00017	0.591
LIG_SH2_STAT3	534	537	PF00017	0.312
LIG_SH2_STAT5	211	214	PF00017	0.399
LIG_SH2_STAT5	218	221	PF00017	0.312
LIG_SH2_STAT5	344	347	PF00017	0.727
LIG_SH2_STAT5	464	467	PF00017	0.326
LIG_SH2_STAT5	561	564	PF00017	0.535
LIG_SH2_STAT5	584	587	PF00017	0.312
LIG_SH3_3	279	285	PF00018	0.728
LIG_SH3_3	542	548	PF00018	0.585
LIG_SH3_3	83	89	PF00018	0.667
LIG_SH3_3	96	102	PF00018	0.621
LIG_SUMO_SIM_anti_2	327	335	PF11976	0.697
LIG_SUMO_SIM_par_1	1	8	PF11976	0.675
LIG_SUMO_SIM_par_1	195	201	PF11976	0.340
LIG_SUMO_SIM_par_1	26	33	PF11976	0.690
LIG_TYR_ITIM	141	146	PF00017	0.312
LIG_TYR_ITIM	582	587	PF00017	0.304
LIG_WRC_WIRS_1	22	27	PF05994	0.614
MOD_CK1_1	156	162	PF00069	0.518
MOD_CK1_1	188	194	PF00069	0.349
MOD_CK1_1	272	278	PF00069	0.825
MOD_CK1_1	384	390	PF00069	0.686
MOD_CK1_1	4	10	PF00069	0.682
MOD_CK1_1	487	493	PF00069	0.599
MOD_CK2_1	111	117	PF00069	0.602
MOD_CK2_1	304	310	PF00069	0.755
MOD_CK2_1	316	322	PF00069	0.677
MOD_CK2_1	440	446	PF00069	0.312
MOD_DYRK1A_RPxSP_1	398	402	PF00069	0.644
MOD_GlcNHglycan	159	162	PF01048	0.491
MOD_GlcNHglycan	173	176	PF01048	0.468
MOD_GlcNHglycan	257	260	PF01048	0.520
MOD_GlcNHglycan	273	277	PF01048	0.474
MOD_GlcNHglycan	306	309	PF01048	0.493
MOD_GlcNHglycan	310	314	PF01048	0.488
MOD_GlcNHglycan	32	35	PF01048	0.431
MOD_GlcNHglycan	383	386	PF01048	0.503
MOD_GlcNHglycan	387	390	PF01048	0.540
MOD_GlcNHglycan	442	445	PF01048	0.502
MOD_GlcNHglycan	486	489	PF01048	0.395
MOD_GlcNHglycan	509	512	PF01048	0.332
MOD_GlcNHglycan	540	543	PF01048	0.361
MOD_GlcNHglycan	83	86	PF01048	0.507
MOD_GlcNHglycan	94	97	PF01048	0.521
MOD_GSK3_1	1	8	PF00069	0.742
MOD_GSK3_1	149	156	PF00069	0.453
MOD_GSK3_1	167	174	PF00069	0.402
MOD_GSK3_1	176	183	PF00069	0.760
MOD_GSK3_1	185	192	PF00069	0.519
MOD_GSK3_1	304	311	PF00069	0.729
MOD_GSK3_1	381	388	PF00069	0.697
MOD_GSK3_1	394	401	PF00069	0.722
MOD_GSK3_1	402	409	PF00069	0.747
MOD_GSK3_1	507	514	PF00069	0.343
MOD_GSK3_1	52	59	PF00069	0.752
MOD_GSK3_1	528	535	PF00069	0.318
MOD_GSK3_1	88	95	PF00069	0.777
MOD_N-GLC_1	166	171	PF02516	0.242
MOD_N-GLC_1	180	185	PF02516	0.508
MOD_NEK2_1	104	109	PF00069	0.570
MOD_NEK2_1	144	149	PF00069	0.313
MOD_NEK2_1	189	194	PF00069	0.395
MOD_NEK2_1	198	203	PF00069	0.297
MOD_NEK2_1	29	34	PF00069	0.732
MOD_NEK2_1	326	331	PF00069	0.667
MOD_NEK2_1	332	337	PF00069	0.699
MOD_NEK2_1	5	10	PF00069	0.725
MOD_NEK2_1	515	520	PF00069	0.346
MOD_NEK2_1	593	598	PF00069	0.612
MOD_NEK2_1	94	99	PF00069	0.803
MOD_PIKK_1	227	233	PF00454	0.291
MOD_PIKK_1	402	408	PF00454	0.746
MOD_PIKK_1	5	11	PF00454	0.747
MOD_PKA_2	233	239	PF00069	0.603
MOD_PKA_2	245	251	PF00069	0.656
MOD_PKA_2	345	351	PF00069	0.673
MOD_PKA_2	406	412	PF00069	0.628
MOD_PKA_2	484	490	PF00069	0.611
MOD_PKA_2	51	57	PF00069	0.661
MOD_Plk_4	1	7	PF00069	0.776
MOD_Plk_4	104	110	PF00069	0.595
MOD_Plk_4	137	143	PF00069	0.388
MOD_Plk_4	189	195	PF00069	0.388
MOD_Plk_4	216	222	PF00069	0.298
MOD_Plk_4	233	239	PF00069	0.603
MOD_Plk_4	298	304	PF00069	0.664
MOD_Plk_4	326	332	PF00069	0.651
MOD_Plk_4	414	420	PF00069	0.657
MOD_Plk_4	497	503	PF00069	0.618
MOD_Plk_4	511	517	PF00069	0.235
MOD_Plk_4	520	526	PF00069	0.312
MOD_Plk_4	528	534	PF00069	0.312
MOD_ProDKin_1	151	157	PF00069	0.449
MOD_ProDKin_1	250	256	PF00069	0.618
MOD_ProDKin_1	281	287	PF00069	0.784
MOD_ProDKin_1	316	322	PF00069	0.656
MOD_ProDKin_1	398	404	PF00069	0.753
MOD_ProDKin_1	408	414	PF00069	0.636
MOD_ProDKin_1	450	456	PF00069	0.312
MOD_ProDKin_1	52	58	PF00069	0.723
MOD_ProDKin_1	76	82	PF00069	0.719
MOD_SUMO_rev_2	114	122	PF00179	0.598
TRG_DiLeu_LyEn_5	446	451	PF01217	0.329
TRG_ENDOCYTIC_2	143	146	PF00928	0.312
TRG_ENDOCYTIC_2	218	221	PF00928	0.312
TRG_ENDOCYTIC_2	570	573	PF00928	0.614
TRG_ENDOCYTIC_2	584	587	PF00928	0.312
TRG_ER_diArg_1	38	41	PF00400	0.710

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDR7	Leptomonas seymouri	50%	100%
A0A3S7X2B9	Leishmania donovani	94%	100%
A4HHD1	Leishmania braziliensis	82%	100%
A4I4H6	Leishmania infantum	94%	100%
E9ALV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%