EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADX5_LEIMA

TriTrypDb:

LmjF.29.1170 , LMJLV39_290018100 , LMJSD75_290018200

Length:

370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADX5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0005509	calcium ion binding	5	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.587
CLV_C14_Caspase3-7	178	182	PF00656	0.703
CLV_C14_Caspase3-7	209	213	PF00656	0.821
CLV_C14_Caspase3-7	24	28	PF00656	0.574
CLV_MEL_PAP_1	140	146	PF00089	0.760
CLV_NRD_NRD_1	160	162	PF00675	0.670
CLV_PCSK_FUR_1	158	162	PF00082	0.646
CLV_PCSK_KEX2_1	160	162	PF00082	0.697
CLV_PCSK_KEX2_1	207	209	PF00082	0.699
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.699
CLV_PCSK_SKI1_1	131	135	PF00082	0.703
CLV_PCSK_SKI1_1	287	291	PF00082	0.653
CLV_PCSK_SKI1_1	314	318	PF00082	0.501
DEG_Nend_Nbox_1	1	3	PF02207	0.773
DOC_AGCK_PIF_1	357	362	PF00069	0.510
DOC_CKS1_1	279	284	PF01111	0.695
DOC_MAPK_gen_1	31	38	PF00069	0.535
DOC_MAPK_gen_1	70	78	PF00069	0.741
DOC_PP2B_LxvP_1	333	336	PF13499	0.676
DOC_PP4_FxxP_1	134	137	PF00568	0.751
DOC_USP7_MATH_1	164	168	PF00917	0.733
DOC_USP7_MATH_1	187	191	PF00917	0.794
DOC_USP7_MATH_1	216	220	PF00917	0.748
DOC_USP7_MATH_2	46	52	PF00917	0.629
DOC_WW_Pin1_4	212	217	PF00397	0.736
DOC_WW_Pin1_4	261	266	PF00397	0.670
DOC_WW_Pin1_4	278	283	PF00397	0.704
LIG_14-3-3_CanoR_1	158	168	PF00244	0.687
LIG_14-3-3_CanoR_1	188	192	PF00244	0.794
LIG_14-3-3_CanoR_1	259	265	PF00244	0.612
LIG_14-3-3_CanoR_1	314	320	PF00244	0.543
LIG_14-3-3_CanoR_1	324	330	PF00244	0.577
LIG_14-3-3_CanoR_1	33	37	PF00244	0.501
LIG_APCC_ABBA_1	193	198	PF00400	0.676
LIG_BIR_III_2	112	116	PF00653	0.579
LIG_BRCT_BRCA1_1	189	193	PF00533	0.784
LIG_CaM_IQ_9	50	66	PF13499	0.669
LIG_Clathr_ClatBox_1	44	48	PF01394	0.534
LIG_deltaCOP1_diTrp_1	352	360	PF00928	0.517
LIG_FHA_1	239	245	PF00498	0.725
LIG_FHA_1	33	39	PF00498	0.554
LIG_FHA_1	339	345	PF00498	0.603
LIG_FHA_1	63	69	PF00498	0.694
LIG_FHA_2	176	182	PF00498	0.742
LIG_FHA_2	279	285	PF00498	0.682
LIG_FHA_2	296	302	PF00498	0.626
LIG_FHA_2	64	70	PF00498	0.464
LIG_LIR_Gen_1	148	157	PF02991	0.594
LIG_LIR_Gen_1	304	311	PF02991	0.516
LIG_LIR_Gen_1	337	347	PF02991	0.531
LIG_LIR_Gen_1	352	362	PF02991	0.378
LIG_LIR_Gen_1	39	47	PF02991	0.515
LIG_LIR_Nem_3	148	153	PF02991	0.607
LIG_LIR_Nem_3	190	196	PF02991	0.703
LIG_LIR_Nem_3	304	309	PF02991	0.517
LIG_LIR_Nem_3	320	325	PF02991	0.532
LIG_LIR_Nem_3	337	342	PF02991	0.438
LIG_LIR_Nem_3	352	357	PF02991	0.383
LIG_LIR_Nem_3	358	363	PF02991	0.443
LIG_LIR_Nem_3	39	44	PF02991	0.573
LIG_LIR_Nem_3	75	80	PF02991	0.743
LIG_PALB2_WD40_1	301	309	PF16756	0.562
LIG_PDZ_Class_2	365	370	PF00595	0.418
LIG_PTAP_UEV_1	245	250	PF05743	0.703
LIG_PTB_Apo_2	249	256	PF02174	0.623
LIG_PTB_Phospho_1	249	255	PF10480	0.633
LIG_SH2_CRK	255	259	PF00017	0.586
LIG_SH2_CRK	41	45	PF00017	0.542
LIG_SH2_CRK	80	84	PF00017	0.660
LIG_SH2_GRB2like	80	83	PF00017	0.651
LIG_SH2_STAT5	267	270	PF00017	0.761
LIG_SH2_STAT5	362	365	PF00017	0.452
LIG_SH2_STAT5	80	83	PF00017	0.606
LIG_SH2_STAT5	95	98	PF00017	0.536
LIG_SH3_2	246	251	PF14604	0.774
LIG_SH3_3	186	192	PF00018	0.747
LIG_SH3_3	197	203	PF00018	0.563
LIG_SH3_3	243	249	PF00018	0.729
LIG_SH3_3	40	46	PF00018	0.627
LIG_SUMO_SIM_par_1	315	321	PF11976	0.609
LIG_SUMO_SIM_par_1	340	345	PF11976	0.578
LIG_TRAF2_1	114	117	PF00917	0.729
LIG_TRAF2_1	298	301	PF00917	0.598
LIG_TRAF2_1	318	321	PF00917	0.280
LIG_UBA3_1	22	31	PF00899	0.516
MOD_CDK_SPK_2	212	217	PF00069	0.749
MOD_CK1_1	106	112	PF00069	0.803
MOD_CK1_1	175	181	PF00069	0.781
MOD_CK1_1	215	221	PF00069	0.790
MOD_CK1_1	239	245	PF00069	0.729
MOD_CK2_1	145	151	PF00069	0.714
MOD_CK2_1	272	278	PF00069	0.782
MOD_CK2_1	295	301	PF00069	0.672
MOD_CK2_1	315	321	PF00069	0.279
MOD_CK2_1	63	69	PF00069	0.461
MOD_Cter_Amidation	205	208	PF01082	0.684
MOD_GlcNHglycan	218	221	PF01048	0.763
MOD_GlcNHglycan	223	226	PF01048	0.702
MOD_GlcNHglycan	246	249	PF01048	0.707
MOD_GlcNHglycan	9	12	PF01048	0.702
MOD_GSK3_1	116	123	PF00069	0.683
MOD_GSK3_1	160	167	PF00069	0.684
MOD_GSK3_1	168	175	PF00069	0.740
MOD_GSK3_1	212	219	PF00069	0.829
MOD_GSK3_1	236	243	PF00069	0.774
MOD_GSK3_1	261	268	PF00069	0.680
MOD_GSK3_1	32	39	PF00069	0.628
MOD_GSK3_1	334	341	PF00069	0.652
MOD_GSK3_1	96	103	PF00069	0.586
MOD_N-GLC_1	169	174	PF02516	0.748
MOD_N-GLC_1	212	217	PF02516	0.817
MOD_N-GLC_1	290	295	PF02516	0.609
MOD_NEK2_1	168	173	PF00069	0.754
MOD_NEK2_1	260	265	PF00069	0.585
MOD_NEK2_1	290	295	PF00069	0.586
MOD_NEK2_1	36	41	PF00069	0.552
MOD_NEK2_2	145	150	PF00069	0.739
MOD_PIKK_1	268	274	PF00454	0.653
MOD_PKA_1	160	166	PF00069	0.684
MOD_PKA_2	106	112	PF00069	0.798
MOD_PKA_2	159	165	PF00069	0.743
MOD_PKA_2	187	193	PF00069	0.710
MOD_PKA_2	244	250	PF00069	0.665
MOD_PKA_2	32	38	PF00069	0.557
MOD_PKA_2	78	84	PF00069	0.695
MOD_PKB_1	158	166	PF00069	0.666
MOD_Plk_1	169	175	PF00069	0.725
MOD_Plk_1	290	296	PF00069	0.651
MOD_Plk_2-3	338	344	PF00069	0.623
MOD_Plk_4	145	151	PF00069	0.661
MOD_Plk_4	32	38	PF00069	0.550
MOD_Plk_4	48	54	PF00069	0.401
MOD_ProDKin_1	212	218	PF00069	0.738
MOD_ProDKin_1	261	267	PF00069	0.672
MOD_ProDKin_1	278	284	PF00069	0.704
TRG_DiLeu_BaEn_2	47	53	PF01217	0.556
TRG_ENDOCYTIC_2	150	153	PF00928	0.639
TRG_ENDOCYTIC_2	255	258	PF00928	0.588
TRG_ENDOCYTIC_2	339	342	PF00928	0.577
TRG_ENDOCYTIC_2	362	365	PF00928	0.464
TRG_ENDOCYTIC_2	41	44	PF00928	0.567
TRG_ER_diArg_1	157	160	PF00400	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7W0	Leptomonas seymouri	47%	100%
A0A1X0NZT2	Trypanosomatidae	27%	100%
A0A3Q8IRA6	Leishmania donovani	95%	100%
A4HHC9	Leishmania braziliensis	71%	100%
A4I4H4	Leishmania infantum	95%	100%
E9ALV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%