LeishMANIAdb
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Tryparedoxin

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Tryparedoxin
Gene product:
tryparedoxin 1, putative
Species:
Leishmania major
UniProt:
E9ADX4_LEIMA
TriTrypDb:
LmjF.29.1160 , LMJLV39_290018000 * , LMJSD75_290018100
Length:
145

Annotations

LeishMANIAdb annotations

A large family of kinetoplastid-specific oxidoreductases. Only expanded in the Leptomonas genus. Localization: ER (by feature) / Mitochondial outer membrane (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 33
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 29
NetGPI no yes: 0, no: 29
Cellular components
Term Name Level Count
GO:0005829 cytosol 2 2
GO:0110165 cellular anatomical entity 1 11
GO:0016020 membrane 2 7
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 3
GO:0043227 membrane-bounded organelle 3 3
GO:0043229 intracellular organelle 3 3
GO:0043231 intracellular membrane-bounded organelle 4 3
GO:0005634 nucleus 5 2
GO:0032473 cytoplasmic side of mitochondrial outer membrane 4 1
GO:0098552 side of membrane 2 1
GO:0098562 cytoplasmic side of membrane 3 1

Expansion

Sequence features

E9ADX4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADX4

PDB structure(s): 3s9f_A

Function

Biological processes
Term Name Level Count
GO:0008152 metabolic process 1 3
GO:0009056 catabolic process 2 3
GO:0009987 cellular process 1 3
GO:0042743 hydrogen peroxide metabolic process 4 3
GO:0042744 hydrogen peroxide catabolic process 4 3
GO:0044237 cellular metabolic process 2 3
GO:0044248 cellular catabolic process 3 3
GO:0072593 reactive oxygen species metabolic process 3 3
GO:0009892 negative regulation of metabolic process 4 2
GO:0009966 regulation of signal transduction 4 2
GO:0009968 negative regulation of signal transduction 5 2
GO:0010605 negative regulation of macromolecule metabolic process 5 2
GO:0010646 regulation of cell communication 4 2
GO:0010648 negative regulation of cell communication 5 2
GO:0019222 regulation of metabolic process 3 2
GO:0023051 regulation of signaling 3 2
GO:0023057 negative regulation of signaling 4 2
GO:0030111 regulation of Wnt signaling pathway 5 2
GO:0030178 negative regulation of Wnt signaling pathway 6 2
GO:0031396 regulation of protein ubiquitination 8 2
GO:0031397 negative regulation of protein ubiquitination 9 2
GO:0031399 regulation of protein modification process 6 2
GO:0031400 negative regulation of protein modification process 7 2
GO:0048519 negative regulation of biological process 3 2
GO:0048523 negative regulation of cellular process 4 2
GO:0048583 regulation of response to stimulus 3 2
GO:0048585 negative regulation of response to stimulus 4 2
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0051171 regulation of nitrogen compound metabolic process 4 2
GO:0051172 negative regulation of nitrogen compound metabolic process 5 2
GO:0051246 regulation of protein metabolic process 5 2
GO:0051248 negative regulation of protein metabolic process 6 2
GO:0060255 regulation of macromolecule metabolic process 4 2
GO:0065007 biological regulation 1 2
GO:0080090 regulation of primary metabolic process 4 2
GO:1903320 regulation of protein modification by small protein conjugation or removal 7 2
GO:1903321 negative regulation of protein modification by small protein conjugation or removal 8 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 20
GO:0004791 thioredoxin-disulfide reductase activity 2 20
GO:0015035 protein-disulfide reductase activity 3 20
GO:0015036 disulfide oxidoreductase activity 4 20
GO:0016209 antioxidant activity 1 20
GO:0016491 oxidoreductase activity 2 20
GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 3 20
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 4 20
GO:0047134 protein-disulfide reductase (NAD(P)) activity 4 20
GO:0140096 catalytic activity, acting on a protein 2 20

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 14 16 PF00675 0.497
CLV_PCSK_SKI1_1 128 132 PF00082 0.574
CLV_PCSK_SKI1_1 29 33 PF00082 0.282
CLV_PCSK_SKI1_1 44 48 PF00082 0.305
DOC_MAPK_MEF2A_6 83 91 PF00069 0.493
DOC_PP1_RVXF_1 27 34 PF00149 0.316
DOC_PP2B_LxvP_1 87 90 PF13499 0.487
DOC_WW_Pin1_4 44 49 PF00397 0.496
LIG_14-3-3_CanoR_1 128 136 PF00244 0.392
LIG_BIR_II_1 1 5 PF00653 0.458
LIG_BRCT_BRCA1_1 59 63 PF00533 0.513
LIG_BRCT_BRCA1_1 87 91 PF00533 0.568
LIG_FHA_1 45 51 PF00498 0.499
LIG_GBD_Chelix_1 4 12 PF00786 0.303
LIG_LIR_Apic_2 36 42 PF02991 0.490
LIG_LIR_Gen_1 60 68 PF02991 0.484
LIG_LIR_Nem_3 30 35 PF02991 0.503
LIG_LIR_Nem_3 60 66 PF02991 0.476
LIG_LIR_Nem_3 74 80 PF02991 0.499
LIG_PCNA_PIPBox_1 1 10 PF02747 0.513
LIG_Pex14_2 35 39 PF04695 0.492
LIG_SH2_STAT5 34 37 PF00017 0.488
MOD_CK1_1 105 111 PF00069 0.506
MOD_CK1_1 27 33 PF00069 0.363
MOD_CK2_1 66 72 PF00069 0.508
MOD_GlcNHglycan 1 4 PF01048 0.455
MOD_GlcNHglycan 26 29 PF01048 0.415
MOD_GlcNHglycan 35 38 PF01048 0.264
MOD_GSK3_1 98 105 PF00069 0.423
MOD_NEK2_1 33 38 PF00069 0.499
MOD_PIKK_1 129 135 PF00454 0.575
MOD_PK_1 102 108 PF00069 0.450
MOD_PKA_1 102 108 PF00069 0.387
MOD_Plk_4 108 114 PF00069 0.512
MOD_Plk_4 27 33 PF00069 0.307
MOD_ProDKin_1 44 50 PF00069 0.496
MOD_SUMO_rev_2 55 63 PF00179 0.477
TRG_ENDOCYTIC_2 81 84 PF00928 0.491
TRG_Pf-PMV_PEXEL_1 6 10 PF00026 0.313
TRG_Pf-PMV_PEXEL_1 94 98 PF00026 0.241

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HT51 Leptomonas seymouri 39% 79%
A0A0N1HZM3 Leptomonas seymouri 53% 95%
A0A0N1I697 Leptomonas seymouri 65% 99%
A0A1X0P005 Trypanosomatidae 61% 100%
A0A1X0P190 Trypanosomatidae 32% 73%
A0A3Q8IED6 Leishmania donovani 86% 100%
A0A3Q8IG90 Leishmania donovani 39% 78%
A0A3S7X2H1 Leishmania donovani 59% 97%
A0A422MZX1 Trypanosoma rangeli 38% 75%
A0A422MZX8 Trypanosoma rangeli 63% 100%
A0A6L0XIW2 Leishmania infantum 59% 97%
A0A6L0XKX4 Leishmania infantum 86% 100%
A4HHC6 Leishmania braziliensis 62% 98%
A4HHC7 Leishmania braziliensis 73% 100%
A4HHC8 Leishmania braziliensis 73% 100%
A4HJH8 Leishmania braziliensis 39% 78%
A4I6X1 Leishmania infantum 39% 78%
B6DTG3 Bodo saltans 45% 83%
B6DTG4 Bodo saltans 59% 100%
C9ZKL4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 73%
C9ZL57 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 100%
E9ADX3 Leishmania major 59% 100%
E9ALV7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
E9ALV8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 58% 97%
E9B1Z5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 76%
E9B1Z6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 81%
O77404 Trypanosoma brucei brucei 60% 100%
Q4Q665 Leishmania major 40% 81%
Q4Q666 Leishmania major 38% 78%
Q5VZ03 Homo sapiens 28% 93%
Q96CM4 Homo sapiens 27% 68%
Q9D531 Mus musculus 28% 93%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS