Tryparedoxin-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tryparedoxin-like protein

Species:

Leishmania major

UniProt:

E9ADX2_LEIMA

TriTrypDb:

LmjF.29.1140 , LMJLV39_290017800 , LMJSD75_290017900

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9ADX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADX2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	98	100	PF00675	0.447
CLV_PCSK_KEX2_1	98	100	PF00082	0.447
CLV_PCSK_SKI1_1	37	41	PF00082	0.275
DEG_APCC_DBOX_1	254	262	PF00400	0.426
DEG_SPOP_SBC_1	103	107	PF00917	0.728
DEG_SPOP_SBC_1	153	157	PF00917	0.699
DOC_MAPK_gen_1	34	43	PF00069	0.475
DOC_MAPK_gen_1	66	75	PF00069	0.475
DOC_MAPK_MEF2A_6	255	264	PF00069	0.478
DOC_MAPK_MEF2A_6	34	43	PF00069	0.501
DOC_MAPK_NFAT4_5	255	263	PF00069	0.442
DOC_PP2B_LxvP_1	185	188	PF13499	0.643
DOC_USP7_MATH_1	102	106	PF00917	0.723
DOC_USP7_MATH_1	110	114	PF00917	0.605
DOC_USP7_MATH_1	176	180	PF00917	0.623
DOC_WW_Pin1_4	104	109	PF00397	0.736
DOC_WW_Pin1_4	169	174	PF00397	0.713
DOC_WW_Pin1_4	52	57	PF00397	0.495
LIG_14-3-3_CanoR_1	200	205	PF00244	0.539
LIG_BRCT_BRCA1_1	29	33	PF00533	0.534
LIG_eIF4E_1	69	75	PF01652	0.529
LIG_FHA_1	126	132	PF00498	0.668
LIG_FHA_1	53	59	PF00498	0.475
LIG_LIR_Apic_2	44	50	PF02991	0.475
LIG_LIR_Gen_1	199	210	PF02991	0.524
LIG_LIR_Nem_3	12	17	PF02991	0.574
LIG_LIR_Nem_3	199	205	PF02991	0.539
LIG_NRBOX	257	263	PF00104	0.239
LIG_Pex14_2	10	14	PF04695	0.570
LIG_Pex14_2	238	242	PF04695	0.548
LIG_Pex14_2	43	47	PF04695	0.503
LIG_Pex14_2	71	75	PF04695	0.475
LIG_REV1ctd_RIR_1	86	96	PF16727	0.475
LIG_SH2_CRK	202	206	PF00017	0.534
LIG_SH2_NCK_1	202	206	PF00017	0.534
LIG_SH2_PTP2	38	41	PF00017	0.503
LIG_SH2_STAT5	271	274	PF00017	0.418
LIG_SH2_STAT5	38	41	PF00017	0.503
LIG_SH2_STAT5	42	45	PF00017	0.503
LIG_SH2_STAT5	96	99	PF00017	0.611
LIG_SH3_3	148	154	PF00018	0.772
LIG_SH3_3	170	176	PF00018	0.794
LIG_SH3_3	202	208	PF00018	0.542
LIG_SH3_3	233	239	PF00018	0.562
LIG_SH3_3	94	100	PF00018	0.611
LIG_SUMO_SIM_anti_2	256	263	PF11976	0.442
LIG_SUMO_SIM_par_1	211	217	PF11976	0.522
MOD_CDK_SPK_2	169	174	PF00069	0.698
MOD_CK1_1	203	209	PF00069	0.532
MOD_CK2_1	75	81	PF00069	0.500
MOD_Cter_Amidation	34	37	PF01082	0.402
MOD_GlcNHglycan	178	181	PF01048	0.413
MOD_GlcNHglycan	43	46	PF01048	0.275
MOD_GSK3_1	117	124	PF00069	0.773
MOD_GSK3_1	132	139	PF00069	0.657
MOD_GSK3_1	162	169	PF00069	0.674
MOD_GSK3_1	196	203	PF00069	0.532
MOD_GSK3_1	23	30	PF00069	0.553
MOD_N-GLC_1	132	137	PF02516	0.495
MOD_N-GLC_1	248	253	PF02516	0.455
MOD_N-GLC_1	90	95	PF02516	0.377
MOD_NEK2_1	117	122	PF00069	0.705
MOD_PIKK_1	9	15	PF00454	0.578
MOD_PK_1	200	206	PF00069	0.540
MOD_PKA_2	254	260	PF00069	0.495
MOD_PKA_2	91	97	PF00069	0.615
MOD_Plk_1	125	131	PF00069	0.700
MOD_Plk_4	200	206	PF00069	0.540
MOD_Plk_4	224	230	PF00069	0.666
MOD_Plk_4	254	260	PF00069	0.526
MOD_ProDKin_1	104	110	PF00069	0.737
MOD_ProDKin_1	169	175	PF00069	0.711
MOD_ProDKin_1	52	58	PF00069	0.495
MOD_SUMO_rev_2	12	20	PF00179	0.559
TRG_DiLeu_BaEn_1	256	261	PF01217	0.388
TRG_DiLeu_BaEn_2	192	198	PF01217	0.580
TRG_DiLeu_BaLyEn_6	53	58	PF01217	0.475
TRG_ENDOCYTIC_2	202	205	PF00928	0.536
TRG_ENDOCYTIC_2	269	272	PF00928	0.388
TRG_ENDOCYTIC_2	38	41	PF00928	0.503
TRG_ER_diArg_1	247	250	PF00400	0.664
TRG_ER_diArg_1	97	99	PF00400	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6E5	Leptomonas seymouri	64%	97%
A0A3Q8IH82	Leishmania donovani	98%	100%
A4HHC5	Leishmania braziliensis	85%	100%
A4I4H1	Leishmania infantum	98%	100%
E9ALV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%