Tryparedoxin-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tryparedoxin-like protein

Species:

Leishmania major

UniProt:

E9ADX1_LEIMA

TriTrypDb:

LmjF.29.1130 , LMJLV39_290017700 , LMJSD75_290017800

Length:

372

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9ADX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADX1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.457
CLV_NRD_NRD_1	103	105	PF00675	0.623
CLV_NRD_NRD_1	111	113	PF00675	0.657
CLV_NRD_NRD_1	151	153	PF00675	0.744
CLV_NRD_NRD_1	289	291	PF00675	0.733
CLV_NRD_NRD_1	98	100	PF00675	0.628
CLV_PCSK_FUR_1	359	363	PF00082	0.364
CLV_PCSK_FUR_1	96	100	PF00082	0.572
CLV_PCSK_KEX2_1	111	113	PF00082	0.657
CLV_PCSK_KEX2_1	170	172	PF00082	0.706
CLV_PCSK_KEX2_1	19	21	PF00082	0.607
CLV_PCSK_KEX2_1	289	291	PF00082	0.733
CLV_PCSK_KEX2_1	361	363	PF00082	0.441
CLV_PCSK_KEX2_1	98	100	PF00082	0.628
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.699
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.607
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.425
CLV_PCSK_PC7_1	94	100	PF00082	0.557
CLV_PCSK_SKI1_1	220	224	PF00082	0.662
CLV_PCSK_SKI1_1	257	261	PF00082	0.679
CLV_PCSK_SKI1_1	80	84	PF00082	0.504
CLV_Separin_Metazoa	11	15	PF03568	0.328
DEG_Nend_UBRbox_3	1	3	PF02207	0.376
DOC_CKS1_1	291	296	PF01111	0.478
DOC_CYCLIN_RxL_1	251	264	PF00134	0.434
DOC_MAPK_FxFP_2	222	225	PF00069	0.367
DOC_MAPK_gen_1	331	340	PF00069	0.292
DOC_MAPK_MEF2A_6	220	229	PF00069	0.348
DOC_MAPK_MEF2A_6	27	36	PF00069	0.284
DOC_PP4_FxxP_1	222	225	PF00568	0.367
DOC_SPAK_OSR1_1	311	315	PF12202	0.339
DOC_USP7_MATH_1	185	189	PF00917	0.572
DOC_USP7_MATH_1	255	259	PF00917	0.575
DOC_USP7_MATH_1	268	272	PF00917	0.499
DOC_USP7_MATH_1	88	92	PF00917	0.371
DOC_USP7_UBL2_3	327	331	PF12436	0.374
DOC_WW_Pin1_4	158	163	PF00397	0.500
DOC_WW_Pin1_4	237	242	PF00397	0.469
DOC_WW_Pin1_4	259	264	PF00397	0.491
DOC_WW_Pin1_4	276	281	PF00397	0.563
DOC_WW_Pin1_4	290	295	PF00397	0.455
DOC_WW_Pin1_4	38	43	PF00397	0.376
LIG_14-3-3_CanoR_1	152	157	PF00244	0.478
LIG_14-3-3_CanoR_1	220	225	PF00244	0.368
LIG_14-3-3_CanoR_1	257	262	PF00244	0.445
LIG_BIR_III_4	134	138	PF00653	0.466
LIG_CSL_BTD_1	265	268	PF09270	0.510
LIG_DLG_GKlike_1	152	160	PF00625	0.456
LIG_FHA_1	238	244	PF00498	0.410
LIG_FHA_1	291	297	PF00498	0.470
LIG_FHA_1	345	351	PF00498	0.353
LIG_HP1_1	30	34	PF01393	0.276
LIG_Integrin_isoDGR_2	136	138	PF01839	0.668
LIG_IRF3_LxIS_1	351	358	PF10401	0.518
LIG_LIR_Apic_2	352	356	PF02991	0.421
LIG_LIR_Gen_1	28	38	PF02991	0.292
LIG_LIR_Gen_1	322	330	PF02991	0.438
LIG_LIR_Gen_1	332	342	PF02991	0.257
LIG_LIR_Gen_1	45	55	PF02991	0.292
LIG_LIR_Nem_3	223	227	PF02991	0.343
LIG_LIR_Nem_3	28	34	PF02991	0.292
LIG_LIR_Nem_3	300	305	PF02991	0.387
LIG_LIR_Nem_3	332	337	PF02991	0.240
LIG_LIR_Nem_3	45	50	PF02991	0.292
LIG_LYPXL_yS_3	224	227	PF13949	0.328
LIG_LYPXL_yS_3	302	305	PF13949	0.365
LIG_MYND_1	241	245	PF01753	0.471
LIG_PCNA_PIPBox_1	48	57	PF02747	0.308
LIG_Pex14_1	201	205	PF04695	0.324
LIG_Pex14_2	36	40	PF04695	0.292
LIG_SH2_NCK_1	205	209	PF00017	0.337
LIG_SH2_NCK_1	73	77	PF00017	0.292
LIG_SH2_PTP2	31	34	PF00017	0.292
LIG_SH2_SRC	205	208	PF00017	0.332
LIG_SH2_STAT3	3	6	PF00017	0.355
LIG_SH2_STAT5	3	6	PF00017	0.355
LIG_SH2_STAT5	31	34	PF00017	0.292
LIG_SH2_STAT5	68	71	PF00017	0.305
LIG_SH3_3	188	194	PF00018	0.548
LIG_SH3_3	208	214	PF00018	0.453
LIG_SH3_3	242	248	PF00018	0.502
LIG_SH3_3	293	299	PF00018	0.590
LIG_SUMO_SIM_anti_2	347	352	PF11976	0.453
LIG_SUMO_SIM_anti_2	8	14	PF11976	0.423
LIG_SUMO_SIM_par_1	341	347	PF11976	0.340
LIG_TYR_ITIM	203	208	PF00017	0.330
LIG_TYR_ITIM	29	34	PF00017	0.292
LIG_WRC_WIRS_1	79	84	PF05994	0.308
MOD_CDK_SPxxK_3	276	283	PF00069	0.483
MOD_CK1_1	126	132	PF00069	0.475
MOD_CK1_1	161	167	PF00069	0.487
MOD_CK2_1	144	150	PF00069	0.546
MOD_CK2_1	268	274	PF00069	0.528
MOD_CK2_1	5	11	PF00069	0.441
MOD_CK2_1	71	77	PF00069	0.292
MOD_GlcNHglycan	113	116	PF01048	0.708
MOD_GlcNHglycan	125	128	PF01048	0.699
MOD_GlcNHglycan	181	184	PF01048	0.769
MOD_GlcNHglycan	187	190	PF01048	0.649
MOD_GlcNHglycan	235	238	PF01048	0.723
MOD_GlcNHglycan	88	91	PF01048	0.690
MOD_GSK3_1	152	159	PF00069	0.517
MOD_GSK3_1	233	240	PF00069	0.411
MOD_GSK3_1	255	262	PF00069	0.477
MOD_GSK3_1	268	275	PF00069	0.532
MOD_GSK3_1	67	74	PF00069	0.298
MOD_GSK3_1	78	85	PF00069	0.305
MOD_LATS_1	218	224	PF00433	0.372
MOD_N-GLC_2	146	148	PF02516	0.641
MOD_NEK2_1	156	161	PF00069	0.490
MOD_NEK2_1	36	41	PF00069	0.276
MOD_NEK2_1	78	83	PF00069	0.308
MOD_PIKK_1	273	279	PF00454	0.546
MOD_PKA_1	111	117	PF00069	0.491
MOD_PKA_1	123	129	PF00069	0.463
MOD_PKA_1	152	158	PF00069	0.546
MOD_PKA_1	361	367	PF00069	0.622
MOD_PKA_2	111	117	PF00069	0.507
MOD_PKA_2	156	162	PF00069	0.592
MOD_PKA_2	361	367	PF00069	0.622
MOD_PKA_2	86	92	PF00069	0.492
MOD_Plk_1	255	261	PF00069	0.533
MOD_Plk_4	344	350	PF00069	0.444
MOD_Plk_4	78	84	PF00069	0.321
MOD_ProDKin_1	158	164	PF00069	0.499
MOD_ProDKin_1	237	243	PF00069	0.469
MOD_ProDKin_1	259	265	PF00069	0.493
MOD_ProDKin_1	276	282	PF00069	0.553
MOD_ProDKin_1	290	296	PF00069	0.452
MOD_ProDKin_1	38	44	PF00069	0.376
MOD_SUMO_rev_2	116	126	PF00179	0.587
MOD_SUMO_rev_2	56	64	PF00179	0.376
TRG_DiLeu_BaEn_2	42	48	PF01217	0.376
TRG_ENDOCYTIC_2	205	208	PF00928	0.332
TRG_ENDOCYTIC_2	224	227	PF00928	0.328
TRG_ENDOCYTIC_2	302	305	PF00928	0.365
TRG_ENDOCYTIC_2	31	34	PF00928	0.292
TRG_ER_diArg_1	111	113	PF00400	0.444
TRG_ER_diArg_1	96	99	PF00400	0.397
TRG_Pf-PMV_PEXEL_1	111	116	PF00026	0.647
TRG_Pf-PMV_PEXEL_1	138	143	PF00026	0.663

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6T6	Leptomonas seymouri	48%	100%
A0A3Q8IE94	Leishmania donovani	87%	100%
A4HHC4	Leishmania braziliensis	72%	100%
A4I4H0	Leishmania infantum	87%	100%
E9ALW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%