Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADW9_LEIMA

TriTrypDb:

LmjF.29.1110 , LMJLV39_290017500 , LMJSD75_290017600

Length:

625

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADW9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADW9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	254	258	PF00656	0.617
CLV_C14_Caspase3-7	314	318	PF00656	0.500
CLV_C14_Caspase3-7	96	100	PF00656	0.606
CLV_NRD_NRD_1	129	131	PF00675	0.612
CLV_NRD_NRD_1	136	138	PF00675	0.573
CLV_NRD_NRD_1	301	303	PF00675	0.520
CLV_NRD_NRD_1	370	372	PF00675	0.459
CLV_PCSK_KEX2_1	129	131	PF00082	0.633
CLV_PCSK_KEX2_1	135	137	PF00082	0.595
CLV_PCSK_KEX2_1	298	300	PF00082	0.530
CLV_PCSK_KEX2_1	370	372	PF00082	0.500
CLV_PCSK_KEX2_1	599	601	PF00082	0.652
CLV_PCSK_KEX2_1	82	84	PF00082	0.631
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.676
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.590
CLV_PCSK_PC1ET2_1	599	601	PF00082	0.664
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.631
CLV_PCSK_PC7_1	125	131	PF00082	0.693
CLV_PCSK_SKI1_1	125	129	PF00082	0.654
CLV_PCSK_SKI1_1	130	134	PF00082	0.622
CLV_PCSK_SKI1_1	346	350	PF00082	0.544
CLV_PCSK_SKI1_1	53	57	PF00082	0.682
DEG_Nend_UBRbox_2	1	3	PF02207	0.735
DEG_SPOP_SBC_1	147	151	PF00917	0.702
DOC_CDC14_PxL_1	188	196	PF14671	0.692
DOC_CYCLIN_yCln2_LP_2	207	210	PF00134	0.673
DOC_MAPK_DCC_7	406	416	PF00069	0.539
DOC_MAPK_gen_1	240	250	PF00069	0.638
DOC_MAPK_gen_1	283	293	PF00069	0.496
DOC_MAPK_gen_1	370	376	PF00069	0.460
DOC_MAPK_MEF2A_6	240	248	PF00069	0.645
DOC_PP2B_LxvP_1	207	210	PF13499	0.673
DOC_PP2B_LxvP_1	336	339	PF13499	0.409
DOC_USP7_MATH_1	147	151	PF00917	0.690
DOC_USP7_MATH_1	156	160	PF00917	0.668
DOC_USP7_MATH_1	23	27	PF00917	0.700
DOC_USP7_MATH_1	319	323	PF00917	0.490
DOC_USP7_MATH_1	400	404	PF00917	0.544
DOC_USP7_MATH_1	466	470	PF00917	0.648
DOC_USP7_MATH_1	531	535	PF00917	0.632
DOC_USP7_MATH_1	585	589	PF00917	0.762
DOC_USP7_MATH_1	611	615	PF00917	0.783
LIG_14-3-3_CanoR_1	199	209	PF00244	0.564
LIG_14-3-3_CanoR_1	217	223	PF00244	0.620
LIG_14-3-3_CanoR_1	276	284	PF00244	0.561
LIG_14-3-3_CanoR_1	354	363	PF00244	0.512
LIG_14-3-3_CanoR_1	401	407	PF00244	0.675
LIG_14-3-3_CanoR_1	498	507	PF00244	0.657
LIG_Actin_WH2_2	392	410	PF00022	0.680
LIG_Actin_WH2_2	484	500	PF00022	0.682
LIG_APCC_ABBA_1	570	575	PF00400	0.650
LIG_BIR_III_4	34	38	PF00653	0.727
LIG_BRCT_BRCA1_1	311	315	PF00533	0.506
LIG_CaM_IQ_9	290	305	PF13499	0.453
LIG_eIF4E_1	202	208	PF01652	0.584
LIG_FHA_1	101	107	PF00498	0.651
LIG_FHA_1	283	289	PF00498	0.434
LIG_FHA_1	331	337	PF00498	0.555
LIG_FHA_1	351	357	PF00498	0.434
LIG_FHA_1	384	390	PF00498	0.601
LIG_FHA_1	561	567	PF00498	0.675
LIG_FHA_1	610	616	PF00498	0.717
LIG_FHA_1	86	92	PF00498	0.659
LIG_FHA_2	232	238	PF00498	0.704
LIG_FHA_2	312	318	PF00498	0.503
LIG_FHA_2	389	395	PF00498	0.573
LIG_FHA_2	400	406	PF00498	0.692
LIG_Integrin_RGD_1	32	34	PF01839	0.745
LIG_LIR_Apic_2	60	65	PF02991	0.601
LIG_LIR_Gen_1	257	268	PF02991	0.444
LIG_LIR_Gen_1	485	495	PF02991	0.719
LIG_LIR_Gen_1	504	515	PF02991	0.699
LIG_LIR_Gen_1	567	576	PF02991	0.581
LIG_LIR_Nem_3	2	6	PF02991	0.692
LIG_LIR_Nem_3	257	263	PF02991	0.455
LIG_LIR_Nem_3	343	348	PF02991	0.450
LIG_LIR_Nem_3	44	48	PF02991	0.623
LIG_LIR_Nem_3	485	491	PF02991	0.681
LIG_LIR_Nem_3	504	510	PF02991	0.631
LIG_LIR_Nem_3	540	546	PF02991	0.679
LIG_LIR_Nem_3	63	69	PF02991	0.521
LIG_LYPXL_yS_3	66	69	PF13949	0.707
LIG_NRBOX	287	293	PF00104	0.471
LIG_Pex14_1	289	293	PF04695	0.414
LIG_Pex14_1	62	66	PF04695	0.608
LIG_Pex14_2	311	315	PF04695	0.506
LIG_PTB_Apo_2	406	413	PF02174	0.683
LIG_PTB_Phospho_1	406	412	PF10480	0.692
LIG_SH2_CRK	507	511	PF00017	0.743
LIG_SH2_CRK	546	550	PF00017	0.586
LIG_SH2_GRB2like	390	393	PF00017	0.566
LIG_SH2_NCK_1	202	206	PF00017	0.658
LIG_SH2_NCK_1	390	394	PF00017	0.569
LIG_SH2_NCK_1	546	550	PF00017	0.671
LIG_SH2_STAP1	352	356	PF00017	0.369
LIG_SH2_STAP1	499	503	PF00017	0.607
LIG_SH2_STAT5	202	205	PF00017	0.572
LIG_SH2_STAT5	341	344	PF00017	0.545
LIG_SH2_STAT5	352	355	PF00017	0.345
LIG_SH2_STAT5	359	362	PF00017	0.434
LIG_SH2_STAT5	385	388	PF00017	0.577
LIG_SH2_STAT5	390	393	PF00017	0.535
LIG_SH2_STAT5	520	523	PF00017	0.594
LIG_SH2_STAT5	543	546	PF00017	0.672
LIG_SH2_STAT5	569	572	PF00017	0.556
LIG_SH3_3	112	118	PF00018	0.630
LIG_SH3_3	194	200	PF00018	0.687
LIG_SH3_3	415	421	PF00018	0.517
LIG_SH3_3	453	459	PF00018	0.608
LIG_SH3_3	61	67	PF00018	0.575
LIG_SUMO_SIM_par_1	346	351	PF11976	0.554
LIG_SUMO_SIM_par_1	4	11	PF11976	0.733
LIG_TRAF2_1	209	212	PF00917	0.666
LIG_TRAF2_1	234	237	PF00917	0.724
LIG_TRAF2_1	7	10	PF00917	0.740
LIG_TRFH_1	114	118	PF08558	0.601
LIG_TYR_ITIM	111	116	PF00017	0.584
LIG_TYR_ITIM	544	549	PF00017	0.662
LIG_TYR_ITIM	64	69	PF00017	0.682
MOD_CK1_1	11	17	PF00069	0.726
MOD_CK1_1	149	155	PF00069	0.707
MOD_CK2_1	231	237	PF00069	0.703
MOD_CK2_1	388	394	PF00069	0.560
MOD_CK2_1	4	10	PF00069	0.733
MOD_GlcNHglycan	153	156	PF01048	0.758
MOD_GlcNHglycan	25	28	PF01048	0.685
MOD_GlcNHglycan	257	260	PF01048	0.435
MOD_GlcNHglycan	277	280	PF01048	0.424
MOD_GlcNHglycan	402	405	PF01048	0.731
MOD_GlcNHglycan	421	424	PF01048	0.593
MOD_GlcNHglycan	501	504	PF01048	0.719
MOD_GlcNHglycan	587	590	PF01048	0.749
MOD_GlcNHglycan	9	13	PF01048	0.740
MOD_GSK3_1	146	153	PF00069	0.654
MOD_GSK3_1	251	258	PF00069	0.573
MOD_GSK3_1	350	357	PF00069	0.480
MOD_GSK3_1	37	44	PF00069	0.654
MOD_GSK3_1	4	11	PF00069	0.736
MOD_GSK3_1	493	500	PF00069	0.621
MOD_GSK3_1	560	567	PF00069	0.674
MOD_GSK3_1	580	587	PF00069	0.645
MOD_N-GLC_1	156	161	PF02516	0.784
MOD_N-GLC_1	558	563	PF02516	0.768
MOD_NEK2_1	282	287	PF00069	0.434
MOD_NEK2_1	293	298	PF00069	0.465
MOD_NEK2_1	311	316	PF00069	0.487
MOD_NEK2_1	399	404	PF00069	0.626
MOD_NEK2_1	407	412	PF00069	0.622
MOD_NEK2_1	493	498	PF00069	0.588
MOD_NEK2_1	84	89	PF00069	0.691
MOD_PIKK_1	11	17	PF00454	0.735
MOD_PIKK_1	218	224	PF00454	0.669
MOD_PIKK_1	251	257	PF00454	0.600
MOD_PIKK_1	37	43	PF00454	0.699
MOD_PKA_2	275	281	PF00069	0.574
MOD_PKA_2	282	288	PF00069	0.510
MOD_PKA_2	330	336	PF00069	0.541
MOD_PKA_2	400	406	PF00069	0.648
MOD_PKA_2	497	503	PF00069	0.697
MOD_Plk_1	449	455	PF00069	0.642
MOD_Plk_1	503	509	PF00069	0.627
MOD_Plk_1	85	91	PF00069	0.693
MOD_Plk_4	246	252	PF00069	0.512
MOD_Plk_4	407	413	PF00069	0.674
MOD_Plk_4	516	522	PF00069	0.588
MOD_SUMO_for_1	598	601	PF00179	0.796
MOD_SUMO_rev_2	394	400	PF00179	0.617
MOD_SUMO_rev_2	79	84	PF00179	0.696
TRG_DiLeu_BaEn_2	440	446	PF01217	0.624
TRG_DiLeu_BaEn_4	441	447	PF01217	0.626
TRG_DiLeu_BaLyEn_6	344	349	PF01217	0.507
TRG_ENDOCYTIC_2	113	116	PF00928	0.583
TRG_ENDOCYTIC_2	202	205	PF00928	0.572
TRG_ENDOCYTIC_2	390	393	PF00928	0.566
TRG_ENDOCYTIC_2	507	510	PF00928	0.720
TRG_ENDOCYTIC_2	546	549	PF00928	0.581
TRG_ENDOCYTIC_2	569	572	PF00928	0.561
TRG_ENDOCYTIC_2	66	69	PF00928	0.628
TRG_ENDOCYTIC_2	81	84	PF00928	0.580
TRG_ER_diArg_1	128	130	PF00400	0.685
TRG_ER_diArg_1	592	595	PF00400	0.775
TRG_Pf-PMV_PEXEL_1	199	204	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	346	351	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	379	383	PF00026	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHI1	Leptomonas seymouri	66%	100%
A0A0S4JMH1	Bodo saltans	29%	100%
A0A1X0P058	Trypanosomatidae	34%	96%
A0A3R7M9T5	Trypanosoma rangeli	33%	98%
A0A3S7X2F4	Leishmania donovani	95%	100%
A4HHC1	Leishmania braziliensis	87%	100%
C9ZLL7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	97%
E9AHI6	Leishmania infantum	95%	100%
E9ALW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5DI43	Trypanosoma cruzi	34%	99%