ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies), putative

Species:

Leishmania major

UniProt:

E9ADW8_LEIMA

TriTrypDb:

LmjF.29.1100 , LMJLV39_290017400 , LMJSD75_290017500

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ADW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADW8

PDB structure(s): 3ljn_A

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	44	50	PF00089	0.344
CLV_NRD_NRD_1	24	26	PF00675	0.301
CLV_NRD_NRD_1	325	327	PF00675	0.647
CLV_NRD_NRD_1	33	35	PF00675	0.298
CLV_PCSK_KEX2_1	325	327	PF00082	0.695
CLV_PCSK_KEX2_1	33	35	PF00082	0.307
CLV_PCSK_KEX2_1	335	337	PF00082	0.577
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.695
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.588
CLV_PCSK_SKI1_1	182	186	PF00082	0.515
CLV_PCSK_SKI1_1	257	261	PF00082	0.275
CLV_PCSK_SKI1_1	335	339	PF00082	0.600
CLV_Separin_Metazoa	311	315	PF03568	0.419
DEG_APCC_DBOX_1	181	189	PF00400	0.438
DOC_CYCLIN_RxL_1	254	264	PF00134	0.276
DOC_MAPK_gen_1	180	187	PF00069	0.559
DOC_MAPK_JIP1_4	82	88	PF00069	0.300
DOC_MAPK_MEF2A_6	180	189	PF00069	0.395
DOC_MAPK_MEF2A_6	225	233	PF00069	0.487
DOC_MAPK_MEF2A_6	92	99	PF00069	0.462
DOC_MAPK_NFAT4_5	182	190	PF00069	0.397
DOC_PP1_RVXF_1	281	287	PF00149	0.392
DOC_USP7_MATH_1	193	197	PF00917	0.470
DOC_USP7_MATH_1	294	298	PF00917	0.429
DOC_USP7_MATH_1	353	357	PF00917	0.708
DOC_USP7_UBL2_3	325	329	PF12436	0.620
DOC_WW_Pin1_4	158	163	PF00397	0.310
DOC_WW_Pin1_4	168	173	PF00397	0.398
DOC_WW_Pin1_4	38	43	PF00397	0.428
LIG_14-3-3_CanoR_1	25	35	PF00244	0.241
LIG_14-3-3_CanoR_1	47	55	PF00244	0.349
LIG_14-3-3_CanoR_1	9	17	PF00244	0.595
LIG_FHA_1	239	245	PF00498	0.460
LIG_FHA_1	254	260	PF00498	0.289
LIG_FHA_1	27	33	PF00498	0.294
LIG_FHA_1	275	281	PF00498	0.423
LIG_FHA_1	91	97	PF00498	0.359
LIG_FHA_2	161	167	PF00498	0.416
LIG_LIR_Gen_1	147	156	PF02991	0.288
LIG_LIR_LC3C_4	93	97	PF02991	0.357
LIG_LIR_Nem_3	2	7	PF02991	0.576
LIG_MAD2	283	291	PF02301	0.381
LIG_PCNA_yPIPBox_3	306	314	PF02747	0.401
LIG_PTAP_UEV_1	340	345	PF05743	0.553
LIG_SH2_GRB2like	202	205	PF00017	0.314
LIG_SH2_GRB2like	273	276	PF00017	0.390
LIG_SH2_STAT5	148	151	PF00017	0.359
LIG_SH2_STAT5	245	248	PF00017	0.412
LIG_SH2_STAT5	67	70	PF00017	0.393
LIG_SH3_1	338	344	PF00018	0.598
LIG_SH3_2	341	346	PF14604	0.560
LIG_SH3_3	338	344	PF00018	0.554
LIG_SUMO_SIM_anti_2	183	191	PF11976	0.394
LIG_SUMO_SIM_par_1	251	256	PF11976	0.472
LIG_SUMO_SIM_par_1	93	101	PF11976	0.357
LIG_TRAF2_1	297	300	PF00917	0.515
MOD_CDK_SPxxK_3	158	165	PF00069	0.300
MOD_CDK_SPxxK_3	168	175	PF00069	0.389
MOD_CK1_1	194	200	PF00069	0.524
MOD_CK1_1	315	321	PF00069	0.549
MOD_CK2_1	294	300	PF00069	0.515
MOD_CK2_1	67	73	PF00069	0.487
MOD_CK2_1	9	15	PF00069	0.650
MOD_GlcNHglycan	341	344	PF01048	0.580
MOD_GlcNHglycan	355	358	PF01048	0.716
MOD_GSK3_1	344	351	PF00069	0.666
MOD_GSK3_1	352	359	PF00069	0.646
MOD_LATS_1	131	137	PF00433	0.428
MOD_N-GLC_1	274	279	PF02516	0.372
MOD_N-GLC_1	90	95	PF02516	0.337
MOD_N-GLC_2	115	117	PF02516	0.319
MOD_NEK2_1	188	193	PF00069	0.512
MOD_NEK2_1	244	249	PF00069	0.417
MOD_NEK2_1	35	40	PF00069	0.361
MOD_NEK2_1	48	53	PF00069	0.290
MOD_PKA_2	353	359	PF00069	0.631
MOD_PKB_1	346	354	PF00069	0.710
MOD_Plk_1	238	244	PF00069	0.441
MOD_Plk_4	109	115	PF00069	0.442
MOD_Plk_4	275	281	PF00069	0.384
MOD_Plk_4	73	79	PF00069	0.507
MOD_ProDKin_1	158	164	PF00069	0.310
MOD_ProDKin_1	168	174	PF00069	0.395
MOD_ProDKin_1	38	44	PF00069	0.428
TRG_DiLeu_BaEn_1	183	188	PF01217	0.388
TRG_DiLeu_BaEn_1	300	305	PF01217	0.443
TRG_DiLeu_BaEn_1	31	36	PF01217	0.321
TRG_DiLeu_LyEn_5	31	36	PF01217	0.381
TRG_ENDOCYTIC_2	148	151	PF00928	0.319
TRG_ENDOCYTIC_2	245	248	PF00928	0.461
TRG_ER_diArg_1	179	182	PF00400	0.455
TRG_ER_diArg_1	32	34	PF00400	0.379
TRG_ER_diArg_1	345	348	PF00400	0.592
TRG_NLS_Bipartite_1	325	339	PF00514	0.731
TRG_NLS_MonoCore_2	324	329	PF00514	0.670
TRG_NLS_MonoExtC_3	324	329	PF00514	0.674
TRG_NLS_MonoExtN_4	325	331	PF00514	0.604
TRG_NLS_MonoExtN_4	332	339	PF00514	0.570
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.344

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9S9	Leptomonas seymouri	71%	99%
A0A1X0NIN0	Trypanosomatidae	25%	91%
A0A1X0NZR2	Trypanosomatidae	56%	100%
A0A3Q8IDM3	Leishmania donovani	97%	100%
A0A3R7N419	Trypanosoma rangeli	24%	91%
A0A422MZY2	Trypanosoma rangeli	56%	100%
A4HHC0	Leishmania braziliensis	87%	100%
A4I4G8	Leishmania infantum	98%	100%
B6DTG8	Bodo saltans	51%	100%
C9ZLL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
D0A6Y4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	92%
E9ALW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q495B1	Homo sapiens	23%	69%
Q91ZT7	Mus musculus	25%	77%