Putative ribosomal protein L1a

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosomal protein L1a, putative

Species:

Leishmania major

UniProt:

E9ADW5_LEIMA

TriTrypDb:

LmjF.29.1070 , LMJLV39_290017300 , LMJSD75_290017400

Length:

373

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 21

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	2
GO:0015934	large ribosomal subunit	4	2
GO:0022625	cytosolic large ribosomal subunit	5	2
GO:0032991	protein-containing complex	1	15
GO:0043226	organelle	2	15
GO:0043228	non-membrane-bounded organelle	3	15
GO:0043229	intracellular organelle	3	15
GO:0043232	intracellular non-membrane-bounded organelle	4	15
GO:0044391	ribosomal subunit	3	2
GO:0110165	cellular anatomical entity	1	15
GO:1990904	ribonucleoprotein complex	2	15
GO:0005840	ribosome	5	13

Expansion

Sequence features

E9ADW5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADW5

PDB structure(s): 6az3_C

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	15
GO:0006518	peptide metabolic process	4	15
GO:0006807	nitrogen compound metabolic process	2	15
GO:0008152	metabolic process	1	15
GO:0009058	biosynthetic process	2	15
GO:0009059	macromolecule biosynthetic process	4	15
GO:0009987	cellular process	1	15
GO:0019538	protein metabolic process	3	15
GO:0034641	cellular nitrogen compound metabolic process	3	15
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	15
GO:0043043	peptide biosynthetic process	5	15
GO:0043170	macromolecule metabolic process	3	15
GO:0043603	amide metabolic process	3	15
GO:0043604	amide biosynthetic process	4	15
GO:0044237	cellular metabolic process	2	15
GO:0044238	primary metabolic process	2	15
GO:0044249	cellular biosynthetic process	3	15
GO:0044260	obsolete cellular macromolecule metabolic process	3	15
GO:0044271	cellular nitrogen compound biosynthetic process	4	15
GO:0071704	organic substance metabolic process	2	15
GO:1901564	organonitrogen compound metabolic process	3	15
GO:1901566	organonitrogen compound biosynthetic process	4	15
GO:1901576	organic substance biosynthetic process	3	15

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003735	structural constituent of ribosome	2	15
GO:0005198	structural molecule activity	1	15
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.329
CLV_NRD_NRD_1	111	113	PF00675	0.328
CLV_NRD_NRD_1	198	200	PF00675	0.328
CLV_NRD_NRD_1	203	205	PF00675	0.328
CLV_NRD_NRD_1	297	299	PF00675	0.328
CLV_NRD_NRD_1	323	325	PF00675	0.361
CLV_NRD_NRD_1	352	354	PF00675	0.532
CLV_PCSK_FUR_1	196	200	PF00082	0.328
CLV_PCSK_KEX2_1	108	110	PF00082	0.329
CLV_PCSK_KEX2_1	119	121	PF00082	0.328
CLV_PCSK_KEX2_1	198	200	PF00082	0.328
CLV_PCSK_KEX2_1	203	205	PF00082	0.328
CLV_PCSK_KEX2_1	297	299	PF00082	0.328
CLV_PCSK_KEX2_1	323	325	PF00082	0.374
CLV_PCSK_KEX2_1	334	336	PF00082	0.371
CLV_PCSK_KEX2_1	352	354	PF00082	0.554
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.328
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.474
CLV_PCSK_PC7_1	199	205	PF00082	0.328
CLV_PCSK_SKI1_1	220	224	PF00082	0.328
CLV_PCSK_SKI1_1	273	277	PF00082	0.432
CLV_PCSK_SKI1_1	297	301	PF00082	0.328
CLV_PCSK_SKI1_1	353	357	PF00082	0.520
CLV_PCSK_SKI1_1	365	369	PF00082	0.523
DEG_ODPH_VHL_1	238	249	PF01847	0.328
DOC_CKS1_1	313	318	PF01111	0.400
DOC_MAPK_gen_1	108	116	PF00069	0.328
DOC_MAPK_gen_1	162	169	PF00069	0.328
DOC_MAPK_gen_1	203	209	PF00069	0.328
DOC_MAPK_gen_1	217	227	PF00069	0.328
DOC_MAPK_gen_1	321	329	PF00069	0.362
DOC_MAPK_MEF2A_6	203	210	PF00069	0.328
DOC_MAPK_MEF2A_6	321	329	PF00069	0.341
DOC_PP1_RVXF_1	244	251	PF00149	0.328
DOC_PP2B_LxvP_1	208	211	PF13499	0.341
DOC_PP2B_LxvP_1	277	280	PF13499	0.328
DOC_PP4_FxxP_1	27	30	PF00568	0.341
DOC_PP4_FxxP_1	275	278	PF00568	0.341
DOC_PP4_FxxP_1	313	316	PF00568	0.384
DOC_SPAK_OSR1_1	120	124	PF12202	0.328
DOC_SPAK_OSR1_1	246	250	PF12202	0.328
DOC_USP7_MATH_1	122	126	PF00917	0.340
DOC_USP7_MATH_1	128	132	PF00917	0.328
DOC_USP7_MATH_1	228	232	PF00917	0.474
DOC_USP7_MATH_1	3	7	PF00917	0.506
DOC_USP7_MATH_1	30	34	PF00917	0.485
DOC_USP7_MATH_1	367	371	PF00917	0.662
DOC_USP7_MATH_1	44	48	PF00917	0.341
DOC_USP7_UBL2_3	304	308	PF12436	0.341
DOC_USP7_UBL2_3	365	369	PF12436	0.578
DOC_WW_Pin1_4	312	317	PF00397	0.467
LIG_14-3-3_CanoR_1	289	299	PF00244	0.341
LIG_14-3-3_CanoR_1	4	10	PF00244	0.455
LIG_BIR_II_1	1	5	PF00653	0.665
LIG_FHA_1	18	24	PF00498	0.425
LIG_FHA_1	26	32	PF00498	0.332
LIG_FHA_2	262	268	PF00498	0.429
LIG_FHA_2	281	287	PF00498	0.317
LIG_IBAR_NPY_1	330	332	PF08397	0.429
LIG_LIR_Apic_2	311	316	PF02991	0.358
LIG_LIR_Gen_1	253	262	PF02991	0.401
LIG_LIR_LC3C_4	148	153	PF02991	0.328
LIG_LIR_Nem_3	216	222	PF02991	0.328
LIG_LIR_Nem_3	253	258	PF02991	0.344
LIG_LIR_Nem_3	259	265	PF02991	0.371
LIG_Pex14_2	219	223	PF04695	0.328
LIG_PTB_Apo_2	194	201	PF02174	0.341
LIG_PTB_Phospho_1	194	200	PF10480	0.341
LIG_SH2_STAT5	200	203	PF00017	0.328
LIG_SH2_STAT5	332	335	PF00017	0.527
LIG_SH3_3	144	150	PF00018	0.474
LIG_SH3_3	296	302	PF00018	0.341
LIG_SUMO_SIM_par_1	148	156	PF11976	0.328
LIG_UBA3_1	207	214	PF00899	0.321
LIG_WRC_WIRS_1	262	267	PF05994	0.404
MOD_CK1_1	131	137	PF00069	0.403
MOD_CK1_1	62	68	PF00069	0.342
MOD_CK1_1	8	14	PF00069	0.448
MOD_CK2_1	250	256	PF00069	0.379
MOD_CK2_1	261	267	PF00069	0.393
MOD_GlcNHglycan	1	4	PF01048	0.605
MOD_GlcNHglycan	10	13	PF01048	0.431
MOD_GlcNHglycan	124	127	PF01048	0.349
MOD_GlcNHglycan	230	233	PF01048	0.476
MOD_GlcNHglycan	252	255	PF01048	0.383
MOD_GlcNHglycan	267	271	PF01048	0.473
MOD_GlcNHglycan	369	372	PF01048	0.689
MOD_GlcNHglycan	56	59	PF01048	0.354
MOD_GlcNHglycan	61	64	PF01048	0.347
MOD_GlcNHglycan	78	81	PF01048	0.423
MOD_GlcNHglycan	85	88	PF01048	0.301
MOD_GSK3_1	127	134	PF00069	0.402
MOD_GSK3_1	13	20	PF00069	0.587
MOD_GSK3_1	308	315	PF00069	0.479
MOD_GSK3_1	76	83	PF00069	0.476
MOD_N-GLC_1	182	187	PF02516	0.328
MOD_N-GLC_1	228	233	PF02516	0.474
MOD_N-GLC_1	59	64	PF02516	0.398
MOD_N-GLC_2	93	95	PF02516	0.341
MOD_NEK2_1	127	132	PF00069	0.338
MOD_NEK2_1	135	140	PF00069	0.348
MOD_NEK2_1	38	43	PF00069	0.351
MOD_NEK2_1	59	64	PF00069	0.481
MOD_NEK2_2	5	10	PF00069	0.443
MOD_PIKK_1	248	254	PF00454	0.478
MOD_PKA_1	308	314	PF00069	0.341
MOD_PKA_1	334	340	PF00069	0.357
MOD_PKA_2	3	9	PF00069	0.455
MOD_PKA_2	334	340	PF00069	0.472
MOD_PKA_2	358	364	PF00069	0.634
MOD_PKA_2	54	60	PF00069	0.341
MOD_PKA_2	76	82	PF00069	0.474
MOD_Plk_1	153	159	PF00069	0.376
MOD_Plk_1	228	234	PF00069	0.474
MOD_Plk_1	266	272	PF00069	0.493
MOD_Plk_1	285	291	PF00069	0.237
MOD_Plk_4	13	19	PF00069	0.464
MOD_Plk_4	131	137	PF00069	0.401
MOD_Plk_4	5	11	PF00069	0.439
MOD_ProDKin_1	312	318	PF00069	0.467
MOD_SUMO_for_1	333	336	PF00179	0.429
TRG_DiLeu_BaEn_2	164	170	PF01217	0.338
TRG_ER_diArg_1	107	109	PF00400	0.329
TRG_ER_diArg_1	195	198	PF00400	0.329
TRG_ER_diArg_1	296	298	PF00400	0.336
TRG_ER_diArg_1	323	326	PF00400	0.357
TRG_NLS_MonoExtN_4	352	357	PF00514	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBP3	Leptomonas seymouri	95%	100%
A0A0S4JFT4	Bodo saltans	83%	100%
A0A1D8PFV1	Candida albicans (strain SC5314 / ATCC MYA-2876)	50%	100%
A0A1X0NDR6	Trypanosomatidae	88%	100%
A0A3S5H7L0	Leishmania donovani	98%	100%
A0A422MZW3	Trypanosoma rangeli	87%	100%
A4FVY1	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	35%	100%
A4HHB9	Leishmania braziliensis	96%	100%
A4I4G7	Leishmania infantum	98%	100%
A5UL88	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	38%	100%
A6UQJ1	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	34%	100%
A6UV67	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	34%	100%
A6VHD3	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	34%	100%
A9A9B7	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	34%	100%
B0R657	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	33%	100%
B6YSL4	Thermococcus onnurineus (strain NA1)	35%	100%
C5A285	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	36%	100%
C6A160	Thermococcus sibiricus (strain DSM 12597 / MM 739)	36%	100%
C9ZLL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
C9ZLL5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	87%	100%
E9AHI5	Leishmania infantum	98%	100%
E9ALW4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	86%
E9ALW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O02056	Caenorhabditis elegans	51%	100%
O26111	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	37%	100%
P02385	Xenopus laevis	53%	93%
P08429	Xenopus laevis	53%	94%
P09180	Drosophila melanogaster	53%	93%
P0DJ55	Tetrahymena thermophila (strain SB210)	52%	91%
P10664	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	53%	100%
P35679	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	55%	100%
P36578	Homo sapiens	57%	87%
P49165	Urechis caupo	56%	97%
P49626	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	53%	100%
P49669	Trypanosoma brucei brucei	82%	100%
P49691	Arabidopsis thaliana	54%	92%
P50878	Rattus norvegicus	57%	89%
P54015	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	33%	100%
P60846	Methanococcus maripaludis (strain S2 / LL)	35%	100%
P60847	Nanoarchaeum equitans (strain Kin4-M)	35%	100%
Q28346	Canis lupus familiaris	56%	89%
Q2NFV7	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	34%	100%
Q4R5P9	Macaca fascicularis	57%	87%
Q54Z69	Dictyostelium discoideum	56%	100%
Q58DW0	Bos taurus	57%	88%
Q5JDI0	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	34%	100%
Q5RCR3	Pongo abelii	57%	87%
Q97BX6	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	33%	100%
Q9D8E6	Mus musculus	57%	89%
Q9HIR0	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	35%	100%
Q9HPD3	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	33%	100%
Q9P784	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	54%	100%
Q9SF40	Arabidopsis thaliana	54%	92%
Q9XF97	Prunus armeniaca	56%	91%
Q9YFM1	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	34%	100%
V5BH60	Trypanosoma cruzi	86%	86%