Putative KU70 protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

KU70 protein, putative

Species:

Leishmania major

UniProt:

E9ADW3_LEIMA

TriTrypDb:

LmjF.29.1050 , LMJLV39_290017100 , LMJSD75_290017100

Length:

925

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Show entries

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	11
GO:0043564	Ku70:Ku80 complex	3	11
GO:0140513	nuclear protein-containing complex	2	11

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Expansion

Sequence features

E9ADW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADW3

Function

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Biological processes
Term	Name	Level	Count
GO:0000723	telomere maintenance	5	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006259	DNA metabolic process	4	11
GO:0006281	DNA repair	5	11
GO:0006302	double-strand break repair	6	11
GO:0006303	double-strand break repair via nonhomologous end joining	7	11
GO:0006310	DNA recombination	5	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0006950	response to stress	2	11

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0003684	damaged DNA binding	5	11
GO:0003824	catalytic activity	1	11
GO:0004386	helicase activity	2	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016787	hydrolase activity	2	11
GO:0017076	purine nucleotide binding	4	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	20	24	PF00656	0.558
CLV_C14_Caspase3-7	270	274	PF00656	0.454
CLV_C14_Caspase3-7	484	488	PF00656	0.519
CLV_C14_Caspase3-7	595	599	PF00656	0.579
CLV_NRD_NRD_1	258	260	PF00675	0.251
CLV_NRD_NRD_1	418	420	PF00675	0.419
CLV_NRD_NRD_1	495	497	PF00675	0.261
CLV_NRD_NRD_1	572	574	PF00675	0.297
CLV_NRD_NRD_1	607	609	PF00675	0.345
CLV_NRD_NRD_1	632	634	PF00675	0.299

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8R7	Leptomonas seymouri	44%	100%
A0A1X0NZS3	Trypanosomatidae	29%	100%
A0A3R7KD14	Trypanosoma rangeli	32%	100%
A4HHB7	Leishmania braziliensis	70%	96%
A4I4G4	Leishmania infantum	87%	96%
C9ZLL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E5KZN0	Leishmania donovani	87%	96%
E9ALW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	98%
V5BH85	Trypanosoma cruzi	31%	100%

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