Putative KU70 protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

KU70 protein, putative

Species:

Leishmania major

UniProt:

E9ADW3_LEIMA

TriTrypDb:

LmjF.29.1050 , LMJLV39_290017100 , LMJSD75_290017100

Length:

925

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	11
GO:0043564	Ku70:Ku80 complex	3	11
GO:0140513	nuclear protein-containing complex	2	11

Expansion

Sequence features

E9ADW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADW3

Function

Biological processes
Term	Name	Level	Count
GO:0000723	telomere maintenance	5	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006259	DNA metabolic process	4	11
GO:0006281	DNA repair	5	11
GO:0006302	double-strand break repair	6	11
GO:0006303	double-strand break repair via nonhomologous end joining	7	11
GO:0006310	DNA recombination	5	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0006950	response to stress	2	11
GO:0006974	DNA damage response	4	11
GO:0006996	organelle organization	4	11
GO:0008152	metabolic process	1	11
GO:0009314	response to radiation	3	2
GO:0009628	response to abiotic stimulus	2	2
GO:0009987	cellular process	1	11
GO:0010165	response to X-ray	5	2
GO:0010212	response to ionizing radiation	4	2
GO:0010332	response to gamma radiation	5	2
GO:0016043	cellular component organization	3	11
GO:0032200	telomere organization	6	11
GO:0033554	cellular response to stress	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0050896	response to stimulus	1	11
GO:0051276	chromosome organization	5	11
GO:0051716	cellular response to stimulus	2	11
GO:0071214	cellular response to abiotic stimulus	3	2
GO:0071478	cellular response to radiation	4	2
GO:0071479	cellular response to ionizing radiation	5	2
GO:0071480	cellular response to gamma radiation	6	2
GO:0071481	cellular response to X-ray	6	2
GO:0071704	organic substance metabolic process	2	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:0104004	cellular response to environmental stimulus	3	2
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0003684	damaged DNA binding	5	11
GO:0003824	catalytic activity	1	11
GO:0004386	helicase activity	2	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016787	hydrolase activity	2	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0042162	telomeric DNA binding	6	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0043565	sequence-specific DNA binding	5	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:0140657	ATP-dependent activity	1	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	20	24	PF00656	0.558
CLV_C14_Caspase3-7	270	274	PF00656	0.454
CLV_C14_Caspase3-7	484	488	PF00656	0.519
CLV_C14_Caspase3-7	595	599	PF00656	0.579
CLV_NRD_NRD_1	258	260	PF00675	0.251
CLV_NRD_NRD_1	418	420	PF00675	0.419
CLV_NRD_NRD_1	495	497	PF00675	0.261
CLV_NRD_NRD_1	572	574	PF00675	0.297
CLV_NRD_NRD_1	607	609	PF00675	0.345
CLV_NRD_NRD_1	632	634	PF00675	0.299
CLV_NRD_NRD_1	758	760	PF00675	0.582
CLV_NRD_NRD_1	843	845	PF00675	0.713
CLV_NRD_NRD_1	908	910	PF00675	0.442
CLV_PCSK_FUR_1	256	260	PF00082	0.287
CLV_PCSK_KEX2_1	258	260	PF00082	0.251
CLV_PCSK_KEX2_1	418	420	PF00082	0.421
CLV_PCSK_KEX2_1	495	497	PF00082	0.252
CLV_PCSK_KEX2_1	574	576	PF00082	0.300
CLV_PCSK_KEX2_1	601	603	PF00082	0.360
CLV_PCSK_KEX2_1	607	609	PF00082	0.342
CLV_PCSK_KEX2_1	632	634	PF00082	0.325
CLV_PCSK_KEX2_1	670	672	PF00082	0.326
CLV_PCSK_KEX2_1	758	760	PF00082	0.571
CLV_PCSK_KEX2_1	843	845	PF00082	0.647
CLV_PCSK_KEX2_1	908	910	PF00082	0.447
CLV_PCSK_PC1ET2_1	574	576	PF00082	0.287
CLV_PCSK_PC1ET2_1	601	603	PF00082	0.287
CLV_PCSK_PC1ET2_1	670	672	PF00082	0.309
CLV_PCSK_SKI1_1	220	224	PF00082	0.574
CLV_PCSK_SKI1_1	244	248	PF00082	0.273
CLV_PCSK_SKI1_1	258	262	PF00082	0.197
CLV_PCSK_SKI1_1	706	710	PF00082	0.593
CLV_PCSK_SKI1_1	758	762	PF00082	0.531
CLV_PCSK_SKI1_1	80	84	PF00082	0.606
CLV_PCSK_SKI1_1	819	823	PF00082	0.476
DEG_APCC_DBOX_1	426	434	PF00400	0.498
DEG_COP1_1	690	698	PF00400	0.470
DEG_Nend_UBRbox_2	1	3	PF02207	0.670
DEG_SCF_TRCP1_1	522	527	PF00400	0.454
DEG_SPOP_SBC_1	442	446	PF00917	0.490
DOC_CDC14_PxL_1	649	657	PF14671	0.390
DOC_CDC14_PxL_1	692	700	PF14671	0.469
DOC_CYCLIN_RxL_1	241	251	PF00134	0.526
DOC_CYCLIN_RxL_1	255	264	PF00134	0.558
DOC_CYCLIN_RxL_1	755	765	PF00134	0.427
DOC_MAPK_gen_1	37	46	PF00069	0.424
DOC_MAPK_gen_1	424	433	PF00069	0.493
DOC_MAPK_gen_1	492	500	PF00069	0.462
DOC_MAPK_gen_1	573	579	PF00069	0.487
DOC_MAPK_gen_1	632	642	PF00069	0.512
DOC_MAPK_gen_1	670	676	PF00069	0.470
DOC_MAPK_gen_1	908	916	PF00069	0.424
DOC_MAPK_MEF2A_6	135	142	PF00069	0.451
DOC_MAPK_MEF2A_6	289	296	PF00069	0.543
DOC_MAPK_RevD_3	245	259	PF00069	0.494
DOC_PP1_RVXF_1	563	569	PF00149	0.497
DOC_PP2B_LxvP_1	471	474	PF13499	0.454
DOC_PP2B_LxvP_1	888	891	PF13499	0.513
DOC_PP4_FxxP_1	357	360	PF00568	0.481
DOC_PP4_FxxP_1	921	924	PF00568	0.524
DOC_USP7_MATH_1	101	105	PF00917	0.697
DOC_USP7_MATH_1	107	111	PF00917	0.510
DOC_USP7_MATH_1	16	20	PF00917	0.590
DOC_USP7_MATH_1	199	203	PF00917	0.528
DOC_USP7_MATH_1	208	212	PF00917	0.533
DOC_USP7_MATH_1	224	228	PF00917	0.440
DOC_USP7_MATH_1	391	395	PF00917	0.571
DOC_USP7_MATH_1	59	63	PF00917	0.767
DOC_USP7_MATH_1	713	717	PF00917	0.698
DOC_USP7_MATH_1	767	771	PF00917	0.439
DOC_USP7_MATH_1	845	849	PF00917	0.711
DOC_USP7_MATH_1	900	904	PF00917	0.426
DOC_USP7_MATH_1	94	98	PF00917	0.720
DOC_USP7_MATH_2	794	800	PF00917	0.400
DOC_WW_Pin1_4	108	113	PF00397	0.456
DOC_WW_Pin1_4	201	206	PF00397	0.735
DOC_WW_Pin1_4	307	312	PF00397	0.646
DOC_WW_Pin1_4	341	346	PF00397	0.677
DOC_WW_Pin1_4	522	527	PF00397	0.540
DOC_WW_Pin1_4	658	663	PF00397	0.469
DOC_WW_Pin1_4	706	711	PF00397	0.554
LIG_14-3-3_CanoR_1	146	150	PF00244	0.454
LIG_14-3-3_CanoR_1	244	250	PF00244	0.484
LIG_14-3-3_CanoR_1	319	324	PF00244	0.606
LIG_14-3-3_CanoR_1	466	472	PF00244	0.350
LIG_14-3-3_CanoR_1	607	612	PF00244	0.555
LIG_Actin_WH2_2	677	695	PF00022	0.494
LIG_APCC_ABBA_1	590	595	PF00400	0.519
LIG_BRCT_BRCA1_1	110	114	PF00533	0.528
LIG_BRCT_BRCA1_1	150	154	PF00533	0.487
LIG_BRCT_BRCA1_1	226	230	PF00533	0.495
LIG_BRCT_BRCA1_1	309	313	PF00533	0.670
LIG_CaM_IQ_9	811	826	PF13499	0.419
LIG_FHA_1	166	172	PF00498	0.390
LIG_FHA_1	348	354	PF00498	0.590
LIG_FHA_1	525	531	PF00498	0.517
LIG_FHA_1	587	593	PF00498	0.495
LIG_FHA_1	707	713	PF00498	0.553
LIG_FHA_1	77	83	PF00498	0.630
LIG_FHA_1	897	903	PF00498	0.621
LIG_FHA_1	9	15	PF00498	0.627
LIG_FHA_2	18	24	PF00498	0.584
LIG_FHA_2	262	268	PF00498	0.484
LIG_FHA_2	449	455	PF00498	0.575
LIG_FHA_2	567	573	PF00498	0.512
LIG_FHA_2	580	586	PF00498	0.474
LIG_FHA_2	88	94	PF00498	0.717
LIG_GBD_Chelix_1	724	732	PF00786	0.377
LIG_LIR_Apic_2	355	360	PF02991	0.521
LIG_LIR_Apic_2	554	560	PF02991	0.470
LIG_LIR_Gen_1	185	195	PF02991	0.415
LIG_LIR_Gen_1	585	596	PF02991	0.469
LIG_LIR_Gen_1	809	817	PF02991	0.491
LIG_LIR_Gen_1	825	833	PF02991	0.529
LIG_LIR_Nem_3	151	157	PF02991	0.538
LIG_LIR_Nem_3	185	191	PF02991	0.393
LIG_LIR_Nem_3	227	233	PF02991	0.392
LIG_LIR_Nem_3	355	361	PF02991	0.403
LIG_LIR_Nem_3	470	475	PF02991	0.484
LIG_LIR_Nem_3	51	57	PF02991	0.503
LIG_LIR_Nem_3	585	591	PF02991	0.469
LIG_LIR_Nem_3	809	813	PF02991	0.498
LIG_LIR_Nem_3	825	829	PF02991	0.517
LIG_LIR_Nem_3	882	888	PF02991	0.587
LIG_NBox_RRM_1	235	245	PF00076	0.487
LIG_NRBOX	408	414	PF00104	0.527
LIG_PCNA_yPIPBox_3	410	424	PF02747	0.445
LIG_PCNA_yPIPBox_3	489	498	PF02747	0.578
LIG_PCNA_yPIPBox_3	50	64	PF02747	0.487
LIG_Pex14_2	352	356	PF04695	0.571
LIG_Pex14_2	810	814	PF04695	0.445
LIG_RPA_C_Fungi	628	640	PF08784	0.406
LIG_SH2_CRK	472	476	PF00017	0.208
LIG_SH2_CRK	558	562	PF00017	0.330
LIG_SH2_CRK	750	754	PF00017	0.466
LIG_SH2_NCK_1	558	562	PF00017	0.397
LIG_SH2_PTP2	682	685	PF00017	0.273
LIG_SH2_SRC	21	24	PF00017	0.460
LIG_SH2_SRC	558	561	PF00017	0.296
LIG_SH2_STAP1	688	692	PF00017	0.338
LIG_SH2_STAT3	158	161	PF00017	0.406
LIG_SH2_STAT3	831	834	PF00017	0.471
LIG_SH2_STAT5	158	161	PF00017	0.273
LIG_SH2_STAT5	567	570	PF00017	0.402
LIG_SH2_STAT5	645	648	PF00017	0.316
LIG_SH2_STAT5	682	685	PF00017	0.273
LIG_SH2_STAT5	831	834	PF00017	0.539
LIG_SH2_STAT5	896	899	PF00017	0.378
LIG_SH3_1	419	425	PF00018	0.386
LIG_SH3_2	422	427	PF14604	0.486
LIG_SH3_3	419	425	PF00018	0.421
LIG_SH3_3	523	529	PF00018	0.206
LIG_SH3_3	656	662	PF00018	0.297
LIG_SH3_3	681	687	PF00018	0.284
LIG_SH3_3	738	744	PF00018	0.416
LIG_SH3_3	79	85	PF00018	0.620
LIG_SUMO_SIM_anti_2	136	142	PF11976	0.335
LIG_SUMO_SIM_anti_2	912	918	PF11976	0.464
LIG_SUMO_SIM_par_1	245	251	PF11976	0.296
LIG_TRAF2_1	187	190	PF00917	0.526
LIG_TRAF2_1	569	572	PF00917	0.270
LIG_TRAF2_1	779	782	PF00917	0.613
LIG_TRAF2_1	793	796	PF00917	0.432
LIG_TRAF2_1	862	865	PF00917	0.657
LIG_TRAF2_1	90	93	PF00917	0.525
LIG_UBA3_1	122	129	PF00899	0.341
LIG_UBA3_1	592	601	PF00899	0.310
LIG_UBA3_1	889	894	PF00899	0.447
LIG_UBA3_1	913	918	PF00899	0.510
LIG_WRC_WIRS_1	807	812	PF05994	0.435
LIG_WRC_WIRS_1	814	819	PF05994	0.404
MOD_CDC14_SPxK_1	525	528	PF00782	0.296
MOD_CDK_SPxK_1	522	528	PF00069	0.296
MOD_CK1_1	110	116	PF00069	0.476
MOD_CK1_1	148	154	PF00069	0.462
MOD_CK1_1	211	217	PF00069	0.602
MOD_CK1_1	248	254	PF00069	0.326
MOD_CK1_1	304	310	PF00069	0.602
MOD_CK1_1	339	345	PF00069	0.728
MOD_CK1_1	437	443	PF00069	0.713
MOD_CK1_1	62	68	PF00069	0.643
MOD_CK1_1	647	653	PF00069	0.438
MOD_CK1_1	730	736	PF00069	0.429
MOD_CK2_1	391	397	PF00069	0.511
MOD_CK2_1	566	572	PF00069	0.292
MOD_CK2_1	579	585	PF00069	0.292
MOD_CK2_1	859	865	PF00069	0.749
MOD_CK2_1	87	93	PF00069	0.718
MOD_GlcNHglycan	147	150	PF01048	0.476
MOD_GlcNHglycan	184	187	PF01048	0.537
MOD_GlcNHglycan	211	214	PF01048	0.610
MOD_GlcNHglycan	226	229	PF01048	0.436
MOD_GlcNHglycan	267	272	PF01048	0.427
MOD_GlcNHglycan	303	306	PF01048	0.679
MOD_GlcNHglycan	307	310	PF01048	0.769
MOD_GlcNHglycan	336	339	PF01048	0.807
MOD_GlcNHglycan	374	377	PF01048	0.605
MOD_GlcNHglycan	393	396	PF01048	0.541
MOD_GlcNHglycan	436	439	PF01048	0.661
MOD_GlcNHglycan	522	525	PF01048	0.407
MOD_GlcNHglycan	61	64	PF01048	0.652
MOD_GlcNHglycan	67	70	PF01048	0.680
MOD_GlcNHglycan	729	732	PF01048	0.490
MOD_GlcNHglycan	769	772	PF01048	0.512
MOD_GlcNHglycan	798	801	PF01048	0.459
MOD_GlcNHglycan	847	850	PF01048	0.735
MOD_GlcNHglycan	861	864	PF01048	0.580
MOD_GlcNHglycan	903	906	PF01048	0.548
MOD_GSK3_1	145	152	PF00069	0.413
MOD_GSK3_1	161	168	PF00069	0.362
MOD_GSK3_1	197	204	PF00069	0.575
MOD_GSK3_1	301	308	PF00069	0.589
MOD_GSK3_1	326	333	PF00069	0.782
MOD_GSK3_1	339	346	PF00069	0.649
MOD_GSK3_1	434	441	PF00069	0.535
MOD_GSK3_1	520	527	PF00069	0.417
MOD_GSK3_1	59	66	PF00069	0.703
MOD_GSK3_1	607	614	PF00069	0.412
MOD_GSK3_1	644	651	PF00069	0.365
MOD_GSK3_1	658	665	PF00069	0.393
MOD_GSK3_1	70	77	PF00069	0.601
MOD_GSK3_1	767	774	PF00069	0.614
MOD_GSK3_1	896	903	PF00069	0.403
MOD_LATS_1	78	84	PF00433	0.593
MOD_N-GLC_1	537	542	PF02516	0.296
MOD_N-GLC_1	70	75	PF02516	0.602
MOD_N-GLC_1	900	905	PF02516	0.479
MOD_N-GLC_2	278	280	PF02516	0.386
MOD_NEK2_1	115	120	PF00069	0.371
MOD_NEK2_1	142	147	PF00069	0.336
MOD_NEK2_1	261	266	PF00069	0.432
MOD_NEK2_1	279	284	PF00069	0.179
MOD_NEK2_1	313	318	PF00069	0.586
MOD_NEK2_1	412	417	PF00069	0.535
MOD_NEK2_1	436	441	PF00069	0.552
MOD_NEK2_1	443	448	PF00069	0.551
MOD_NEK2_1	467	472	PF00069	0.297
MOD_NEK2_1	611	616	PF00069	0.373
MOD_NEK2_1	712	717	PF00069	0.676
MOD_NEK2_1	732	737	PF00069	0.275
MOD_NEK2_1	813	818	PF00069	0.458
MOD_NEK2_1	87	92	PF00069	0.710
MOD_NEK2_2	330	335	PF00069	0.525
MOD_PIKK_1	63	69	PF00454	0.614
MOD_PKA_1	607	613	PF00069	0.373
MOD_PKA_2	145	151	PF00069	0.296
MOD_PKA_2	334	340	PF00069	0.614
MOD_PKA_2	372	378	PF00069	0.607
MOD_PKA_2	502	508	PF00069	0.375
MOD_PKA_2	606	612	PF00069	0.437
MOD_PKA_2	845	851	PF00069	0.586
MOD_Plk_1	161	167	PF00069	0.386
MOD_Plk_1	17	23	PF00069	0.602
MOD_Plk_1	330	336	PF00069	0.766
MOD_Plk_1	456	462	PF00069	0.627
MOD_Plk_1	713	719	PF00069	0.533
MOD_Plk_4	110	116	PF00069	0.453
MOD_Plk_4	412	418	PF00069	0.568
MOD_Plk_4	467	473	PF00069	0.292
MOD_Plk_4	540	546	PF00069	0.318
MOD_Plk_4	607	613	PF00069	0.281
MOD_ProDKin_1	108	114	PF00069	0.438
MOD_ProDKin_1	201	207	PF00069	0.739
MOD_ProDKin_1	307	313	PF00069	0.645
MOD_ProDKin_1	341	347	PF00069	0.673
MOD_ProDKin_1	522	528	PF00069	0.417
MOD_ProDKin_1	658	664	PF00069	0.316
MOD_ProDKin_1	706	712	PF00069	0.554
MOD_SUMO_for_1	600	603	PF00179	0.341
MOD_SUMO_rev_2	570	576	PF00179	0.296
TRG_DiLeu_BaEn_3	571	577	PF01217	0.296
TRG_DiLeu_BaLyEn_6	357	362	PF01217	0.475
TRG_ENDOCYTIC_2	188	191	PF00928	0.385
TRG_ENDOCYTIC_2	472	475	PF00928	0.273
TRG_ENDOCYTIC_2	558	561	PF00928	0.332
TRG_ENDOCYTIC_2	750	753	PF00928	0.446
TRG_ENDOCYTIC_2	804	807	PF00928	0.451
TRG_ENDOCYTIC_2	826	829	PF00928	0.512
TRG_ER_diArg_1	255	258	PF00400	0.301
TRG_ER_diArg_1	417	419	PF00400	0.494
TRG_ER_diArg_1	476	479	PF00400	0.350
TRG_ER_diArg_1	494	496	PF00400	0.295
TRG_ER_diArg_1	573	576	PF00400	0.356
TRG_ER_diArg_1	606	608	PF00400	0.422
TRG_ER_diArg_1	631	633	PF00400	0.406
TRG_ER_diArg_1	758	760	PF00400	0.584
TRG_ER_diArg_1	843	846	PF00400	0.744
TRG_NES_CRM1_1	723	737	PF08389	0.463
TRG_Pf-PMV_PEXEL_1	751	755	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8R7	Leptomonas seymouri	44%	100%
A0A1X0NZS3	Trypanosomatidae	29%	100%
A0A3R7KD14	Trypanosoma rangeli	32%	100%
A4HHB7	Leishmania braziliensis	70%	96%
A4I4G4	Leishmania infantum	87%	96%
C9ZLL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E5KZN0	Leishmania donovani	87%	96%
E9ALW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	98%
V5BH85	Trypanosoma cruzi	31%	100%