Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADW1_LEIMA

TriTrypDb:

LmjF.29.1030 , LMJLV39_290016900 , LMJSD75_290016900

Length:

197

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADW1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADW1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.529
CLV_NRD_NRD_1	122	124	PF00675	0.407
CLV_NRD_NRD_1	13	15	PF00675	0.497
CLV_NRD_NRD_1	42	44	PF00675	0.602
CLV_NRD_NRD_1	85	87	PF00675	0.480
CLV_PCSK_KEX2_1	109	111	PF00082	0.511
CLV_PCSK_KEX2_1	117	119	PF00082	0.437
CLV_PCSK_KEX2_1	122	124	PF00082	0.405
CLV_PCSK_KEX2_1	13	15	PF00082	0.586
CLV_PCSK_KEX2_1	158	160	PF00082	0.488
CLV_PCSK_KEX2_1	42	44	PF00082	0.549
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.469
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.488
CLV_PCSK_PC7_1	118	124	PF00082	0.402
CLV_PCSK_PC7_1	38	44	PF00082	0.499
CLV_PCSK_SKI1_1	142	146	PF00082	0.522
CLV_PCSK_SKI1_1	30	34	PF00082	0.510
CLV_PCSK_SKI1_1	43	47	PF00082	0.469
DOC_PP1_RVXF_1	24	30	PF00149	0.323
DOC_USP7_UBL2_3	137	141	PF12436	0.463
DOC_USP7_UBL2_3	55	59	PF12436	0.582
DOC_USP7_UBL2_3	94	98	PF12436	0.654
DOC_WW_Pin1_4	13	18	PF00397	0.562
LIG_14-3-3_CanoR_1	150	156	PF00244	0.480
LIG_Actin_WH2_2	101	119	PF00022	0.326
LIG_FHA_1	173	179	PF00498	0.522
LIG_LIR_Gen_1	4	10	PF02991	0.675
LIG_LIR_Nem_3	124	130	PF02991	0.424
LIG_LIR_Nem_3	161	167	PF02991	0.446
LIG_LIR_Nem_3	4	9	PF02991	0.670
LIG_Rb_pABgroove_1	64	72	PF01858	0.571
LIG_SH2_CRK	6	10	PF00017	0.678
LIG_SH2_PTP2	167	170	PF00017	0.538
LIG_SH2_SRC	167	170	PF00017	0.524
LIG_SH2_STAP1	112	116	PF00017	0.409
LIG_SH2_STAP1	127	131	PF00017	0.560
LIG_SH2_STAP1	70	74	PF00017	0.465
LIG_SH2_STAT3	28	31	PF00017	0.436
LIG_SH2_STAT3	70	73	PF00017	0.431
LIG_SH2_STAT5	167	170	PF00017	0.563
LIG_SH2_STAT5	28	31	PF00017	0.624
LIG_SH3_1	167	173	PF00018	0.468
LIG_SH3_3	167	173	PF00018	0.457
LIG_TRAF2_1	16	19	PF00917	0.460
MOD_CK2_1	13	19	PF00069	0.495
MOD_CK2_1	55	61	PF00069	0.499
MOD_CK2_1	77	83	PF00069	0.489
MOD_Cter_Amidation	139	142	PF01082	0.605
MOD_GSK3_1	172	179	PF00069	0.514
MOD_NEK2_1	116	121	PF00069	0.430
MOD_NEK2_1	190	195	PF00069	0.679
MOD_NEK2_1	46	51	PF00069	0.521
MOD_NEK2_1	77	82	PF00069	0.600
MOD_PIKK_1	116	122	PF00454	0.518
MOD_PKA_2	149	155	PF00069	0.483
MOD_PKA_2	188	194	PF00069	0.513
MOD_ProDKin_1	13	19	PF00069	0.557
MOD_SUMO_rev_2	113	119	PF00179	0.583
MOD_SUMO_rev_2	80	88	PF00179	0.561
MOD_SUMO_rev_2	90	99	PF00179	0.391
TRG_DiLeu_BaEn_1	19	24	PF01217	0.454
TRG_DiLeu_BaEn_1	5	10	PF01217	0.494
TRG_DiLeu_BaEn_1	61	66	PF01217	0.485
TRG_DiLeu_BaEn_3	40	46	PF01217	0.344
TRG_ENDOCYTIC_2	6	9	PF00928	0.680
TRG_ER_diArg_1	108	110	PF00400	0.519
TRG_ER_diArg_1	13	15	PF00400	0.536
TRG_Pf-PMV_PEXEL_1	109	113	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	13	18	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	43	47	PF00026	0.350
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HS21	Leptomonas seymouri	30%	100%
A0A0N1PE73	Leptomonas seymouri	64%	99%
A0A0S4KEQ5	Bodo saltans	37%	100%
A0A1X0P0C6	Trypanosomatidae	59%	100%
A0A1X0P828	Trypanosomatidae	31%	100%
A0A3Q8IR92	Leishmania donovani	94%	100%
A0A3R7K1K7	Trypanosoma rangeli	33%	100%
A0A3S7XAJ8	Leishmania donovani	27%	94%
A0A422NF15	Trypanosoma rangeli	58%	100%
A0A422NMA5	Trypanosoma rangeli	27%	100%
A4HHB5	Leishmania braziliensis	82%	100%
A4I4G2	Leishmania infantum	94%	100%
A4ICK7	Leishmania infantum	27%	94%
C9ZLL0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9ALW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9ASP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	94%
V5B1S3	Trypanosoma cruzi	57%	100%