DNA-directed DNA polymerase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADW0_LEIMA

TriTrypDb:

LmjF.29.1020 , LMJLV39_290016800 , LMJSD75_290016800

Length:

731

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADW0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.448
CLV_C14_Caspase3-7	228	232	PF00656	0.801
CLV_C14_Caspase3-7	252	256	PF00656	0.631
CLV_C14_Caspase3-7	534	538	PF00656	0.485
CLV_C14_Caspase3-7	665	669	PF00656	0.588
CLV_NRD_NRD_1	112	114	PF00675	0.510
CLV_NRD_NRD_1	128	130	PF00675	0.708
CLV_NRD_NRD_1	25	27	PF00675	0.476
CLV_NRD_NRD_1	338	340	PF00675	0.638
CLV_NRD_NRD_1	354	356	PF00675	0.553
CLV_NRD_NRD_1	372	374	PF00675	0.619
CLV_NRD_NRD_1	45	47	PF00675	0.351
CLV_NRD_NRD_1	551	553	PF00675	0.637
CLV_NRD_NRD_1	690	692	PF00675	0.554
CLV_PCSK_FUR_1	644	648	PF00082	0.504
CLV_PCSK_KEX2_1	112	114	PF00082	0.519
CLV_PCSK_KEX2_1	128	130	PF00082	0.726
CLV_PCSK_KEX2_1	24	26	PF00082	0.486
CLV_PCSK_KEX2_1	340	342	PF00082	0.688
CLV_PCSK_KEX2_1	353	355	PF00082	0.567
CLV_PCSK_KEX2_1	372	374	PF00082	0.566
CLV_PCSK_KEX2_1	44	46	PF00082	0.343
CLV_PCSK_KEX2_1	551	553	PF00082	0.637
CLV_PCSK_KEX2_1	646	648	PF00082	0.590
CLV_PCSK_KEX2_1	690	692	PF00082	0.554
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.669
CLV_PCSK_PC1ET2_1	646	648	PF00082	0.590
CLV_PCSK_PC7_1	350	356	PF00082	0.626
CLV_PCSK_PC7_1	368	374	PF00082	0.644
CLV_PCSK_SKI1_1	244	248	PF00082	0.690
CLV_PCSK_SKI1_1	427	431	PF00082	0.632
CLV_PCSK_SKI1_1	480	484	PF00082	0.489
CLV_Separin_Metazoa	109	113	PF03568	0.566
DEG_APCC_DBOX_1	104	112	PF00400	0.556
DEG_APCC_DBOX_1	23	31	PF00400	0.466
DEG_APCC_DBOX_1	43	51	PF00400	0.346
DEG_Nend_Nbox_1	1	3	PF02207	0.536
DEG_SPOP_SBC_1	60	64	PF00917	0.675
DOC_CKS1_1	287	292	PF01111	0.624
DOC_CKS1_1	428	433	PF01111	0.546
DOC_MAPK_gen_1	102	110	PF00069	0.458
DOC_MAPK_gen_1	11	20	PF00069	0.430
DOC_PP2B_LxvP_1	271	274	PF13499	0.606
DOC_PP4_FxxP_1	122	125	PF00568	0.572
DOC_PP4_FxxP_1	438	441	PF00568	0.596
DOC_PP4_FxxP_1	707	710	PF00568	0.621
DOC_USP7_MATH_1	177	181	PF00917	0.587
DOC_USP7_MATH_1	230	234	PF00917	0.692
DOC_USP7_MATH_1	382	386	PF00917	0.678
DOC_USP7_MATH_1	448	452	PF00917	0.533
DOC_USP7_MATH_1	60	64	PF00917	0.684
DOC_USP7_MATH_1	670	674	PF00917	0.583
DOC_WW_Pin1_4	121	126	PF00397	0.508
DOC_WW_Pin1_4	274	279	PF00397	0.727
DOC_WW_Pin1_4	286	291	PF00397	0.678
DOC_WW_Pin1_4	419	424	PF00397	0.546
DOC_WW_Pin1_4	427	432	PF00397	0.565
DOC_WW_Pin1_4	469	474	PF00397	0.545
DOC_WW_Pin1_4	557	562	PF00397	0.602
LIG_14-3-3_CanoR_1	113	122	PF00244	0.512
LIG_14-3-3_CanoR_1	354	364	PF00244	0.793
LIG_14-3-3_CanoR_1	480	487	PF00244	0.547
LIG_14-3-3_CanoR_1	551	561	PF00244	0.686
LIG_14-3-3_CanoR_1	580	586	PF00244	0.492
LIG_BRCT_BRCA1_1	508	512	PF00533	0.484
LIG_CaM_IQ_9	38	54	PF13499	0.490
LIG_eIF4E_1	585	591	PF01652	0.424
LIG_FHA_1	3	9	PF00498	0.584
LIG_FHA_1	481	487	PF00498	0.492
LIG_FHA_1	569	575	PF00498	0.562
LIG_FHA_1	582	588	PF00498	0.435
LIG_FHA_1	694	700	PF00498	0.569
LIG_FHA_1	720	726	PF00498	0.570
LIG_FHA_2	104	110	PF00498	0.462
LIG_FHA_2	150	156	PF00498	0.608
LIG_FHA_2	220	226	PF00498	0.658
LIG_FHA_2	270	276	PF00498	0.723
LIG_FHA_2	287	293	PF00498	0.571
LIG_FHA_2	592	598	PF00498	0.530
LIG_FHA_2	614	620	PF00498	0.516
LIG_Integrin_isoDGR_2	549	551	PF01839	0.557
LIG_IRF3_LxIS_1	94	99	PF10401	0.516
LIG_LIR_Apic_2	121	125	PF02991	0.568
LIG_LIR_Apic_2	704	710	PF02991	0.561
LIG_LIR_Gen_1	143	151	PF02991	0.504
LIG_LIR_Gen_1	153	164	PF02991	0.426
LIG_LIR_Gen_1	299	310	PF02991	0.577
LIG_LIR_Gen_1	507	514	PF02991	0.444
LIG_LIR_Gen_1	584	591	PF02991	0.489
LIG_LIR_Gen_1	597	606	PF02991	0.395
LIG_LIR_Nem_3	127	133	PF02991	0.497
LIG_LIR_Nem_3	143	148	PF02991	0.586
LIG_LIR_Nem_3	153	159	PF02991	0.426
LIG_LIR_Nem_3	507	511	PF02991	0.400
LIG_LIR_Nem_3	584	588	PF02991	0.521
LIG_LIR_Nem_3	597	603	PF02991	0.434
LIG_LIR_Nem_3	704	709	PF02991	0.627
LIG_LYPXL_SIV_4	496	504	PF13949	0.423
LIG_MLH1_MIPbox_1	508	512	PF16413	0.484
LIG_MYND_1	437	441	PF01753	0.507
LIG_NRBOX	46	52	PF00104	0.564
LIG_Pex14_2	160	164	PF04695	0.450
LIG_Pex14_2	438	442	PF04695	0.517
LIG_Pex14_2	508	512	PF04695	0.395
LIG_Rb_pABgroove_1	296	304	PF01858	0.471
LIG_SH2_PTP2	145	148	PF00017	0.495
LIG_SH2_STAP1	585	589	PF00017	0.430
LIG_SH2_STAP1	657	661	PF00017	0.707
LIG_SH2_STAT5	145	148	PF00017	0.495
LIG_SH2_STAT5	156	159	PF00017	0.444
LIG_SH2_STAT5	446	449	PF00017	0.504
LIG_SH2_STAT5	49	52	PF00017	0.402
LIG_SH2_STAT5	497	500	PF00017	0.489
LIG_SH2_STAT5	706	709	PF00017	0.601
LIG_SH2_STAT5	714	717	PF00017	0.522
LIG_SH3_3	165	171	PF00018	0.466
LIG_SH3_3	464	470	PF00018	0.511
LIG_SH3_3	524	530	PF00018	0.440
LIG_SUMO_SIM_anti_2	106	112	PF11976	0.562
LIG_SUMO_SIM_anti_2	462	468	PF11976	0.548
LIG_SUMO_SIM_anti_2	586	595	PF11976	0.420
LIG_SUMO_SIM_anti_2	616	623	PF11976	0.450
LIG_SUMO_SIM_par_1	586	595	PF11976	0.420
LIG_TRAF2_1	222	225	PF00917	0.634
LIG_TRAF2_1	385	388	PF00917	0.641
LIG_TRAF2_1	595	598	PF00917	0.528
LIG_TYR_ITIM	154	159	PF00017	0.451
LIG_TYR_ITIM	583	588	PF00017	0.478
LIG_UBA3_1	306	313	PF00899	0.568
LIG_WRC_WIRS_1	119	124	PF05994	0.559
MOD_CDK_SPxxK_3	121	128	PF00069	0.605
MOD_CK1_1	121	127	PF00069	0.521
MOD_CK1_1	178	184	PF00069	0.588
MOD_CK1_1	277	283	PF00069	0.692
MOD_CK1_1	318	324	PF00069	0.666
MOD_CK1_1	521	527	PF00069	0.481
MOD_CK1_1	553	559	PF00069	0.678
MOD_CK1_1	59	65	PF00069	0.557
MOD_CK1_1	702	708	PF00069	0.637
MOD_CK2_1	103	109	PF00069	0.464
MOD_CK2_1	149	155	PF00069	0.479
MOD_CK2_1	219	225	PF00069	0.658
MOD_CK2_1	382	388	PF00069	0.686
MOD_CK2_1	469	475	PF00069	0.507
MOD_CK2_1	557	563	PF00069	0.602
MOD_CK2_1	591	597	PF00069	0.524
MOD_CK2_1	639	645	PF00069	0.612
MOD_Cter_Amidation	370	373	PF01082	0.665
MOD_Cter_Amidation	549	552	PF01082	0.630
MOD_GlcNHglycan	170	174	PF01048	0.499
MOD_GlcNHglycan	177	180	PF01048	0.476
MOD_GlcNHglycan	184	187	PF01048	0.563
MOD_GlcNHglycan	231	235	PF01048	0.638
MOD_GlcNHglycan	260	263	PF01048	0.756
MOD_GlcNHglycan	318	321	PF01048	0.657
MOD_GlcNHglycan	394	397	PF01048	0.737
MOD_GlcNHglycan	507	511	PF01048	0.549
MOD_GlcNHglycan	520	523	PF01048	0.415
MOD_GlcNHglycan	555	558	PF01048	0.645
MOD_GlcNHglycan	56	59	PF01048	0.625
MOD_GlcNHglycan	609	612	PF01048	0.482
MOD_GlcNHglycan	64	67	PF01048	0.714
MOD_GlcNHglycan	68	71	PF01048	0.732
MOD_GlcNHglycan	701	704	PF01048	0.588
MOD_GSK3_1	114	121	PF00069	0.586
MOD_GSK3_1	175	182	PF00069	0.563
MOD_GSK3_1	196	203	PF00069	0.691
MOD_GSK3_1	314	321	PF00069	0.679
MOD_GSK3_1	382	389	PF00069	0.616
MOD_GSK3_1	414	421	PF00069	0.631
MOD_GSK3_1	476	483	PF00069	0.554
MOD_GSK3_1	54	61	PF00069	0.539
MOD_GSK3_1	552	559	PF00069	0.658
MOD_GSK3_1	592	599	PF00069	0.526
MOD_GSK3_1	62	69	PF00069	0.590
MOD_GSK3_1	708	715	PF00069	0.556
MOD_N-GLC_1	115	120	PF02516	0.585
MOD_N-GLC_1	455	460	PF02516	0.489
MOD_NEK2_1	1	6	PF00069	0.663
MOD_NEK2_1	114	119	PF00069	0.543
MOD_NEK2_1	175	180	PF00069	0.591
MOD_NEK2_1	30	35	PF00069	0.540
MOD_NEK2_1	476	481	PF00069	0.518
MOD_NEK2_1	590	595	PF00069	0.463
MOD_NEK2_1	596	601	PF00069	0.465
MOD_NEK2_1	613	618	PF00069	0.520
MOD_NEK2_2	19	24	PF00069	0.466
MOD_PIKK_1	540	546	PF00454	0.555
MOD_PK_1	386	392	PF00069	0.530
MOD_PKA_1	339	345	PF00069	0.774
MOD_PKA_2	30	36	PF00069	0.438
MOD_PKA_2	314	320	PF00069	0.557
MOD_PKA_2	367	373	PF00069	0.651
MOD_PKA_2	550	556	PF00069	0.715
MOD_PKB_1	337	345	PF00069	0.617
MOD_PKB_1	353	361	PF00069	0.483
MOD_Plk_1	115	121	PF00069	0.585
MOD_Plk_1	219	225	PF00069	0.709
MOD_Plk_1	386	392	PF00069	0.530
MOD_Plk_1	448	454	PF00069	0.480
MOD_Plk_1	455	461	PF00069	0.470
MOD_Plk_1	506	512	PF00069	0.466
MOD_Plk_1	568	574	PF00069	0.583
MOD_Plk_1	596	602	PF00069	0.598
MOD_Plk_1	657	663	PF00069	0.735
MOD_Plk_2-3	103	109	PF00069	0.450
MOD_Plk_2-3	639	645	PF00069	0.553
MOD_Plk_4	115	121	PF00069	0.491
MOD_Plk_4	196	202	PF00069	0.526
MOD_Plk_4	3	9	PF00069	0.545
MOD_Plk_4	449	455	PF00069	0.498
MOD_Plk_4	702	708	PF00069	0.565
MOD_ProDKin_1	121	127	PF00069	0.513
MOD_ProDKin_1	274	280	PF00069	0.729
MOD_ProDKin_1	286	292	PF00069	0.676
MOD_ProDKin_1	419	425	PF00069	0.550
MOD_ProDKin_1	427	433	PF00069	0.560
MOD_ProDKin_1	469	475	PF00069	0.541
MOD_ProDKin_1	557	563	PF00069	0.602
MOD_SUMO_for_1	498	501	PF00179	0.517
MOD_SUMO_rev_2	131	137	PF00179	0.523
MOD_SUMO_rev_2	243	249	PF00179	0.641
MOD_SUMO_rev_2	401	406	PF00179	0.507
MOD_SUMO_rev_2	408	413	PF00179	0.564
MOD_SUMO_rev_2	723	727	PF00179	0.658
TRG_DiLeu_BaEn_1	569	574	PF01217	0.657
TRG_DiLeu_BaEn_1	586	591	PF01217	0.337
TRG_DiLeu_LyEn_5	569	574	PF01217	0.548
TRG_ENDOCYTIC_2	145	148	PF00928	0.495
TRG_ENDOCYTIC_2	156	159	PF00928	0.444
TRG_ENDOCYTIC_2	497	500	PF00928	0.427
TRG_ENDOCYTIC_2	585	588	PF00928	0.466
TRG_ENDOCYTIC_2	706	709	PF00928	0.623
TRG_ER_diArg_1	10	13	PF00400	0.633
TRG_ER_diArg_1	111	113	PF00400	0.485
TRG_ER_diArg_1	128	130	PF00400	0.721
TRG_ER_diArg_1	23	26	PF00400	0.444
TRG_ER_diArg_1	324	327	PF00400	0.631
TRG_ER_diArg_1	334	337	PF00400	0.570
TRG_ER_diArg_1	352	355	PF00400	0.519
TRG_ER_diArg_1	44	46	PF00400	0.504
TRG_ER_diArg_1	570	573	PF00400	0.543
TRG_ER_diArg_1	689	691	PF00400	0.556
TRG_NLS_MonoExtC_3	338	343	PF00514	0.741
TRG_NLS_MonoExtN_4	337	344	PF00514	0.748
TRG_Pf-PMV_PEXEL_1	28	32	PF00026	0.611
TRG_Pf-PMV_PEXEL_1	363	367	PF00026	0.596
TRG_Pf-PMV_PEXEL_1	485	490	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	572	576	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	659	663	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Y8	Leptomonas seymouri	53%	100%
A0A1X0NZR8	Trypanosomatidae	38%	100%
A0A3R7NBZ9	Trypanosoma rangeli	40%	100%
A0A3S7X2C1	Leishmania donovani	92%	100%
A4HHB4	Leishmania braziliensis	75%	100%
A4I4G1	Leishmania infantum	92%	100%
E9ALX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%