Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADV8_LEIMA

TriTrypDb:

LmjF.29.1000 , LMJLV39_290016500 , LMJSD75_290016500

Length:

625

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADV8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADV8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	139	145	PF00089	0.489
CLV_MEL_PAP_1	339	345	PF00089	0.567
CLV_NRD_NRD_1	172	174	PF00675	0.511
CLV_NRD_NRD_1	341	343	PF00675	0.550
CLV_NRD_NRD_1	459	461	PF00675	0.641
CLV_NRD_NRD_1	506	508	PF00675	0.646
CLV_PCSK_KEX2_1	172	174	PF00082	0.511
CLV_PCSK_KEX2_1	291	293	PF00082	0.617
CLV_PCSK_KEX2_1	341	343	PF00082	0.550
CLV_PCSK_KEX2_1	459	461	PF00082	0.695
CLV_PCSK_KEX2_1	506	508	PF00082	0.659
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.598
CLV_PCSK_SKI1_1	188	192	PF00082	0.600
CLV_PCSK_SKI1_1	207	211	PF00082	0.295
CLV_PCSK_SKI1_1	517	521	PF00082	0.524
CLV_PCSK_SKI1_1	594	598	PF00082	0.567
CLV_PCSK_SKI1_1	69	73	PF00082	0.686
CLV_Separin_Metazoa	204	208	PF03568	0.435
CLV_Separin_Metazoa	456	460	PF03568	0.649
DEG_APCC_DBOX_1	398	406	PF00400	0.518
DEG_APCC_DBOX_1	47	55	PF00400	0.501
DEG_APCC_DBOX_1	505	513	PF00400	0.463
DEG_COP1_1	5	14	PF00400	0.576
DEG_MDM2_SWIB_1	156	163	PF02201	0.440
DEG_SPOP_SBC_1	598	602	PF00917	0.609
DOC_CKS1_1	550	555	PF01111	0.628
DOC_CYCLIN_yCln2_LP_2	592	598	PF00134	0.644
DOC_MAPK_gen_1	186	193	PF00069	0.562
DOC_MAPK_gen_1	472	479	PF00069	0.686
DOC_MAPK_MEF2A_6	25	34	PF00069	0.411
DOC_MAPK_MEF2A_6	472	479	PF00069	0.667
DOC_PP2B_LxvP_1	191	194	PF13499	0.469
DOC_PP2B_LxvP_1	430	433	PF13499	0.523
DOC_PP2B_PxIxI_1	1	7	PF00149	0.642
DOC_PP4_FxxP_1	582	585	PF00568	0.690
DOC_USP7_MATH_1	220	224	PF00917	0.547
DOC_USP7_MATH_1	226	230	PF00917	0.538
DOC_USP7_MATH_1	245	249	PF00917	0.637
DOC_USP7_MATH_1	275	279	PF00917	0.616
DOC_USP7_MATH_1	383	387	PF00917	0.643
DOC_USP7_MATH_1	419	423	PF00917	0.703
DOC_USP7_MATH_1	470	474	PF00917	0.516
DOC_USP7_MATH_1	519	523	PF00917	0.540
DOC_USP7_MATH_1	543	547	PF00917	0.753
DOC_WW_Pin1_4	357	362	PF00397	0.720
DOC_WW_Pin1_4	420	425	PF00397	0.733
DOC_WW_Pin1_4	431	436	PF00397	0.672
DOC_WW_Pin1_4	549	554	PF00397	0.685
DOC_WW_Pin1_4	615	620	PF00397	0.696
LIG_14-3-3_CanoR_1	129	133	PF00244	0.527
LIG_14-3-3_CanoR_1	142	150	PF00244	0.399
LIG_14-3-3_CanoR_1	172	179	PF00244	0.644
LIG_14-3-3_CanoR_1	188	194	PF00244	0.384
LIG_14-3-3_CanoR_1	227	235	PF00244	0.521
LIG_14-3-3_CanoR_1	25	33	PF00244	0.490
LIG_14-3-3_CanoR_1	313	318	PF00244	0.490
LIG_14-3-3_CanoR_1	341	346	PF00244	0.502
LIG_14-3-3_CanoR_1	355	361	PF00244	0.615
LIG_14-3-3_CanoR_1	437	442	PF00244	0.659
LIG_14-3-3_CanoR_1	472	478	PF00244	0.693
LIG_14-3-3_CanoR_1	559	567	PF00244	0.683
LIG_14-3-3_CanoR_1	584	592	PF00244	0.700
LIG_14-3-3_CanoR_1	86	90	PF00244	0.339
LIG_DLG_GKlike_1	230	238	PF00625	0.562
LIG_eIF4E_1	550	556	PF01652	0.655
LIG_FHA_1	185	191	PF00498	0.546
LIG_FHA_1	25	31	PF00498	0.466
LIG_FHA_1	452	458	PF00498	0.740
LIG_FHA_1	550	556	PF00498	0.625
LIG_FHA_1	587	593	PF00498	0.719
LIG_FHA_1	77	83	PF00498	0.559
LIG_FHA_1	98	104	PF00498	0.631
LIG_FHA_2	294	300	PF00498	0.602
LIG_FHA_2	306	312	PF00498	0.511
LIG_FHA_2	78	84	PF00498	0.602
LIG_Integrin_RGD_1	578	580	PF01839	0.622
LIG_LIR_Apic_2	547	553	PF02991	0.656
LIG_LIR_Apic_2	564	570	PF02991	0.638
LIG_LIR_Apic_2	580	585	PF02991	0.690
LIG_LIR_Gen_1	195	203	PF02991	0.429
LIG_LIR_Gen_1	20	30	PF02991	0.405
LIG_LIR_Nem_3	158	163	PF02991	0.597
LIG_LIR_Nem_3	195	199	PF02991	0.475
LIG_LIR_Nem_3	20	26	PF02991	0.404
LIG_MYND_1	553	557	PF01753	0.688
LIG_MYND_3	273	277	PF01753	0.610
LIG_NRBOX	205	211	PF00104	0.528
LIG_NRBOX	313	319	PF00104	0.605
LIG_Pex14_2	156	160	PF04695	0.428
LIG_RPA_C_Fungi	225	237	PF08784	0.549
LIG_SH2_CRK	23	27	PF00017	0.398
LIG_SH2_CRK	550	554	PF00017	0.659
LIG_SH2_NCK_1	550	554	PF00017	0.659
LIG_SH2_NCK_1	567	571	PF00017	0.445
LIG_SH2_STAT5	189	192	PF00017	0.428
LIG_SH2_STAT5	234	237	PF00017	0.571
LIG_SH2_STAT5	605	608	PF00017	0.593
LIG_SH3_3	554	560	PF00018	0.625
LIG_SUMO_SIM_anti_2	454	459	PF11976	0.644
LIG_SUMO_SIM_par_1	189	195	PF11976	0.464
LIG_TRAF2_1	323	326	PF00917	0.505
LIG_TYR_ITIM	21	26	PF00017	0.401
LIG_WRC_WIRS_1	193	198	PF05994	0.462
MOD_CDC14_SPxK_1	434	437	PF00782	0.494
MOD_CDK_SPxK_1	431	437	PF00069	0.502
MOD_CK1_1	192	198	PF00069	0.472
MOD_CK1_1	24	30	PF00069	0.461
MOD_CK1_1	420	426	PF00069	0.730
MOD_CK1_1	439	445	PF00069	0.476
MOD_CK1_1	473	479	PF00069	0.606
MOD_CK1_1	583	589	PF00069	0.662
MOD_CK1_1	600	606	PF00069	0.527
MOD_CK2_1	141	147	PF00069	0.497
MOD_CK2_1	291	297	PF00069	0.619
MOD_CK2_1	305	311	PF00069	0.384
MOD_CK2_1	341	347	PF00069	0.507
MOD_CK2_1	365	371	PF00069	0.636
MOD_CK2_1	515	521	PF00069	0.493
MOD_CK2_1	77	83	PF00069	0.587
MOD_Cter_Amidation	170	173	PF01082	0.559
MOD_GlcNHglycan	143	146	PF01048	0.538
MOD_GlcNHglycan	246	250	PF01048	0.605
MOD_GlcNHglycan	277	280	PF01048	0.600
MOD_GlcNHglycan	293	296	PF01048	0.633
MOD_GlcNHglycan	367	370	PF01048	0.614
MOD_GlcNHglycan	405	408	PF01048	0.702
MOD_GlcNHglycan	419	422	PF01048	0.691
MOD_GlcNHglycan	517	520	PF01048	0.558
MOD_GlcNHglycan	547	550	PF01048	0.674
MOD_GlcNHglycan	561	564	PF01048	0.669
MOD_GlcNHglycan	586	589	PF01048	0.653
MOD_GSK3_1	17	24	PF00069	0.412
MOD_GSK3_1	226	233	PF00069	0.526
MOD_GSK3_1	356	363	PF00069	0.706
MOD_GSK3_1	437	444	PF00069	0.594
MOD_GSK3_1	515	522	PF00069	0.616
MOD_GSK3_1	545	552	PF00069	0.684
MOD_GSK3_1	580	587	PF00069	0.617
MOD_GSK3_1	613	620	PF00069	0.625
MOD_N-GLC_1	613	618	PF02516	0.635
MOD_NEK2_1	128	133	PF00069	0.583
MOD_NEK2_1	179	184	PF00069	0.473
MOD_NEK2_1	19	24	PF00069	0.407
MOD_NEK2_1	318	323	PF00069	0.657
MOD_NEK2_1	441	446	PF00069	0.713
MOD_NEK2_1	512	517	PF00069	0.525
MOD_NEK2_1	520	525	PF00069	0.603
MOD_NEK2_1	597	602	PF00069	0.612
MOD_NEK2_1	85	90	PF00069	0.486
MOD_PIKK_1	305	311	PF00454	0.398
MOD_PIKK_1	321	327	PF00454	0.467
MOD_PIKK_1	461	467	PF00454	0.720
MOD_PIKK_1	52	58	PF00454	0.434
MOD_PKA_1	291	297	PF00069	0.579
MOD_PKA_1	341	347	PF00069	0.551
MOD_PKA_2	128	134	PF00069	0.558
MOD_PKA_2	141	147	PF00069	0.447
MOD_PKA_2	171	177	PF00069	0.647
MOD_PKA_2	226	232	PF00069	0.489
MOD_PKA_2	24	30	PF00069	0.481
MOD_PKA_2	291	297	PF00069	0.579
MOD_PKA_2	341	347	PF00069	0.591
MOD_PKA_2	390	396	PF00069	0.784
MOD_PKA_2	403	409	PF00069	0.523
MOD_PKA_2	436	442	PF00069	0.632
MOD_PKA_2	473	479	PF00069	0.680
MOD_PKA_2	583	589	PF00069	0.722
MOD_PKA_2	85	91	PF00069	0.412
MOD_Plk_1	146	152	PF00069	0.518
MOD_Plk_1	179	185	PF00069	0.541
MOD_Plk_1	346	352	PF00069	0.608
MOD_Plk_1	470	476	PF00069	0.513
MOD_Plk_1	512	518	PF00069	0.625
MOD_Plk_1	6	12	PF00069	0.508
MOD_Plk_1	613	619	PF00069	0.665
MOD_Plk_2-3	451	457	PF00069	0.571
MOD_Plk_2-3	7	13	PF00069	0.466
MOD_Plk_4	179	185	PF00069	0.575
MOD_Plk_4	230	236	PF00069	0.579
MOD_Plk_4	313	319	PF00069	0.633
MOD_Plk_4	341	347	PF00069	0.551
MOD_Plk_4	551	557	PF00069	0.585
MOD_Plk_4	600	606	PF00069	0.653
MOD_ProDKin_1	357	363	PF00069	0.718
MOD_ProDKin_1	420	426	PF00069	0.734
MOD_ProDKin_1	431	437	PF00069	0.674
MOD_ProDKin_1	549	555	PF00069	0.684
MOD_ProDKin_1	615	621	PF00069	0.697
TRG_DiLeu_BaEn_3	493	499	PF01217	0.510
TRG_DiLeu_BaEn_4	201	207	PF01217	0.467
TRG_ENDOCYTIC_2	23	26	PF00928	0.399
TRG_ER_diArg_1	186	189	PF00400	0.471
TRG_ER_diArg_1	341	343	PF00400	0.590
TRG_ER_diArg_1	458	460	PF00400	0.693
TRG_ER_diArg_1	472	475	PF00400	0.456
TRG_ER_diArg_1	485	488	PF00400	0.331
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	259	263	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	507	511	PF00026	0.675

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IB58	Leptomonas seymouri	54%	100%
A0A1X0P0W9	Trypanosomatidae	32%	100%
A0A3R7MKA9	Trypanosoma rangeli	28%	100%
A0A3S7X2E5	Leishmania donovani	91%	100%
A4HHB2	Leishmania braziliensis	74%	100%
A4I4F8	Leishmania infantum	89%	98%
E9ALX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BH56	Trypanosoma cruzi	31%	100%