Bromo domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADV7_LEIMA

TriTrypDb:

LmjF.29.0990 , LMJLV39_290016400 , LMJSD75_290016400

Length:

991

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ADV7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADV7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	559	565	PF00089	0.507
CLV_NRD_NRD_1	188	190	PF00675	0.538
CLV_NRD_NRD_1	218	220	PF00675	0.676
CLV_NRD_NRD_1	238	240	PF00675	0.660
CLV_NRD_NRD_1	282	284	PF00675	0.682
CLV_NRD_NRD_1	320	322	PF00675	0.528
CLV_NRD_NRD_1	425	427	PF00675	0.441
CLV_NRD_NRD_1	52	54	PF00675	0.549
CLV_NRD_NRD_1	615	617	PF00675	0.471
CLV_NRD_NRD_1	811	813	PF00675	0.637
CLV_PCSK_FUR_1	139	143	PF00082	0.402
CLV_PCSK_KEX2_1	141	143	PF00082	0.420
CLV_PCSK_KEX2_1	188	190	PF00082	0.538
CLV_PCSK_KEX2_1	217	219	PF00082	0.667
CLV_PCSK_KEX2_1	282	284	PF00082	0.666
CLV_PCSK_KEX2_1	320	322	PF00082	0.528
CLV_PCSK_KEX2_1	425	427	PF00082	0.499
CLV_PCSK_KEX2_1	485	487	PF00082	0.601
CLV_PCSK_KEX2_1	52	54	PF00082	0.549
CLV_PCSK_KEX2_1	640	642	PF00082	0.476
CLV_PCSK_KEX2_1	811	813	PF00082	0.637
CLV_PCSK_KEX2_1	846	848	PF00082	0.674
CLV_PCSK_KEX2_1	891	893	PF00082	0.784
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.420
CLV_PCSK_PC1ET2_1	485	487	PF00082	0.572
CLV_PCSK_PC1ET2_1	640	642	PF00082	0.536
CLV_PCSK_PC1ET2_1	846	848	PF00082	0.690
CLV_PCSK_PC1ET2_1	891	893	PF00082	0.608
CLV_PCSK_SKI1_1	105	109	PF00082	0.528
CLV_PCSK_SKI1_1	362	366	PF00082	0.574
CLV_PCSK_SKI1_1	425	429	PF00082	0.450
CLV_PCSK_SKI1_1	651	655	PF00082	0.611
CLV_PCSK_SKI1_1	72	76	PF00082	0.532
CLV_PCSK_SKI1_1	963	967	PF00082	0.481
DEG_COP1_1	24	32	PF00400	0.578
DEG_MDM2_SWIB_1	146	154	PF02201	0.529
DEG_Nend_UBRbox_2	1	3	PF02207	0.685
DEG_SCF_FBW7_1	667	674	PF00400	0.556
DEG_SCF_FBW7_2	382	388	PF00400	0.655
DEG_SPOP_SBC_1	231	235	PF00917	0.674
DEG_SPOP_SBC_1	275	279	PF00917	0.591
DEG_SPOP_SBC_1	516	520	PF00917	0.682
DEG_SPOP_SBC_1	773	777	PF00917	0.639
DOC_ANK_TNKS_1	111	118	PF00023	0.523
DOC_CKS1_1	168	173	PF01111	0.579
DOC_CKS1_1	382	387	PF01111	0.655
DOC_CKS1_1	668	673	PF01111	0.630
DOC_CYCLIN_yClb3_PxF_3	855	861	PF00134	0.665
DOC_MAPK_gen_1	139	149	PF00069	0.407
DOC_MAPK_gen_1	258	264	PF00069	0.403
DOC_MAPK_gen_1	47	56	PF00069	0.567
DOC_MAPK_gen_1	616	626	PF00069	0.446
DOC_PP1_RVXF_1	50	57	PF00149	0.522
DOC_PP2B_LxvP_1	387	390	PF13499	0.636
DOC_PP2B_LxvP_1	4	7	PF13499	0.593
DOC_PP2B_LxvP_1	524	527	PF13499	0.549
DOC_PP2B_LxvP_1	752	755	PF13499	0.501
DOC_PP2B_LxvP_1	853	856	PF13499	0.653
DOC_USP7_MATH_1	124	128	PF00917	0.616
DOC_USP7_MATH_1	173	177	PF00917	0.562
DOC_USP7_MATH_1	209	213	PF00917	0.567
DOC_USP7_MATH_1	231	235	PF00917	0.674
DOC_USP7_MATH_1	276	280	PF00917	0.720
DOC_USP7_MATH_1	284	288	PF00917	0.667
DOC_USP7_MATH_1	409	413	PF00917	0.515
DOC_USP7_MATH_1	445	449	PF00917	0.516
DOC_USP7_MATH_1	507	511	PF00917	0.712
DOC_USP7_MATH_1	646	650	PF00917	0.576
DOC_USP7_MATH_1	671	675	PF00917	0.642
DOC_USP7_MATH_1	723	727	PF00917	0.661
DOC_USP7_MATH_1	755	759	PF00917	0.575
DOC_USP7_MATH_1	837	841	PF00917	0.588
DOC_USP7_MATH_1	9	13	PF00917	0.663
DOC_USP7_MATH_1	916	920	PF00917	0.639
DOC_USP7_MATH_1	953	957	PF00917	0.661
DOC_USP7_UBL2_3	528	532	PF12436	0.692
DOC_WW_Pin1_4	167	172	PF00397	0.523
DOC_WW_Pin1_4	219	224	PF00397	0.652
DOC_WW_Pin1_4	28	33	PF00397	0.586
DOC_WW_Pin1_4	381	386	PF00397	0.790
DOC_WW_Pin1_4	477	482	PF00397	0.762
DOC_WW_Pin1_4	5	10	PF00397	0.655
DOC_WW_Pin1_4	667	672	PF00397	0.746
DOC_WW_Pin1_4	715	720	PF00397	0.647
DOC_WW_Pin1_4	774	779	PF00397	0.765
DOC_WW_Pin1_4	926	931	PF00397	0.655
DOC_WW_Pin1_4	948	953	PF00397	0.629
LIG_14-3-3_CanoR_1	440	445	PF00244	0.551
LIG_14-3-3_CanoR_1	465	474	PF00244	0.613
LIG_14-3-3_CanoR_1	826	833	PF00244	0.613
LIG_14-3-3_CanoR_1	84	92	PF00244	0.650
LIG_14-3-3_CanoR_1	892	896	PF00244	0.650
LIG_14-3-3_CanoR_1	924	929	PF00244	0.699
LIG_14-3-3_CanoR_1	941	950	PF00244	0.620
LIG_Actin_WH2_2	427	442	PF00022	0.470
LIG_Actin_WH2_2	696	713	PF00022	0.438
LIG_BIR_III_2	793	797	PF00653	0.646
LIG_CaM_IQ_9	626	642	PF13499	0.427
LIG_FHA_1	173	179	PF00498	0.497
LIG_FHA_1	252	258	PF00498	0.610
LIG_FHA_1	382	388	PF00498	0.655
LIG_FHA_1	518	524	PF00498	0.700
LIG_FHA_1	554	560	PF00498	0.472
LIG_FHA_1	668	674	PF00498	0.684
LIG_FHA_1	774	780	PF00498	0.633
LIG_FHA_1	861	867	PF00498	0.624
LIG_FHA_1	923	929	PF00498	0.630
LIG_FHA_2	185	191	PF00498	0.496
LIG_FHA_2	246	252	PF00498	0.563
LIG_FHA_2	36	42	PF00498	0.665
LIG_FHA_2	409	415	PF00498	0.449
LIG_FHA_2	826	832	PF00498	0.599
LIG_Integrin_RGD_1	486	488	PF01839	0.550
LIG_Integrin_RGD_1	736	738	PF01839	0.517
LIG_LIR_Apic_2	162	167	PF02991	0.494
LIG_LIR_Gen_1	144	154	PF02991	0.523
LIG_LIR_Gen_1	572	581	PF02991	0.475
LIG_LIR_Gen_1	814	824	PF02991	0.635
LIG_LIR_LC3C_4	970	975	PF02991	0.516
LIG_LIR_Nem_3	144	149	PF02991	0.425
LIG_LIR_Nem_3	172	177	PF02991	0.564
LIG_LIR_Nem_3	424	430	PF02991	0.496
LIG_LIR_Nem_3	814	819	PF02991	0.739
LIG_LIR_Nem_3	831	836	PF02991	0.506
LIG_MYND_1	385	389	PF01753	0.742
LIG_Pex14_2	146	150	PF04695	0.451
LIG_Pex14_2	63	67	PF04695	0.486
LIG_PTAP_UEV_1	676	681	PF05743	0.606
LIG_PTB_Apo_2	920	927	PF02174	0.597
LIG_SH2_CRK	816	820	PF00017	0.638
LIG_SH2_STAP1	174	178	PF00017	0.499
LIG_SH2_STAP1	685	689	PF00017	0.514
LIG_SH2_STAT5	174	177	PF00017	0.502
LIG_SH2_STAT5	317	320	PF00017	0.498
LIG_SH2_STAT5	80	83	PF00017	0.504
LIG_SH2_STAT5	920	923	PF00017	0.589
LIG_SH3_1	268	274	PF00018	0.594
LIG_SH3_2	677	682	PF14604	0.608
LIG_SH3_3	165	171	PF00018	0.583
LIG_SH3_3	176	182	PF00018	0.555
LIG_SH3_3	26	32	PF00018	0.602
LIG_SH3_3	268	274	PF00018	0.595
LIG_SH3_3	387	393	PF00018	0.738
LIG_SH3_3	452	458	PF00018	0.645
LIG_SH3_3	520	526	PF00018	0.804
LIG_SH3_3	535	541	PF00018	0.614
LIG_SH3_3	674	680	PF00018	0.638
LIG_SH3_3	760	766	PF00018	0.649
LIG_SH3_3	853	859	PF00018	0.677
LIG_SH3_3	868	874	PF00018	0.723
LIG_SH3_3	925	931	PF00018	0.640
LIG_SH3_3	949	955	PF00018	0.651
LIG_SUMO_SIM_anti_2	411	418	PF11976	0.524
LIG_SUMO_SIM_anti_2	757	764	PF11976	0.676
LIG_TRAF2_1	552	555	PF00917	0.465
LIG_TRAF2_1	576	579	PF00917	0.427
LIG_UBA3_1	626	634	PF00899	0.486
LIG_UBA3_1	91	97	PF00899	0.446
LIG_WW_2	390	393	PF00397	0.611
MOD_CDK_SPK_2	28	33	PF00069	0.586
MOD_CDK_SPxK_1	715	721	PF00069	0.573
MOD_CDK_SPxxK_3	219	226	PF00069	0.653
MOD_CK1_1	127	133	PF00069	0.711
MOD_CK1_1	199	205	PF00069	0.509
MOD_CK1_1	222	228	PF00069	0.733
MOD_CK1_1	230	236	PF00069	0.641
MOD_CK1_1	296	302	PF00069	0.742
MOD_CK1_1	329	335	PF00069	0.503
MOD_CK1_1	448	454	PF00069	0.611
MOD_CK1_1	466	472	PF00069	0.759
MOD_CK1_1	480	486	PF00069	0.563
MOD_CK1_1	518	524	PF00069	0.748
MOD_CK1_1	649	655	PF00069	0.509
MOD_CK1_1	771	777	PF00069	0.660
MOD_CK1_1	825	831	PF00069	0.618
MOD_CK1_1	840	846	PF00069	0.566
MOD_CK1_1	894	900	PF00069	0.642
MOD_CK2_1	184	190	PF00069	0.497
MOD_CK2_1	194	200	PF00069	0.541
MOD_CK2_1	221	227	PF00069	0.661
MOD_CK2_1	232	238	PF00069	0.648
MOD_CK2_1	245	251	PF00069	0.562
MOD_CK2_1	35	41	PF00069	0.665
MOD_CK2_1	451	457	PF00069	0.676
MOD_CK2_1	486	492	PF00069	0.616
MOD_CK2_1	916	922	PF00069	0.608
MOD_Cter_Amidation	483	486	PF01082	0.609
MOD_Cter_Amidation	889	892	PF01082	0.541
MOD_DYRK1A_RPxSP_1	477	481	PF00069	0.590
MOD_GlcNHglycan	126	129	PF01048	0.605
MOD_GlcNHglycan	131	134	PF01048	0.619
MOD_GlcNHglycan	196	199	PF01048	0.515
MOD_GlcNHglycan	204	207	PF01048	0.513
MOD_GlcNHglycan	229	232	PF01048	0.700
MOD_GlcNHglycan	285	289	PF01048	0.690
MOD_GlcNHglycan	295	298	PF01048	0.737
MOD_GlcNHglycan	332	335	PF01048	0.472
MOD_GlcNHglycan	431	434	PF01048	0.471
MOD_GlcNHglycan	450	453	PF01048	0.752
MOD_GlcNHglycan	465	468	PF01048	0.715
MOD_GlcNHglycan	482	485	PF01048	0.609
MOD_GlcNHglycan	509	512	PF01048	0.694
MOD_GlcNHglycan	591	594	PF01048	0.539
MOD_GlcNHglycan	644	647	PF01048	0.522
MOD_GlcNHglycan	648	651	PF01048	0.521
MOD_GlcNHglycan	676	680	PF01048	0.615
MOD_GlcNHglycan	725	728	PF01048	0.741
MOD_GlcNHglycan	842	845	PF01048	0.605
MOD_GlcNHglycan	897	900	PF01048	0.742
MOD_GSK3_1	184	191	PF00069	0.562
MOD_GSK3_1	196	203	PF00069	0.488
MOD_GSK3_1	209	216	PF00069	0.535
MOD_GSK3_1	221	228	PF00069	0.620
MOD_GSK3_1	230	237	PF00069	0.698
MOD_GSK3_1	326	333	PF00069	0.464
MOD_GSK3_1	377	384	PF00069	0.732
MOD_GSK3_1	447	454	PF00069	0.568
MOD_GSK3_1	463	470	PF00069	0.688
MOD_GSK3_1	473	480	PF00069	0.752
MOD_GSK3_1	5	12	PF00069	0.662
MOD_GSK3_1	507	514	PF00069	0.784
MOD_GSK3_1	553	560	PF00069	0.475
MOD_GSK3_1	642	649	PF00069	0.565
MOD_GSK3_1	663	670	PF00069	0.672
MOD_GSK3_1	671	678	PF00069	0.680
MOD_GSK3_1	738	745	PF00069	0.679
MOD_GSK3_1	768	775	PF00069	0.599
MOD_GSK3_1	890	897	PF00069	0.657
MOD_GSK3_1	922	929	PF00069	0.663
MOD_N-GLC_1	446	451	PF02516	0.678
MOD_N-GLC_1	663	668	PF02516	0.595
MOD_N-GLC_1	731	736	PF02516	0.741
MOD_N-GLC_1	922	927	PF02516	0.600
MOD_NEK2_1	184	189	PF00069	0.500
MOD_NEK2_1	194	199	PF00069	0.500
MOD_NEK2_1	330	335	PF00069	0.403
MOD_NEK2_1	589	594	PF00069	0.636
MOD_NEK2_1	822	827	PF00069	0.702
MOD_NEK2_1	838	843	PF00069	0.503
MOD_PIKK_1	13	19	PF00454	0.634
MOD_PK_1	891	897	PF00069	0.655
MOD_PK_1	924	930	PF00069	0.629
MOD_PKA_1	188	194	PF00069	0.537
MOD_PKA_1	891	897	PF00069	0.782
MOD_PKA_2	184	190	PF00069	0.485
MOD_PKA_2	225	231	PF00069	0.671
MOD_PKA_2	48	54	PF00069	0.596
MOD_PKA_2	681	687	PF00069	0.583
MOD_PKA_2	728	734	PF00069	0.694
MOD_PKA_2	825	831	PF00069	0.616
MOD_PKA_2	83	89	PF00069	0.516
MOD_PKA_2	891	897	PF00069	0.782
MOD_PKA_2	942	948	PF00069	0.678
MOD_Plk_1	199	205	PF00069	0.547
MOD_Plk_1	419	425	PF00069	0.546
MOD_Plk_1	663	669	PF00069	0.596
MOD_Plk_1	922	928	PF00069	0.602
MOD_Plk_2-3	21	27	PF00069	0.593
MOD_Plk_2-3	83	89	PF00069	0.467
MOD_Plk_4	173	179	PF00069	0.545
MOD_Plk_4	326	332	PF00069	0.528
MOD_Plk_4	622	628	PF00069	0.441
MOD_Plk_4	663	669	PF00069	0.637
MOD_Plk_4	73	79	PF00069	0.521
MOD_Plk_4	815	821	PF00069	0.699
MOD_Plk_4	916	922	PF00069	0.590
MOD_ProDKin_1	167	173	PF00069	0.520
MOD_ProDKin_1	219	225	PF00069	0.653
MOD_ProDKin_1	28	34	PF00069	0.586
MOD_ProDKin_1	381	387	PF00069	0.791
MOD_ProDKin_1	477	483	PF00069	0.763
MOD_ProDKin_1	5	11	PF00069	0.655
MOD_ProDKin_1	667	673	PF00069	0.745
MOD_ProDKin_1	715	721	PF00069	0.648
MOD_ProDKin_1	774	780	PF00069	0.758
MOD_ProDKin_1	926	932	PF00069	0.654
MOD_ProDKin_1	948	954	PF00069	0.627
MOD_SUMO_rev_2	324	330	PF00179	0.372
MOD_SUMO_rev_2	488	496	PF00179	0.685
MOD_SUMO_rev_2	58	63	PF00179	0.499
MOD_SUMO_rev_2	683	690	PF00179	0.521
TRG_AP2beta_CARGO_1	144	153	PF09066	0.518
TRG_DiLeu_BaEn_2	189	195	PF01217	0.566
TRG_DiLeu_BaEn_3	578	584	PF01217	0.444
TRG_DiLeu_BaEn_4	554	560	PF01217	0.454
TRG_DiLeu_BaLyEn_6	538	543	PF01217	0.664
TRG_ENDOCYTIC_2	816	819	PF00928	0.637
TRG_ER_diArg_1	102	105	PF00400	0.503
TRG_ER_diArg_1	217	219	PF00400	0.667
TRG_ER_diArg_1	319	321	PF00400	0.527
TRG_ER_diArg_1	425	427	PF00400	0.499
TRG_ER_diArg_1	46	49	PF00400	0.601
TRG_ER_diArg_1	52	54	PF00400	0.533
TRG_ER_diArg_1	580	583	PF00400	0.451
TRG_ER_diArg_1	852	855	PF00400	0.677
TRG_ER_diArg_1	941	944	PF00400	0.719

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8D5	Leptomonas seymouri	42%	100%
A0A1X0P045	Trypanosomatidae	31%	97%
A0A3Q8IH72	Leishmania donovani	93%	100%
A4HHB1	Leishmania braziliensis	74%	100%
A4I4F7	Leishmania infantum	93%	100%
E9ALX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%