Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9ADV6_LEIMA

TriTrypDb:

LmjF.29.0980 , LMJLV39_290016300 , LMJSD75_290016300

Length:

545

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADV6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	398	402	PF00656	0.611
CLV_NRD_NRD_1	174	176	PF00675	0.765
CLV_NRD_NRD_1	19	21	PF00675	0.493
CLV_NRD_NRD_1	191	193	PF00675	0.488
CLV_NRD_NRD_1	270	272	PF00675	0.753
CLV_NRD_NRD_1	323	325	PF00675	0.731
CLV_PCSK_FUR_1	166	170	PF00082	0.625
CLV_PCSK_FUR_1	17	21	PF00082	0.493
CLV_PCSK_FUR_1	189	193	PF00082	0.593
CLV_PCSK_KEX2_1	168	170	PF00082	0.657
CLV_PCSK_KEX2_1	174	176	PF00082	0.665
CLV_PCSK_KEX2_1	188	190	PF00082	0.567
CLV_PCSK_KEX2_1	19	21	PF00082	0.493
CLV_PCSK_KEX2_1	191	193	PF00082	0.539
CLV_PCSK_KEX2_1	270	272	PF00082	0.753
CLV_PCSK_KEX2_1	323	325	PF00082	0.731
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.657
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.650
CLV_PCSK_SKI1_1	19	23	PF00082	0.493
DEG_APCC_DBOX_1	18	26	PF00400	0.498
DEG_Nend_UBRbox_1	1	4	PF02207	0.646
DEG_ODPH_VHL_1	36	47	PF01847	0.674
DEG_SCF_FBW7_1	202	209	PF00400	0.683
DEG_SCF_FBW7_2	535	541	PF00400	0.749
DEG_SPOP_SBC_1	59	63	PF00917	0.666
DOC_CKS1_1	182	187	PF01111	0.759
DOC_CKS1_1	203	208	PF01111	0.745
DOC_CKS1_1	457	462	PF01111	0.630
DOC_CKS1_1	535	540	PF01111	0.630
DOC_CKS1_1	83	88	PF01111	0.625
DOC_PP4_FxxP_1	457	460	PF00568	0.813
DOC_USP7_MATH_1	146	150	PF00917	0.731
DOC_USP7_MATH_1	206	210	PF00917	0.660
DOC_USP7_MATH_1	211	215	PF00917	0.630
DOC_USP7_MATH_1	226	230	PF00917	0.679
DOC_USP7_MATH_1	244	248	PF00917	0.732
DOC_USP7_MATH_1	370	374	PF00917	0.603
DOC_USP7_MATH_1	396	400	PF00917	0.620
DOC_USP7_MATH_1	41	45	PF00917	0.629
DOC_USP7_MATH_1	424	428	PF00917	0.777
DOC_USP7_MATH_1	501	505	PF00917	0.608
DOC_USP7_MATH_1	509	513	PF00917	0.635
DOC_USP7_MATH_1	527	531	PF00917	0.550
DOC_USP7_MATH_1	59	63	PF00917	0.678
DOC_USP7_MATH_2	378	384	PF00917	0.567
DOC_WW_Pin1_4	178	183	PF00397	0.817
DOC_WW_Pin1_4	202	207	PF00397	0.644
DOC_WW_Pin1_4	221	226	PF00397	0.757
DOC_WW_Pin1_4	289	294	PF00397	0.634
DOC_WW_Pin1_4	31	36	PF00397	0.582
DOC_WW_Pin1_4	322	327	PF00397	0.574
DOC_WW_Pin1_4	389	394	PF00397	0.713
DOC_WW_Pin1_4	404	409	PF00397	0.584
DOC_WW_Pin1_4	417	422	PF00397	0.745
DOC_WW_Pin1_4	427	432	PF00397	0.650
DOC_WW_Pin1_4	435	440	PF00397	0.615
DOC_WW_Pin1_4	45	50	PF00397	0.636
DOC_WW_Pin1_4	456	461	PF00397	0.626
DOC_WW_Pin1_4	478	483	PF00397	0.640
DOC_WW_Pin1_4	534	539	PF00397	0.623
DOC_WW_Pin1_4	60	65	PF00397	0.662
DOC_WW_Pin1_4	68	73	PF00397	0.655
DOC_WW_Pin1_4	82	87	PF00397	0.545
LIG_14-3-3_CanoR_1	121	126	PF00244	0.499
LIG_14-3-3_CanoR_1	175	185	PF00244	0.767
LIG_14-3-3_CanoR_1	2	11	PF00244	0.510
LIG_14-3-3_CanoR_1	227	234	PF00244	0.618
LIG_14-3-3_CanoR_1	270	278	PF00244	0.745
LIG_14-3-3_CanoR_1	280	286	PF00244	0.587
LIG_14-3-3_CanoR_1	308	317	PF00244	0.591
LIG_14-3-3_CanoR_1	328	334	PF00244	0.616
LIG_14-3-3_CanoR_1	40	46	PF00244	0.681
LIG_14-3-3_CanoR_1	496	500	PF00244	0.642
LIG_14-3-3_CanoR_1	516	526	PF00244	0.631
LIG_14-3-3_CanoR_1	528	536	PF00244	0.612
LIG_Actin_WH2_2	106	123	PF00022	0.565
LIG_deltaCOP1_diTrp_1	321	329	PF00928	0.695
LIG_EH_1	266	270	PF12763	0.555
LIG_FHA_1	182	188	PF00498	0.821
LIG_FHA_1	260	266	PF00498	0.648
LIG_FHA_1	310	316	PF00498	0.707
LIG_FHA_1	443	449	PF00498	0.737
LIG_FHA_1	450	456	PF00498	0.574
LIG_FHA_1	457	463	PF00498	0.524
LIG_FHA_1	5	11	PF00498	0.488
LIG_FHA_1	501	507	PF00498	0.744
LIG_FHA_2	154	160	PF00498	0.678
LIG_FHA_2	396	402	PF00498	0.628
LIG_FHA_2	459	465	PF00498	0.716
LIG_FHA_2	479	485	PF00498	0.711
LIG_FHA_2	74	80	PF00498	0.753
LIG_LIR_Apic_2	195	201	PF02991	0.618
LIG_LIR_Apic_2	292	297	PF02991	0.664
LIG_LIR_Apic_2	456	460	PF02991	0.805
LIG_MYND_1	202	206	PF01753	0.737
LIG_MYND_1	66	70	PF01753	0.707
LIG_NRBOX	115	121	PF00104	0.538
LIG_Pex14_1	329	333	PF04695	0.545
LIG_RPA_C_Fungi	523	535	PF08784	0.715
LIG_SH2_CRK	198	202	PF00017	0.618
LIG_SH2_NCK_1	198	202	PF00017	0.618
LIG_SH2_SRC	198	201	PF00017	0.620
LIG_SH2_STAT3	526	529	PF00017	0.711
LIG_SH2_STAT5	118	121	PF00017	0.658
LIG_SH3_1	197	203	PF00018	0.738
LIG_SH3_1	32	38	PF00018	0.613
LIG_SH3_2	35	40	PF14604	0.704
LIG_SH3_2	405	410	PF14604	0.705
LIG_SH3_2	432	437	PF14604	0.777
LIG_SH3_3	179	185	PF00018	0.649
LIG_SH3_3	197	203	PF00018	0.518
LIG_SH3_3	262	268	PF00018	0.688
LIG_SH3_3	32	38	PF00018	0.590
LIG_SH3_3	402	408	PF00018	0.750
LIG_SH3_3	420	426	PF00018	0.584
LIG_SH3_3	429	435	PF00018	0.636
LIG_SH3_3	80	86	PF00018	0.711
LIG_SH3_3	95	101	PF00018	0.552
LIG_TRAF2_1	481	484	PF00917	0.715
LIG_TRAF2_1	539	542	PF00917	0.661
LIG_WRC_WIRS_1	330	335	PF05994	0.542
LIG_WW_3	100	104	PF00397	0.614
LIG_WW_3	430	434	PF00397	0.623
MOD_CDC14_SPxK_1	224	227	PF00782	0.734
MOD_CDC14_SPxK_1	292	295	PF00782	0.707
MOD_CDC14_SPxK_1	325	328	PF00782	0.606
MOD_CDC14_SPxK_1	407	410	PF00782	0.707
MOD_CDC14_SPxK_1	430	433	PF00782	0.618
MOD_CDK_SPxK_1	221	227	PF00069	0.734
MOD_CDK_SPxK_1	289	295	PF00069	0.704
MOD_CDK_SPxK_1	322	328	PF00069	0.612
MOD_CDK_SPxK_1	404	410	PF00069	0.699
MOD_CDK_SPxK_1	427	433	PF00069	0.669
MOD_CDK_SPxK_1	45	51	PF00069	0.756
MOD_CDK_SPxxK_3	181	188	PF00069	0.759
MOD_CK1_1	123	129	PF00069	0.665
MOD_CK1_1	141	147	PF00069	0.567
MOD_CK1_1	181	187	PF00069	0.761
MOD_CK1_1	282	288	PF00069	0.678
MOD_CK1_1	383	389	PF00069	0.747
MOD_CK1_1	399	405	PF00069	0.577
MOD_CK1_1	4	10	PF00069	0.573
MOD_CK1_1	427	433	PF00069	0.782
MOD_CK2_1	206	212	PF00069	0.706
MOD_CK2_1	260	266	PF00069	0.679
MOD_CK2_1	315	321	PF00069	0.671
MOD_CK2_1	458	464	PF00069	0.716
MOD_CK2_1	478	484	PF00069	0.711
MOD_CK2_1	536	542	PF00069	0.606
MOD_CK2_1	73	79	PF00069	0.793
MOD_DYRK1A_RPxSP_1	437	441	PF00069	0.689
MOD_GlcNHglycan	178	181	PF01048	0.821
MOD_GlcNHglycan	217	220	PF01048	0.610
MOD_GlcNHglycan	228	231	PF01048	0.786
MOD_GlcNHglycan	262	265	PF01048	0.679
MOD_GlcNHglycan	27	31	PF01048	0.541
MOD_GlcNHglycan	281	284	PF01048	0.741
MOD_GlcNHglycan	3	6	PF01048	0.595
MOD_GlcNHglycan	312	315	PF01048	0.593
MOD_GlcNHglycan	362	365	PF01048	0.560
MOD_GlcNHglycan	372	375	PF01048	0.601
MOD_GlcNHglycan	385	388	PF01048	0.623
MOD_GlcNHglycan	487	490	PF01048	0.714
MOD_GlcNHglycan	507	510	PF01048	0.612
MOD_GlcNHglycan	511	514	PF01048	0.603
MOD_GlcNHglycan	530	533	PF01048	0.504
MOD_GSK3_1	121	128	PF00069	0.500
MOD_GSK3_1	202	209	PF00069	0.683
MOD_GSK3_1	211	218	PF00069	0.641
MOD_GSK3_1	226	233	PF00069	0.721
MOD_GSK3_1	329	336	PF00069	0.654
MOD_GSK3_1	360	367	PF00069	0.701
MOD_GSK3_1	385	392	PF00069	0.714
MOD_GSK3_1	395	402	PF00069	0.801
MOD_GSK3_1	41	48	PF00069	0.637
MOD_GSK3_1	449	456	PF00069	0.773
MOD_GSK3_1	478	485	PF00069	0.787
MOD_GSK3_1	501	508	PF00069	0.613
MOD_GSK3_1	514	521	PF00069	0.667
MOD_GSK3_1	54	61	PF00069	0.703
MOD_GSK3_1	68	75	PF00069	0.649
MOD_N-GLC_1	138	143	PF02516	0.633
MOD_N-GLC_1	176	181	PF02516	0.771
MOD_N-GLC_1	272	277	PF02516	0.746
MOD_NEK2_1	1	6	PF00069	0.556
MOD_NEK2_1	120	125	PF00069	0.607
MOD_NEK2_1	153	158	PF00069	0.588
MOD_NEK2_1	215	220	PF00069	0.588
MOD_NEK2_1	260	265	PF00069	0.678
MOD_NEK2_1	360	365	PF00069	0.563
MOD_NEK2_1	442	447	PF00069	0.709
MOD_NEK2_1	448	453	PF00069	0.586
MOD_NEK2_1	471	476	PF00069	0.832
MOD_NEK2_1	515	520	PF00069	0.696
MOD_NEK2_2	272	277	PF00069	0.682
MOD_NEK2_2	482	487	PF00069	0.684
MOD_OFUCOSY	89	94	PF10250	0.556
MOD_PIKK_1	125	131	PF00454	0.689
MOD_PIKK_1	146	152	PF00454	0.721
MOD_PIKK_1	4	10	PF00454	0.497
MOD_PKA_2	1	7	PF00069	0.614
MOD_PKA_2	102	108	PF00069	0.720
MOD_PKA_2	120	126	PF00069	0.439
MOD_PKA_2	226	232	PF00069	0.660
MOD_PKA_2	279	285	PF00069	0.750
MOD_PKA_2	396	402	PF00069	0.758
MOD_PKA_2	495	501	PF00069	0.687
MOD_PKA_2	515	521	PF00069	0.709
MOD_PKA_2	527	533	PF00069	0.522
MOD_Plk_1	211	217	PF00069	0.716
MOD_Plk_1	272	278	PF00069	0.761
MOD_Plk_1	297	303	PF00069	0.770
MOD_Plk_1	355	361	PF00069	0.667
MOD_Plk_2-3	380	386	PF00069	0.621
MOD_Plk_4	272	278	PF00069	0.745
MOD_Plk_4	355	361	PF00069	0.635
MOD_Plk_4	453	459	PF00069	0.662
MOD_ProDKin_1	178	184	PF00069	0.815
MOD_ProDKin_1	202	208	PF00069	0.644
MOD_ProDKin_1	221	227	PF00069	0.760
MOD_ProDKin_1	289	295	PF00069	0.637
MOD_ProDKin_1	31	37	PF00069	0.583
MOD_ProDKin_1	322	328	PF00069	0.574
MOD_ProDKin_1	389	395	PF00069	0.712
MOD_ProDKin_1	404	410	PF00069	0.588
MOD_ProDKin_1	417	423	PF00069	0.745
MOD_ProDKin_1	427	433	PF00069	0.653
MOD_ProDKin_1	435	441	PF00069	0.609
MOD_ProDKin_1	45	51	PF00069	0.638
MOD_ProDKin_1	456	462	PF00069	0.626
MOD_ProDKin_1	478	484	PF00069	0.642
MOD_ProDKin_1	534	540	PF00069	0.626
MOD_ProDKin_1	60	66	PF00069	0.660
MOD_ProDKin_1	68	74	PF00069	0.653
MOD_ProDKin_1	82	88	PF00069	0.548
TRG_DiLeu_BaEn_3	354	360	PF01217	0.637
TRG_DiLeu_BaEn_4	355	361	PF01217	0.667
TRG_ER_diArg_1	174	176	PF00400	0.761
TRG_ER_diArg_1	19	21	PF00400	0.493
TRG_ER_diArg_1	269	271	PF00400	0.753
TRG_ER_diArg_1	322	324	PF00400	0.739
TRG_Pf-PMV_PEXEL_1	20	24	PF00026	0.491
TRG_PTS2	1	25	PF00400	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMH2	Leptomonas seymouri	32%	100%
A0A3S7X2C5	Leishmania donovani	91%	100%
A4HHB0	Leishmania braziliensis	64%	100%
A4I4F6	Leishmania infantum	91%	100%
E9ALX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%