Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9ADV4_LEIMA

TriTrypDb:

LmjF.29.0960 , LMJLV39_290016100 , LMJSD75_290016100

Length:

440

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADV4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.679
CLV_C14_Caspase3-7	273	277	PF00656	0.769
CLV_C14_Caspase3-7	413	417	PF00656	0.736
CLV_NRD_NRD_1	189	191	PF00675	0.682
CLV_NRD_NRD_1	228	230	PF00675	0.720
CLV_NRD_NRD_1	67	69	PF00675	0.697
CLV_PCSK_KEX2_1	123	125	PF00082	0.610
CLV_PCSK_KEX2_1	228	230	PF00082	0.720
CLV_PCSK_KEX2_1	67	69	PF00082	0.697
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.666
CLV_PCSK_SKI1_1	124	128	PF00082	0.649
CLV_PCSK_SKI1_1	151	155	PF00082	0.726
CLV_PCSK_SKI1_1	336	340	PF00082	0.750
CLV_PCSK_SKI1_1	341	345	PF00082	0.690
CLV_PCSK_SKI1_1	409	413	PF00082	0.815
CLV_PCSK_SKI1_1	49	53	PF00082	0.718
CLV_PCSK_SKI1_1	61	65	PF00082	0.813
CLV_Separin_Metazoa	58	62	PF03568	0.579
DEG_SCF_FBW7_1	241	247	PF00400	0.588
DOC_CKS1_1	241	246	PF01111	0.768
DOC_CKS1_1	418	423	PF01111	0.732
DOC_MAPK_gen_1	35	45	PF00069	0.651
DOC_PP1_RVXF_1	312	319	PF00149	0.726
DOC_PP1_RVXF_1	39	46	PF00149	0.647
DOC_PP2B_LxvP_1	176	179	PF13499	0.719
DOC_PP2B_LxvP_1	355	358	PF13499	0.747
DOC_USP7_MATH_1	155	159	PF00917	0.794
DOC_USP7_MATH_1	179	183	PF00917	0.630
DOC_USP7_MATH_1	19	23	PF00917	0.787
DOC_USP7_MATH_1	284	288	PF00917	0.780
DOC_USP7_MATH_1	325	329	PF00917	0.704
DOC_WW_Pin1_4	114	119	PF00397	0.741
DOC_WW_Pin1_4	163	168	PF00397	0.704
DOC_WW_Pin1_4	200	205	PF00397	0.693
DOC_WW_Pin1_4	214	219	PF00397	0.679
DOC_WW_Pin1_4	240	245	PF00397	0.639
DOC_WW_Pin1_4	267	272	PF00397	0.726
DOC_WW_Pin1_4	280	285	PF00397	0.677
DOC_WW_Pin1_4	316	321	PF00397	0.829
DOC_WW_Pin1_4	323	328	PF00397	0.572
DOC_WW_Pin1_4	336	341	PF00397	0.678
DOC_WW_Pin1_4	417	422	PF00397	0.743
LIG_14-3-3_CanoR_1	124	133	PF00244	0.654
LIG_14-3-3_CanoR_1	156	164	PF00244	0.661
LIG_14-3-3_CanoR_1	200	204	PF00244	0.679
LIG_14-3-3_CanoR_1	228	236	PF00244	0.756
LIG_14-3-3_CanoR_1	409	418	PF00244	0.804
LIG_14-3-3_CanoR_1	424	432	PF00244	0.576
LIG_Actin_WH2_2	39	54	PF00022	0.710
LIG_BIR_II_1	1	5	PF00653	0.620
LIG_BRCT_BRCA1_1	184	188	PF00533	0.750
LIG_BRCT_BRCA1_1	361	365	PF00533	0.799
LIG_deltaCOP1_diTrp_1	77	82	PF00928	0.722
LIG_FHA_1	117	123	PF00498	0.659
LIG_FHA_1	128	134	PF00498	0.689
LIG_FHA_1	157	163	PF00498	0.693
LIG_FHA_1	171	177	PF00498	0.759
LIG_FHA_1	311	317	PF00498	0.698
LIG_FHA_1	350	356	PF00498	0.770
LIG_FHA_1	387	393	PF00498	0.636
LIG_FHA_1	413	419	PF00498	0.708
LIG_FHA_1	433	439	PF00498	0.603
LIG_FHA_1	54	60	PF00498	0.789
LIG_FHA_2	424	430	PF00498	0.642
LIG_FHA_2	52	58	PF00498	0.714
LIG_GBD_Chelix_1	43	51	PF00786	0.767
LIG_LIR_Gen_1	100	109	PF02991	0.675
LIG_LIR_Nem_3	100	105	PF02991	0.673
LIG_LIR_Nem_3	396	400	PF02991	0.751
LIG_MYND_1	214	218	PF01753	0.705
LIG_SH2_CRK	254	258	PF00017	0.719
LIG_SH2_NCK_1	111	115	PF00017	0.598
LIG_SH2_STAP1	111	115	PF00017	0.622
LIG_SH3_3	133	139	PF00018	0.715
LIG_SH3_3	212	218	PF00018	0.705
LIG_SH3_3	238	244	PF00018	0.739
LIG_SH3_3	301	307	PF00018	0.722
LIG_TRAF2_1	75	78	PF00917	0.713
LIG_TRAF2_2	358	363	PF00917	0.726
LIG_TYR_ITIM	109	114	PF00017	0.593
MOD_CDC14_SPxK_1	283	286	PF00782	0.756
MOD_CDC14_SPxK_1	326	329	PF00782	0.763
MOD_CDK_SPK_2	240	245	PF00069	0.639
MOD_CDK_SPK_2	336	341	PF00069	0.763
MOD_CDK_SPxK_1	280	286	PF00069	0.758
MOD_CDK_SPxK_1	323	329	PF00069	0.828
MOD_CDK_SPxxK_3	316	323	PF00069	0.730
MOD_CDK_SPxxK_3	417	424	PF00069	0.805
MOD_CK1_1	165	171	PF00069	0.700
MOD_CK1_1	182	188	PF00069	0.580
MOD_CK1_1	196	202	PF00069	0.607
MOD_CK1_1	203	209	PF00069	0.655
MOD_CK1_1	22	28	PF00069	0.671
MOD_CK1_1	287	293	PF00069	0.812
MOD_CK1_1	328	334	PF00069	0.844
MOD_CK1_1	376	382	PF00069	0.730
MOD_CK1_1	386	392	PF00069	0.720
MOD_CK1_1	403	409	PF00069	0.709
MOD_CK1_1	9	15	PF00069	0.793
MOD_CK2_1	165	171	PF00069	0.711
MOD_CK2_1	22	28	PF00069	0.795
MOD_CK2_1	423	429	PF00069	0.697
MOD_CK2_1	51	57	PF00069	0.729
MOD_Cter_Amidation	65	68	PF01082	0.741
MOD_DYRK1A_RPxSP_1	200	204	PF00069	0.626
MOD_DYRK1A_RPxSP_1	336	340	PF00069	0.728
MOD_GlcNHglycan	1	4	PF01048	0.654
MOD_GlcNHglycan	106	109	PF01048	0.558
MOD_GlcNHglycan	15	18	PF01048	0.660
MOD_GlcNHglycan	151	154	PF01048	0.713
MOD_GlcNHglycan	167	170	PF01048	0.607
MOD_GlcNHglycan	181	184	PF01048	0.591
MOD_GlcNHglycan	24	27	PF01048	0.694
MOD_GlcNHglycan	82	85	PF01048	0.754
MOD_GSK3_1	151	158	PF00069	0.719
MOD_GSK3_1	165	172	PF00069	0.779
MOD_GSK3_1	178	185	PF00069	0.596
MOD_GSK3_1	195	202	PF00069	0.683
MOD_GSK3_1	20	27	PF00069	0.595
MOD_GSK3_1	228	235	PF00069	0.831
MOD_GSK3_1	240	247	PF00069	0.692
MOD_GSK3_1	266	273	PF00069	0.772
MOD_GSK3_1	280	287	PF00069	0.628
MOD_GSK3_1	319	326	PF00069	0.795
MOD_GSK3_1	339	346	PF00069	0.773
MOD_GSK3_1	372	379	PF00069	0.717
MOD_GSK3_1	382	389	PF00069	0.728
MOD_GSK3_1	9	16	PF00069	0.675
MOD_N-GLC_1	310	315	PF02516	0.783
MOD_N-GLC_1	383	388	PF02516	0.735
MOD_NEK2_1	266	271	PF00069	0.744
MOD_NEK2_1	372	377	PF00069	0.801
MOD_NEK2_1	410	415	PF00069	0.761
MOD_NEK2_1	432	437	PF00069	0.589
MOD_NEK2_2	183	188	PF00069	0.566
MOD_PIKK_1	400	406	PF00454	0.712
MOD_PKA_1	228	234	PF00069	0.717
MOD_PKA_2	155	161	PF00069	0.646
MOD_PKA_2	199	205	PF00069	0.717
MOD_PKA_2	228	234	PF00069	0.740
MOD_PKA_2	244	250	PF00069	0.644
MOD_PKA_2	285	291	PF00069	0.765
MOD_PKA_2	367	373	PF00069	0.759
MOD_PKA_2	423	429	PF00069	0.666
MOD_PKA_2	432	438	PF00069	0.780
MOD_PKA_2	73	79	PF00069	0.718
MOD_Plk_1	170	176	PF00069	0.690
MOD_Plk_1	20	26	PF00069	0.682
MOD_Plk_1	232	238	PF00069	0.733
MOD_Plk_1	383	389	PF00069	0.733
MOD_Plk_2-3	53	59	PF00069	0.560
MOD_Plk_4	183	189	PF00069	0.625
MOD_Plk_4	351	357	PF00069	0.724
MOD_Plk_4	367	373	PF00069	0.515
MOD_ProDKin_1	114	120	PF00069	0.741
MOD_ProDKin_1	163	169	PF00069	0.704
MOD_ProDKin_1	200	206	PF00069	0.691
MOD_ProDKin_1	214	220	PF00069	0.679
MOD_ProDKin_1	240	246	PF00069	0.637
MOD_ProDKin_1	267	273	PF00069	0.727
MOD_ProDKin_1	280	286	PF00069	0.680
MOD_ProDKin_1	316	322	PF00069	0.829
MOD_ProDKin_1	323	329	PF00069	0.575
MOD_ProDKin_1	336	342	PF00069	0.677
MOD_ProDKin_1	417	423	PF00069	0.743
MOD_SUMO_rev_2	48	54	PF00179	0.784
TRG_DiLeu_BaLyEn_6	215	220	PF01217	0.709
TRG_DiLeu_BaLyEn_6	434	439	PF01217	0.705
TRG_ENDOCYTIC_2	111	114	PF00928	0.586
TRG_ER_diArg_1	228	230	PF00400	0.720
TRG_ER_diArg_1	91	94	PF00400	0.590
TRG_Pf-PMV_PEXEL_1	228	233	PF00026	0.781
TRG_Pf-PMV_PEXEL_1	237	242	PF00026	0.736
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.789

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8D7	Leptomonas seymouri	39%	100%
A0A3Q8IFA6	Leishmania donovani	91%	100%
A4HHA8	Leishmania braziliensis	70%	100%
A4I4F4	Leishmania infantum	90%	100%
E9ALX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%