Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADV3_LEIMA

TriTrypDb:

LmjF.29.0950 , LMJLV39_290016000 , LMJSD75_290016000

Length:

494

Annotations

LeishMANIAdb annotations

Kinetoplastid-unique proteins with many disordered segments and a hydrophobic C-terminal region.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9ADV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADV3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	340	342	PF00675	0.452
CLV_NRD_NRD_1	348	350	PF00675	0.478
CLV_NRD_NRD_1	381	383	PF00675	0.343
CLV_NRD_NRD_1	48	50	PF00675	0.511
CLV_PCSK_KEX2_1	340	342	PF00082	0.452
CLV_PCSK_KEX2_1	381	383	PF00082	0.343
CLV_PCSK_KEX2_1	48	50	PF00082	0.449
CLV_PCSK_KEX2_1	488	490	PF00082	0.433
CLV_PCSK_PC1ET2_1	488	490	PF00082	0.475
CLV_PCSK_PC7_1	484	490	PF00082	0.417
CLV_PCSK_SKI1_1	17	21	PF00082	0.426
CLV_PCSK_SKI1_1	177	181	PF00082	0.501
CLV_PCSK_SKI1_1	247	251	PF00082	0.555
CLV_PCSK_SKI1_1	385	389	PF00082	0.382
CLV_PCSK_SKI1_1	453	457	PF00082	0.484
DEG_APCC_DBOX_1	130	138	PF00400	0.687
DEG_SPOP_SBC_1	83	87	PF00917	0.707
DOC_CDC14_PxL_1	445	453	PF14671	0.425
DOC_CKS1_1	10	15	PF01111	0.702
DOC_CKS1_1	223	228	PF01111	0.545
DOC_CYCLIN_RxL_1	368	377	PF00134	0.644
DOC_CYCLIN_yCln2_LP_2	451	457	PF00134	0.259
DOC_MAPK_gen_1	48	55	PF00069	0.645
DOC_PP1_SILK_1	297	302	PF00149	0.525
DOC_PP2B_LxvP_1	20	23	PF13499	0.616
DOC_PP4_FxxP_1	36	39	PF00568	0.695
DOC_PP4_FxxP_1	468	471	PF00568	0.341
DOC_USP7_MATH_1	167	171	PF00917	0.695
DOC_USP7_MATH_1	329	333	PF00917	0.644
DOC_USP7_MATH_1	394	398	PF00917	0.518
DOC_USP7_MATH_1	90	94	PF00917	0.692
DOC_USP7_UBL2_3	206	210	PF12436	0.675
DOC_WW_Pin1_4	146	151	PF00397	0.671
DOC_WW_Pin1_4	189	194	PF00397	0.787
DOC_WW_Pin1_4	222	227	PF00397	0.547
DOC_WW_Pin1_4	38	43	PF00397	0.664
DOC_WW_Pin1_4	9	14	PF00397	0.673
LIG_14-3-3_CanoR_1	385	393	PF00244	0.601
LIG_14-3-3_CanoR_1	396	404	PF00244	0.574
LIG_14-3-3_CanoR_1	48	56	PF00244	0.694
LIG_14-3-3_CanoR_1	84	89	PF00244	0.682
LIG_BIR_II_1	1	5	PF00653	0.588
LIG_BRCT_BRCA1_1	182	186	PF00533	0.730
LIG_BRCT_BRCA1_1	32	36	PF00533	0.589
LIG_BRCT_BRCA1_1	396	400	PF00533	0.526
LIG_BRCT_BRCA1_2	32	38	PF00533	0.613
LIG_deltaCOP1_diTrp_1	410	415	PF00928	0.300
LIG_FHA_1	154	160	PF00498	0.741
LIG_FHA_1	308	314	PF00498	0.599
LIG_FHA_1	365	371	PF00498	0.682
LIG_FHA_1	407	413	PF00498	0.491
LIG_FHA_1	458	464	PF00498	0.340
LIG_FHA_2	171	177	PF00498	0.717
LIG_FHA_2	190	196	PF00498	0.691
LIG_FHA_2	253	259	PF00498	0.579
LIG_FHA_2	387	393	PF00498	0.647
LIG_FXI_DFP_1	388	392	PF00024	0.384
LIG_LIR_Apic_2	33	39	PF02991	0.678
LIG_LIR_Gen_1	183	193	PF02991	0.725
LIG_LIR_Gen_1	225	235	PF02991	0.572
LIG_LIR_Gen_1	354	361	PF02991	0.741
LIG_LIR_Gen_1	397	408	PF02991	0.593
LIG_LIR_Gen_1	409	419	PF02991	0.457
LIG_LIR_Nem_3	103	109	PF02991	0.606
LIG_LIR_Nem_3	183	189	PF02991	0.731
LIG_LIR_Nem_3	225	231	PF02991	0.603
LIG_LIR_Nem_3	409	414	PF02991	0.460
LIG_LIR_Nem_3	435	440	PF02991	0.384
LIG_Pex14_1	411	415	PF04695	0.300
LIG_SH2_CRK	107	111	PF00017	0.734
LIG_SH2_CRK	228	232	PF00017	0.620
LIG_SH2_CRK	288	292	PF00017	0.597
LIG_SH2_CRK	305	309	PF00017	0.593
LIG_SH2_CRK	371	375	PF00017	0.625
LIG_SH2_CRK	416	420	PF00017	0.335
LIG_SH2_NCK_1	107	111	PF00017	0.659
LIG_SH2_NCK_1	288	292	PF00017	0.622
LIG_SH2_PTP2	21	24	PF00017	0.578
LIG_SH2_SRC	21	24	PF00017	0.578
LIG_SH2_SRC	288	291	PF00017	0.582
LIG_SH2_STAP1	228	232	PF00017	0.622
LIG_SH2_STAP1	408	412	PF00017	0.459
LIG_SH2_STAP1	437	441	PF00017	0.420
LIG_SH2_STAT3	425	428	PF00017	0.434
LIG_SH2_STAT5	21	24	PF00017	0.578
LIG_SH2_STAT5	254	257	PF00017	0.572
LIG_SH2_STAT5	356	359	PF00017	0.712
LIG_SH2_STAT5	408	411	PF00017	0.585
LIG_SH2_STAT5	440	443	PF00017	0.422
LIG_SH3_1	107	113	PF00018	0.642
LIG_SH3_3	10	16	PF00018	0.659
LIG_SH3_3	107	113	PF00018	0.768
LIG_SH3_3	36	42	PF00018	0.631
LIG_SH3_3	487	493	PF00018	0.625
LIG_SH3_3	50	56	PF00018	0.715
LIG_SH3_4	206	213	PF00018	0.659
LIG_SUMO_SIM_anti_2	289	295	PF11976	0.568
LIG_SUMO_SIM_anti_2	460	465	PF11976	0.340
LIG_SUMO_SIM_par_1	470	476	PF11976	0.344
LIG_TRAF2_1	192	195	PF00917	0.665
LIG_TRAF2_1	23	26	PF00917	0.594
LIG_TRAF2_1	255	258	PF00917	0.601
LIG_TYR_ITIM	369	374	PF00017	0.621
LIG_TYR_ITIM	414	419	PF00017	0.300
LIG_WW_3	14	18	PF00397	0.620
MOD_CK1_1	129	135	PF00069	0.759
MOD_CK1_1	146	152	PF00069	0.620
MOD_CK1_1	161	167	PF00069	0.729
MOD_CK1_1	169	175	PF00069	0.699
MOD_CK1_1	30	36	PF00069	0.619
MOD_CK1_1	476	482	PF00069	0.476
MOD_CK2_1	111	117	PF00069	0.711
MOD_CK2_1	170	176	PF00069	0.667
MOD_CK2_1	189	195	PF00069	0.691
MOD_CK2_1	252	258	PF00069	0.566
MOD_CK2_1	61	67	PF00069	0.720
MOD_Cter_Amidation	347	350	PF01082	0.460
MOD_GlcNHglycan	101	105	PF01048	0.503
MOD_GlcNHglycan	113	116	PF01048	0.527
MOD_GlcNHglycan	119	123	PF01048	0.444
MOD_GlcNHglycan	160	163	PF01048	0.514
MOD_GlcNHglycan	239	242	PF01048	0.533
MOD_GlcNHglycan	282	285	PF01048	0.420
MOD_GlcNHglycan	97	100	PF01048	0.508
MOD_GSK3_1	166	173	PF00069	0.674
MOD_GSK3_1	237	244	PF00069	0.604
MOD_GSK3_1	360	367	PF00069	0.671
MOD_GSK3_1	402	409	PF00069	0.613
MOD_GSK3_1	473	480	PF00069	0.335
MOD_GSK3_1	90	97	PF00069	0.707
MOD_NEK2_1	126	131	PF00069	0.718
MOD_NEK2_1	370	375	PF00069	0.626
MOD_NEK2_1	473	478	PF00069	0.385
MOD_NEK2_1	94	99	PF00069	0.694
MOD_PK_1	61	67	PF00069	0.654
MOD_PK_1	84	90	PF00069	0.700
MOD_PKA_2	143	149	PF00069	0.707
MOD_PKA_2	395	401	PF00069	0.592
MOD_PKA_2	47	53	PF00069	0.643
MOD_PKA_2	83	89	PF00069	0.671
MOD_PKA_2	95	101	PF00069	0.626
MOD_PKB_1	82	90	PF00069	0.643
MOD_Plk_1	100	106	PF00069	0.657
MOD_Plk_1	118	124	PF00069	0.677
MOD_Plk_1	175	181	PF00069	0.728
MOD_Plk_1	30	36	PF00069	0.578
MOD_Plk_1	364	370	PF00069	0.656
MOD_Plk_4	289	295	PF00069	0.621
MOD_Plk_4	331	337	PF00069	0.515
MOD_Plk_4	90	96	PF00069	0.732
MOD_ProDKin_1	146	152	PF00069	0.671
MOD_ProDKin_1	189	195	PF00069	0.786
MOD_ProDKin_1	222	228	PF00069	0.542
MOD_ProDKin_1	38	44	PF00069	0.664
MOD_ProDKin_1	9	15	PF00069	0.669
MOD_SUMO_rev_2	213	219	PF00179	0.611
MOD_SUMO_rev_2	319	326	PF00179	0.648
MOD_SUMO_rev_2	354	363	PF00179	0.659
TRG_DiLeu_BaEn_1	365	370	PF01217	0.662
TRG_DiLeu_BaEn_2	31	37	PF01217	0.620
TRG_DiLeu_BaLyEn_6	468	473	PF01217	0.329
TRG_ENDOCYTIC_2	106	109	PF00928	0.619
TRG_ENDOCYTIC_2	228	231	PF00928	0.543
TRG_ENDOCYTIC_2	288	291	PF00928	0.598
TRG_ENDOCYTIC_2	356	359	PF00928	0.663
TRG_ENDOCYTIC_2	371	374	PF00928	0.582
TRG_ENDOCYTIC_2	416	419	PF00928	0.311
TRG_ENDOCYTIC_2	440	443	PF00928	0.397
TRG_ER_diArg_1	131	134	PF00400	0.722
TRG_ER_diArg_1	339	341	PF00400	0.657
TRG_Pf-PMV_PEXEL_1	372	377	PF00026	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF35	Leptomonas seymouri	68%	87%
A0A0S4JJG2	Bodo saltans	34%	100%
A0A3Q8IF28	Leishmania donovani	94%	86%
A4HHA7	Leishmania braziliensis	82%	100%
A4I4F3	Leishmania infantum	94%	86%
C9ZLK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	99%
E9ALX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	86%
V5BH52	Trypanosoma cruzi	40%	96%