Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADV3_LEIMA

TriTrypDb:

LmjF.29.0950 , LMJLV39_290016000 , LMJSD75_290016000

Length:

494

Annotations

LeishMANIAdb annotations

Kinetoplastid-unique proteins with many disordered segments and a hydrophobic C-terminal region.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

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Expansion

Sequence features

E9ADV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADV3

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	340	342	PF00675	0.452
CLV_NRD_NRD_1	348	350	PF00675	0.478
CLV_NRD_NRD_1	381	383	PF00675	0.343
CLV_NRD_NRD_1	48	50	PF00675	0.511
CLV_PCSK_KEX2_1	340	342	PF00082	0.452
CLV_PCSK_KEX2_1	381	383	PF00082	0.343
CLV_PCSK_KEX2_1	48	50	PF00082	0.449
CLV_PCSK_KEX2_1	488	490	PF00082	0.433
CLV_PCSK_PC1ET2_1	488	490	PF00082	0.475
CLV_PCSK_PC7_1	484	490	PF00082	0.417

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF35	Leptomonas seymouri	68%	87%
A0A0S4JJG2	Bodo saltans	34%	100%
A0A3Q8IF28	Leishmania donovani	94%	86%
A4HHA7	Leishmania braziliensis	82%	100%
A4I4F3	Leishmania infantum	94%	86%
C9ZLK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	99%
E9ALX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	86%
V5BH52	Trypanosoma cruzi	40%	96%

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