FGE-sulfatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

5-histidylcysteine sulfoxide synthase, putative

Species:

Leishmania major

UniProt:

E9ADV2_LEIMA

TriTrypDb:

LmjF.29.0940 , LMJLV39_290015900 , LMJSD75_290015900

Length:

757

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ADV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADV2

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	4
GO:0010035	response to inorganic substance	3	2
GO:0010038	response to metal ion	4	2
GO:0010039	response to iron ion	5	2
GO:0010040	response to iron(II) ion	6	2
GO:0018158	protein oxidation	5	2
GO:0018171	peptidyl-cysteine oxidation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018198	peptidyl-cysteine modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0042221	response to chemical	2	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0050896	response to stimulus	1	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005506	iron ion binding	6	2
GO:0008198	ferrous iron binding	7	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046914	transition metal ion binding	5	2
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.509
CLV_C14_Caspase3-7	692	696	PF00656	0.711
CLV_NRD_NRD_1	143	145	PF00675	0.431
CLV_NRD_NRD_1	476	478	PF00675	0.356
CLV_NRD_NRD_1	536	538	PF00675	0.484
CLV_NRD_NRD_1	579	581	PF00675	0.484
CLV_NRD_NRD_1	754	756	PF00675	0.454
CLV_PCSK_KEX2_1	143	145	PF00082	0.431
CLV_PCSK_KEX2_1	361	363	PF00082	0.368
CLV_PCSK_KEX2_1	476	478	PF00082	0.356
CLV_PCSK_KEX2_1	536	538	PF00082	0.468
CLV_PCSK_KEX2_1	579	581	PF00082	0.480
CLV_PCSK_KEX2_1	622	624	PF00082	0.556
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.368
CLV_PCSK_PC1ET2_1	622	624	PF00082	0.553
CLV_PCSK_PC7_1	472	478	PF00082	0.356
CLV_PCSK_SKI1_1	19	23	PF00082	0.507
CLV_PCSK_SKI1_1	364	368	PF00082	0.368
CLV_PCSK_SKI1_1	472	476	PF00082	0.341
CLV_PCSK_SKI1_1	477	481	PF00082	0.341
CLV_PCSK_SKI1_1	536	540	PF00082	0.439
CLV_PCSK_SKI1_1	559	563	PF00082	0.432
CLV_PCSK_SKI1_1	622	626	PF00082	0.543
CLV_PCSK_SKI1_1	666	670	PF00082	0.527
DEG_APCC_DBOX_1	189	197	PF00400	0.300
DEG_Nend_UBRbox_1	1	4	PF02207	0.603
DOC_CKS1_1	20	25	PF01111	0.554
DOC_CYCLIN_yClb3_PxF_3	308	316	PF00134	0.356
DOC_CYCLIN_yCln2_LP_2	161	167	PF00134	0.409
DOC_CYCLIN_yCln2_LP_2	71	74	PF00134	0.446
DOC_CYCLIN_yCln2_LP_2	78	84	PF00134	0.337
DOC_MAPK_gen_1	147	155	PF00069	0.368
DOC_MAPK_gen_1	666	675	PF00069	0.434
DOC_MAPK_gen_1	77	84	PF00069	0.382
DOC_MAPK_HePTP_8	155	167	PF00069	0.466
DOC_MAPK_MEF2A_6	158	167	PF00069	0.414
DOC_PP1_RVXF_1	299	306	PF00149	0.400
DOC_PP1_RVXF_1	557	563	PF00149	0.383
DOC_PP2B_LxvP_1	161	164	PF13499	0.418
DOC_PP2B_LxvP_1	71	74	PF13499	0.486
DOC_PP4_FxxP_1	443	446	PF00568	0.324
DOC_PP4_FxxP_1	70	73	PF00568	0.421
DOC_USP7_MATH_1	350	354	PF00917	0.484
DOC_USP7_UBL2_3	158	162	PF12436	0.440
DOC_WW_Pin1_4	19	24	PF00397	0.487
LIG_14-3-3_CanoR_1	327	336	PF00244	0.356
LIG_14-3-3_CanoR_1	364	373	PF00244	0.370
LIG_14-3-3_CanoR_1	605	611	PF00244	0.541
LIG_14-3-3_CanoR_1	623	627	PF00244	0.328
LIG_AP2alpha_1	439	443	PF02296	0.352
LIG_AP2alpha_1	517	521	PF02296	0.553
LIG_BRCT_BRCA1_1	155	159	PF00533	0.519
LIG_BRCT_BRCA1_1	611	615	PF00533	0.502
LIG_deltaCOP1_diTrp_1	296	305	PF00928	0.343
LIG_deltaCOP1_diTrp_1	309	314	PF00928	0.347
LIG_deltaCOP1_diTrp_1	334	339	PF00928	0.341
LIG_deltaCOP1_diTrp_1	368	375	PF00928	0.356
LIG_eIF4E_1	576	582	PF01652	0.543
LIG_eIF4E_1	66	72	PF01652	0.467
LIG_eIF4E_1	698	704	PF01652	0.592
LIG_FHA_1	101	107	PF00498	0.541
LIG_FHA_1	193	199	PF00498	0.376
LIG_FHA_1	328	334	PF00498	0.356
LIG_FHA_1	51	57	PF00498	0.352
LIG_FHA_1	698	704	PF00498	0.627
LIG_FHA_1	741	747	PF00498	0.575
LIG_FHA_2	136	142	PF00498	0.403
LIG_FHA_2	169	175	PF00498	0.492
LIG_FHA_2	365	371	PF00498	0.341
LIG_LIR_Apic_2	128	134	PF02991	0.444
LIG_LIR_Apic_2	334	340	PF02991	0.341
LIG_LIR_Apic_2	441	446	PF02991	0.441
LIG_LIR_Apic_2	592	598	PF02991	0.579
LIG_LIR_Apic_2	67	73	PF02991	0.414
LIG_LIR_Gen_1	120	131	PF02991	0.470
LIG_LIR_Gen_1	279	289	PF02991	0.341
LIG_LIR_Gen_1	368	379	PF02991	0.341
LIG_LIR_Gen_1	412	420	PF02991	0.435
LIG_LIR_Gen_1	55	65	PF02991	0.384
LIG_LIR_Gen_1	565	576	PF02991	0.396
LIG_LIR_Gen_1	678	688	PF02991	0.595
LIG_LIR_Gen_1	712	723	PF02991	0.412
LIG_LIR_LC3C_4	640	645	PF02991	0.508
LIG_LIR_Nem_3	120	126	PF02991	0.462
LIG_LIR_Nem_3	132	136	PF02991	0.410
LIG_LIR_Nem_3	279	283	PF02991	0.341
LIG_LIR_Nem_3	297	303	PF02991	0.341
LIG_LIR_Nem_3	309	315	PF02991	0.339
LIG_LIR_Nem_3	368	374	PF02991	0.341
LIG_LIR_Nem_3	412	417	PF02991	0.435
LIG_LIR_Nem_3	519	524	PF02991	0.489
LIG_LIR_Nem_3	55	60	PF02991	0.364
LIG_LIR_Nem_3	565	571	PF02991	0.386
LIG_LIR_Nem_3	678	684	PF02991	0.553
LIG_LIR_Nem_3	712	718	PF02991	0.429
LIG_PCNA_yPIPBox_3	707	718	PF02747	0.506
LIG_Pex14_1	252	256	PF04695	0.341
LIG_Pex14_1	371	375	PF04695	0.484
LIG_Pex14_2	439	443	PF04695	0.334
LIG_Pex14_2	475	479	PF04695	0.341
LIG_Pex14_2	517	521	PF04695	0.469
LIG_Pex14_2	57	61	PF04695	0.441
LIG_PTB_Apo_2	274	281	PF02174	0.355
LIG_SH2_CRK	414	418	PF00017	0.435
LIG_SH2_CRK	595	599	PF00017	0.483
LIG_SH2_GRB2like	256	259	PF00017	0.435
LIG_SH2_GRB2like	93	96	PF00017	0.379
LIG_SH2_NCK_1	414	418	PF00017	0.435
LIG_SH2_NCK_1	595	599	PF00017	0.424
LIG_SH2_PTP2	482	485	PF00017	0.375
LIG_SH2_SRC	256	259	PF00017	0.344
LIG_SH2_SRC	487	490	PF00017	0.377
LIG_SH2_SRC	654	657	PF00017	0.444
LIG_SH2_SRC	66	69	PF00017	0.582
LIG_SH2_STAP1	534	538	PF00017	0.410
LIG_SH2_STAP1	66	70	PF00017	0.450
LIG_SH2_STAT3	142	145	PF00017	0.466
LIG_SH2_STAT3	289	292	PF00017	0.341
LIG_SH2_STAT3	9	12	PF00017	0.557
LIG_SH2_STAT5	207	210	PF00017	0.472
LIG_SH2_STAT5	378	381	PF00017	0.356
LIG_SH2_STAT5	482	485	PF00017	0.348
LIG_SH2_STAT5	487	490	PF00017	0.368
LIG_SH2_STAT5	49	52	PF00017	0.365
LIG_SH2_STAT5	576	579	PF00017	0.505
LIG_SH2_STAT5	698	701	PF00017	0.625
LIG_SH2_STAT5	93	96	PF00017	0.379
LIG_SH3_3	305	311	PF00018	0.341
LIG_SH3_3	485	491	PF00018	0.484
LIG_SH3_3	728	734	PF00018	0.440
LIG_SUMO_SIM_anti_2	639	645	PF11976	0.373
LIG_SxIP_EBH_1	652	665	PF03271	0.466
LIG_TRAF2_1	367	370	PF00917	0.368
LIG_TRAF2_1	65	68	PF00917	0.459
LIG_WRC_WIRS_1	280	285	PF05994	0.416
LIG_WRC_WIRS_1	351	356	PF05994	0.435
LIG_WRC_WIRS_1	445	450	PF05994	0.341
LIG_WRC_WIRS_1	564	569	PF05994	0.315
LIG_WRC_WIRS_1	703	708	PF05994	0.465
MOD_CDK_SPK_2	19	24	PF00069	0.536
MOD_CK1_1	132	138	PF00069	0.512
MOD_CK1_1	353	359	PF00069	0.409
MOD_CK1_1	444	450	PF00069	0.341
MOD_CK1_1	498	504	PF00069	0.405
MOD_CK1_1	629	635	PF00069	0.555
MOD_CK1_1	639	645	PF00069	0.410
MOD_CK2_1	135	141	PF00069	0.429
MOD_CK2_1	273	279	PF00069	0.341
MOD_CK2_1	364	370	PF00069	0.341
MOD_CMANNOS	302	305	PF00535	0.341
MOD_Cter_Amidation	359	362	PF01082	0.400
MOD_GlcNHglycan	155	158	PF01048	0.452
MOD_GlcNHglycan	321	324	PF01048	0.417
MOD_GlcNHglycan	35	38	PF01048	0.528
MOD_GlcNHglycan	599	602	PF01048	0.673
MOD_GlcNHglycan	656	659	PF01048	0.493
MOD_GSK3_1	163	170	PF00069	0.414
MOD_GSK3_1	206	213	PF00069	0.571
MOD_GSK3_1	399	406	PF00069	0.344
MOD_GSK3_1	456	463	PF00069	0.435
MOD_GSK3_1	593	600	PF00069	0.487
MOD_GSK3_1	622	629	PF00069	0.494
MOD_GSK3_1	650	657	PF00069	0.431
MOD_N-GLC_1	168	173	PF02516	0.454
MOD_N-GLC_2	112	114	PF02516	0.466
MOD_N-GLC_2	258	260	PF02516	0.368
MOD_N-GLC_2	526	528	PF02516	0.379
MOD_NEK2_1	153	158	PF00069	0.431
MOD_NEK2_1	268	273	PF00069	0.341
MOD_NEK2_1	517	522	PF00069	0.457
MOD_NEK2_1	562	567	PF00069	0.386
MOD_NEK2_1	650	655	PF00069	0.424
MOD_NEK2_2	350	355	PF00069	0.435
MOD_NEK2_2	702	707	PF00069	0.445
MOD_PIKK_1	327	333	PF00454	0.344
MOD_PKA_1	622	628	PF00069	0.549
MOD_PKA_2	319	325	PF00069	0.417
MOD_PKA_2	517	523	PF00069	0.437
MOD_PKA_2	622	628	PF00069	0.460
MOD_PKB_1	362	370	PF00069	0.368
MOD_Plk_1	119	125	PF00069	0.463
MOD_Plk_1	441	447	PF00069	0.341
MOD_Plk_1	562	568	PF00069	0.311
MOD_Plk_1	639	645	PF00069	0.378
MOD_Plk_1	650	656	PF00069	0.390
MOD_Plk_1	66	72	PF00069	0.467
MOD_Plk_1	694	700	PF00069	0.628
MOD_Plk_2-3	119	125	PF00069	0.463
MOD_Plk_4	207	213	PF00069	0.516
MOD_Plk_4	563	569	PF00069	0.345
MOD_Plk_4	622	628	PF00069	0.483
MOD_Plk_4	639	645	PF00069	0.429
MOD_Plk_4	66	72	PF00069	0.473
MOD_Plk_4	694	700	PF00069	0.655
MOD_ProDKin_1	19	25	PF00069	0.487
MOD_SUMO_for_1	354	357	PF00179	0.356
MOD_SUMO_for_1	41	44	PF00179	0.575
MOD_SUMO_for_1	610	613	PF00179	0.476
MOD_SUMO_for_1	738	741	PF00179	0.457
TRG_DiLeu_BaEn_1	369	374	PF01217	0.338
TRG_DiLeu_BaEn_1	67	72	PF01217	0.466
TRG_DiLeu_BaEn_1	713	718	PF01217	0.415
TRG_DiLeu_BaEn_2	278	284	PF01217	0.341
TRG_DiLeu_BaEn_4	15	21	PF01217	0.518
TRG_DiLeu_BaLyEn_6	699	704	PF01217	0.453
TRG_ENDOCYTIC_2	414	417	PF00928	0.429
TRG_ENDOCYTIC_2	440	443	PF00928	0.354
TRG_ENDOCYTIC_2	482	485	PF00928	0.375
TRG_ER_diArg_1	142	144	PF00400	0.415
TRG_ER_diArg_1	362	365	PF00400	0.368
TRG_ER_diArg_1	475	477	PF00400	0.356
TRG_ER_diArg_1	536	538	PF00400	0.514
TRG_ER_diArg_1	579	581	PF00400	0.454
TRG_NES_CRM1_1	44	58	PF08389	0.392
TRG_NES_CRM1_1	563	575	PF08389	0.400
TRG_Pf-PMV_PEXEL_1	24	29	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	364	368	PF00026	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMA1	Leptomonas seymouri	78%	100%
A0A0S4JIK4	Bodo saltans	57%	100%
A0A1X0NZP4	Trypanosomatidae	62%	100%
A0A3S7X2D6	Leishmania donovani	96%	100%
A0A422NF05	Trypanosoma rangeli	60%	100%
A4HHA6	Leishmania braziliensis	84%	100%
A4I4F2	Leishmania infantum	96%	100%
C9ZLK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9ALX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BR85	Trypanosoma cruzi	61%	100%