Putative A-1 protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

A-1 protein, putative

Species:

Leishmania major

UniProt:

E9ADV1_LEIMA

TriTrypDb:

LmjF.29.0935 , LMJLV39_290015800 , LMJSD75_290015800

Length:

175

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADV1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADV1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	77	81	PF00656	0.556
CLV_NRD_NRD_1	154	156	PF00675	0.632
CLV_NRD_NRD_1	29	31	PF00675	0.597
CLV_NRD_NRD_1	4	6	PF00675	0.814
CLV_PCSK_KEX2_1	29	31	PF00082	0.597
CLV_PCSK_KEX2_1	6	8	PF00082	0.817
CLV_PCSK_KEX2_1	64	66	PF00082	0.515
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.817
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.671
CLV_PCSK_SKI1_1	156	160	PF00082	0.684
CLV_PCSK_SKI1_1	76	80	PF00082	0.738
CLV_PCSK_SKI1_1	92	96	PF00082	0.733
DEG_Nend_UBRbox_2	1	3	PF02207	0.842
DEG_SPOP_SBC_1	44	48	PF00917	0.716
DOC_CYCLIN_RxL_1	153	162	PF00134	0.682
DOC_PP2B_LxvP_1	121	124	PF13499	0.778
DOC_USP7_MATH_1	36	40	PF00917	0.599
DOC_USP7_MATH_1	44	48	PF00917	0.640
DOC_WW_Pin1_4	45	50	PF00397	0.663
LIG_14-3-3_CanoR_1	65	73	PF00244	0.653
LIG_Dynein_DLC8_1	140	146	PF01221	0.796
LIG_FHA_1	65	71	PF00498	0.489
LIG_FHA_2	142	148	PF00498	0.778
LIG_FHA_2	46	52	PF00498	0.643
LIG_FHA_2	88	94	PF00498	0.828
LIG_LIR_Gen_1	164	174	PF02991	0.646
LIG_LIR_Gen_1	56	63	PF02991	0.699
LIG_LIR_Nem_3	164	170	PF02991	0.486
LIG_LIR_Nem_3	56	62	PF02991	0.542
LIG_NRBOX	165	171	PF00104	0.632
LIG_SH2_CRK	167	171	PF00017	0.501
LIG_SH2_CRK	59	63	PF00017	0.517
LIG_SH2_STAP1	59	63	PF00017	0.678
LIG_SH2_STAT5	167	170	PF00017	0.611
LIG_SxIP_EBH_1	40	49	PF03271	0.718
LIG_TRAF2_1	48	51	PF00917	0.713
LIG_TRAF2_1	83	86	PF00917	0.813
MOD_CK1_1	117	123	PF00069	0.765
MOD_CK1_1	148	154	PF00069	0.617
MOD_CK2_1	141	147	PF00069	0.786
MOD_CK2_1	44	50	PF00069	0.720
MOD_CK2_1	87	93	PF00069	0.831
MOD_GlcNHglycan	116	119	PF01048	0.725
MOD_GlcNHglycan	20	26	PF01048	0.718
MOD_GlcNHglycan	40	43	PF01048	0.487
MOD_GSK3_1	141	148	PF00069	0.684
MOD_GSK3_1	161	168	PF00069	0.540
MOD_GSK3_1	81	88	PF00069	0.657
MOD_GSK3_1	92	99	PF00069	0.761
MOD_N-GLC_1	10	15	PF02516	0.735
MOD_PIKK_1	141	147	PF00454	0.701
MOD_PIKK_1	81	87	PF00454	0.750
MOD_PIKK_1	92	98	PF00454	0.666
MOD_PKA_1	64	70	PF00069	0.514
MOD_PKA_2	138	144	PF00069	0.713
MOD_PKA_2	64	70	PF00069	0.656
MOD_Plk_4	107	113	PF00069	0.657
MOD_Plk_4	117	123	PF00069	0.720
MOD_Plk_4	165	171	PF00069	0.471
MOD_ProDKin_1	45	51	PF00069	0.661
TRG_DiLeu_BaEn_1	165	170	PF01217	0.629
TRG_ENDOCYTIC_2	167	170	PF00928	0.498
TRG_ENDOCYTIC_2	59	62	PF00928	0.520
TRG_ER_diArg_1	28	30	PF00400	0.593
TRG_NLS_MonoExtC_3	4	9	PF00514	0.818
TRG_NLS_MonoExtN_4	5	10	PF00514	0.818

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X2A2	Leishmania donovani	92%	100%
A4HHA5	Leishmania braziliensis	74%	100%
A4I4F1	Leishmania infantum	92%	100%
E9ALX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%